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Protein

Regulatory protein SWI6

Gene

SWI6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).

Miscellaneous

Present with 3340 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
  • transcription coactivator activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32306-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein SWI6
Alternative name(s):
Cell-cycle box factor subunit SWI6
MBF subunit P90
Trans-acting activator of HO endonuclease gene
Gene namesi
Name:SWI6
Ordered Locus Names:YLR182W
ORF Names:L9470.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004172 SWI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670711 – 803Regulatory protein SWI6Add BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineCombined sources1
Modified residuei160Phosphoserine; by CDC28Combined sources1 Publication1
Modified residuei176PhosphoserineCombined sources1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei547PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC28 and dephosphorylated by CDC14.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09959
PaxDbiP09959
PRIDEiP09959

PTM databases

CarbonylDBiP09959
iPTMnetiP09959

Interactioni

Subunit structurei

Component of the transcription complex MCB-binding factor (MBF) composed of SWI6 and MBP1. Component of the transcription complex SCB-binding factor (SBF) composed of SWI6 and SWI4. Interacts with MSA1 and STB1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi31453, 692 interactors
ComplexPortaliCPX-946 SBF transcription complex
CPX-950 MBP transcription complex
DIPiDIP-598N
ELMiP09959
IntActiP09959, 57 interactors
MINTiP09959
STRINGi4932.YLR182W

Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09959
SMRiP09959
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09959

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati318 – 346ANK 1Add BLAST29
Repeati347 – 383ANK 2Add BLAST37
Repeati384 – 469ANK 3Add BLAST86
Repeati470 – 498ANK 4Add BLAST29
Repeati499 – 514ANK 5Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi631 – 640Glu-rich (acidic)10

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000067565
HOGENOMiHOG000057104
InParanoidiP09959
KOiK06648
OMAiYYLDILM
OrthoDBiEOG092C0OUJ

Family and domain databases

CDDicd00204 ANK, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF13606 Ank_3, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

P09959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALEEVVRYL GPHNEIPLTL TRDSETGHFL LKHFLPILQQ YHDTGNINET
60 70 80 90 100
NPDSFPTDEE RNKLLAHYGI AVNTDDRGEL WIELEKCLQL LNMLNLFGLF
110 120 130 140 150
QDAFEFEEPE TDQDEEDPSH SKLPENKTKS ENSKDNISSK RINNLQDMSL
160 170 180 190 200
DSDAHRELGS PLKKLKIDTS VIDAESDSTP NTARGKPNDD INKGPSGDNE
210 220 230 240 250
NNGTDDNDRT AGPIITFTHD LTSDFLSSPL KIMKALPSPV VNDNEQKMKL
260 270 280 290 300
EAFLQRLLFP EIQEMPTSLN NDSSNRNSEG GSSNQQQQHV SFDSLLQEVN
310 320 330 340 350
DAFPNTQLNL NIPVDEHGNT PLHWLTSIAN LELVKHLVKH GSNRLYGDNM
360 370 380 390 400
GESCLVKAVK SVNNYDSGTF EALLDYLYPC LILEDSMNRT ILHHIIITSG
410 420 430 440 450
MTGCSAAAKY YLDILMGWIV KKQNRPIQSG TNEKESKPND KNGERKDSIL
460 470 480 490 500
ENLDLKWIIA NMLNAQDSNG DTCLNIAARL GNISIVDALL DYGADPFIAN
510 520 530 540 550
KSGLRPVDFG AGTSKLQNTN GGDENSKMVS KGDYDGQKNG KAKKIRSQLL
560 570 580 590 600
KNPPETTSLI NDVQNLLNSI SKDYENETVQ YNEKLEKLHK ELNEQREELA
610 620 630 640 650
NSREQLANVK QLKDEYSLMQ EQLTNLKAGI EEEEESFREE SKKLGIIADE
660 670 680 690 700
SSGIDWDSSE YDADEPFKVE FLSDFLEDKL QKNYEGDISK LLEAESKEQI
710 720 730 740 750
MEQIRNQLPA EKIQSMLPPT VLLKARINAY KRNDKHLTNV LDTISTKQSE
760 770 780 790 800
LENKFRRVLS LCLKIDENKV DNMLDGLLQA ISSEDPQDID TDEMQDFLKK

HAS
Length:803
Mass (Da):90,560
Last modified:July 1, 1989 - v1
Checksum:i9B317FCACEEC493C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06238 Genomic DNA Translation: CAA29581.1
U17246 Genomic DNA Translation: AAB67460.1
BK006945 Genomic DNA Translation: DAA09502.1
PIRiS03161 RGBYW6
RefSeqiNP_013283.1, NM_001182069.1

Genome annotation databases

EnsemblFungiiYLR182W; YLR182W; YLR182W
GeneIDi850879
KEGGisce:YLR182W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06238 Genomic DNA Translation: CAA29581.1
U17246 Genomic DNA Translation: AAB67460.1
BK006945 Genomic DNA Translation: DAA09502.1
PIRiS03161 RGBYW6
RefSeqiNP_013283.1, NM_001182069.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SW6X-ray2.10A/B188-512[»]
2XFVX-ray1.90A/B2-126[»]
5XW5X-ray1.85C155-164[»]
ProteinModelPortaliP09959
SMRiP09959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31453, 692 interactors
ComplexPortaliCPX-946 SBF transcription complex
CPX-950 MBP transcription complex
DIPiDIP-598N
ELMiP09959
IntActiP09959, 57 interactors
MINTiP09959
STRINGi4932.YLR182W

PTM databases

CarbonylDBiP09959
iPTMnetiP09959

Proteomic databases

MaxQBiP09959
PaxDbiP09959
PRIDEiP09959

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR182W; YLR182W; YLR182W
GeneIDi850879
KEGGisce:YLR182W

Organism-specific databases

SGDiS000004172 SWI6

Phylogenomic databases

GeneTreeiENSGT00530000067565
HOGENOMiHOG000057104
InParanoidiP09959
KOiK06648
OMAiYYLDILM
OrthoDBiEOG092C0OUJ

Enzyme and pathway databases

BioCyciYEAST:G3O-32306-MONOMER

Miscellaneous databases

EvolutionaryTraceiP09959
PROiPR:P09959

Family and domain databases

CDDicd00204 ANK, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF13606 Ank_3, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSWI6_YEAST
AccessioniPrimary (citable) accession number: P09959
Secondary accession number(s): D6VYI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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