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Protein

Granulocyte colony-stimulating factor

Gene

CSF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Caution

PubMed:2420009 misquotes the gene name as "CSF1".Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • granulocyte colony-stimulating factor receptor binding Source: GO_Central
  • growth factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P09919

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09919

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Granulocyte colony-stimulating factor
Short name:
G-CSF
Alternative name(s):
Pluripoietin
INN: Filgrastim
INN: Lenograstim
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSF3
Synonyms:C17orf33, GCSF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108342.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2438 CSF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138970 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09919

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).

Organism-specific databases

DisGeNET

More...
DisGeNETi
1440

Open Targets

More...
OpenTargetsi
ENSG00000108342

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26941

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
8367 Hom s G-CSF

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001557030 – 207Granulocyte colony-stimulating factorAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 75
Disulfide bondi97 ↔ 107
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166O-linked (GalNAc...) threonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09919

PeptideAtlas

More...
PeptideAtlasi
P09919

PRoteomics IDEntifications database

More...
PRIDEi
P09919

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52279
52280 [P09919-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09919

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09919

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108342 Expressed in 128 organ(s), highest expression level in smooth muscle tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_CSF3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09919 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09919 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107827, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-61120N

Protein interaction database and analysis system

More...
IntActi
P09919, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225474

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CD9X-ray2.80A/C31-207[»]
1GNCNMR-A31-207[»]
1PGRX-ray3.50A/C/E/G31-207[»]
1RHGX-ray2.20A/B/C31-207[»]
2D9QX-ray2.80A31-207[»]
5GW9X-ray1.65A/B/C/D40-205[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P09919

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09919

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09919

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIM2 Eukaryota
ENOG4111DA4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015371

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005411

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09919

KEGG Orthology (KO)

More...
KOi
K05423

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKLCHPE

Database of Orthologous Groups

More...
OrthoDBi
1289639at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09919

TreeFam database of animal gene trees

More...
TreeFami
TF337698

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR040117 GCSF/MGF
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10511 PTHR10511, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16647 GCSF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001935 IL6_MGF_GCSF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00433 IL6GCSFMGF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00126 IL6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P09919-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPATQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ
60 70 80 90 100
VRKIQGDGAA LQEKLVSECA TYKLCHPEEL VLLGHSLGIP WAPLSSCPSQ
110 120 130 140 150
ALQLAGCLSQ LHSGLFLYQG LLQALEGISP ELGPTLDTLQ LDVADFATTI
160 170 180 190 200
WQQMEELGMA PALQPTQGAM PAFASAFQRR AGGVLVASHL QSFLEVSYRV

LRHLAQP
Length:207
Mass (Da):22,293
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i421F635ECC776996
GO
Isoform Short (identifier: P09919-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-68: Missing.

Show »
Length:204
Mass (Da):21,978
Checksum:i5F07C52F13D6A6D3
GO
Isoform 3 (identifier: P09919-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):18,434
Checksum:iC62B366732AD7664
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N4W3Q8N4W3_HUMAN
Colony stimulating factor 3 (Granul...
CSF3 hCG_30013
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTH8J3KTH8_HUMAN
Granulocyte colony-stimulating fact...
CSF3
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRX2J3QRX2_HUMAN
Granulocyte colony-stimulating fact...
CSF3
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRD4J3QRD4_HUMAN
Granulocyte colony-stimulating fact...
CSF3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30A → M AA sequence (PubMed:8554326).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013073157L → M1 PublicationCorresponds to variant dbSNP:rs2227329Ensembl.1
Natural variantiVAR_013074174A → T1 PublicationCorresponds to variant dbSNP:rs2227330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00267366 – 68Missing in isoform Short. 3 Publications3
Alternative sequenceiVSP_04524669 – 104Missing in isoform 3. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X03438 mRNA Translation: CAA27168.1
X03656 Genomic DNA Translation: CAA27291.1
X03655 mRNA Translation: CAA27290.1
M17706 mRNA Translation: AAA35882.1
AF388025 Genomic DNA Translation: AAK62469.1
CD013926 mRNA No translation available.
AC090844 Genomic DNA No translation available.
M13008 mRNA Translation: AAA03056.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11357.1 [P09919-1]
CCDS11358.2 [P09919-3]
CCDS42314.1 [P09919-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A24573
A25093 FQHUGL

