Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P09833 (MODC_ECOLI)

Entry version 181 (07 Apr 2021)
Sequence version 4 (20 Jun 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Molybdenum import ATP-binding protein ModC

Gene

modC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi31 – 38ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Molybdenum, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:MODC-MONOMER
MetaCyc:MODC-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.8.1, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdenum import ATP-binding protein ModCUniRule annotation (EC:7.3.2.5UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:modCUniRule annotation
Synonyms:chlD, narD
Ordered Locus Names:b0765, JW0748
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000925371 – 352Molybdenum import ATP-binding protein ModCAdd BLAST352

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09833

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09833

PRoteomics IDEntifications database

More...PRIDEi		P09833

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).

UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261147, 9 interactors
849738, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4342, Molybdate ABC transporter complex

Protein interaction database and analysis system

More...IntActi		P09833, 2 interactors

STRING: functional protein association networks

More...STRINGi		511145.b0765

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09833

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 229ABC transporterUniRule annotationAdd BLAST229
Domaini289 – 352MopPROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. [View classification]UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG4148, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09833

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09833

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR015852, ABC_transpr_ModC
IPR008995, Mo/tungstate-bd_C_term_dom
IPR011868, ModC_ABC_ATP-bd
IPR004606, Mop_domain
IPR027417, P-loop_NTPase
IPR005116, Transp-assoc_OB_typ1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00005, ABC_tran, 1 hit
PF03459, TOBE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50331, SSF50331, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02142, modC_ABC, 1 hit
TIGR00638, Mop, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit
PS51241, MODC, 1 hit
PS51866, MOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P09833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLELNFSQTL GNHCLTINET LPANGITAIF GVSGAGKTSL INAISGLTRP 
        60         70         80         90        100
QKGRIVLNGR VLNDAEKGIC LTPEKRRVGY VFQDARLFPH YKVRGNLRYG 
       110        120        130        140        150
MSKSMVDQFD KLVALLGIEP LLDRLPGSLS GGEKQRVAIG RALLTAPELL 
       160        170        180        190        200
LLDEPLASLD IPRKRELLPY LQRLTREINI PMLYVSHSLD EILHLADRVM 
       210        220        230        240        250
VLENGQVKAF GALEEVWGSS VMNPWLPKEQ QSSILKVTVL EHHPHYAMTA 
       260        270        280        290        300
LALGDQHLWV NKLDEPLQAA LRIRIQASDV SLVLQPPQQT SIRNVLRAKV 
       310        320        330        340        350
VNSYDDNGQV EVELEVGGKT LWARISPWAR DELAIKPGLW LYAQIKSVSI 

TA
Length:352
Mass (Da):39,102
Last modified:June 20, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15D9CAAE511AF7D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244 – 250PHYAMTA → SALRDDR in AAB06895 (PubMed:8564363).Curated7
Sequence conflicti244 – 250PHYAMTA → SALRDDR in AAA83840 (PubMed:3553151).Curated7
Sequence conflicti269 – 352AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAA83840 (PubMed:3553151).CuratedAdd BLAST84
Sequence conflicti269 – 352AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAB00837 (PubMed:3553151).CuratedAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U27192 Genomic DNA Translation: AAB60173.1
M16182 Genomic DNA Translation: AAA83840.1
U07867 Genomic DNA Translation: AAB06895.1
L34009 Genomic DNA Translation: AAB00837.1
U00096 Genomic DNA Translation: AAC73852.1
AP009048 Genomic DNA Translation: BAA35429.1

Protein sequence database of the Protein Information Resource

More...PIRi		E64812, BVECHD

NCBI Reference Sequences

More...RefSeqi		NP_415286.1, NC_000913.3
WP_000891692.1, NZ_STEB01000028.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73852; AAC73852; b0765
BAA35429; BAA35429; BAA35429

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57728440
945362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0748
eco:b0765

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1513

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27192 Genomic DNA Translation: AAB60173.1
M16182 Genomic DNA Translation: AAA83840.1
U07867 Genomic DNA Translation: AAB06895.1
L34009 Genomic DNA Translation: AAB00837.1
U00096 Genomic DNA Translation: AAC73852.1
AP009048 Genomic DNA Translation: BAA35429.1
PIRiE64812, BVECHD
RefSeqiNP_415286.1, NC_000913.3
WP_000891692.1, NZ_STEB01000028.1

3D structure databases

SMRiP09833
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261147, 9 interactors
849738, 1 interactor
ComplexPortaliCPX-4342, Molybdate ABC transporter complex
IntActiP09833, 2 interactors
STRINGi511145.b0765

Protein family/group databases

TCDBi3.A.1.8.1, the atp-binding cassette (abc) superfamily

Proteomic databases

jPOSTiP09833
PaxDbiP09833
PRIDEiP09833

Genome annotation databases

EnsemblBacteriaiAAC73852; AAC73852; b0765
BAA35429; BAA35429; BAA35429
GeneIDi57728440
945362
KEGGiecj:JW0748
eco:b0765
PATRICifig|1411691.4.peg.1513

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0150

Phylogenomic databases

eggNOGiCOG4148, Bacteria
HOGENOMiCLU_000604_1_1_6
InParanoidiP09833
PhylomeDBiP09833

Enzyme and pathway databases

BioCyciEcoCyc:MODC-MONOMER
MetaCyc:MODC-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P09833

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR015852, ABC_transpr_ModC
IPR008995, Mo/tungstate-bd_C_term_dom
IPR011868, ModC_ABC_ATP-bd
IPR004606, Mop_domain
IPR027417, P-loop_NTPase
IPR005116, Transp-assoc_OB_typ1
PfamiView protein in Pfam
PF00005, ABC_tran, 1 hit
PF03459, TOBE, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF50331, SSF50331, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR02142, modC_ABC, 1 hit
TIGR00638, Mop, 1 hit
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit
PS51241, MODC, 1 hit
PS51866, MOP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMODC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09833
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: June 20, 2003
Last modified: April 7, 2021
This is version 181 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again