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Protein

Fructose-bisphosphate aldolase C

Gene

ALDOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.7 µM for fructose 1,6-bisphosphate1 Publication
  2. KM=16 mM for fructose 1-phosphate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
    3. ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
    4. Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (BQ8482_350140), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase B (ALDOB)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
    Binding sitei147Substrate1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • cytoskeletal protein binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: UniProtKB

    GO - Biological processi

    • canonical glycolysis Source: Reactome
    • epithelial cell differentiation Source: UniProtKB
    • fructose 1,6-bisphosphate metabolic process Source: UniProtKB
    • fructose metabolic process Source: ProtInc
    • gluconeogenesis Source: Reactome
    • neutrophil degranulation Source: Reactome

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processGlycolysis
    LigandSchiff base

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS03200-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P09972

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00183

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ALDOC
    Synonyms:ALDC
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000109107.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:418 ALDOC

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    103870 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P09972

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    230

    Open Targets

    More...
    OpenTargetsi
    ENSG00000109107

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24711

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ALDOC

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    113613

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169471 – 364Fructose-bisphosphate aldolase CAdd BLAST364

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphotyrosineBy similarity1
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphoserineCombined sources1
    Modified residuei45PhosphoserineCombined sources1
    Modified residuei111N6-acetyllysineCombined sources1
    Modified residuei132PhosphoserineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P09972

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P09972

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P09972

    PeptideAtlas

    More...
    PeptideAtlasi
    P09972

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P09972

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    52287

    2D gel databases

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    P09972

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P09972

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P09972

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P09972

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000109107 Expressed in 218 organ(s), highest expression level in right hemisphere of cerebellum

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ALDOC

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P09972 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P09972 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB020828
    HPA003282
    HPA067442

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    106731, 69 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P09972, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000226253

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P09972

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P09972

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P09972

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1557 Eukaryota
    COG3588 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155990

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG002386

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P09972

    KEGG Orthology (KO)

    More...
    KOi
    K01623

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MTHQYPA

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0A9T

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P09972

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314203

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00274 Glycolytic, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

    P09972-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE
    60 70 80 90 100
    NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD
    110 120 130 140 150
    KGIVVGIKVD KGVVPLAGTD GETTTQGLDG LSERCAQYKK DGADFAKWRC
    160 170 180 190 200
    VLKISERTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
    210 220 230 240 250
    RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYTPEEIA
    260 270 280 290 300
    MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF
    310 320 330 340 350
    SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG
    360
    GAAAQSLYIA NHAY
    Length:364
    Mass (Da):39,456
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i506A570B3E507971
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A8MVZ9A8MVZ9_HUMAN
    Fructose-bisphosphate aldolase
    ALDOC
    336Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J8F3C9J8F3_HUMAN
    Fructose-bisphosphate aldolase C
    ALDOC
    149Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KSV6J3KSV6_HUMAN
    Fructose-bisphosphate aldolase C
    ALDOC
    175Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EKH5K7EKH5_HUMAN
    Fructose-bisphosphate aldolase C
    ALDOC
    135Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QKP5J3QKP5_HUMAN
    Fructose-bisphosphate aldolase C
    ALDOC
    180Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QKK1J3QKK1_HUMAN
    Fructose-bisphosphate aldolase C
    ALDOC
    122Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAI03761 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti311L → V in CAA30270 (PubMed:3267224).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X05196 Genomic DNA Translation: CAA28825.1
    X07292 Genomic DNA Translation: CAA30270.1
    AF054987 mRNA Translation: AAC09348.1
    BT007006 mRNA Translation: AAP35652.1
    CR541862 mRNA Translation: CAG46660.1
    CR541881 mRNA Translation: CAG46679.1
    AK312281 mRNA Translation: BAG35210.1
    CH471159 Genomic DNA Translation: EAW51104.1
    BC003613 mRNA Translation: AAH03613.3
    BC103760 mRNA Translation: AAI03761.1 Different initiation.
    BC065565 mRNA Translation: AAH65565.2
    BC106925 mRNA Translation: AAI06926.1
    BC106926 mRNA Translation: AAI06927.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11236.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A25861 ADHUC

