UniProtKB - P09925 (SURF1_MOUSE)
Protein
Surfeit locus protein 1
Gene
Surf1
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex (By similarity). Regulates cytochrome c oxidase assembly (PubMed:17210671, PubMed:23838831, PubMed:24911525).By similarity3 Publications
GO - Molecular functioni
- cytochrome-c oxidase activity Source: UniProtKB
GO - Biological processi
- mitochondrial cytochrome c oxidase assembly Source: UniProtKB
- oxidative phosphorylation Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-5628897, TP53 Regulates Metabolic Genes R-MMU-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: Surfeit locus protein 1 |
Gene namesi | Name:Surf1 Synonyms:Surf-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98443, Surf1 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 86 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 280 – 300 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Disruption phenotypei
Results in smaller animals with mild decreased motor skills, enhanced working spatial and recognition memory, and increased longevity (PubMed:17210671, PubMed:23838831, PubMed:24911525). Increases global and regional cerebral blood flow (PubMed:23838831). Increases lactate levels in blood and brain, and increases glucose consumption in the brain (PubMed:17210671, PubMed:23838831, PubMed:24911525). Increases hydrogen peroxide production and succinate dehydrogenase (SDH) activity, but decreases COX activity and respiration (PubMed:17210671, PubMed:21167962, PubMed:23838831, PubMed:24911525). In the brain, increases Hif1a and phosphorylated cyclic AMP response element-binding protein levels (PubMed:23838831). In the brain, increases resistance to calcium-related excitotoxic brain damage (PubMed:17210671). In skeletal muscles, results in mitochondrial unfolded protein response (PubMed:24911525). In the heart, results in elevated Nfe2l2 and Hmox1 expression (PubMed:24911525). Primary cultures of mutant neuronal cells show reduced sensitivity to glutamate-induced cytosolic calcium signal and impaired mitochondrial calcium uptake without changing the mitochondrial structure and membrane potential (PubMed:17210671). Primary cultures of phrenic and central vagus nerves show increased respiratory frequency and altered response to systemic hypoxia and hypercapnia (PubMed:21167962).4 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215653 | 1 – 306 | Surfeit locus protein 1Add BLAST | 306 |
Proteomic databases
EPDi | P09925 |
jPOSTi | P09925 |
MaxQBi | P09925 |
PaxDbi | P09925 |
PRIDEi | P09925 |
PTM databases
iPTMneti | P09925 |
PhosphoSitePlusi | P09925 |
SwissPalmi | P09925 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000015790, Expressed in facial nucleus and 301 other tissues |
ExpressionAtlasi | P09925, baseline and differential |
Genevisiblei | P09925, MM |
Interactioni
Subunit structurei
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14.
Interacts with COA3.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000015934 |
Miscellaneous databases
RNActi | P09925, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SURF1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1563, Eukaryota |
GeneTreei | ENSGT00530000064194 |
InParanoidi | P09925 |
OMAi | WYSRDVA |
OrthoDBi | 923657at2759 |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P09925-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVMALAVL PRRMTRWSQW AYAGRAQFCA VRRSVFGFSV RSGMVCRPRR
60 70 80 90 100
CCSSTAETAA AKAEDDSFLQ WFLLLIPATA FGLGTWQVQR RKWKLKLIAE
110 120 130 140 150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV
160 170 180 190 200
REARDAGRLS STESGAHVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQK
210 220 230 240 250
GQVLGEVDLV GIVRLTENRK PFVPENSPER NHWYYRDLEA MAKITGADPI
260 270 280 290 300
FIDADFHSTA PGGPIGGQTR VTLRNEHMQY ILTWYGLCAA TSYLWFQKFV
RRTPIM
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YVR9 | A0A0A6YVR9_MOUSE | SURF1-like protein | Surf1 | 240 | Annotation score: | ||
V9GXE6 | V9GXE6_MOUSE | SURF1-like protein | Surf1 | 248 | Annotation score: | ||
A0A0A6YVY3 | A0A0A6YVY3_MOUSE | SURF1-like protein | Surf1 | 63 | Annotation score: | ||
A0A0A6YXB3 | A0A0A6YXB3_MOUSE | Surfeit locus protein 1 | Surf1 | 49 | Annotation score: | ||
A0A0A6YVX3 | A0A0A6YVX3_MOUSE | Surfeit locus protein 1 | Surf1 | 41 | Annotation score: | ||
A0A0R4J232 | A0A0R4J232_MOUSE | Surfeit locus protein 1 | Surf1 | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | V → G in AAA40153 (PubMed:3025660).Curated | 1 | |
Sequence conflicti | 14 | M → I in BAB22123 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 284 | W → CR in AAA40153 (PubMed:3025660).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14689 Genomic DNA Translation: AAA40153.1 AK002469 mRNA Translation: BAB22123.1 BC004755 mRNA Translation: AAH04755.1 |
CCDSi | CCDS50543.1 |
PIRi | B25394 |
RefSeqi | NP_001258653.2, NM_001271724.1 NP_038705.2, NM_013677.2 |
Genome annotation databases
Ensembli | ENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790 |
GeneIDi | 20930 |
KEGGi | mmu:20930 |
UCSCi | uc008iwh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14689 Genomic DNA Translation: AAA40153.1 AK002469 mRNA Translation: BAB22123.1 BC004755 mRNA Translation: AAH04755.1 |
CCDSi | CCDS50543.1 |
PIRi | B25394 |
RefSeqi | NP_001258653.2, NM_001271724.1 NP_038705.2, NM_013677.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000015934 |
PTM databases
iPTMneti | P09925 |
PhosphoSitePlusi | P09925 |
SwissPalmi | P09925 |
Proteomic databases
EPDi | P09925 |
jPOSTi | P09925 |
MaxQBi | P09925 |
PaxDbi | P09925 |
PRIDEi | P09925 |
Protocols and materials databases
Antibodypediai | 18363, 156 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790 |
GeneIDi | 20930 |
KEGGi | mmu:20930 |
UCSCi | uc008iwh.2, mouse |
Organism-specific databases
CTDi | 6834 |
MGIi | MGI:98443, Surf1 |
Phylogenomic databases
eggNOGi | KOG1563, Eukaryota |
GeneTreei | ENSGT00530000064194 |
InParanoidi | P09925 |
OMAi | WYSRDVA |
OrthoDBi | 923657at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-5628897, TP53 Regulates Metabolic Genes R-MMU-611105, Respiratory electron transport |
Miscellaneous databases
BioGRID-ORCSi | 20930, 0 hits in 17 CRISPR screens |
ChiTaRSi | Surf1, mouse |
PROi | PR:P09925 |
RNActi | P09925, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015790, Expressed in facial nucleus and 301 other tissues |
ExpressionAtlasi | P09925, baseline and differential |
Genevisiblei | P09925, MM |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SURF1_MOUSE | |
Accessioni | P09925Primary (citable) accession number: P09925 Secondary accession number(s): Q99KB4, Q9DCU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | June 6, 2002 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families