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Protein

Interferon alpha-inducible protein 6

Gene

IFI6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571).5 Publications

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Apoptosis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 6Curated
Alternative name(s):
Interferon-induced protein 6-161 Publication
Short name:
Ifi-6-161 Publication
Gene namesi
Name:IFI6Imported
Synonyms:G1P31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000126709.14
HGNCiHGNC:4054 IFI6
MIMi147572 gene
neXtProtiNX_P09912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2537
OpenTargetsiENSG00000126709
PharmGKBiPA28466

Polymorphism and mutation databases

BioMutaiIFI6
DMDMi20178294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000087411 – 130Interferon alpha-inducible protein 6Add BLAST130

Post-translational modificationi

Glycosylated.1 Publication

Proteomic databases

PeptideAtlasiP09912
PRIDEiP09912
ProteomicsDBi52273
52274 [P09912-2]
52275 [P09912-3]

PTM databases

iPTMnetiP09912
PhosphoSitePlusiP09912

Expressioni

Inductioni

Up-regulated by type-I interferon (PubMed:14728724, PubMed:17823654). Up-regulated upon Dengue virus type 2/DENV2 infection (at protein level) (PubMed:26244642).3 Publications

Gene expression databases

BgeeiENSG00000126709 Expressed in 196 organ(s), highest expression level in placenta
CleanExiHS_IFI6
GenevisibleiP09912 HS

Organism-specific databases

HPAiHPA005543

Interactioni

Subunit structurei

Interacts with CIB1; the interaction is direct.1 Publication

Protein-protein interaction databases

BioGridi108812, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP09912
SMRiP09912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002592
HOGENOMiHOG000112988
HOVERGENiHBG006160
InParanoidiP09912
OMAiMSWSAIM
OrthoDBiEOG091G0VGD
PhylomeDBiP09912
TreeFamiTF340510

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P09912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG
60 70 80 90 100
LAVAGLPALG FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG
110 120 130
AGGSSVVIGN IGALMGYATH KYLDSEEDEE
Length:130
Mass (Da):12,927
Last modified:April 16, 2002 - v2
Checksum:iB1C2992A59203B38
GO
Isoform B (identifier: P09912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAG

Show »
Length:134
Mass (Da):13,298
Checksum:iAEEE9641CDAF5CA1
GO
Isoform C (identifier: P09912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GENAGKDAG

Show »
Length:138
Mass (Da):13,670
Checksum:iD6498E4F200EB939
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → V (PubMed:3017706).Curated1
Sequence conflicti8L → V (PubMed:7596809).Curated1
Sequence conflicti116G → R (PubMed:3017706).Curated1
Sequence conflicti116G → R (PubMed:7596809).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00150224G → GENAG in isoform B. 1 Publication1
Alternative sequenceiVSP_00150324G → GENAGKDAG in isoform C. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02492 mRNA Translation: CAA26322.1
U22970 Genomic DNA Translation: AAC50159.1
U22970 Genomic DNA Translation: AAC50160.1
U22970 Genomic DNA Translation: AAC50161.1
BT006850 mRNA Translation: AAP35496.1
AK314488 mRNA Translation: BAG37089.1
AL445490 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07744.1
CH471059 Genomic DNA Translation: EAX07745.1
CH471059 Genomic DNA Translation: EAX07746.1
BC011601 mRNA Translation: AAH11601.1
BC015603 mRNA Translation: AAH15603.1
BN000257 mRNA Translation: CAE12275.1
CCDSiCCDS306.1 [P09912-1]
CCDS307.1 [P09912-2]
CCDS308.1 [P09912-3]
PIRiA26316
RefSeqiNP_002029.3, NM_002038.3 [P09912-1]
NP_075010.1, NM_022872.2 [P09912-2]
NP_075011.1, NM_022873.2 [P09912-3]
UniGeneiHs.523847
Hs.730125

Genome annotation databases

EnsembliENST00000339145; ENSP00000342513; ENSG00000126709 [P09912-3]
ENST00000361157; ENSP00000354736; ENSG00000126709 [P09912-1]
ENST00000362020; ENSP00000355152; ENSG00000126709 [P09912-2]
GeneIDi2537
KEGGihsa:2537
UCSCiuc001bon.2 human [P09912-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02492 mRNA Translation: CAA26322.1
U22970 Genomic DNA Translation: AAC50159.1
U22970 Genomic DNA Translation: AAC50160.1
U22970 Genomic DNA Translation: AAC50161.1
BT006850 mRNA Translation: AAP35496.1
AK314488 mRNA Translation: BAG37089.1
AL445490 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07744.1
CH471059 Genomic DNA Translation: EAX07745.1
CH471059 Genomic DNA Translation: EAX07746.1
BC011601 mRNA Translation: AAH11601.1
BC015603 mRNA Translation: AAH15603.1
BN000257 mRNA Translation: CAE12275.1
CCDSiCCDS306.1 [P09912-1]
CCDS307.1 [P09912-2]
CCDS308.1 [P09912-3]
PIRiA26316
RefSeqiNP_002029.3, NM_002038.3 [P09912-1]
NP_075010.1, NM_022872.2 [P09912-2]
NP_075011.1, NM_022873.2 [P09912-3]
UniGeneiHs.523847
Hs.730125

3D structure databases

ProteinModelPortaliP09912
SMRiP09912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108812, 2 interactors

PTM databases

iPTMnetiP09912
PhosphoSitePlusiP09912

Polymorphism and mutation databases

BioMutaiIFI6
DMDMi20178294

Proteomic databases

PeptideAtlasiP09912
PRIDEiP09912
ProteomicsDBi52273
52274 [P09912-2]
52275 [P09912-3]

Protocols and materials databases

DNASUi2537
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339145; ENSP00000342513; ENSG00000126709 [P09912-3]
ENST00000361157; ENSP00000354736; ENSG00000126709 [P09912-1]
ENST00000362020; ENSP00000355152; ENSG00000126709 [P09912-2]
GeneIDi2537
KEGGihsa:2537
UCSCiuc001bon.2 human [P09912-1]

Organism-specific databases

CTDi2537
DisGeNETi2537
EuPathDBiHostDB:ENSG00000126709.14
GeneCardsiIFI6
HGNCiHGNC:4054 IFI6
HPAiHPA005543
MIMi147572 gene
neXtProtiNX_P09912
OpenTargetsiENSG00000126709
PharmGKBiPA28466
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002592
HOGENOMiHOG000112988
HOVERGENiHBG006160
InParanoidiP09912
OMAiMSWSAIM
OrthoDBiEOG091G0VGD
PhylomeDBiP09912
TreeFamiTF340510

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRSiIFI6 human
GeneWikiiIFI6
GenomeRNAii2537
PROiPR:P09912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126709 Expressed in 196 organ(s), highest expression level in placenta
CleanExiHS_IFI6
GenevisibleiP09912 HS

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFI6_HUMAN
AccessioniPrimary (citable) accession number: P09912
Secondary accession number(s): Q13141
, Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 16, 2002
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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