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_005156.1, NM_005165.2
    XP_005258006.1, XM_005257949.2
    XP_011522858.1, XM_011524556.1

    UniGene gene-oriented nucleotide sequence clusters

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    UniGenei
    Hs.155247

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000226253; ENSP00000226253; ENSG00000109107
    ENST00000395321; ENSP00000378731; ENSG00000109107

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    230

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:230

    UCSC genome browser

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    UCSCi
    uc002hbp.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X05196 Genomic DNA Translation: CAA28825.1
    X07292 Genomic DNA Translation: CAA30270.1
    AF054987 mRNA Translation: AAC09348.1
    BT007006 mRNA Translation: AAP35652.1
    CR541862 mRNA Translation: CAG46660.1
    CR541881 mRNA Translation: CAG46679.1
    AK312281 mRNA Translation: BAG35210.1
    CH471159 Genomic DNA Translation: EAW51104.1
    BC003613 mRNA Translation: AAH03613.3
    BC103760 mRNA Translation: AAI03761.1 Different initiation.
    BC065565 mRNA Translation: AAH65565.2
    BC106925 mRNA Translation: AAI06926.1
    BC106926 mRNA Translation: AAI06927.1
    CCDSiCCDS11236.1
    PIRiA25861 ADHUC
    RefSeqiNP_005156.1, NM_005165.2
    XP_005258006.1, XM_005257949.2
    XP_011522858.1, XM_011524556.1
    UniGeneiHs.155247

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1XFBX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L1-364[»]
    ProteinModelPortaliP09972
    SMRiP09972
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106731, 69 interactors
    IntActiP09972, 8 interactors
    STRINGi9606.ENSP00000226253

    PTM databases

    iPTMnetiP09972
    PhosphoSitePlusiP09972
    SwissPalmiP09972

    Polymorphism and mutation databases

    BioMutaiALDOC
    DMDMi113613

    2D gel databases

    UCD-2DPAGEiP09972

    Proteomic databases

    EPDiP09972
    MaxQBiP09972
    PaxDbiP09972
    PeptideAtlasiP09972
    PRIDEiP09972
    ProteomicsDBi52287

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    230
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000226253; ENSP00000226253; ENSG00000109107
    ENST00000395321; ENSP00000378731; ENSG00000109107
    GeneIDi230
    KEGGihsa:230
    UCSCiuc002hbp.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    230
    DisGeNETi230
    EuPathDBiHostDB:ENSG00000109107.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ALDOC
    HGNCiHGNC:418 ALDOC
    HPAiCAB020828
    HPA003282
    HPA067442
    MIMi103870 gene
    neXtProtiNX_P09972
    OpenTargetsiENSG00000109107
    PharmGKBiPA24711

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00940000155990
    HOVERGENiHBG002386
    InParanoidiP09972
    KOiK01623
    OMAiMTHQYPA
    OrthoDBiEOG091G0A9T
    PhylomeDBiP09972
    TreeFamiTF314203

    Enzyme and pathway databases

    UniPathwayi
    UPA00109;UER00183

    BioCyciMetaCyc:HS03200-MONOMER
    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    SABIO-RKiP09972

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ALDOC human
    EvolutionaryTraceiP09972

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Aldolase_C

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    230

    Protein Ontology

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    PROi
    PR:P09972

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000109107 Expressed in 218 organ(s), highest expression level in right hemisphere of cerebellum
    CleanExiHS_ALDOC
    ExpressionAtlasiP09972 baseline and differential
    GenevisibleiP09972 HS

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALDOC_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09972
    Secondary accession number(s): B2R5R3
    , Q3SYL3, Q6FH94, Q6P0L5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: December 5, 2018
    This is version 189 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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