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Entry version 239 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Leukotriene A-4 hydrolase

Gene

LTA4H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921).

Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029).

In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641).

Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).

10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+5 PublicationsNote: Binds 1 zinc ion per subunit.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by bestatin (PubMed:11175901). The epoxide hydrolase activity is restrained by suicide inactivation that involves binding of LTA4 to Tyr-379 (PubMed:7667299). 4-(4-benzylphenyl)thiazol-2-amine (ARM1) selectively inhibits the epoxide hydrolase activity (PubMed:24591641).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.29 mM for Pro-Gly-Pro1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: leukotriene B4 biosynthesis

    This protein is involved in the pathway leukotriene B4 biosynthesis, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway leukotriene B4 biosynthesis and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei272Pro-Gly-Pro binding1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi296Zinc; catalyticCombined sources8 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei297Proton acceptorCombined sources2 Publications1 Publication1
    Metal bindingi300Zinc; catalyticCombined sources8 Publications1
    Metal bindingi319Zinc; catalyticCombined sources2 Publications1
    Sitei376Essential for epoxide hydrolase activity, but not for aminopeptidase activity1 Publication1
    Sitei379Covalently modified during suicide inhibition by leukotrienes1 Publication1
    Active sitei384Proton donorCombined sources2 Publications1 Publication1
    Sitei563Pro-Gly-Pro binding1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Metalloprotease, Protease
    Biological processLeukotriene biosynthesis, Lipid metabolism
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS03372-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.3.2.6, 2681
    3.4.11.6, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P09960

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-6798695, Neutrophil degranulation
    R-HSA-9018676, Biosynthesis of D-series resolvins
    R-HSA-9018681, Biosynthesis of protectins
    R-HSA-9018896, Biosynthesis of E-series 18(S)-resolvins
    R-HSA-9020265, Biosynthesis of aspirin-triggered D-series resolvins
    R-HSA-9023661, Biosynthesis of E-series 18(R)-resolvins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P09960

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00878

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M01.004

    MoonProt database of moonlighting proteins

    More...
    MoonProti
    P09960

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001118

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Leukotriene A-4 hydrolase (EC:3.3.2.68 Publications)
    Short name:
    LTA-4 hydrolase
    Alternative name(s):
    Leukotriene A(4) hydrolase
    Tripeptide aminopeptidase LTA4HCurated (EC:3.4.11.45 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:LTA4H
    Synonyms:LTA4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:6710, LTA4H

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    151570, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P09960

