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Protein

Bacterioferritin A

Gene

bfrA

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bCuratedNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.Curated
  • Fe cationBy similarityNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 1PROSITE-ProRule annotation1
Metal bindingi48Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi51Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 2PROSITE-ProRule annotation1
Metal bindingi54Iron 1PROSITE-ProRule annotation1
Metal bindingi93Iron 2PROSITE-ProRule annotation1
Metal bindingi127Iron 1PROSITE-ProRule annotation1
Metal bindingi127Iron 2PROSITE-ProRule annotation1
Metal bindingi130Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin A (EC:1.16.3.1)
Short name:
BFR A
Gene namesi
Name:bfrA
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926051 – 154Bacterioferritin AAdd BLAST154

Interactioni

Subunit structurei

Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A0R2
SMRiP0A0R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated

Phylogenomic databases

eggNOGiENOG4108YRX Bacteria
COG2193 LUCA

Family and domain databases

CDDicd00907 Bacterioferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR002024 Bacterioferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
PIRSFiPIRSF002560 Bacterioferritin, 1 hit
PRINTSiPR00601 BACFERRITIN
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR00754 bfr, 1 hit
PROSITEiView protein in PROSITE
PS00549 BACTERIOFERRITIN, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGNQAVVDY MNELLSGELA ARDQYFIHSR LYSEWGYTKL FERLNHEMEE
60 70 80 90 100
ETTHAEDFIR RILMLGGTPK MARAELNIGT DVVSCLKADL QTEYEVRDAL
110 120 130 140 150
KKGIKLCEEA QDYVTRDLMV AQLKDTEEDH AHWLEQQLRL IELIGEGNYY

QSQL
Length:154
Mass (Da):17,961
Last modified:February 15, 2005 - v1
Checksum:i15136D10DDA4346A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76633 Genomic DNA Translation: AAB18968.1
RefSeqiWP_002217177.1, NZ_PTPT01000001.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76633 Genomic DNA Translation: AAB18968.1
RefSeqiWP_002217177.1, NZ_PTPT01000001.1

3D structure databases

ProteinModelPortaliP0A0R2
SMRiP0A0R2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108YRX Bacteria
COG2193 LUCA

Family and domain databases

CDDicd00907 Bacterioferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR002024 Bacterioferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
PIRSFiPIRSF002560 Bacterioferritin, 1 hit
PRINTSiPR00601 BACFERRITIN
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR00754 bfr, 1 hit
PROSITEiView protein in PROSITE
PS00549 BACTERIOFERRITIN, 1 hit
PS50905 FERRITIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBFRA_NEIGO
AccessioniPrimary (citable) accession number: P0A0R2
Secondary accession number(s): P72080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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