Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon-induced GTP-binding protein Mx1

Gene

Mx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV). Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50GTPSequence analysis8
Nucleotide bindingi144 – 148GTPSequence analysis5
Nucleotide bindingi213 – 216GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: MGI
  • microtubule binding Source: GO_Central

GO - Biological processi

  • defense response to virus Source: GO_Central
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • innate immune response Source: UniProtKB
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • response to virus Source: UniProtKB

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Influenza resistance protein
Myxoma resistance protein 1
Myxovirus resistance protein 1
Gene namesi
Name:Mx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97243 Mx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi47S → C: No effect on viral infection. 1 Publication1
Mutagenesisi49K → A or M: Loss of protection against viral infection. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065931 – 631Interferon-induced GTP-binding protein Mx1Add BLAST631

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP09922
PRIDEiP09922

PTM databases

iPTMnetiP09922
PhosphoSitePlusiP09922

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

CleanExiMM_MX1

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B.By similarity1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP09922
SMRiP09922
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 306Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini543 – 631GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 50G1 motifPROSITE-ProRule annotation8
Regioni68 – 70G2 motifPROSITE-ProRule annotation3
Regioni144 – 147G3 motifPROSITE-ProRule annotation4
Regioni213 – 216G4 motifPROSITE-ProRule annotation4
Regioni245 – 248G5 motifPROSITE-ProRule annotation4
Regioni307 – 332Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni332 – 499Middle domainBy similarityAdd BLAST168
Regioni333 – 601StalkBy similarityAdd BLAST269
Regioni520 – 522Critical for lipid-bindingBy similarity3

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788
InParanoidiP09922

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P09922-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVNNLCRH YEEKVRPCID LIDTLRALGV EQDLALPAIA VIGDQSSGKS
60 70 80 90 100
SVLEALSGVA LPRGSGIVTR CPLVLKLRKL KEGEEWRGKV SYDDIEVELS
110 120 130 140 150
DPSEVEEAIN KGQNFIAGVG LGISDKLISL DVSSPNVPDL TLIDLPGITR
160 170 180 190 200
VAVGNQPADI GRQIKRLIKT YIQKQETINL VVVPSNVDIA TTEALSMAQE
210 220 230 240 250
VDPEGDRTIG VLTKPDLVDR GAEGKVLDVM RNLVYPLKKG YMIVKCRGQQ
260 270 280 290 300
DIQEQLSLTE AFQKEQVFFK DHSYFSILLE DGKATVPCLA ERLTEELTSH
310 320 330 340 350
ICKSLPLLED QINSSHQSAS EELQKYGADI PEDDRTRMSF LVNKISAFNR
360 370 380 390 400
NIMNLIQAQE TVSEGDSRLF TKLRNEFLAW DDHIEEYFKK DSPEVQSKMK
410 420 430 440 450
EFENQYRGRE LPGFVDYKAF ESIIKKRVKA LEESAVNMLR RVTKMVQTAF
460 470 480 490 500
VKILSNDFGD FLNLCCTAKS KIKEIRLNQE KEAENLIRLH FQMEQIVYCQ
510 520 530 540 550
DQVYKETLKT IREKEAEKEK TKALINPATF QNNSQFPQKG LTTTEMTQHL
560 570 580 590 600
KAYYQECRRN IGRQIPLIIQ YFILKTFGEE IEKMMLQLLQ DTSKCSWFLE
610 620 630
EQSDTREKKK FLKRRLLRLD EARQKLAKFS D
Length:631
Mass (Da):72,038
Last modified:July 1, 1989 - v1
Checksum:i7F0827668D190D68
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0J3E9Q0J3_MOUSE
Interferon-induced GTP-binding prot...
Mx1
627Annotation score:
Q3UD61Q3UD61_MOUSE
Interferon-induced GTP-binding prot...
Mx1
397Annotation score:
V9GWS9V9GWS9_MOUSE
Interferon-induced GTP-binding prot...
Mx1
165Annotation score:
S4R279S4R279_MOUSE
Interferon-induced GTP-binding prot...
Mx1 mCG_4784
309Annotation score:
A0A338P7J0A0A338P7J0_MOUSE
Interferon-induced GTP-binding prot...
Mx1
299Annotation score:
D3YV39D3YV39_MOUSE
Interferon-induced GTP-binding prot...
Mx1
65Annotation score:
A0A338P725A0A338P725_MOUSE
Interferon-induced GTP-binding prot...
Mx1
288Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12279 mRNA Translation: AAA39776.1
M21117
, M21105, M21106, M21107, M21108, M21109, M21110, M21111, M21112, M21113, M21114, M21115, M21116 Genomic DNA Translation: AAA39777.1
BC011113 mRNA Translation: AAH11113.1
PIRiA31203
RefSeqiNP_034976.1, NM_010846.1
UniGeneiMm.33996

Genome annotation databases

GeneIDi17857
KEGGimmu:17857
UCSCiuc008adf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12279 mRNA Translation: AAA39776.1
M21117
, M21105, M21106, M21107, M21108, M21109, M21110, M21111, M21112, M21113, M21114, M21115, M21116 Genomic DNA Translation: AAA39777.1
BC011113 mRNA Translation: AAH11113.1
PIRiA31203
RefSeqiNP_034976.1, NM_010846.1
UniGeneiMm.33996

3D structure databases

ProteinModelPortaliP09922
SMRiP09922
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP09922
PhosphoSitePlusiP09922

Proteomic databases

MaxQBiP09922
PRIDEiP09922

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17857
KEGGimmu:17857
UCSCiuc008adf.1 mouse

Organism-specific databases

CTDi4599
MGIiMGI:97243 Mx1

Phylogenomic databases

HOVERGENiHBG008788
InParanoidiP09922

Miscellaneous databases

PROiPR:P09922
SOURCEiSearch...

Gene expression databases

CleanExiMM_MX1

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMX1_MOUSE
AccessioniPrimary (citable) accession number: P09922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again