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000111144.9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135Q → A or L: Srongly increased epoxide hydrolase activity. 1 Publication1
    Mutagenesisi135Q → A: Strongly reduced aminopeptidase activity. Strongly decreased affinity for leukotriene. Abolishes epoxide hydrolase activity. 1 Publication1
    Mutagenesisi137Q → A: No loss of activity. 1 Publication1
    Mutagenesisi137Q → L: Aminopeptidase activity strongly impaired, but keeps LTA4 activity. 1 Publication1
    Mutagenesisi137Q → N: Aminopeptidase activity almost absent, but keeps LTA4 activity. 1 Publication1
    Mutagenesisi140H → Q: Aminopeptidase activity almost absent, but keeps LTA4 activity. 1 Publication1
    Mutagenesisi269G → A: No loss of activity. 1 Publication1
    Mutagenesisi270G → A: No loss of activity. 1 Publication1
    Mutagenesisi271M → L: No loss of activity. 1 Publication1
    Mutagenesisi272E → A or D: Complete loss of epoxide hydrolase activity and aminopeptidase activity. 1 Publication1
    Mutagenesisi272E → Q: Loss of LTA4 hydrolase activity, and aminopeptidase activity strongly impaired. 1 Publication1
    Mutagenesisi273N → A: No loss of epoxide hydrolase activity and aminopeptidase activity. 1 Publication1
    Mutagenesisi296H → Y: Complete loss of LTA4 hydrolase and peptidase enzyme activities. 1 Publication1
    Mutagenesisi297E → A: Loss of epoxide hydrolase and aminopeptidase activities. 3 Publications1
    Mutagenesisi297E → K: Loss of epoxide hydrolase and aminopeptidase activities. 3 Publications1
    Mutagenesisi297E → Q: Loss of aminopeptidase activity, but keeps LTA4 hydrolase activity. 3 Publications1
    Mutagenesisi300H → L: Complete loss of LTA4 hydrolase and peptidase enzyme activities. 1 Publication1
    Mutagenesisi319E → A: Complete loss of LTA4 hydrolase and peptidase enzyme activities. 1 Publication1
    Mutagenesisi372D → N: No loss of activity. 1 Publication1
    Mutagenesisi374D → N: No loss of activity. 1 Publication1
    Mutagenesisi376D → A: Strongly reduced hydrolysis of peptides starting with Arg. Small effect on hydrolysis of peptides starting with Ala. Abolishes epoxide hydrolase activity. 2 Publications1
    Mutagenesisi376D → E: Strongly reduced aminopeptidase activity. Abolishes epoxide hydrolase activity. 2 Publications1
    Mutagenesisi376D → N: Abolishes aminopeptidase activity. Decreased epoxide hydrolase activity. 2 Publications1
    Mutagenesisi385E → Q: Reduced aminopeptidase activity. Minor effect on epoxide hydrolase activity. 1 Publication1
    Mutagenesisi564R → A, K or M: Abolishes epoxide hydrolase activity. Reduced aminopeptidase activity. 1 Publication1
    Mutagenesisi566K → A or M: Strongly reduced affinity for peptide substrates. Reduced epoxide hydrolase and aminopeptidase activity. 1 Publication1
    Mutagenesisi566K → R: No effect on epoxide hydrolase and aminopeptidase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4048

    Open Targets

    More...
    OpenTargetsi
    ENSG00000111144

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24345

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P09960, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4618

    Drug and drug target database

    More...
    DrugBanki
    DB07102, (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid
    DB06917, (4-fluorophenyl)(pyridin-4-yl)methanone
    DB07258, (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol
    DB07094, 1-(2,2'-bithiophen-5-yl)methanamine
    DB07259, 1-(4-thiophen-2-ylphenyl)methanamine
    DB02352, 3-(Benzyloxy)Pyridin-2-Amine
    DB07292, 4-(2-amino-1,3-thiazol-4-yl)phenol
    DB07104, 4-amino-N-[4-(benzyloxy)phenyl]butanamide
    DB06828, 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole
    DB08466, 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol
    DB01197, Captopril
    DB05177, DG051
    DB03366, Imidazole
    DB08040, Kelatorphan
    DB06851, N-(pyridin-3-ylmethyl)aniline
    DB02062, N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
    DB07099, N-[4-(benzyloxy)phenyl]glycinamide
    DB07260, N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline
    DB07196, N-methyl-1-(2-thiophen-2-ylphenyl)methanamine
    DB11781, Tosedostat
    DB03424, Ubenimex
    DB07237, {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone

    DrugCentral

    More...
    DrugCentrali
    P09960

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1395

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    LTA4H

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    126353

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000951242 – 611Leukotriene A-4 hydrolaseAdd BLAST610

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73N6-acetyllysineCombined sources1
    Modified residuei337N6-acetyllysineCombined sources1
    Modified residuei414N6-acetyllysineCombined sources1
    Modified residuei416Phosphoserine1 Publication1
    Modified residuei573N6-acetyllysineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-92
    CPTAC-93

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P09960

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P09960

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P09960

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P09960

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P09960

    PeptideAtlas

    More...
    PeptideAtlasi
    P09960

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P09960

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    28779
    52284 [P09960-1]
    52285 [P09960-2]
    52286 [P09960-3]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00219077

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P09960

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    P09960

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P09960

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P09960

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000111144, Expressed in visceral pleura and 247 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P09960, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P09960, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000111144, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    110226, 35 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P09960, 11 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000228740

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P09960

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P09960, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1611
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P09960

