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Protein

Surfeit locus protein 1

Gene

Surf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.By similarity

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 1
Gene namesi
Name:Surf1
Synonyms:Surf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98443 Surf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 86HelicalSequence analysisAdd BLAST19
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156531 – 306Surfeit locus protein 1Add BLAST306

Proteomic databases

EPDiP09925
MaxQBiP09925
PaxDbiP09925
PRIDEiP09925

PTM databases

iPTMnetiP09925
PhosphoSitePlusiP09925
SwissPalmiP09925

Expressioni

Gene expression databases

BgeeiENSMUSG00000015790 Expressed in 283 organ(s), highest expression level in facial nucleus
CleanExiMM_SURF1
ExpressionAtlasiP09925 baseline and differential
GenevisibleiP09925 MM

Interactioni

Subunit structurei

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128488

Structurei

3D structure databases

ProteinModelPortaliP09925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1563 Eukaryota
COG3346 LUCA
GeneTreeiENSGT00530000064194
HOVERGENiHBG058486
InParanoidiP09925
KOiK14998
OMAiWYSRDVA
OrthoDBiEOG091G0IWR

Family and domain databases

CDDicd06662 SURF1, 1 hit
InterProiView protein in InterPro
IPR002994 Surf1/Shy1
PfamiView protein in Pfam
PF02104 SURF1, 1 hit
PROSITEiView protein in PROSITE
PS50895 SURF1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P09925-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVMALAVL PRRMTRWSQW AYAGRAQFCA VRRSVFGFSV RSGMVCRPRR
60 70 80 90 100
CCSSTAETAA AKAEDDSFLQ WFLLLIPATA FGLGTWQVQR RKWKLKLIAE
110 120 130 140 150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV
160 170 180 190 200
REARDAGRLS STESGAHVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQK
210 220 230 240 250
GQVLGEVDLV GIVRLTENRK PFVPENSPER NHWYYRDLEA MAKITGADPI
260 270 280 290 300
FIDADFHSTA PGGPIGGQTR VTLRNEHMQY ILTWYGLCAA TSYLWFQKFV

RRTPIM
Length:306
Mass (Da):34,798
Last modified:June 6, 2002 - v3
Checksum:i8D9ECE9FB726AEB7
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXE6V9GXE6_MOUSE
SURF1-like protein
Surf1
248Annotation score:
A0A0A6YVR9A0A0A6YVR9_MOUSE
SURF1-like protein
Surf1
240Annotation score:
A0A0A6YVY3A0A0A6YVY3_MOUSE
SURF1-like protein
Surf1
63Annotation score:
A0A0A6YXB3A0A0A6YXB3_MOUSE
Surfeit locus protein 1
Surf1
49Annotation score:
A0A0A6YVX3A0A0A6YVX3_MOUSE
Surfeit locus protein 1
Surf1
41Annotation score:
A0A0R4J232A0A0R4J232_MOUSE
Surfeit locus protein 1
Surf1
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → G in AAA40153 (PubMed:3025660).Curated1
Sequence conflicti14M → I in BAB22123 (PubMed:16141072).Curated1
Sequence conflicti284W → CR in AAA40153 (PubMed:3025660).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689 Genomic DNA Translation: AAA40153.1
AK002469 mRNA Translation: BAB22123.1
BC004755 mRNA Translation: AAH04755.1
CCDSiCCDS50543.1
PIRiB25394
RefSeqiNP_001258653.2, NM_001271724.1
NP_038705.2, NM_013677.2
UniGeneiMm.347512

Genome annotation databases

EnsembliENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790
GeneIDi20930
KEGGimmu:20930
UCSCiuc008iwh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689 Genomic DNA Translation: AAA40153.1
AK002469 mRNA Translation: BAB22123.1
BC004755 mRNA Translation: AAH04755.1
CCDSiCCDS50543.1
PIRiB25394
RefSeqiNP_001258653.2, NM_001271724.1
NP_038705.2, NM_013677.2
UniGeneiMm.347512

3D structure databases

ProteinModelPortaliP09925
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128488

PTM databases

iPTMnetiP09925
PhosphoSitePlusiP09925
SwissPalmiP09925

Proteomic databases

EPDiP09925
MaxQBiP09925
PaxDbiP09925
PRIDEiP09925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015934; ENSMUSP00000015934; ENSMUSG00000015790
GeneIDi20930
KEGGimmu:20930
UCSCiuc008iwh.2 mouse

Organism-specific databases

CTDi6834
MGIiMGI:98443 Surf1

Phylogenomic databases

eggNOGiKOG1563 Eukaryota
COG3346 LUCA
GeneTreeiENSGT00530000064194
HOVERGENiHBG058486
InParanoidiP09925
KOiK14998
OMAiWYSRDVA
OrthoDBiEOG091G0IWR

Miscellaneous databases

PROiPR:P09925
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015790 Expressed in 283 organ(s), highest expression level in facial nucleus
CleanExiMM_SURF1
ExpressionAtlasiP09925 baseline and differential
GenevisibleiP09925 MM

Family and domain databases

CDDicd06662 SURF1, 1 hit
InterProiView protein in InterPro
IPR002994 Surf1/Shy1
PfamiView protein in Pfam
PF02104 SURF1, 1 hit
PROSITEiView protein in PROSITE
PS50895 SURF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSURF1_MOUSE
AccessioniPrimary (citable) accession number: P09925
Secondary accession number(s): Q99KB4, Q9DCU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: June 6, 2002
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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