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Protein

Synapsin-1

Gene

Syn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATP binding Source: InterPro
  • calcium-dependent protein binding Source: RGD
  • protein kinase binding Source: Ensembl

GO - Biological processi

  • neuron development Source: RGD
  • neurotransmitter secretion Source: GO_Central
  • regulation of synaptic vesicle cycle Source: Ensembl
  • synapse organization Source: RGD
  • synaptic vesicle clustering Source: Ensembl

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-1
Alternative name(s):
Synapsin I
Gene namesi
Name:Syn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi3797 Syn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830201 – 704Synapsin-1Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by CaMK1 and PKA1 Publication1
Modified residuei39PhosphoserineCombined sources1
Glycosylationi55O-linked (GlcNAc) serine2 Publications1
Glycosylationi56O-linked (GlcNAc) threonine1 Publication1
Modified residuei62PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Glycosylationi87O-linked (GlcNAc) threonine2 Publications1
Glycosylationi96O-linked (GlcNAc) serine1 Publication1
Glycosylationi103O-linked (GlcNAc) serine1 Publication1
Glycosylationi261O-linked (GlcNAc) serine1 Publication1
Modified residuei312PhosphotyrosineBy similarity1
Modified residuei425PhosphoserineCombined sources1
Modified residuei428Omega-N-methylarginineBy similarity1
Modified residuei430Phosphoserine; alternateBy similarity1
Glycosylationi430O-linked (GlcNAc) serine; alternate1 Publication1
Modified residuei432PhosphoserineBy similarity1
Modified residuei434PhosphothreonineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei474Omega-N-methylarginineBy similarity1
Glycosylationi516O-linked (GlcNAc) serine2 Publications1
Glycosylationi524O-linked (GlcNAc) threonine1 Publication1
Modified residuei532Omega-N-methylarginineBy similarity1
Modified residuei545Omega-N-methylarginineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Modified residuei551Phosphoserine; by PDPK1By similarity1
Modified residuei554Omega-N-methylarginineBy similarity1
Glycosylationi562O-linked (GlcNAc) threonine1 Publication1
Modified residuei566PhosphoserineCombined sources1
Modified residuei566Phosphoserine; by CaMK2Combined sources1 Publication1
Glycosylationi576O-linked (GlcNAc) serine1 Publication1
Modified residuei603Phosphoserine; by CaMK21 Publication1
Modified residuei620Omega-N-methylarginineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei664PhosphoserineCombined sources1
Modified residuei678Asymmetric dimethylarginineBy similarity1
Modified residuei682PhosphoserineBy similarity1

Post-translational modificationi

Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal (By similarity).By similarity
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP09951
PRIDEiP09951

PTM databases

iPTMnetiP09951
PhosphoSitePlusiP09951

Expressioni

Gene expression databases

BgeeiENSRNOG00000010365 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP09951 RN

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247051, 3 interactors
CORUMiP09951
IntActiP09951, 5 interactors
MINTiP09951
STRINGi10116.ENSRNOP00000014250

Structurei

Secondary structure

1704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09951
SMRiP09951
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09951

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni29 – 112B; linkerAdd BLAST84
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 655D; Pro-rich linkerAdd BLAST235
Regioni656 – 704EAdd BLAST49

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiP09951
KOiK19941
OMAiNGDHRNI
OrthoDBiEOG091G0BZ1
PhylomeDBiP09951

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF22 PTHR10841:SF22, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform IA (identifier: P09951-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSAAAS
60 70 80 90 100
AERASTAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMTQALPR QRDASPGRGS HSQTPSPGAL PLGRQTSQQP
460 470 480 490 500
AGPPAQQRPP PQGGPPQPGP GPQRQGPPLQ QRPPPQGQQH LSGLGPPAGS
510 520 530 540 550
PLPQRLPSPT AAPQQSASQA TPMTQGQGRQ SRPVAGGPGA PPAARPPASP
560 570 580 590 600
SPQRQAGPPQ ATRQASISGP APPKVSGASP GGQQRQGPPQ KPPGPAGPIR
610 620 630 640 650
QASQAGPGPR TGPPTTQQPR PSGPGPAGRP TKPQLAQKPS QDVPPPIIAA
660 670 680 690 700
AGGPPHPQLN KSQSLTNAFN LPEPAPPRPS LSQDEVKAET IRSLRKSFAS

LFSD
Length:704
Mass (Da):73,988
Last modified:May 30, 2000 - v3
Checksum:i65799FEF7CFE18B5
GO
Isoform IB (identifier: P09951-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-668: NKSQSLTNA → KASPAQAQP
     669-704: Missing.

Show »
Length:668
Mass (Da):69,910
Checksum:iCE225AE8FCC92F8F
GO

Sequence cautioni

The sequence CAA28353 differs from that shown. Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006318660 – 668NKSQSLTNA → KASPAQAQP in isoform IB. Curated9
Alternative sequenceiVSP_006319669 – 704Missing in isoform IB. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27812 mRNA Translation: AAA42145.1
M27924 mRNA Translation: AAA42148.1
X04655 mRNA Translation: CAA28353.1 Sequence problems.
PIRiA25704
A30411
RefSeqiNP_001104252.1, NM_001110782.2 [P09951-2]
NP_062006.1, NM_019133.2 [P09951-1]
UniGeneiRn.9923

Genome annotation databases

EnsembliENSRNOT00000014250; ENSRNOP00000014250; ENSRNOG00000010365 [P09951-1]
GeneIDi24949
KEGGirno:24949
UCSCiRGD:3797 rat [P09951-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27812 mRNA Translation: AAA42145.1
M27924 mRNA Translation: AAA42148.1
X04655 mRNA Translation: CAA28353.1 Sequence problems.
PIRiA25704
A30411
RefSeqiNP_001104252.1, NM_001110782.2 [P09951-2]
NP_062006.1, NM_019133.2 [P09951-1]
UniGeneiRn.9923

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PK8X-ray2.10A/B/C/D/E/F/G/H2-421[»]
1PX2X-ray2.23A/B2-421[»]
ProteinModelPortaliP09951
SMRiP09951
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247051, 3 interactors
CORUMiP09951
IntActiP09951, 5 interactors
MINTiP09951
STRINGi10116.ENSRNOP00000014250

PTM databases

iPTMnetiP09951
PhosphoSitePlusiP09951

Proteomic databases

PaxDbiP09951
PRIDEiP09951

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014250; ENSRNOP00000014250; ENSRNOG00000010365 [P09951-1]
GeneIDi24949
KEGGirno:24949
UCSCiRGD:3797 rat [P09951-1]

Organism-specific databases

CTDi6853
RGDi3797 Syn1

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiP09951
KOiK19941
OMAiNGDHRNI
OrthoDBiEOG091G0BZ1
PhylomeDBiP09951

Enzyme and pathway databases

ReactomeiR-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle

Miscellaneous databases

EvolutionaryTraceiP09951
PROiPR:P09951

Gene expression databases

BgeeiENSRNOG00000010365 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP09951 RN

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF22 PTHR10841:SF22, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYN1_RAT
AccessioniPrimary (citable) accession number: P09951
Secondary accession number(s): Q9WUX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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