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Entry version 199 (29 Sep 2021)
Sequence version 4 (05 Dec 2018)
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Protein

DNA nucleotidylexotransferase

Gene

Dntt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transferase that catalyzes the nontemplated addition of nucleoside triphosphate to coding ends during V(D)J recombination (N addition). Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Does not act on double-stranded DNA with blunt ends.

5 Publications

3'-to-5' DNA exonuclease. Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Acts on single-stranded and double-stranded DNA with 3' or 5' extensions, but not on double-stranded DNA with blunt ends. Attenuates not only isoform TDT-S-catalyzed N addition, but also P (palindromic) addition in coding joins (PubMed:11938351).

Lacks terminal transferase activity (PubMed:11136823, PubMed:7556063).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Can also utilize other divalent cations, such as Mn2+ and Co2+ (in vitro).Curated1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

In assays with isoform TDT-S.1 Publication
  1. KM=300 µM for dATP (at 35 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi343MagnesiumCombined sourcesCurated1
Metal bindingi345MagnesiumCombined sourcesCurated1
Metal bindingi434MagnesiumCombined sourcesCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Transferase
Biological processTerminal addition
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.31, 3474

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA nucleotidylexotransferase (EC:2.7.7.313 Publications, EC:3.1.11.-1 Publication)
Alternative name(s):
Terminal addition enzyme
Terminal deoxynucleotidyltransferase1 Publication
Short name:
TDT
Short name:
Terminal transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dntt
Synonyms:Tdt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98659, Dntt

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000025014

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29D → A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-170 and A-473. Decreased transferase activity in TDT-S; when associated with A-170 and A-473. 1 Publication1
Mutagenesisi170D → A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-29 and A-473. Decreased transferase activity in TDT-S; when associated with A-29 and A-473. 1 Publication1
Mutagenesisi342H → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi398L → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi399D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi400H → A: Reduces enzyme activity. 1 Publication1
Mutagenesisi403K → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi473D → A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-29 and A-170. Decreased transferase activity in TDT-S; when associated with A-29 and A-170. 1 Publication1
Mutagenesisi473D → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi475H → A: Nearly abolishes enzyme activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187921 – 510DNA nucleotidylexotransferaseAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09838

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09838

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09838

PRoteomics IDEntifications database

More...
PRIDEi
P09838

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
263150 [P09838-2]
263151 [P09838-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09838

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09838

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform TDT-L: Expressed in the thymus, and, at lower levels, in the bone marrow (PubMed:8464703, PubMed:11136823, PubMed:7556063). Detected in both cycling and noncycling pro-B and pre-B cells (at protein level) (PubMed:11938351). Isoform TDT-S: Expressed in both cycling and noncycling pro-B, but not pre-B, cells (at protein level) (PubMed:11938351). Not detected in mature peripheral or germinal center B cells (PubMed:11938351).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025014, Expressed in thymus and 61 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09838, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09838, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRP19 and DNTTIP1.

Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.

Interacts with TRERF1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204095, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000062078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P09838, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09838

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09838

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 124BRCTPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni151 – 510Mediates interaction with DNTTIP2By similarityAdd BLAST360
Regioni258 – 262Involved in DNA binding2 Publications5
Regioni333 – 338Deoxynucleoside triphosphate bindingCombined sourcesCurated6
Regioni342 – 345Deoxynucleoside triphosphate bindingCombined sourcesCurated4
Regioni449 – 450Deoxynucleoside triphosphate bindingCombined sourcesCurated2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi11 – 17Nuclear localization signalBy similarity7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2534, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158584

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008698_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09838

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKVINLW

Database of Orthologous Groups

More...
OrthoDBi
1212057at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09838

TreeFam database of animal gene trees

More...
TreeFami
TF103012

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00141, NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR043519, NT_sf
IPR029398, PolB_thumb
IPR027292, TdT
IPR001726, TdT/Mu

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533, BRCT, 1 hit
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000817, DNA_NT, 1 hit
PIRSF501175, TDT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00869, DNAPOLX
PR00871, DNAPOLXTDT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 1 hit
SM00483, POLXc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform TDT-S (identifier: P09838-2) [UniParc]FASTAAdd to basket
Also known as: TDT-Small, TdtS1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA
60 70 80 90 100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE
110 120 130 140 150
LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI
160 170 180 190 200
SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMRASSVLKS
210 220 230 240 250
LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK
260 270 280 290 300
LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTQMQK AGFLYYEDLV
310 320 330 340 350
SCVNRPEAEA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS
360 370 380 390 400
PEATEDEEQQ LLHKVTDFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH
410 420 430 440 450
FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY DRRAFALLGW
460 470 480 490 500
TGSRQFERDL RRYATHERKM MLDNHALYDR TKRVFLEAES EEEIFAHLGL
510
DYIEPWERNA
Note: Major form in the thymus and the bone marrow (PubMed:8464703, PubMed:11136823). Catalyzes the nontemplated addition of nucleoside triphosphate to coding ends during V(D)J recombination (PubMed:23856622). May have a longer half-life than isoform TDT-L (PubMed:7556063).4 Publications
Length:510
Mass (Da):58,266
Last modified:December 5, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF6E850EE36EE3BF
GO
Isoform TDT-L (identifier: P09838-1) [UniParc]FASTAAdd to basket
Also known as: TDT-Large, TdtL1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: K → KGKTVTISPLDGKVSKLQKAL

Note: Exhibits 3'-to-5' DNA exonuclease activity (EC=3.1.11.-) (PubMed:23856622). May have a shorter half-life than isoform TDT-S (PubMed:7556063, PubMed:10878023).3 Publications
Show »
Length:530
Mass (Da):60,331
Checksum:iE6B109DCF39C8107
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26T → M in CAA48634 (PubMed:8464703).Curated1
Sequence conflicti99L → F in CAA48634 (PubMed:8464703).Curated1
Sequence conflicti193R → G in CAA27735 (PubMed:3755527).Curated1
Sequence conflicti287Q → K in CAA27735 (PubMed:3755527).Curated1
Sequence conflicti309E → Q in CAA27735 (PubMed:3755527).Curated1
Sequence conflicti367D → H in CAA27735 (PubMed:3755527).Curated1
Sequence conflicti441 – 445DRRAF → ECAC in CAA27735 (PubMed:3755527).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059967482K → KGKTVTISPLDGKVSKLQKA L in isoform TDT-L. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04123 mRNA Translation: CAA27735.1
X68670 mRNA Translation: CAA48634.2
AF316014 mRNA Translation: AAK07884.1
AF316015 mRNA Translation: AAK07885.1
AK087978 mRNA Translation: BAC40071.1
AK088709 mRNA Translation: BAC40518.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29807.1 [P09838-1]
CCDS37984.1 [P09838-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
B23595

NCBI Reference Sequences

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RefSeqi
NP_001036693.1, NM_001043228.1 [P09838-2]
NP_033371.2, NM_009345.2 [P09838-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000051806; ENSMUSP00000062078; ENSMUSG00000025014 [P09838-1]
ENSMUST00000112200; ENSMUSP00000107819; ENSMUSG00000025014 [P09838-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21673

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21673

UCSC genome browser

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UCSCi
uc008hlo.1, mouse [P09838-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04123 mRNA Translation: CAA27735.1
X68670 mRNA Translation: CAA48634.2
AF316014 mRNA Translation: AAK07884.1
AF316015 mRNA Translation: AAK07885.1
AK087978 mRNA Translation: BAC40071.1
AK088709 mRNA Translation: BAC40518.1
CCDSiCCDS29807.1 [P09838-1]
CCDS37984.1 [P09838-2]
PIRiB23595
RefSeqiNP_001036693.1, NM_001043228.1 [P09838-2]
NP_033371.2, NM_009345.2 [P09838-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMSX-ray2.36A130-510[»]
1KDHX-ray3.00A148-510[»]
1KEJX-ray3.00A148-510[»]
4I27X-ray2.60A132-510[»]
4I28X-ray2.15A132-510[»]
4I29X-ray2.20A132-510[»]
4I2AX-ray1.90A132-510[»]
4I2BX-ray2.20A132-510[»]
4I2CX-ray2.10A132-510[»]
4I2DX-ray2.30A132-510[»]
4I2EX-ray2.00A132-510[»]
4I2FX-ray2.10A132-510[»]
4I2GX-ray2.50A132-510[»]
4I2HX-ray2.75A132-510[»]
4I2IX-ray2.50A132-510[»]
4I2JX-ray2.70A132-510[»]
4IQTX-ray2.60A132-510[»]
4IQUX-ray2.40A132-510[»]
4IQVX-ray2.90A132-510[»]
4IQWX-ray2.60A132-510[»]
4QZ8X-ray2.70A132-510[»]
4QZ9X-ray2.05A132-510[»]
4QZAX-ray2.15A132-510[»]
4QZBX-ray2.15A132-510[»]
4QZCX-ray2.75A132-510[»]
4QZDX-ray2.70A132-510[»]
4QZEX-ray2.25A132-510[»]
4QZFX-ray2.60A132-510[»]
4QZGX-ray2.75A132-510[»]
4QZHX-ray2.60A132-510[»]
4QZIX-ray2.65A132-510[»]
5D46X-ray2.80A132-510[»]
5D49X-ray1.99A132-510[»]
5D4BX-ray2.66A/B132-510[»]
6GO3X-ray2.20A132-377[»]
A409-510[»]
6GO4X-ray1.96A132-377[»]
A409-510[»]
6GO5X-ray2.35A/B132-377[»]
A/B409-510[»]
6GO6X-ray2.09A132-377[»]
A409-510[»]
6GO7X-ray2.55A132-377[»]
A409-510[»]
SMRiP09838
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi204095, 4 interactors
STRINGi10090.ENSMUSP00000062078

PTM databases

iPTMnetiP09838
PhosphoSitePlusiP09838

Proteomic databases

jPOSTiP09838
MaxQBiP09838
PaxDbiP09838
PRIDEiP09838
ProteomicsDBi263150 [P09838-2]
263151 [P09838-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
16924, 586 antibodies

The DNASU plasmid repository

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DNASUi
21673

Genome annotation databases

EnsembliENSMUST00000051806; ENSMUSP00000062078; ENSMUSG00000025014 [P09838-1]
ENSMUST00000112200; ENSMUSP00000107819; ENSMUSG00000025014 [P09838-2]
GeneIDi21673
KEGGimmu:21673
UCSCiuc008hlo.1, mouse [P09838-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1791
MGIiMGI:98659, Dntt
VEuPathDBiHostDB:ENSMUSG00000025014

Phylogenomic databases

eggNOGiKOG2534, Eukaryota
GeneTreeiENSGT00940000158584
HOGENOMiCLU_008698_0_0_1
InParanoidiP09838
OMAiPKVINLW
OrthoDBi1212057at2759
PhylomeDBiP09838
TreeFamiTF103012

Enzyme and pathway databases

BRENDAi2.7.7.31, 3474

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
21673, 7 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dntt, mouse
EvolutionaryTraceiP09838

Protein Ontology

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PROi
PR:P09838
RNActiP09838, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025014, Expressed in thymus and 61 other tissues
ExpressionAtlasiP09838, baseline and differential
GenevisibleiP09838, MM

Family and domain databases

CDDicd00141, NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR043519, NT_sf
IPR029398, PolB_thumb
IPR027292, TdT
IPR001726, TdT/Mu
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit
PIRSFiPIRSF000817, DNA_NT, 1 hit
PIRSF501175, TDT, 1 hit
PRINTSiPR00869, DNAPOLX
PR00871, DNAPOLXTDT
SMARTiView protein in SMART
SM00292, BRCT, 1 hit
SM00483, POLXc, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDT_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09838
Secondary accession number(s): Q99PD0, Q99PD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 5, 2018
Last modified: September 29, 2021
This is version 199 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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