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UniProtKB - P0A0T1 (G6PI_XANCI)
Protein
Glucose-6-phosphate isomerase
Gene
pgi
Organism
Xanthomonas citri (Xanthomonas campestris pv. citri)
Status
Functioni
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
UniRule annotationRequired for pathogenicity.
Miscellaneous
Mutation in pgi results in the inability of X.c.citri to utilize fructose or glycerol as carbon sources, to grow in plant tissue, and to cause typical canker symptoms.
Catalytic activityi
- EC:5.3.1.9UniRule annotation
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
Pathwayi: glycolysis
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 333 | Proton donorUniRule annotation | 1 | |
Active sitei | 364 | UniRule annotation | 1 | |
Active sitei | 473 | UniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: UniProtKB-UniRule
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniRule
- glycolytic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00181 UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation |
Gene namesi | Name:pgiUniRule annotation |
Organismi | Xanthomonas citri (Xanthomonas campestris pv. citri) |
Taxonomic identifieri | 346 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180771 | 1 – 504 | Glucose-6-phosphate isomeraseAdd BLAST | 504 |
Expressioni
Inductioni
Inhibited by growth in complex medium but induced by culture in plant extract.
Family & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd05015, SIS_PGI_1, 1 hit cd05016, SIS_PGI_2, 1 hit |
Gene3Di | 1.10.1390.10, 1 hit |
HAMAPi | MF_00473, G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672, G6P_Isomerase IPR023096, G6P_Isomerase_C IPR018189, Phosphoglucose_isomerase_CS IPR035476, SIS_PGI_1 IPR035482, SIS_PGI_2 |
PANTHERi | PTHR11469, PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342, PGI, 1 hit |
PRINTSi | PR00662, G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765, P_GLUCOSE_ISOMERASE_1, 1 hit PS00174, P_GLUCOSE_ISOMERASE_2, 1 hit PS51463, P_GLUCOSE_ISOMERASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A0T1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQTNGFDAL HAHAQRLRGA AIPALLAAEP ERPTQYARQV GPLYFNFARQ
60 70 80 90 100
KYDRAALDAL FAIARERDLS GAFQRLFRGE QVNVTEQRAA LHTALRGDLT
110 120 130 140 150
DAPVASEAYA TAEEVRQRMG SLIQQLEATD VTDIVSVGIG GSDLGPRLVA
160 170 180 190 200
DALRAPSGAR FRVHFVSNVD GAAMQRTLAT LDPARTAGIL ISKTFGTQET
210 220 230 240 250
LLNGSILHAW LGGSERLYAV SANPERAAKA FDIAPGRVLP MWDWVGGRYS
260 270 280 290 300
LWSAVGFPIA LAIGFERFEQ LLEGAAQFDA HVLNTPLEEN VAVLHGLTAV
310 320 330 340 350
WNRNLLGSAT HAVMTYDQRL ALLPAYLQQL VMESLGKRVK LDGSAVDSDT
360 370 380 390 400
VSVWWGGAGT DVQHSFFQAL HQGTSVVPAD FIGTVHNDDP YAENHTALMA
410 420 430 440 450
NVLAQTEALA NGQDSSDPHR SYPGGRPSTV ILLDALTPQA LGALISMYEH
460 470 480 490 500
SVYVQSVMWG INAFDQFGVE LGKQLASQLL PALKGESVDV ADPVTRELLN
KLRG
Sequence cautioni
The sequence AAC08426 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054807 Genomic DNA Translation: AAC08426.1 Different initiation. |
PIRi | T46970 |
RefSeqi | WP_011051139.1, NZ_CP059992.1 |
Genome annotation databases
GeneIDi | 66910936 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054807 Genomic DNA Translation: AAC08426.1 Different initiation. |
PIRi | T46970 |
RefSeqi | WP_011051139.1, NZ_CP059992.1 |
3D structure databases
SMRi | P0A0T1 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 66910936 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00181 UPA00138 |
Family and domain databases
CDDi | cd05015, SIS_PGI_1, 1 hit cd05016, SIS_PGI_2, 1 hit |
Gene3Di | 1.10.1390.10, 1 hit |
HAMAPi | MF_00473, G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672, G6P_Isomerase IPR023096, G6P_Isomerase_C IPR018189, Phosphoglucose_isomerase_CS IPR035476, SIS_PGI_1 IPR035482, SIS_PGI_2 |
PANTHERi | PTHR11469, PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342, PGI, 1 hit |
PRINTSi | PR00662, G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765, P_GLUCOSE_ISOMERASE_1, 1 hit PS00174, P_GLUCOSE_ISOMERASE_2, 1 hit PS51463, P_GLUCOSE_ISOMERASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G6PI_XANCI | |
Accessioni | P0A0T1Primary (citable) accession number: P0A0T1 Secondary accession number(s): O68824 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families