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Protein

Bacterioferritin A

Gene

bfrA

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bCuratedNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.Curated
  • Fe cationBy similarityNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 1PROSITE-ProRule annotation1
Metal bindingi48Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi51Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 2PROSITE-ProRule annotation1
Metal bindingi54Iron 1PROSITE-ProRule annotation1
Metal bindingi93Iron 2PROSITE-ProRule annotation1
Metal bindingi127Iron 1PROSITE-ProRule annotation1
Metal bindingi127Iron 2PROSITE-ProRule annotation1
Metal bindingi130Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-1166-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin A (EC:1.16.3.1)
Short name:
BFR A
Gene namesi
Name:bfrA
Ordered Locus Names:NMB1207
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926041 – 154Bacterioferritin AAdd BLAST154

Proteomic databases

PaxDbiP0A0R1

Interactioni

Subunit structurei

Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Protein-protein interaction databases

STRINGi122586.NMB1207

Structurei

3D structure databases

ProteinModelPortaliP0A0R1
SMRiP0A0R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated

Phylogenomic databases

eggNOGiENOG4108YRX Bacteria
COG2193 LUCA
HOGENOMiHOG000262383
KOiK03594
OMAiHEMQDET
OrthoDBiPOG091H0B0I

Family and domain databases

CDDicd00907 Bacterioferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR002024 Bacterioferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
PIRSFiPIRSF002560 Bacterioferritin, 1 hit
PRINTSiPR00601 BACFERRITIN
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR00754 bfr, 1 hit
PROSITEiView protein in PROSITE
PS00549 BACTERIOFERRITIN, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGNQAVVDY MNELLSGELA ARDQYFIHSR LYSEWGYTKL FERLNHEMEE
60 70 80 90 100
ETTHAEDFIR RILMLGGTPK MARAELNIGT DVVSCLKADL QTEYEVRDAL
110 120 130 140 150
KKGIKLCEEA QDYVTRDLMV AQLKDTEEDH AHWLEQQLRL IELIGEGNYY

QSQL
Length:154
Mass (Da):17,961
Last modified:February 15, 2005 - v1
Checksum:i15136D10DDA4346A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF41589.1
PIRiF81110
RefSeqiNP_274232.1, NC_003112.2
WP_002217177.1, NC_003112.2

Genome annotation databases

EnsemblBacteriaiAAF41589; AAF41589; NMB1207
GeneIDi903629
KEGGinme:NMB1207
PATRICifig|122586.8.peg.1514

Similar proteinsi

Entry informationi

Entry nameiBFRA_NEIMB
AccessioniPrimary (citable) accession number: P0A0R1
Secondary accession number(s): P72080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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