UniProtKB - P09833 (MODC_ECOLI)
Protein
Molybdenum import ATP-binding protein ModC
Gene
modC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.UniRule annotation
Catalytic activityi
- EC:7.3.2.5UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 38 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ABC-type molybdate transporter activity Source: UniProtKB-UniRule
- ATPase activity Source: InterPro
- ATP binding Source: EcoCyc
- molybdenum ion transmembrane transporter activity Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Molybdenum, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:MODC-MONOMER MetaCyc:MODC-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.8.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Molybdenum import ATP-binding protein ModCUniRule annotation (EC:7.3.2.5UniRule annotation) |
Gene namesi | Name:modCUniRule annotation Synonyms:chlD, narD Ordered Locus Names:b0765, JW0748 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092537 | 1 – 352 | Molybdenum import ATP-binding protein ModCAdd BLAST | 352 |
Proteomic databases
jPOSTi | P09833 |
PaxDbi | P09833 |
PRIDEi | P09833 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4261147, 9 interactors 849738, 1 interactor |
ComplexPortali | CPX-4342, Molybdate ABC transporter complex |
IntActi | P09833, 2 interactors |
STRINGi | 511145.b0765 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 229 | ABC transporterUniRule annotationAdd BLAST | 229 | |
Domaini | 289 – 352 | MopPROSITE-ProRule annotationAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. [View classification]UniRule annotation
Phylogenomic databases
eggNOGi | COG4148, Bacteria |
HOGENOMi | CLU_000604_1_1_6 |
InParanoidi | P09833 |
PhylomeDBi | P09833 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015852, ABC_transpr_ModC IPR008995, Mo/tungstate-bd_C_term_dom IPR011868, ModC_ABC_ATP-bd IPR004606, Mop_domain IPR027417, P-loop_NTPase IPR005116, Transp-assoc_OB_typ1 |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF03459, TOBE, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02142, modC_ABC, 1 hit TIGR00638, Mop, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51241, MODC, 1 hit PS51866, MOP, 1 hit |
i Sequence
Sequence statusi: Complete.
P09833-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLELNFSQTL GNHCLTINET LPANGITAIF GVSGAGKTSL INAISGLTRP
60 70 80 90 100
QKGRIVLNGR VLNDAEKGIC LTPEKRRVGY VFQDARLFPH YKVRGNLRYG
110 120 130 140 150
MSKSMVDQFD KLVALLGIEP LLDRLPGSLS GGEKQRVAIG RALLTAPELL
160 170 180 190 200
LLDEPLASLD IPRKRELLPY LQRLTREINI PMLYVSHSLD EILHLADRVM
210 220 230 240 250
VLENGQVKAF GALEEVWGSS VMNPWLPKEQ QSSILKVTVL EHHPHYAMTA
260 270 280 290 300
LALGDQHLWV NKLDEPLQAA LRIRIQASDV SLVLQPPQQT SIRNVLRAKV
310 320 330 340 350
VNSYDDNGQV EVELEVGGKT LWARISPWAR DELAIKPGLW LYAQIKSVSI
TA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 – 250 | PHYAMTA → SALRDDR in AAB06895 (PubMed:8564363).Curated | 7 | |
Sequence conflicti | 244 – 250 | PHYAMTA → SALRDDR in AAA83840 (PubMed:3553151).Curated | 7 | |
Sequence conflicti | 269 – 352 | AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAA83840 (PubMed:3553151).CuratedAdd BLAST | 84 | |
Sequence conflicti | 269 – 352 | AALRI…VSITA → LRYYPHSGFRCFSWFYNRRS KPAFVTIAGKSC in AAB00837 (PubMed:3553151).CuratedAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27192 Genomic DNA Translation: AAB60173.1 M16182 Genomic DNA Translation: AAA83840.1 U07867 Genomic DNA Translation: AAB06895.1 L34009 Genomic DNA Translation: AAB00837.1 U00096 Genomic DNA Translation: AAC73852.1 AP009048 Genomic DNA Translation: BAA35429.1 |
PIRi | E64812, BVECHD |
RefSeqi | NP_415286.1, NC_000913.3 WP_000891692.1, NZ_STEB01000028.1 |
Genome annotation databases
EnsemblBacteriai | AAC73852; AAC73852; b0765 BAA35429; BAA35429; BAA35429 |
GeneIDi | 57728440 945362 |
KEGGi | ecj:JW0748 eco:b0765 |
PATRICi | fig|1411691.4.peg.1513 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27192 Genomic DNA Translation: AAB60173.1 M16182 Genomic DNA Translation: AAA83840.1 U07867 Genomic DNA Translation: AAB06895.1 L34009 Genomic DNA Translation: AAB00837.1 U00096 Genomic DNA Translation: AAC73852.1 AP009048 Genomic DNA Translation: BAA35429.1 |
PIRi | E64812, BVECHD |
RefSeqi | NP_415286.1, NC_000913.3 WP_000891692.1, NZ_STEB01000028.1 |
3D structure databases
SMRi | P09833 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261147, 9 interactors 849738, 1 interactor |
ComplexPortali | CPX-4342, Molybdate ABC transporter complex |
IntActi | P09833, 2 interactors |
STRINGi | 511145.b0765 |
Protein family/group databases
TCDBi | 3.A.1.8.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P09833 |
PaxDbi | P09833 |
PRIDEi | P09833 |
Genome annotation databases
EnsemblBacteriai | AAC73852; AAC73852; b0765 BAA35429; BAA35429; BAA35429 |
GeneIDi | 57728440 945362 |
KEGGi | ecj:JW0748 eco:b0765 |
PATRICi | fig|1411691.4.peg.1513 |
Organism-specific databases
EchoBASEi | EB0150 |
Phylogenomic databases
eggNOGi | COG4148, Bacteria |
HOGENOMi | CLU_000604_1_1_6 |
InParanoidi | P09833 |
PhylomeDBi | P09833 |
Enzyme and pathway databases
BioCyci | EcoCyc:MODC-MONOMER MetaCyc:MODC-MONOMER |
Miscellaneous databases
PROi | PR:P09833 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015852, ABC_transpr_ModC IPR008995, Mo/tungstate-bd_C_term_dom IPR011868, ModC_ABC_ATP-bd IPR004606, Mop_domain IPR027417, P-loop_NTPase IPR005116, Transp-assoc_OB_typ1 |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF03459, TOBE, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50331, SSF50331, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02142, modC_ABC, 1 hit TIGR00638, Mop, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51241, MODC, 1 hit PS51866, MOP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MODC_ECOLI | |
Accessioni | P09833Primary (citable) accession number: P09833 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | June 20, 2003 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families