NCBI Reference Sequences

More...
RefSeqi
NP_000750.1, NM_000759.3 [P09919-1]
NP_001171618.1, NM_001178147.1
NP_757373.1, NM_172219.2 [P09919-2]
NP_757374.2, NM_172220.2 [P09919-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2233

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225474; ENSP00000225474; ENSG00000108342 [P09919-1]
ENST00000394148; ENSP00000377704; ENSG00000108342 [P09919-3]
ENST00000394149; ENSP00000377705; ENSG00000108342 [P09919-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1440

UCSC genome browser

More...
UCSCi
uc002htp.4 human [P09919-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Neupogen/Granulokine

Clinical information on Neupogen/Granulokine

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03438 mRNA Translation: CAA27168.1
X03656 Genomic DNA Translation: CAA27291.1
X03655 mRNA Translation: CAA27290.1
M17706 mRNA Translation: AAA35882.1
AF388025 Genomic DNA Translation: AAK62469.1
CD013926 mRNA No translation available.
AC090844 Genomic DNA No translation available.
M13008 mRNA Translation: AAA03056.1
CCDSiCCDS11357.1 [P09919-1]
CCDS11358.2 [P09919-3]
CCDS42314.1 [P09919-2]
PIRiA24573
A25093 FQHUGL
RefSeqiNP_000750.1, NM_000759.3 [P09919-1]
NP_001171618.1, NM_001178147.1
NP_757373.1, NM_172219.2 [P09919-2]
NP_757374.2, NM_172220.2 [P09919-3]
UniGeneiHs.2233

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CD9X-ray2.80A/C31-207[»]
1GNCNMR-A31-207[»]
1PGRX-ray3.50A/C/E/G31-207[»]
1RHGX-ray2.20A/B/C31-207[»]
2D9QX-ray2.80A31-207[»]
5GW9X-ray1.65A/B/C/D40-205[»]
ProteinModelPortaliP09919
SMRiP09919
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107827, 10 interactors
DIPiDIP-61120N
IntActiP09919, 2 interactors
STRINGi9606.ENSP00000225474

Protein family/group databases

Allergomei8367 Hom s G-CSF

PTM databases

iPTMnetiP09919
PhosphoSitePlusiP09919

Polymorphism and mutation databases

BioMutaiCSF3
DMDMi117564

Proteomic databases

PaxDbiP09919
PeptideAtlasiP09919
PRIDEiP09919
ProteomicsDBi52279
52280 [P09919-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1440
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225474; ENSP00000225474; ENSG00000108342 [P09919-1]
ENST00000394148; ENSP00000377704; ENSG00000108342 [P09919-3]
ENST00000394149; ENSP00000377705; ENSG00000108342 [P09919-2]
GeneIDi1440
KEGGihsa:1440
UCSCiuc002htp.4 human [P09919-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1440
DisGeNETi1440
EuPathDBiHostDB:ENSG00000108342.12

GeneCards: human genes, protein and diseases

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GeneCardsi
CSF3
HGNCiHGNC:2438 CSF3
MIMi138970 gene
neXtProtiNX_P09919
OpenTargetsiENSG00000108342
PharmGKBiPA26941

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIM2 Eukaryota
ENOG4111DA4 LUCA
GeneTreeiENSGT00390000017328
HOGENOMiHOG000015371
HOVERGENiHBG005411
InParanoidiP09919
KOiK05423
OMAiHKLCHPE
OrthoDBi1289639at2759
PhylomeDBiP09919
TreeFamiTF337698

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
SignaLinkiP09919
SIGNORiP09919

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CSF3 human
EvolutionaryTraceiP09919

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Granulocyte_colony-stimulating_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1440

Protein Ontology

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PROi
PR:P09919

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108342 Expressed in 128 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CSF3
ExpressionAtlasiP09919 baseline and differential
GenevisibleiP09919 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR040117 GCSF/MGF
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR10511 PTHR10511, 1 hit
PfamiView protein in Pfam
PF16647 GCSF, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09919
Secondary accession number(s): A8MXR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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