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Protein

Mercuric resistance operon regulatory protein

Gene

merR

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Mercury1
Metal bindingi117Mercury1
Metal bindingi126Mercury1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 29H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processMercuric resistance, Transcription, Transcription regulation
LigandMercury, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mercuric resistance operon regulatory protein
Gene namesi
Name:merR
Encoded oniPlasmid pVS10 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82C → A: Abolishes transcriptional activation. 1 Publication1
Mutagenesisi115C → A: Slight increase in transcriptional activation. 1 Publication1
Mutagenesisi117C → A: Decrease in transcriptional activation. 1 Publication1
Mutagenesisi126C → S: Abolishes transcriptional activation; loss of Hg binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981361 – 144Mercuric resistance operon regulatory proteinAdd BLAST144

Proteomic databases

PRIDEiP0A183

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A183
SMRiP0A183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 76HTH merR-typePROSITE-ProRule annotationAdd BLAST70

Family and domain databases

CDDicd04783 HTH_MerR1, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR011794 MerR
IPR000551 MerR-type_HTH_dom
IPR015358 Tscrpt_reg_MerR_DNA-bd
PfamiView protein in Pfam
PF00376 MerR, 1 hit
PF09278 MerR-DNA-bind, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02051 MerR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLLEPDKPY GSIRRYGEAD
60 70 80 90 100
VTRVRFVKSA QRLGFSLDEI AELLRLEDGT HCEEASSLAE HKLKDVREKM
110 120 130 140
ADLARMEAVL SELVCACHAR RGNVSCPLIA SLQGGASLAG SAMP
Length:144
Mass (Da):15,763
Last modified:January 1, 1988 - v1
Checksum:iC573298AFF0846EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z00027 Genomic DNA Translation: CAA77320.1
PIRiA47593
RefSeqiWP_003131969.1, NZ_QBEP01000010.1

Genome annotation databases

GeneIDi34794311

Similar proteinsi

Entry informationi

Entry nameiMERR_PSEAI
AccessioniPrimary (citable) accession number: P0A183
Secondary accession number(s): P06688
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 18, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid, Transposable element
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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