UniProtKB - P09838 (TDT_MOUSE)

BLAST

>sp|P09838|TDT_MOUSE DNA nucleotidylexotransferase OS=Mus musculus OX=10090 GN=Dntt PE=1 SV=3
MDPLQAVHLGPRKKRPRQLGTPVASTPYDIRFRDLVLFILEKKMGTTRRAFLMELARRKG
FRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSELELLDISWLIECMGAGKPVEMM
GRHQLVVNRNSSPSPVPGSQNVPAPAVKKISQYACQRRTTLNNYNQLFTDALDILAENDE
LRENEGSCLAFMRASSVLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAV
LNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYEDLV
SCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLITSPEATEDEEQQ
LLHKVTDFWKQQGLLLYCDILESTFEKFKQPSRKVDALDHFQKCFLILKLDHGRVHSEKS
GQQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDNHALYDR
TKGKTVTISPLDGKVSKLQKALRVFLEAESEEEIFAHLGLDYIEPWERNA

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History
Entry version 182 (07 Nov 2018)
Sequence version 3 (16 Nov 2001)
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Protein

DNA nucleotidylexotransferase

Gene

Dntt

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator (PubMed:23856622). One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.Curated1 Publication

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).2 Publications

Cofactorⁱ

Mg²⁺1 PublicationNote: Can also utilize other divalent cations, such as Mn²⁺ and Co²⁺ (in vitro).Curated1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	343	MagnesiumCombined sourcesCurated	1
Metal bindingⁱ	345	MagnesiumCombined sourcesCurated	1
Metal bindingⁱ	434	MagnesiumCombined sourcesCurated	1

GO - Molecular functionⁱ

DNA binding Source: InterPro
DNA-directed DNA polymerase activity Source: InterPro
DNA nucleotidylexotransferase activity
Source: MGI
Inferred from direct assayⁱ
- 8464703
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA metabolic process
Source: MGI
Inferred from direct assayⁱ
- 8464703
DNA modification Source: UniProtKB-KW
response to ATP Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, Transferase
Biological process	Terminal addition
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.7.31 3474

BRENDAⁱ

2.7.7.31 3474

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA nucleotidylexotransferase (EC:2.7.7.312 Publications) Alternative name(s): Terminal addition enzyme Terminal deoxynucleotidyltransferase1 Publication Short name: TDT Short name: Terminal transferase
Gene namesⁱ	Name:Dntt Synonyms:Tdt
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:98659 Dntt

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	342	H → A: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	398	L → A: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	399	D → A: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	400	H → A: Reduces enzyme activity. 1 Publication	1
Mutagenesisⁱ	403	K → A: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	473	D → A: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	475	H → A: Nearly abolishes enzyme activity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218792	1 – 530	DNA nucleotidylexotransferaseAdd BLAST		530

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	134	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09838
PaxDbⁱ	P09838
PRIDEⁱ	P09838

PTM databases

iPTMnetⁱ	P09838
PhosphoSitePlusⁱ	P09838

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000025014 Expressed in 27 organ(s), highest expression level in thymus
CleanExⁱ	MM_DNTT
ExpressionAtlasⁱ	P09838 baseline and differential
Genevisibleⁱ	P09838 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA. Interacts with TRERF1.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000062078

STRINGⁱ

10090.ENSMUSP00000062078

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	154 – 156	Combined sources	3
Helixⁱ	166 – 181	Combined sources	16
Helixⁱ	185 – 199	Combined sources	15
Helixⁱ	208 – 211	Combined sources	4
Helixⁱ	219 – 231	Combined sources	13
Helixⁱ	235 – 242	Combined sources	8
Helixⁱ	244 – 253	Combined sources	10
Helixⁱ	260 – 268	Combined sources	9
Helixⁱ	274 – 279	Combined sources	6
Helixⁱ	287 – 294	Combined sources	8
Helixⁱ	296 – 300	Combined sources	5
Helixⁱ	305 – 322	Combined sources	18
Beta strandⁱ	327 – 330	Combined sources	4
Helixⁱ	332 – 335	Combined sources	4
Beta strandⁱ	339 – 342	Combined sources	4
Beta strandⁱ	344 – 349	Combined sources	6
Helixⁱ	355 – 372	Combined sources	18
Beta strandⁱ	375 – 381	Combined sources	7
Helixⁱ	387 – 389	Combined sources	3
Beta strandⁱ	394 – 396	Combined sources	3
Beta strandⁱ	401 – 411	Combined sources	11
Helixⁱ	412 – 414	Combined sources	3
Beta strandⁱ	425 – 437	Combined sources	13
Helixⁱ	440 – 442	Combined sources	3
Helixⁱ	443 – 451	Combined sources	9
Helixⁱ	454 – 468	Combined sources	15
Beta strandⁱ	470 – 472	Combined sources	3
Beta strandⁱ	477 – 479	Combined sources	3
Turnⁱ	480 – 482	Combined sources	3
Beta strandⁱ	504 – 506	Combined sources	3
Helixⁱ	511 – 518	Combined sources	8
Helixⁱ	525 – 527	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P09838
SMRⁱ	P09838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P09838

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 124	BRCTPROSITE-ProRule annotationAdd BLAST		98

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	151 – 530	Mediates interaction with DNTTIP2By similarityAdd BLAST	380
Regionⁱ	258 – 262	Involved in DNA binding2 Publications	5
Regionⁱ	333 – 338	Deoxynucleoside triphosphate bindingCombined sourcesCurated	6
Regionⁱ	342 – 345	Deoxynucleoside triphosphate bindingCombined sourcesCurated	4
Regionⁱ	449 – 450	Deoxynucleoside triphosphate bindingCombined sourcesCurated	2

Sequence similaritiesⁱ

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2534 Eukaryota COG1796 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063002
HOGENOMⁱ	HOG000263600
HOVERGENⁱ	HBG003670
InParanoidⁱ	P09838
KEGG Orthology (KO) More...KOⁱ	K00977
OMAⁱ	KTWKAIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G073W
PhylomeDBⁱ	P09838
TreeFamⁱ	TF103012

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027 BRCT, 1 hit cd00141 NT_POLXc, 1 hit
Gene3Dⁱ	1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR002054 DNA-dir_DNA_pol_X IPR019843 DNA_pol-X_BS IPR010996 DNA_pol_b-like_N IPR028207 DNA_pol_B_palm_palm IPR018944 DNA_pol_lambd_fingers_domain IPR027421 DNA_pol_lamdba_lyase_dom_sf IPR037160 DNA_Pol_thumb_sf IPR022312 DNA_pol_X IPR029398 PolB_thumb IPR027292 TdT IPR001726 TdT/Mu
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF14792 DNA_pol_B_palm, 1 hit PF14791 DNA_pol_B_thumb, 1 hit PF10391 DNA_pol_lambd_f, 1 hit PF14716 HHH_8, 1 hit
PIRSFⁱ	PIRSF000817 DNA_NT, 1 hit PIRSF501175 TDT, 1 hit
PRINTSⁱ	PR00869 DNAPOLX PR00871 DNAPOLXTDT
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM00483 POLXc, 1 hit
SUPFAMⁱ	SSF47802 SSF47802, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS00522 DNA_POLYMERASE_X, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform TDT-L (identifier: P09838-1) [UniParc]FASTA Add to basket

Also known as: TDT-Large, TdtL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA 
        60         70         80         90        100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE 
       110        120        130        140        150
LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI 
       160        170        180        190        200
SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMRASSVLKS 
       210        220        230        240        250
LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK 
       260        270        280        290        300
LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTQMQK AGFLYYEDLV 
       310        320        330        340        350
SCVNRPEAEA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS 
       360        370        380        390        400
PEATEDEEQQ LLHKVTDFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH 
       410        420        430        440        450
FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY DRRAFALLGW 
       460        470        480        490        500
TGSRQFERDL RRYATHERKM MLDNHALYDR TKGKTVTISP LDGKVSKLQK 
       510        520        530
ALRVFLEAES EEEIFAHLGL DYIEPWERNA

Note: Inactivated at physiological temperature but is stable at lower temperatures.

Length:530

Mass (Da):60,331

Last modified:November 16, 2001 - v3

Checksum:ⁱE6B109DCF39C8107

Isoform TDT-S (identifier: P09838-2) [UniParc]FASTA Add to basket

Also known as: TDT-Small, TdtS

The sequence of this isoform differs from the canonical sequence as follows:
483-502: Missing.

« Hide

        10         20         30         40         50
MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA 
        60         70         80         90        100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE 
       110        120        130        140        150
LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI 
       160        170        180        190        200
SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMRASSVLKS 
       210        220        230        240        250
LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK 
       260        270        280        290        300
LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTQMQK AGFLYYEDLV 
       310        320        330        340        350
SCVNRPEAEA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS 
       360        370        380        390        400
PEATEDEEQQ LLHKVTDFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH 
       410        420        430        440        450
FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY DRRAFALLGW 
       460        470        480        490        500
TGSRQFERDL RRYATHERKM MLDNHALYDR TKRVFLEAES EEEIFAHLGL 
       510
DYIEPWERNA

Note: Major form.

Show »

Length:510

Mass (Da):58,266

Checksum:ⁱCF6E850EE36EE3BF

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	T → M in CAA48634 (PubMed:8464703).Curated	1
Sequence conflictⁱ	99	L → F in CAA48634 (PubMed:8464703).Curated	1
Sequence conflictⁱ	193	R → G in CAA27735 (PubMed:3755527).Curated	1
Sequence conflictⁱ	287	Q → K in CAA27735 (PubMed:3755527).Curated	1
Sequence conflictⁱ	309	E → Q in CAA27735 (PubMed:3755527).Curated	1
Sequence conflictⁱ	367	D → H in CAA27735 (PubMed:3755527).Curated	1
Sequence conflictⁱ	441 – 445	DRRAF → ECAC in CAA27735 (PubMed:3755527).Curated	5

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001309	483 – 502	Missing in isoform TDT-S. 1 PublicationAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04123 mRNA Translation: CAA27735.1 X68670 mRNA Translation: CAA48634.2 AF316014 mRNA Translation: AAK07884.1 AF316015 mRNA Translation: AAK07885.1 AK087978 mRNA Translation: BAC40071.1 AK088709 mRNA Translation: BAC40518.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29807.1 [P09838-1] CCDS37984.1 [P09838-2]
PIRⁱ	B23595
NCBI Reference Sequences More...RefSeqⁱ	NP_001036693.1, NM_001043228.1 [P09838-2] NP_033371.2, NM_009345.2 [P09838-1]
UniGeneⁱ	Mm.25620

Genome annotation databases

Ensemblⁱ	ENSMUST00000051806; ENSMUSP00000062078; ENSMUSG00000025014 [P09838-1] ENSMUST00000112200; ENSMUSP00000107819; ENSMUSG00000025014 [P09838-2]
GeneIDⁱ	21673
KEGGⁱ	mmu:21673
UCSC genome browser More...UCSCⁱ	uc008hlo.1 mouse [P09838-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09838-2	DNA nucleotidylexotransferase		RAT		510	UniRef90_E9PT58
DNA nucleotidylexotransferase		MOUSE		510
UPI000A315E94		MUSCR		510
DNA nucleotidylexotransferase		RAT		510
UPI0000112133		MOUSE		363
+2

Protein	Similar proteins		Species	Score	Length	Source
P09838	DNA nucleotidylexotransferase	)	HUMAN		509	UniRef50_P09838
DNA nucleotidylexotransferase		CHICK		506
DNA nucleotidylexotransferase		EULMA		511
DNA nucleotidylexotransferase		AMBME		510
DNA nucleotidylexotransferase		MONDO		518
+303

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04123 mRNA Translation: CAA27735.1 X68670 mRNA Translation: CAA48634.2 AF316014 mRNA Translation: AAK07884.1 AF316015 mRNA Translation: AAK07885.1 AK087978 mRNA Translation: BAC40071.1 AK088709 mRNA Translation: BAC40518.1
CCDSⁱ	CCDS29807.1 [P09838-1] CCDS37984.1 [P09838-2]
PIRⁱ	B23595
RefSeqⁱ	NP_001036693.1, NM_001043228.1 [P09838-2] NP_033371.2, NM_009345.2 [P09838-1]
UniGeneⁱ	Mm.25620

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JMS	X-ray	2.36	A	130-530	[»]
	1KDH	X-ray	3.00	A	148-530	[»]
	1KEJ	X-ray	3.00	A	148-530	[»]
	4I27	X-ray	2.60	A	132-530	[»]
	4I28	X-ray	2.15	A	132-530	[»]
	4I29	X-ray	2.20	A	132-530	[»]
	4I2A	X-ray	1.90	A	132-530	[»]
	4I2B	X-ray	2.20	A	132-530	[»]
	4I2C	X-ray	2.10	A	132-530	[»]
	4I2D	X-ray	2.30	A	132-530	[»]
	4I2E	X-ray	2.00	A	132-530	[»]
	4I2F	X-ray	2.10	A	132-530	[»]
	4I2G	X-ray	2.50	A	132-530	[»]
	4I2H	X-ray	2.75	A	132-530	[»]
	4I2I	X-ray	2.50	A	132-530	[»]
	4I2J	X-ray	2.70	A	132-530	[»]
	4IQT	X-ray	2.60	A	132-530	[»]
	4IQU	X-ray	2.40	A	132-530	[»]
	4IQV	X-ray	2.90	A	132-530	[»]
	4IQW	X-ray	2.60	A	132-530	[»]
	4QZ8	X-ray	2.70	A	132-530	[»]
	4QZ9	X-ray	2.05	A	132-530	[»]
	4QZA	X-ray	2.15	A	132-530	[»]
	4QZB	X-ray	2.15	A	132-530	[»]
	4QZC	X-ray	2.75	A	132-530	[»]
	4QZD	X-ray	2.70	A	132-530	[»]
	4QZE	X-ray	2.25	A	132-530	[»]
	4QZF	X-ray	2.60	A	132-530	[»]
	4QZG	X-ray	2.75	A	132-530	[»]
	4QZH	X-ray	2.60	A	132-530	[»]
	4QZI	X-ray	2.65	A	132-530	[»]
	5D46	X-ray	2.80	A	132-530	[»]
	5D49	X-ray	1.99	A	132-530	[»]
	5D4B	X-ray	2.66	A/B	132-530	[»]
ProteinModelPortalⁱ	P09838
SMRⁱ	P09838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000062078

STRINGⁱ

10090.ENSMUSP00000062078

PTM databases

iPTMnetⁱ	P09838
PhosphoSitePlusⁱ	P09838

Proteomic databases

MaxQBⁱ	P09838
PaxDbⁱ	P09838
PRIDEⁱ	P09838

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	21673
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000051806; ENSMUSP00000062078; ENSMUSG00000025014 [P09838-1] ENSMUST00000112200; ENSMUSP00000107819; ENSMUSG00000025014 [P09838-2]
GeneIDⁱ	21673
KEGGⁱ	mmu:21673
UCSCⁱ	uc008hlo.1 mouse [P09838-1]

Organism-specific databases

CTDⁱ	1791
MGIⁱ	MGI:98659 Dntt

Phylogenomic databases

eggNOGⁱ	KOG2534 Eukaryota COG1796 LUCA
GeneTreeⁱ	ENSGT00530000063002
HOGENOMⁱ	HOG000263600
HOVERGENⁱ	HBG003670
InParanoidⁱ	P09838
KOⁱ	K00977
OMAⁱ	KTWKAIR
OrthoDBⁱ	EOG091G073W
PhylomeDBⁱ	P09838
TreeFamⁱ	TF103012

Enzyme and pathway databases

BRENDAⁱ	2.7.7.31 3474

BRENDAⁱ

2.7.7.31 3474

Miscellaneous databases

EvolutionaryTraceⁱ	P09838
Protein Ontology More...PROⁱ	PR:P09838
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025014 Expressed in 27 organ(s), highest expression level in thymus
CleanExⁱ	MM_DNTT
ExpressionAtlasⁱ	P09838 baseline and differential
Genevisibleⁱ	P09838 MM

Family and domain databases

CDDⁱ	cd00027 BRCT, 1 hit cd00141 NT_POLXc, 1 hit
Gene3Dⁱ	1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR002054 DNA-dir_DNA_pol_X IPR019843 DNA_pol-X_BS IPR010996 DNA_pol_b-like_N IPR028207 DNA_pol_B_palm_palm IPR018944 DNA_pol_lambd_fingers_domain IPR027421 DNA_pol_lamdba_lyase_dom_sf IPR037160 DNA_Pol_thumb_sf IPR022312 DNA_pol_X IPR029398 PolB_thumb IPR027292 TdT IPR001726 TdT/Mu
Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF14792 DNA_pol_B_palm, 1 hit PF14791 DNA_pol_B_thumb, 1 hit PF10391 DNA_pol_lambd_f, 1 hit PF14716 HHH_8, 1 hit
PIRSFⁱ	PIRSF000817 DNA_NT, 1 hit PIRSF501175 TDT, 1 hit
PRINTSⁱ	PR00869 DNAPOLX PR00871 DNAPOLXTDT
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM00483 POLXc, 1 hit
SUPFAMⁱ	SSF47802 SSF47802, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS00522 DNA_POLYMERASE_X, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TDT_MOUSE
Accessionⁱ	P09838Primary (citable) accession number: P09838 Secondary accession number(s): Q99PD0, Q99PD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	November 16, 2001
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P09838 (TDT_MOUSE)

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DNA nucleotidylexotransferase

Dntt

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