UniProtKB - P09871 (C1S_HUMAN)
Protein
Complement C1s subcomponent
Gene
C1S
Organism
Homo sapiens (Human)
Status
Functioni
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Catalytic activityi
- Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.1 Publication EC:3.4.21.42
Activity regulationi
Inhibited by SERPING1.1 Publication
Kineticsi
Less efficient than MASP2 in C4 cleavage.
- KM=12.3 µM for complement component C2 (at 37 degrees Celsius)1 Publication
- KM=1.9 µM for complement component C4 (at 37 degrees Celsius)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 60 | Calcium | 1 | |
Metal bindingi | 68 | Calcium | 1 | |
Metal bindingi | 113 | Calcium | 1 | |
Metal bindingi | 131 | Calcium | 1 | |
Metal bindingi | 132 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 134 | Calcium | 1 | |
Metal bindingi | 149 | Calcium | 1 | |
Metal bindingi | 150 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 153 | Calcium; via carbonyl oxygen | 1 | |
Active sitei | 475 | Charge relay system | 1 | |
Active sitei | 529 | Charge relay system | 1 | |
Active sitei | 632 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- identical protein binding Source: IntAct
- serine-type endopeptidase activity Source: UniProtKB
GO - Biological processi
- complement activation Source: Reactome
- complement activation, classical pathway Source: Reactome
- innate immune response Source: UniProtKB-KW
- regulation of complement activation Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Complement pathway, Immunity, Innate immunity |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.4.21.42, 2681 |
PathwayCommonsi | P09871 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-977606, Regulation of Complement cascade |
SABIO-RKi | P09871 |
Protein family/group databases
MEROPSi | S01.193 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C1s subcomponent (EC:3.4.21.42)Alternative name(s): C1 esterase Complement component 1 subcomponent s Cleaved into the following 2 chains: |
Gene namesi | Name:C1S |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182326.14 |
HGNCi | HGNC:1247, C1S |
MIMi | 120580, gene |
neXtProti | NX_P09871 |
Subcellular locationi
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Pathology & Biotechi
Involvement in diseasei
Complement component C1s deficiency (C1SD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Related information in OMIMEhlers-Danlos syndrome, periodontal type, 2 (EDSPD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD2 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth. EDSPD2 transmission pattern is consistent with autosomal dominant inheritance.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077120 | 294 | C → R in EDSPD2. 1 PublicationCorresponds to variant dbSNP:rs886040975EnsemblClinVar. | 1 | |
Natural variantiVAR_077121 | 316 | Missing in EDSPD2; unknown pathological significance. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Ehlers-Danlos syndromeOrganism-specific databases
DisGeNETi | 716 |
MalaCardsi | C1S |
MIMi | 613783, phenotype 617174, phenotype |
OpenTargetsi | ENSG00000182326 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency 75392, Periodontal Ehlers-Danlos syndrome |
PharmGKBi | PA25636 |
Miscellaneous databases
Pharosi | P09871, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3913 |
DrugBanki | DB02371, 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid DB09228, Conestat alfa DB09130, Copper DB12831, Gabexate DB06404, Human C1-esterase inhibitor DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
DrugCentrali | P09871 |
GuidetoPHARMACOLOGYi | 2335 |
Polymorphism and mutation databases
BioMutai | C1S |
DMDMi | 115205 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | 1 PublicationAdd BLAST | 15 | |
ChainiPRO_0000027586 | 16 – 688 | Complement C1s subcomponentAdd BLAST | 673 | |
ChainiPRO_0000027587 | 16 – 437 | Complement C1s subcomponent heavy chainAdd BLAST | 422 | |
ChainiPRO_0000027588 | 438 – 688 | Complement C1s subcomponent light chainAdd BLAST | 251 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 65 ↔ 83 | 1 Publication | ||
Disulfide bondi | 135 ↔ 147 | 1 Publication | ||
Disulfide bondi | 143 ↔ 156 | 1 Publication | ||
Modified residuei | 149 | (3R)-3-hydroxyasparagine1 Publication | 1 | |
Disulfide bondi | 158 ↔ 171 | 1 Publication | ||
Glycosylationi | 174 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 175 ↔ 202 | 1 Publication | ||
Disulfide bondi | 234 ↔ 251 | 1 Publication | ||
Disulfide bondi | 294 ↔ 341 | 1 Publication | ||
Disulfide bondi | 321 ↔ 354 | 1 Publication | ||
Disulfide bondi | 359 ↔ 403 | 1 Publication | ||
Disulfide bondi | 386 ↔ 421 | 1 Publication | ||
Glycosylationi | 406 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 425 ↔ 549 | Interchain (between heavy and light chains)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 595 ↔ 618 | 1 Publication | ||
Disulfide bondi | 628 ↔ 659 | 1 Publication |
Post-translational modificationi
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
CPTACi | non-CPTAC-1103 |
EPDi | P09871 |
jPOSTi | P09871 |
MassIVEi | P09871 |
MaxQBi | P09871 |
PaxDbi | P09871 |
PeptideAtlasi | P09871 |
PRIDEi | P09871 |
ProteomicsDBi | 52270 |
2D gel databases
SWISS-2DPAGEi | P09871 |
PTM databases
GlyConnecti | 1144, 4 N-Linked glycans (2 sites) |
GlyGeni | P09871, 2 sites, 3 N-linked glycans (2 sites) |
iPTMneti | P09871 |
PhosphoSitePlusi | P09871 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182326, Expressed in right lobe of liver and 240 other tissues |
ExpressionAtlasi | P09871, baseline and differential |
Genevisiblei | P09871, HS |
Organism-specific databases
HPAi | ENSG00000182326, Tissue enhanced (liver) |
Interactioni
Subunit structurei
C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.
1 PublicationBinary interactionsi
Hide detailsP09871
With | #Exp. | IntAct |
---|---|---|
C1R [P00736] | 6 | EBI-2810045,EBI-3926504 |
itself | 2 | EBI-2810045,EBI-2810045 |
CREB3 - isoform 1 [O43889-2] | 3 | EBI-2810045,EBI-625022 |
REEP4 [Q9H6H4] | 3 | EBI-2810045,EBI-7545592 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107177, 8 interactors |
ComplexPortali | CPX-1920, Complement C1 complex |
IntActi | P09871, 14 interactors |
MINTi | P09871 |
STRINGi | 9606.ENSP00000385035 |
Chemistry databases
BindingDBi | P09871 |
Miscellaneous databases
RNActi | P09871, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P09871 |
SMRi | P09871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09871 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 130 | CUB 1PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 131 – 172 | EGF-like; calcium-bindingAdd BLAST | 42 | |
Domaini | 175 – 290 | CUB 2PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 292 – 356 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 357 – 423 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 438 – 680 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 243 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
EGF-like domain, Repeat, Signal, SushiPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000157473 |
HOGENOMi | CLU_006842_14_1_1 |
InParanoidi | P09871 |
OMAi | ADAPCSH |
OrthoDBi | 6580at2759 |
PhylomeDBi | P09871 |
TreeFami | TF330373 |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd00041, CUB, 2 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR035708, Complement_C1s_subcomponent IPR000859, CUB_dom IPR001881, EGF-like_Ca-bd_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24255:SF18, PTHR24255:SF18, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00042, CUB, 2 hits SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50494, SSF50494, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01180, CUB, 2 hits PS01187, EGF_CA, 1 hit PS50923, SUSHI, 2 hits PS50240, TRYPSIN_DOM, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
P09871-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI
