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Entry version 209 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Fructose-bisphosphate aldolase C

Gene

ALDOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.7 µM for fructose 1,6-bisphosphate1 Publication
  2. KM=16 mM for fructose 1-phosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose. This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
Binding sitei147Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03200-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P09972

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695, Neutrophil degranulation
R-HSA-70171, Glycolysis
R-HSA-70263, Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P09972

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00183

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C (EC:4.1.2.13)
Alternative name(s):
Brain-type aldolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALDOC
Synonyms:ALDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:418, ALDOC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103870, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09972

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000109107

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
230

Open Targets

More...
OpenTargetsi
ENSG00000109107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24711

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P09972, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295709

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALDOC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113613

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169471 – 364Fructose-bisphosphate aldolase CAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei132PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1372
CPTAC-1373
CPTAC-1374
CPTAC-1375
CPTAC-1376

Encyclopedia of Proteome Dynamics

More...
EPDi
P09972

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09972

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P09972

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09972

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09972

PeptideAtlas

More...
PeptideAtlasi
P09972

PRoteomics IDEntifications database

More...
PRIDEi
P09972

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52287

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P09972

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P09972, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09972

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09972

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109107, Expressed in right hemisphere of cerebellum and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09972, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09972, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000109107, Group enriched (brain, heart muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with ATP6V1E1. May interact with PLD2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
106731, 88 interactors

Protein interaction database and analysis system

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IntActi
P09972, 16 interactors

Molecular INTeraction database

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MINTi
P09972

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226253

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P09972, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09972

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09972

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1557, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031243_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09972

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWRAPIL

Database of Orthologous Groups

More...
OrthoDBi
799973at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09972

TreeFam database of animal gene trees

More...
TreeFami
TF314203

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00274, Glycolytic, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P09972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE
60 70 80 90 100
NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD
110 120 130 140 150
KGIVVGIKVD KGVVPLAGTD GETTTQGLDG LSERCAQYKK DGADFAKWRC
160 170 180 190 200
VLKISERTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
210 220 230 240 250
RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYTPEEIA
260 270 280 290 300
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF
310 320 330 340 350
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG
360
GAAAQSLYIA NHAY
Length:364
Mass (Da):39,456
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i506A570B3E507971
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MVZ9A8MVZ9_HUMAN
Fructose-bisphosphate aldolase
ALDOC
336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8F3C9J8F3_HUMAN
Fructose-bisphosphate aldolase
ALDOC
149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKK1J3QKK1_HUMAN
Fructose-bisphosphate aldolase
ALDOC
122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKP5J3QKP5_HUMAN
Fructose-bisphosphate aldolase
ALDOC
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSV6J3KSV6_HUMAN
Fructose-bisphosphate aldolase
ALDOC
175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKH5K7EKH5_HUMAN
Fructose-bisphosphate aldolase
ALDOC
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI03761 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti311L → V in CAA30270 (PubMed:3267224).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X05196 Genomic DNA Translation: CAA28825.1
X07292 Genomic DNA Translation: CAA30270.1
AF054987 mRNA Translation: AAC09348.1
BT007006 mRNA Translation: AAP35652.1
CR541862 mRNA Translation: CAG46660.1
CR541881 mRNA Translation: CAG46679.1
AK312281 mRNA Translation: BAG35210.1
CH471159 Genomic DNA Translation: EAW51104.1
BC003613 mRNA Translation: AAH03613.3
BC103760 mRNA Translation: AAI03761.1 Different initiation.
BC065565 mRNA Translation: AAH65565.2
BC106925 mRNA Translation: AAI06926.1
BC106926 mRNA Translation: AAI06927.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11236.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25861, ADHUC

NCBI Reference Sequences

More...
RefSeqi
NP_005156.1, NM_005165.2
XP_005258006.1, XM_005257949.2
XP_011522858.1, XM_011524556.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000226253; ENSP00000226253; ENSG00000109107
ENST00000395321; ENSP00000378731; ENSG00000109107

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
230

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:230

UCSC genome browser

More...
UCSCi
uc002hbp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05196 Genomic DNA Translation: CAA28825.1
X07292 Genomic DNA Translation: CAA30270.1
AF054987 mRNA Translation: AAC09348.1
BT007006 mRNA Translation: AAP35652.1
CR541862 mRNA Translation: CAG46660.1
CR541881 mRNA Translation: CAG46679.1
AK312281 mRNA Translation: BAG35210.1
CH471159 Genomic DNA Translation: EAW51104.1
BC003613 mRNA Translation: AAH03613.3
BC103760 mRNA Translation: AAI03761.1 Different initiation.
BC065565 mRNA Translation: AAH65565.2
BC106925 mRNA Translation: AAI06926.1
BC106926 mRNA Translation: AAI06927.1
CCDSiCCDS11236.1
PIRiA25861, ADHUC
RefSeqiNP_005156.1, NM_005165.2
XP_005258006.1, XM_005257949.2
XP_011522858.1, XM_011524556.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XFBX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L1-364[»]
SMRiP09972
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106731, 88 interactors
IntActiP09972, 16 interactors
MINTiP09972
STRINGi9606.ENSP00000226253

Chemistry databases

ChEMBLiCHEMBL4295709

PTM databases

GlyGeniP09972, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP09972
PhosphoSitePlusiP09972
SwissPalmiP09972

Genetic variation databases

BioMutaiALDOC
DMDMi113613

2D gel databases

UCD-2DPAGEiP09972

Proteomic databases

CPTACiCPTAC-1372
CPTAC-1373
CPTAC-1374
CPTAC-1375
CPTAC-1376
EPDiP09972
jPOSTiP09972
MassIVEiP09972
MaxQBiP09972
PaxDbiP09972
PeptideAtlasiP09972
PRIDEiP09972
ProteomicsDBi52287

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1111, 454 antibodies

The DNASU plasmid repository

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DNASUi
230

Genome annotation databases

EnsembliENST00000226253; ENSP00000226253; ENSG00000109107
ENST00000395321; ENSP00000378731; ENSG00000109107
GeneIDi230
KEGGihsa:230
UCSCiuc002hbp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
230
DisGeNETi230

GeneCards: human genes, protein and diseases

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GeneCardsi
ALDOC
HGNCiHGNC:418, ALDOC
HPAiENSG00000109107, Group enriched (brain, heart muscle)
MIMi103870, gene
neXtProtiNX_P09972
OpenTargetsiENSG00000109107
PharmGKBiPA24711
VEuPathDBiHostDB:ENSG00000109107

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1557, Eukaryota
GeneTreeiENSGT00950000182987
HOGENOMiCLU_031243_0_0_1
InParanoidiP09972
OMAiKWRAPIL
OrthoDBi799973at2759
PhylomeDBiP09972
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayiUPA00109;UER00183
BioCyciMetaCyc:HS03200-MONOMER
PathwayCommonsiP09972
ReactomeiR-HSA-6798695, Neutrophil degranulation
R-HSA-70171, Glycolysis
R-HSA-70263, Gluconeogenesis
SABIO-RKiP09972

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
230, 32 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ALDOC, human
EvolutionaryTraceiP09972

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Aldolase_C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
230
PharosiP09972, Tbio

Protein Ontology

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PROi
PR:P09972
RNActiP09972, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000109107, Expressed in right hemisphere of cerebellum and 230 other tissues
ExpressionAtlasiP09972, baseline and differential
GenevisibleiP09972, HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I
PfamiView protein in Pfam
PF00274, Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALDOC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09972
Secondary accession number(s): B2R5R3
, Q3SYL3, Q6FH94, Q6P0L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 209 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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