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Protein

Mannitol-specific phosphotransferase enzyme IIA component

Gene

mtlF

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Tele-phosphohistidine intermediatePROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol-specific phosphotransferase enzyme IIA componentBy similarity
Alternative name(s):
EIIABy similarity
EIIIBy similarity
PTS system mannitol-specific EIIA componentBy similarity
Gene namesi
Name:mtlF
Synonyms:mtlA
Ordered Locus Names:SAV2158
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001866372 – 144Mannitol-specific phosphotransferase enzyme IIA componentAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Phosphohistidine; by HPrBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0A0D7
PRIDEiP0A0D7

Interactioni

Subunit structurei

Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.By similarity

Protein-protein interaction databases

STRINGi158878.SAV2158

Structurei

3D structure databases

ProteinModelPortaliP0A0D7
SMRiP0A0D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST140

Domaini

The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DTZ Bacteria
COG4668 LUCA
HOGENOMiHOG000227563
KOiK02798
OMAiISIVQVP
PhylomeDBiP0A0D7

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELFSNDNI FLNVNVNSQN EAIEKAGKAL VDSGAVTDAY IQAMKDREQV
60 70 80 90 100
VSTFMGNGLA IPHGTDEAKT NVIHSGLTLL QIPEGVDWDG EVVKVVVGIA
110 120 130 140
GKDGEHLDLL SKIAITFSEE ENVDRIVQAK SAEEIKQVFE EADA
Length:144
Mass (Da):15,542
Last modified:January 23, 2007 - v2
Checksum:iB166851EEBC3A5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58320.1
RefSeqiWP_001292149.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58320; BAB58320; SAV2158
KEGGisav:SAV2158

Similar proteinsi

Entry informationi

Entry nameiPTMA_STAAM
AccessioniPrimary (citable) accession number: P0A0D7
Secondary accession number(s): P17875, Q9RL67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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