60 70 80 90 100
HLYFTHLDIE LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ
110 120 130 140 150
VPYNKLQVIF KSDFSNEERF TGFAAYYVAT DINECTDFVD VPCSHFCNNF
160 170 180 190 200
IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF TALIGEIASP NYPKPYPENS
210 220 230 240 250
RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF VAGDRQFGPY
260 270 280 290 300
CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP
310 320 330 340 350
NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS
360 370 380 390 400
KLKCQPVDCG IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE
410 420 430 440 450
YHCAGNGSWV NEVLGPELPK CVPVCGVPRE PFEEKQRIIG GSDADIKNFP
460 470 480 490 500
WQVFFDNPWA GGALINEYWV LTAAHVVEGN REPTMYVGST SVQTSRLAKS
510 520 530 540 550
KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK MGPTVSPICL
560 570 580 590 600
PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV
610 620 630 640 650
EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA
660 670 680
GLVSWGPQCG TYGLYTRVKN YVDWIMKTMQ ENSTPRED
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X232 | A0A087X232_HUMAN | Complement C1s subcomponent | C1S | 682 | Annotation score: | ||
B5MCV4 | B5MCV4_HUMAN | Complement C1s subcomponent | C1S | 168 | Annotation score: | ||
C9JY52 | C9JY52_HUMAN | Complement C1s subcomponent | C1S | 100 | Annotation score: | ||
F8WCZ6 | F8WCZ6_HUMAN | Complement C1s subcomponent | C1S | 521 | Annotation score: | ||
H0Y5D1 | H0Y5D1_HUMAN | Complement C1s subcomponent | C1S | 355 | Annotation score: | ||
C9IZP8 | C9IZP8_HUMAN | Complement C1s subcomponent | C1S | 103 | Annotation score: | ||
F5H7T4 | F5H7T4_HUMAN | Complement C1s subcomponent | C1S | 157 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 294 | C → K AA sequence (PubMed:3007145).Curated | 1 | |
Sequence conflicti | 513 | G → GG (PubMed:2553984).Curated | 1 | |
Sequence conflicti | 573 | T → A AA sequence (PubMed:6362661).Curated | 1 | |
Sequence conflicti | 645 – 646 | TK → GR AA sequence (PubMed:6362661).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033643 | 119 | R → H. Corresponds to variant dbSNP:rs12146727Ensembl. | 1 | |
Natural variantiVAR_077120 | 294 | C → R in EDSPD2. 1 PublicationCorresponds to variant dbSNP:rs886040975EnsemblClinVar. | 1 | |
Natural variantiVAR_077121 | 316 | Missing in EDSPD2; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_033644 | 327 | V → L. Corresponds to variant dbSNP:rs2239170EnsemblClinVar. | 1 | |
Natural variantiVAR_014565 | 383 | R → H. Corresponds to variant dbSNP:rs20573EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06596 mRNA Translation: CAA29817.1 M18767 mRNA Translation: AAA51853.1 J04080 mRNA Translation: AAA51852.1 CH471116 Genomic DNA Translation: EAW88689.1 CH471116 Genomic DNA Translation: EAW88690.1 BC056903 mRNA Translation: AAH56903.1 AB009076 Genomic DNA Translation: BAA86864.1 |
CCDSi | CCDS31735.1 |
PIRi | A40496, C1HUS |
RefSeqi | NP_001333779.1, NM_001346850.1 NP_001725.1, NM_001734.4 NP_958850.1, NM_201442.3 XP_005253817.1, XM_005253760.1 |
Genome annotation databases
Ensembli | ENST00000328916; ENSP00000328173; ENSG00000182326 ENST00000360817; ENSP00000354057; ENSG00000182326 ENST00000406697; ENSP00000385035; ENSG00000182326 |
GeneIDi | 716 |
KEGGi | hsa:716 |
UCSCi | uc001qsj.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
C1Sbase C1S mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06596 mRNA Translation: CAA29817.1 M18767 mRNA Translation: AAA51853.1 J04080 mRNA Translation: AAA51852.1 CH471116 Genomic DNA Translation: EAW88689.1 CH471116 Genomic DNA Translation: EAW88690.1 BC056903 mRNA Translation: AAH56903.1 AB009076 Genomic DNA Translation: BAA86864.1 |
CCDSi | CCDS31735.1 |
PIRi | A40496, C1HUS |
RefSeqi | NP_001333779.1, NM_001346850.1 NP_001725.1, NM_001734.4 NP_958850.1, NM_201442.3 XP_005253817.1, XM_005253760.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ELV | X-ray | 1.70 | A | 356-688 | [»] | |
1NZI | X-ray | 1.50 | A/B | 16-174 | [»] | |