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P09960

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 137Substrate binding1 Publication3
    Regioni267 – 272Substrate binding1 Publication6
    Regioni362 – 365Inhibitor ARM1 binding1 Publication4
    Regioni564 – 566Substrate binding1 Publication3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1047, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156375

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_014505_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P09960

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NSNFRMK

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P09960

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300758

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09599, M1_LTA4H, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.390.10, 1 hit
    1.25.40.320, 1 hit
    2.60.40.1730, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR042097, Aminopeptidase_N-like_N
    IPR016024, ARM-type_fold
    IPR012777, LTA4H
    IPR038502, M1_LTA-4_hydro/amino_C_sf
    IPR034015, M1_LTA4H
    IPR001930, Peptidase_M1
    IPR015211, Peptidase_M1_C
    IPR014782, Peptidase_M1_dom
    IPR027268, Peptidase_M4/M1_CTD_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45726, PTHR45726, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF09127, Leuk-A4-hydro_C, 1 hit
    PF01433, Peptidase_M1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00756, ALADIPTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01263, Leuk-A4-hydro_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48371, SSF48371, 1 hit
    SSF63737, SSF63737, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02411, leuko_A4_hydro, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00142, ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P09960-1) [UniParc]FASTAAdd to basket
    Also known as: L-LTA4

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL
    60 70 80 90 100
    RSLVLDTKDL TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE
    110 120 130 140 150
    IVIEISFETS PKSSALQWLT PEQTSGKEHP YLFSQCQAIH CRAILPCQDT
    160 170 180 190 200
    PSVKLTYTAE VSVPKELVAL MSAIRDGETP DPEDPSRKIY KFIQKVPIPC
    210 220 230 240 250
    YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES MLKIAEDLGG
    260 270 280 290 300
    PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH
    310 320 330 340 350
    SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL
    360 370 380 390 400
    QNSVKTFGET HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG
    410 420 430 440 450
    PEIFLGFLKA YVEKFSYKSI TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY
    460 470 480 490 500
    SPGLPPIKPN YDMTLTNACI ALSQRWITAK EDDLNSFNAT DLKDLSSHQL
    510 520 530 540 550
    NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL RLCIQSKWED
    560 570 580 590 600
    AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT
    610
    AMLVGKDLKV D
    Length:611
    Mass (Da):69,285
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i329BF6D04D4A06E1
    GO
    Isoform 2 (identifier: P09960-2) [UniParc]FASTAAdd to basket
    Also known as: S-LTA4

    The sequence of this isoform differs from the canonical sequence as follows:
         511-532: APLPLGHIKRMQEVYNFNAINN → MAAALHSIQVGGRNSFGAKDGN
         533-611: Missing.

    Show »
    Length:532
    Mass (Da):59,733
    Checksum:i474891F08B0215A8
    GO
    Isoform 3 (identifier: P09960-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-53: MPEIVDTCSL...QSQEDNLRSL → MLPQRNLSKRQVPTMHIPVKTRRLLAALK
         511-532: APLPLGHIKRMQEVYNFNAINN → MAAALHSIQVGGRNSFGAKDGN
         533-611: Missing.

    Show »
    Length:508
    Mass (Da):57,300
    Checksum:iA1CDA72AF83A875C
    GO
    Isoform 4 (identifier: P09960-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-53: MPEIVDTCSL...QSQEDNLRSL → MLPQRNLSKRQVPTMHIPVKTRRLLAALK

    Show »
    Length:587
    Mass (Da):66,852
    Checksum:iA70BF2792A0427C7
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B4DEH5B4DEH5_HUMAN
    Leukotriene A-4 hydrolase
    LTA4H
    132Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115A → T in BX647158 (PubMed:17974005).Curated1
    Sequence conflicti123Q → R in BX647158 (PubMed:17974005).Curated1
    Sequence conflicti297E → G in BAG60321 (PubMed:14702039).Curated1
    Sequence conflicti309N → S in BX647158 (PubMed:17974005).Curated1
    Sequence conflicti378A → V in BX647158 (PubMed:17974005).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051570131Y → H. Corresponds to variant dbSNP:rs45630737Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0411071 – 53MPEIV…NLRSL → MLPQRNLSKRQVPTMHIPVK TRRLLAALK in isoform 3 and isoform 4. 2 PublicationsAdd BLAST53
    Alternative sequenceiVSP_041108511 – 532APLPL…NAINN → MAAALHSIQVGGRNSFGAKD GN in isoform 2 and isoform 3. 1 PublicationAdd BLAST22
    Alternative sequenceiVSP_041109533 – 611Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST79

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J03459 mRNA Translation: AAA36176.1
    J02959 mRNA Translation: AAA36177.1
    U27293 U27292 Genomic DNA Translation: AAA89077.1
    AK298017 mRNA Translation: BAG60321.1
    CR457068 mRNA Translation: CAG33349.1
    BX647158 mRNA No translation available.
    AC007298 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97559.1
    BC032528 mRNA Translation: AAH32528.1
    U43410 Genomic DNA No translation available.
    U43411 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS58266.1 [P09960-3]
    CCDS58267.1 [P09960-4]
    CCDS9059.1 [P09960-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S65947

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000886.1, NM_000895.2 [P09960-1]
    NP_001243572.1, NM_001256643.1 [P09960-4]
    NP_001243573.1, NM_001256644.1 [P09960-3]
    XP_005268928.1, XM_005268871.1 [P09960-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000228740; ENSP00000228740; ENSG00000111144 [P09960-1]
    ENST00000413268; ENSP00000395051; ENSG00000111144 [P09960-3]
    ENST00000552789; ENSP00000449958; ENSG00000111144 [P09960-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4048

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4048

    UCSC genome browser

    More...
    UCSCi
    uc001ten.3, human [P09960-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J03459 mRNA Translation: AAA36176.1
    J02959 mRNA Translation: AAA36177.1
    U27293 U27292 Genomic DNA Translation: AAA89077.1
    AK298017 mRNA Translation: BAG60321.1
    CR457068 mRNA Translation: CAG33349.1
    BX647158 mRNA No translation available.
    AC007298 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97559.1
    BC032528 mRNA Translation: AAH32528.1
    U43410 Genomic DNA No translation available.
    U43411 Genomic DNA No translation available.
    CCDSiCCDS58266.1 [P09960-3]
    CCDS58267.1 [P09960-4]
    CCDS9059.1 [P09960-1]
    PIRiS65947
    RefSeqiNP_000886.1, NM_000895.2 [P09960-1]
    NP_001243572.1, NM_001256643.1 [P09960-4]
    NP_001243573.1, NM_001256644.1 [P09960-3]
    XP_005268928.1, XM_005268871.1 [P09960-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GW6X-ray2.20A2-611[»]
    1H19X-ray2.10A2-611[»]
    1HS6X-ray1.95A1-611[»]
    1SQMX-ray2.30A2-611[»]
    2R59X-ray1.89A2-611[»]
    2VJ8X-ray1.80A1-611[»]
    3B7RX-ray1.81L2-611[»]
    3B7SX-ray1.47A2-611[»]
    3B7TX-ray2.30A2-611[»]
    3B7UX-ray1.90X2-611[»]
    3CHOX-ray1.80A2-611[»]
    3CHPX-ray2.10A2-611[»]
    3CHQX-ray2.09A2-611[»]
    3CHRX-ray2.20A2-611[»]
    3CHSX-ray2.55A2-611[»]
    3FH5X-ray1.63A1-611[»]
    3FH7X-ray2.05A1-611[»]
    3FH8X-ray1.67A1-611[»]
    3FHEX-ray2.16A1-611[»]
    3FTSX-ray2.33A1-611[»]
    3FTUX-ray1.90A1-611[»]
    3FTVX-ray1.70A1-611[»]
    3FTWX-ray1.85A1-611[»]
    3FTXX-ray1.96A1-611[»]
    3FTYX-ray2.15A1-611[»]
    3FTZX-ray2.00A1-611[»]
    3FU0X-ray1.80A1-611[»]
    3FU3X-ray2.00A1-611[»]
    3FU5X-ray2.30A1-611[»]
    3FU6X-ray2.05A1-611[»]
    3FUDX-ray2.20A1-611[»]
    3FUEX-ray2.38A1-611[»]
    3FUFX-ray2.60A1-611[»]
    3FUHX-ray1.80A1-611[»]
    3FUIX-ray2.20A1-611[»]
    3FUJX-ray1.90A1-611[»]
    3FUKX-ray1.95A1-611[»]
    3FULX-ray2.39A1-611[»]
    3FUMX-ray2.15A1-611[»]
    3FUNX-ray1.58A1-611[»]
    3U9WX-ray1.25A4-611[»]
    4DPRX-ray2.02A1-611[»]
    4L2LX-ray1.65A1-611[»]
    4MKTX-ray1.62A1-611[»]
    4MS6X-ray1.72A1-611[»]
    4R7LX-ray1.66A1-611[»]
    4RSYX-ray1.93A1-611[»]
    4RVBX-ray1.93A1-611[»]
    5AENX-ray1.86A4-611[»]
    5BPPX-ray2.03A1-611[»]
    5FWQX-ray2.05A1-611[»]
    5N3WX-ray2.30A1-611[»]
    5NI2X-ray1.50A2-611[»]
    5NI4X-ray1.90A/B/C2-611[»]
    5NI6X-ray1.54A2-611[»]
    5NIAX-ray1.76A2-611[»]
    5NIDX-ray1.57A2-611[»]
    5NIEX-ray2.60A/B/C2-611[»]
    6ENBX-ray1.84A2-611[»]
    6ENCX-ray1.95A2-611[»]
    6ENDX-ray2.24A2-611[»]
    6O5HX-ray2.84A/B/C4-611[»]
    7AUZX-ray1.90A2-611[»]
    7AV0X-ray1.90A2-611[»]
    7AV1X-ray1.79A2-611[»]
    7AV2X-ray1.95A2-611[»]
    SMRiP09960
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi110226, 35 interactors
    IntActiP09960, 11 interactors
    STRINGi9606.ENSP00000228740

    Chemistry databases

    BindingDBiP09960
    ChEMBLiCHEMBL4618
    DrugBankiDB07102, (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid
    DB06917, (4-fluorophenyl)(pyridin-4-yl)methanone
    DB07258, (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol
    DB07094, 1-(2,2'-bithiophen-5-yl)methanamine
    DB07259, 1-(4-thiophen-2-ylphenyl)methanamine
    DB02352, 3-(Benzyloxy)Pyridin-2-Amine
    DB07292, 4-(2-amino-1,3-thiazol-4-yl)phenol
    DB07104, 4-amino-N-[4-(benzyloxy)phenyl]butanamide
    DB06828, 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole
    DB08466, 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol
    DB01197, Captopril
    DB05177, DG051
    DB03366, Imidazole
    DB08040, Kelatorphan
    DB06851, N-(pyridin-3-ylmethyl)aniline
    DB02062, N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
    DB07099, N-[4-(benzyloxy)phenyl]glycinamide
    DB07260, N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline
    DB07196, N-methyl-1-(2-thiophen-2-ylphenyl)methanamine
    DB11781, Tosedostat
    DB03424, Ubenimex
    DB07237, {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone
    DrugCentraliP09960
    GuidetoPHARMACOLOGYi1395
    SwissLipidsiSLP:000001118

    Protein family/group databases

    MEROPSiM01.004
    MoonProtiP09960

    PTM databases

    iPTMnetiP09960
    MetOSiteiP09960
    PhosphoSitePlusiP09960
    SwissPalmiP09960

    Genetic variation databases

    BioMutaiLTA4H
    DMDMi126353

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00219077

    Proteomic databases

    CPTACiCPTAC-92
    CPTAC-93
    EPDiP09960
    jPOSTiP09960
    MassIVEiP09960
    MaxQBiP09960
    PaxDbiP09960
    PeptideAtlasiP09960
    PRIDEiP09960
    ProteomicsDBi28779
    52284 [P09960-1]
    52285 [P09960-2]
    52286 [P09960-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    4453, 503 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    4048

    Genome annotation databases

    EnsembliENST00000228740; ENSP00000228740; ENSG00000111144 [P09960-1]
    ENST00000413268; ENSP00000395051; ENSG00000111144 [P09960-3]
    ENST00000552789; ENSP00000449958; ENSG00000111144 [P09960-4]
    GeneIDi4048
    KEGGihsa:4048
    UCSCiuc001ten.3, human [P09960-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4048
    DisGeNETi4048

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    LTA4H
    HGNCiHGNC:6710, LTA4H
    HPAiENSG00000111144, Low tissue specificity
    MIMi151570, gene
    neXtProtiNX_P09960
    OpenTargetsiENSG00000111144
    PharmGKBiPA24345
    VEuPathDBiHostDB:ENSG00000111144.9

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1047, Eukaryota
    GeneTreeiENSGT00940000156375
    HOGENOMiCLU_014505_0_0_1
    InParanoidiP09960
    OMAiNSNFRMK
    PhylomeDBiP09960
    TreeFamiTF300758

    Enzyme and pathway databases

    UniPathwayiUPA00878
    BioCyciMetaCyc:HS03372-MONOMER
    BRENDAi3.3.2.6, 2681
    3.4.11.6, 2681
    PathwayCommonsiP09960
    ReactomeiR-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-6798695, Neutrophil degranulation
    R-HSA-9018676, Biosynthesis of D-series resolvins
    R-HSA-9018681, Biosynthesis of protectins
    R-HSA-9018896, Biosynthesis of E-series 18(S)-resolvins
    R-HSA-9020265, Biosynthesis of aspirin-triggered D-series resolvins
    R-HSA-9023661, Biosynthesis of E-series 18(R)-resolvins
    SABIO-RKiP09960

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    4048, 4 hits in 998 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    LTA4H, human
    EvolutionaryTraceiP09960

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4048
    PharosiP09960, Tchem

    Protein Ontology

    More...
    PROi
    PR:P09960
    RNActiP09960, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000111144, Expressed in visceral pleura and 247 other tissues
    ExpressionAtlasiP09960, baseline and differential
    GenevisibleiP09960, HS

    Family and domain databases

    CDDicd09599, M1_LTA4H, 1 hit
    Gene3Di1.10.390.10, 1 hit
    1.25.40.320, 1 hit
    2.60.40.1730, 1 hit
    InterProiView protein in InterPro
    IPR042097, Aminopeptidase_N-like_N
    IPR016024, ARM-type_fold
    IPR012777, LTA4H
    IPR038502, M1_LTA-4_hydro/amino_C_sf
    IPR034015, M1_LTA4H
    IPR001930, Peptidase_M1
    IPR015211, Peptidase_M1_C
    IPR014782, Peptidase_M1_dom
    IPR027268, Peptidase_M4/M1_CTD_sf
    PANTHERiPTHR45726, PTHR45726, 1 hit
    PfamiView protein in Pfam
    PF09127, Leuk-A4-hydro_C, 1 hit
    PF01433, Peptidase_M1, 1 hit
    PRINTSiPR00756, ALADIPTASE
    SMARTiView protein in SMART
    SM01263, Leuk-A4-hydro_C, 1 hit
    SUPFAMiSSF48371, SSF48371, 1 hit
    SSF63737, SSF63737, 1 hit
    TIGRFAMsiTIGR02411, leuko_A4_hydro, 1 hit
    PROSITEiView protein in PROSITE
    PS00142, ZINC_PROTEASE, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLKHA4_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09960
    Secondary accession number(s): B4DNQ9
    , F8VV40, Q6IAT6, Q9UCT7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: June 2, 2021
    This is version 239 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with genetic variants
      List of human entries with genetic variants
    4. Human variants curated from literature reports
      Index of human variants curated from literature reports
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families
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