UniProtKB - P09925 (SURF1_MOUSE)

BLAST

>sp|P09925|SURF1_MOUSE Surfeit locus protein 1 OS=Mus musculus OX=10090 GN=Surf1 PE=1 SV=3
MAAVMALAVLPRRMTRWSQWAYAGRAQFCAVRRSVFGFSVRSGMVCRPRRCCSSTAETAA
AKAEDDSFLQWFLLLIPATAFGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPADPMELK
NLEYRPVKVRGHFDHSKELYIMPRTMVDPVREARDAGRLSSTESGAHVVTPFHCSDLGVT
ILVNRGFVPRKKVNPETRQKGQVLGEVDLVGIVRLTENRKPFVPENSPERNHWYYRDLEA
MAKITGADPIFIDADFHSTAPGGPIGGQTRVTLRNEHMQYILTWYGLCAATSYLWFQKFV
RRTPIM

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History
Entry version 133 (12 Sep 2018)
Sequence version 3 (06 Jun 2002)
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Protein

Surfeit locus protein 1

Gene

Surf1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.By similarity

GO - Molecular functionⁱ

cytochrome-c oxidase activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 12566387

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP biosynthetic process Source: MGI
mitochondrial respiratory chain complex IV assembly Source: UniProtKB
oxidative phosphorylation Source: MGI

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Surfeit locus protein 1
Gene namesⁱ	Name:Surf1 Synonyms:Surf-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:98443 Surf1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	68 – 86	HelicalSequence analysisAdd BLAST		19
Transmembraneⁱ	280 – 300	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215653	1 – 306	Surfeit locus protein 1Add BLAST		306

Proteomic databases

EPDⁱ	P09925
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09925
PaxDbⁱ	P09925
PRIDEⁱ	P09925

PTM databases

iPTMnetⁱ	P09925
PhosphoSitePlusⁱ	P09925
SwissPalmⁱ	P09925

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000015790 Expressed in 283 organ(s), highest expression level in facial nucleus
CleanExⁱ	MM_SURF1
ExpressionAtlasⁱ	P09925 baseline and differential
Genevisibleⁱ	P09925 MM

Interactionⁱ

Subunit structureⁱ

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000128488

STRINGⁱ

10090.ENSMUSP00000128488

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P09925
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SURF1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1563 Eukaryota COG3346 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064194
HOVERGENⁱ	HBG058486
InParanoidⁱ	P09925
KEGG Orthology (KO) More...KOⁱ	K14998
OMAⁱ	WYSRDVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IWR

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06662 SURF1, 1 hit
InterProⁱ	View protein in InterPro IPR002994 Surf1/Shy1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02104 SURF1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50895 SURF1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P09925-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAVMALAVL PRRMTRWSQW AYAGRAQFCA VRRSVFGFSV RSGMVCRPRR 
        60         70         80         90        100
CCSSTAETAA AKAEDDSFLQ WFLLLIPATA FGLGTWQVQR RKWKLKLIAE 
       110        120        130        140        150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV 
       160        170        180        190        200
REARDAGRLS STESGAHVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQK 
       210        220        230        240        250
GQVLGEVDLV GIVRLTENRK PFVPENSPER NHWYYRDLEA MAKITGADPI 
       260        270        280        290        300
FIDADFHSTA PGGPIGGQTR VTLRNEHMQY ILTWYGLCAA TSYLWFQKFV 