4J1Y | X-ray | 2.66 | A/B | 292-688 | [»] | |
4LMF | X-ray | 2.92 | A/B/C/D | 17-292 | [»] | |
4LOR | X-ray | 2.50 | A | 17-292 | [»] | |
4LOS | X-ray | 2.00 | A | 172-358 | [»] | |
4LOT | X-ray | 2.92 | A | 175-423 | [»] | |
6F1C | X-ray | 4.20 | B/D | 16-292 | [»] | |
6F1H | X-ray | 4.50 | B/D | 17-292 | [»] | |
SASBDBi | P09871 | |||||
SMRi | P09871 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107177, 8 interactors |
ComplexPortali | CPX-1920, Complement C1 complex |
IntActi | P09871, 14 interactors |
MINTi | P09871 |
STRINGi | 9606.ENSP00000385035 |
Chemistry databases
BindingDBi | P09871 |
ChEMBLi | CHEMBL3913 |
DrugBanki | DB02371, 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid DB09228, Conestat alfa DB09130, Copper DB12831, Gabexate DB06404, Human C1-esterase inhibitor DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
DrugCentrali | P09871 |
GuidetoPHARMACOLOGYi | 2335 |
Protein family/group databases
MEROPSi | S01.193 |
PTM databases
GlyConnecti | 1144, 4 N-Linked glycans (2 sites) |
GlyGeni | P09871, 2 sites, 3 N-linked glycans (2 sites) |
iPTMneti | P09871 |
PhosphoSitePlusi | P09871 |
Polymorphism and mutation databases
BioMutai | C1S |
DMDMi | 115205 |
2D gel databases
SWISS-2DPAGEi | P09871 |
Proteomic databases
CPTACi | non-CPTAC-1103 |
EPDi | P09871 |
jPOSTi | P09871 |
MassIVEi | P09871 |
MaxQBi | P09871 |
PaxDbi | P09871 |
PeptideAtlasi | P09871 |
PRIDEi | P09871 |
ProteomicsDBi | 52270 |
Protocols and materials databases
ABCDi | P09871, 28 sequenced antibodies |
Antibodypediai | 3384, 583 antibodies |
Genome annotation databases
Ensembli | ENST00000328916; ENSP00000328173; ENSG00000182326 ENST00000360817; ENSP00000354057; ENSG00000182326 ENST00000406697; ENSP00000385035; ENSG00000182326 |
GeneIDi | 716 |
KEGGi | hsa:716 |
UCSCi | uc001qsj.4, human |
Organism-specific databases
CTDi | 716 |
DisGeNETi | 716 |
EuPathDBi | HostDB:ENSG00000182326.14 |
GeneCardsi | C1S |
HGNCi | HGNC:1247, C1S |
HPAi | ENSG00000182326, Tissue enhanced (liver) |
MalaCardsi | C1S |
MIMi | 120580, gene 613783, phenotype 617174, phenotype |
neXtProti | NX_P09871 |
OpenTargetsi | ENSG00000182326 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency 75392, Periodontal Ehlers-Danlos syndrome |
PharmGKBi | PA25636 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000157473 |
HOGENOMi | CLU_006842_14_1_1 |
InParanoidi | P09871 |
OMAi | ADAPCSH |
OrthoDBi | 6580at2759 |
PhylomeDBi | P09871 |
TreeFami | TF330373 |
Enzyme and pathway databases
BRENDAi | 3.4.21.42, 2681 |
PathwayCommonsi | P09871 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-977606, Regulation of Complement cascade |
SABIO-RKi | P09871 |
Miscellaneous databases
BioGRID-ORCSi | 716, 5 hits in 845 CRISPR screens |
ChiTaRSi | C1S, human |
EvolutionaryTracei | P09871 |
GeneWikii | C1S |
GenomeRNAii | 716 |
Pharosi | P09871, Tchem |
PROi | PR:P09871 |
RNActi | P09871, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182326, Expressed in right lobe of liver and 240 other tissues |
ExpressionAtlasi | P09871, baseline and differential |
Genevisiblei | P09871, HS |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd00041, CUB, 2 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR035708, Complement_C1s_subcomponent IPR000859, CUB_dom IPR001881, EGF-like_Ca-bd_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24255:SF18, PTHR24255:SF18, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00042, CUB, 2 hits SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50494, SSF50494, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01180, CUB, 2 hits PS01187, EGF_CA, 1 hit PS50923, SUSHI, 2 hits PS50240, TRYPSIN_DOM, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C1S_HUMAN | |
Accessioni | P09871Primary (citable) accession number: P09871 Secondary accession number(s): D3DUT4 Q9UM14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 243 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries