UniProtKB - P0A0D7 (PTMA_STAAM)
Protein
Mannitol-specific phosphotransferase enzyme IIA component
Gene
mtlF
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | Tele-phosphohistidine intermediatePROSITE-ProRule annotationBy similarity | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | SAUR158878:SAV_RS11770-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Mannitol-specific phosphotransferase enzyme IIA componentBy similarityAlternative name(s): EIIABy similarity EIIIBy similarity PTS system mannitol-specific EIIA componentBy similarity |
Gene namesi | Name:mtlF Synonyms:mtlA Ordered Locus Names:SAV2158 |
Organismi | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
Taxonomic identifieri | 158878 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000186637 | 2 – 144 | Mannitol-specific phosphotransferase enzyme IIA componentAdd BLAST | 143 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | Phosphohistidine; by HPrBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P0A0D7 |
Interactioni
Subunit structurei
Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 142 | PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST | 140 |
Domaini
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | CLU_072531_3_0_9 |
OMAi | HGVSEYV |
PhylomeDBi | P0A0D7 |
Family and domain databases
CDDi | cd00211, PTS_IIA_fru, 1 hit |
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR016152, PTrfase/Anion_transptr IPR002178, PTS_EIIA_type-2_dom |
Pfami | View protein in Pfam PF00359, PTS_EIIA_2, 1 hit |
SUPFAMi | SSF55804, SSF55804, 1 hit |
PROSITEi | View protein in PROSITE PS51094, PTS_EIIA_TYPE_2, 1 hit PS00372, PTS_EIIA_TYPE_2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A0D7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSELFSNDNI FLNVNVNSQN EAIEKAGKAL VDSGAVTDAY IQAMKDREQV
60 70 80 90 100
VSTFMGNGLA IPHGTDEAKT NVIHSGLTLL QIPEGVDWDG EVVKVVVGIA
110 120 130 140
GKDGEHLDLL SKIAITFSEE ENVDRIVQAK SAEEIKQVFE EADA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000017 Genomic DNA Translation: BAB58320.1 |
RefSeqi | WP_001292149.1, NC_002758.2 |
Genome annotation databases
EnsemblBacteriai | BAB58320; BAB58320; SAV2158 |
GeneIDi | 58068007 59700961 |
KEGGi | sav:SAV2158 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000017 Genomic DNA Translation: BAB58320.1 |
RefSeqi | WP_001292149.1, NC_002758.2 |
3D structure databases
SMRi | P0A0D7 |
ModBasei | Search... |
Proteomic databases
PaxDbi | P0A0D7 |
Genome annotation databases
EnsemblBacteriai | BAB58320; BAB58320; SAV2158 |
GeneIDi | 58068007 59700961 |
KEGGi | sav:SAV2158 |
Phylogenomic databases
HOGENOMi | CLU_072531_3_0_9 |
OMAi | HGVSEYV |
PhylomeDBi | P0A0D7 |
Enzyme and pathway databases
BioCyci | SAUR158878:SAV_RS11770-MONOMER |
Family and domain databases
CDDi | cd00211, PTS_IIA_fru, 1 hit |
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR016152, PTrfase/Anion_transptr IPR002178, PTS_EIIA_type-2_dom |
Pfami | View protein in Pfam PF00359, PTS_EIIA_2, 1 hit |
SUPFAMi | SSF55804, SSF55804, 1 hit |
PROSITEi | View protein in PROSITE PS51094, PTS_EIIA_TYPE_2, 1 hit PS00372, PTS_EIIA_TYPE_2_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTMA_STAAM | |
Accessioni | P0A0D7Primary (citable) accession number: P0A0D7 Secondary accession number(s): P17875, Q9RL67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 87 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |