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Protein

Protein yellow

Gene

y

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Controls the pigmentation pattern of the adult cuticle and larval mouth parts.2 Publications

GO - Biological processi

  • cuticle pigmentation Source: FlyBase
  • developmental pigmentation Source: FlyBase
  • male courtship behavior, veined wing extension Source: FlyBase
  • male mating behavior Source: FlyBase
  • melanin biosynthetic process Source: FlyBase
  • melanin biosynthetic process from tyrosine Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yellow
Gene namesi
Name:y
ORF Names:CG3757
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004034 y

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Flies fail to pigment the adult cuticle and larval mouth parts and show reduced level of locomotor activity and male competitive mating ability.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003105222 – 541Protein yellowAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP09957
PRIDEiP09957

Expressioni

Developmental stagei

Required during the later half of pupal development for the normal pigmentation of the adult cuticle.

Gene expression databases

BgeeiFBgn0004034
GenevisibleiP09957 DM

Interactioni

Protein-protein interaction databases

BioGridi57553, 17 interactors
DIPiDIP-23590N
IntActiP09957, 1 interactor
STRINGi7227.FBpp0070070

Structurei

3D structure databases

ProteinModelPortaliP09957
SMRiP09957
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major royal jelly protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIRV Eukaryota
COG3386 LUCA
GeneTreeiENSGT00530000064224
InParanoidiP09957
OMAiDQNAVGC
OrthoDBiEOG091G140M
PhylomeDBiP09957

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR017996 Royal_jelly/protein_yellow
IPR029846 Yellow
PANTHERiPTHR10009 PTHR10009, 1 hit
PTHR10009:SF14 PTHR10009:SF14, 1 hit
PfamiView protein in Pfam
PF03022 MRJP, 1 hit
PRINTSiPR01366 ROYALJELLY

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDKGWILV TLITLVTPSW AAYKLQERYS WSQLDFAFPN TRLKDQALAS
60 70 80 90 100
GDYIPQNALP VGVEHFGNRL FVTVPRWRDG IPATLTYINM DRSLTGSPEL
110 120 130 140 150
IPYPDWRSNT AGDCANSITT AYRIKVDECG RLWVLDTGTV GIGNTTTNPC
160 170 180 190 200
PYAVNVFDLT TDTRIRRYEL PGVDTNPNTF IANIAVDIGK NCDDAYAYFA
210 220 230 240 250
DELGYGLIAY SWELNKSWRF SAHSYFFPDP LRGDFNVAGI NFQWGEEGIF
260 270 280 290 300
GMSLSPIRSD GYRTLYFSPL ASHRQFAVST RILRDETRTE DSYHDFVALD
310 320 330 340 350
ERGPNSHTTS RVMSDDGIEL FNLIDQNAVG CWHSSMPYSP QFHGIVDRDD
360 370 380 390 400
VGLVFPADVK IDENKNVWVL SDRMPVFLLS DLDYSDTNFR IYTAPLATLI
410 420 430 440 450
ENTVCDLRNN AYGPPNTVSI PKQAVLPMGP PLYTKQYRPV LPQKPQTSWA
460 470 480 490 500
SSPPPPSRTY LPANSGNVVS SISVSTNSVG PAGVEVPKAY IFNQHNGINY
510 520 530 540
ETSGPHLFPT HQPAQPGGQD GGLKTYVNAR QSGWWHHQHQ G
Length:541
Mass (Da):60,520
Last modified:July 1, 1989 - v1
Checksum:i7728D1FA9A4ECB7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04427 Genomic DNA Translation: CAA28024.1
AE014298 Genomic DNA Translation: AAF45497.1
AL023873 Genomic DNA Translation: CAA19640.1
PIRiA25696
RefSeqiNP_476792.1, NM_057444.3
UniGeneiDm.23761

Genome annotation databases

EnsemblMetazoaiFBtr0070071; FBpp0070070; FBgn0004034
GeneIDi30980
KEGGidme:Dmel_CG3757
UCSCiCG3757-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiYELL_DROME
AccessioniPrimary (citable) accession number: P09957
Secondary accession number(s): Q9W5G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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