RRTPIM

Length:306

Mass (Da):34,798

Last modified:June 6, 2002 - v3

Checksum:ⁱ8D9ECE9FB726AEB7

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

V9GXE6	V9GXE6_MOUSE	SURF1-like protein SURF1-like protein	Surf1	248	Annotation score:
A0A0A6YVR9	A0A0A6YVR9_MOUSE	SURF1-like protein SURF1-like protein	Surf1	240	Annotation score:
A0A0A6YVY3	A0A0A6YVY3_MOUSE	SURF1-like protein SURF1-like protein	Surf1	63	Annotation score:
A0A0A6YXB3	A0A0A6YXB3_MOUSE	Surfeit locus protein 1 Surfeit locus protein 1	Surf1	49	Annotation score:
A0A0A6YVX3	A0A0A6YVX3_MOUSE	Surfeit locus protein 1 Surfeit locus protein 1	Surf1	41	Annotation score:
A0A0R4J232	A0A0R4J232_MOUSE	Surfeit locus protein 1 Surfeit locus protein 1	Surf1	59	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	9	V → G in AAA40153 (PubMed:3025660).Curated	1
Sequence conflictⁱ	14	M → I in BAB22123 (PubMed:16141072).Curated	1
Sequence conflictⁱ	284	W → CR in AAA40153 (PubMed:3025660).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14689 Genomic DNA Translation: AAA40153.1 AK002469 mRNA Translation: BAB22123.1 BC004755 mRNA Translation: AAH04755.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50543.1
PIRⁱ	B25394
NCBI Reference Sequences More...RefSeqⁱ	NP_001258653.2, NM_001271724.1 NP_038705.2, NM_013677.2
UniGeneⁱ	Mm.347512

Genome annotation databases

Ensemblⁱ	ENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790
GeneIDⁱ	20930
KEGGⁱ	mmu:20930
UCSC genome browser More...UCSCⁱ	uc008iwh.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09925	SURF1-like protein		MOUSE		263	UniRef100_P09925

Protein	Similar proteins		Species	Score	Length	Source
P09925	SURF1-like protein		MOUSE		263	UniRef90_P09925
UPI000A308253		MUSPA		338
UPI000A318CB7		MUSCR		303
SURF1-like protein		MOUSE		308
SURF1-like protein (Fragment)		MOUSE		240
+5

Protein	Similar proteins		Species	Score	Length	Source
P09925	Surfeit locus protein 1		HUMAN		300	UniRef50_Q15526
SURF1-like protein		PONAB		305
SURF1-like protein		GORGO		301
SURF1-like protein		PANTR		300
SURF1-like protein		CERAT		300
+103

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14689 Genomic DNA Translation: AAA40153.1 AK002469 mRNA Translation: BAB22123.1 BC004755 mRNA Translation: AAH04755.1
CCDSⁱ	CCDS50543.1
PIRⁱ	B25394
RefSeqⁱ	NP_001258653.2, NM_001271724.1 NP_038705.2, NM_013677.2
UniGeneⁱ	Mm.347512

3D structure databases

ProteinModelPortalⁱ	P09925
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000128488

STRINGⁱ

10090.ENSMUSP00000128488

PTM databases

iPTMnetⁱ	P09925
PhosphoSitePlusⁱ	P09925
SwissPalmⁱ	P09925

Proteomic databases

EPDⁱ	P09925
MaxQBⁱ	P09925
PaxDbⁱ	P09925
PRIDEⁱ	P09925

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790
GeneIDⁱ	20930
KEGGⁱ	mmu:20930
UCSCⁱ	uc008iwh.2 mouse

Organism-specific databases

CTDⁱ	6834
MGIⁱ	MGI:98443 Surf1

Phylogenomic databases

eggNOGⁱ	KOG1563 Eukaryota COG3346 LUCA
GeneTreeⁱ	ENSGT00530000064194
HOVERGENⁱ	HBG058486
InParanoidⁱ	P09925
KOⁱ	K14998
OMAⁱ	WYSRDVA
OrthoDBⁱ	EOG091G0IWR

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P09925
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015790 Expressed in 283 organ(s), highest expression level in facial nucleus
CleanExⁱ	MM_SURF1
ExpressionAtlasⁱ	P09925 baseline and differential
Genevisibleⁱ	P09925 MM

Family and domain databases

CDDⁱ	cd06662 SURF1, 1 hit
InterProⁱ	View protein in InterPro IPR002994 Surf1/Shy1
Pfamⁱ	View protein in Pfam PF02104 SURF1, 1 hit
PROSITEⁱ	View protein in PROSITE PS50895 SURF1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SURF1_MOUSE
Accessionⁱ	P09925Primary (citable) accession number: P09925 Secondary accession number(s): Q99KB4, Q9DCU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	June 6, 2002
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09925 (SURF1_MOUSE)

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Surfeit locus protein 1

Surf1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