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Entry version 177 (02 Dec 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Glutamate synthase [NADPH] large chain

Gene

gltB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate.

1 Publication

Miscellaneous

Glutamine binds to the large subunit and transfers the amido group to 2-oxoglutarate that apparently binds to the small subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.3 µM for 2-oxoglutarate1 Publication
  2. KM=250 µM for L-glutamine1 Publication

    pH dependencei

    Optimum pH is 7.6.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-glutamate biosynthesis via GLT pathway

    This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route). This subpathway is part of the pathway L-glutamate biosynthesis via GLT pathway, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route), the pathway L-glutamate biosynthesis via GLT pathway and in Amino-acid biosynthesis.

    Pathwayi: nitrogen metabolism

    This protein is involved in the pathway nitrogen metabolism, which is part of Energy metabolism.
    View all proteins of this organism that are known to be involved in the pathway nitrogen metabolism and in Energy metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei12NucleophilePROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1102Iron-sulfur (3Fe-4S)By similarity1
    Metal bindingi1108Iron-sulfur (3Fe-4S)By similarity1
    Metal bindingi1113Iron-sulfur (3Fe-4S)By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1049 – 1101FMNBy similarityAdd BLAST53

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processAmino-acid biosynthesis, Glutamate biosynthesis
    Ligand3Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:GLUSYNLARGE-MONOMER
    MetaCyc:GLUSYNLARGE-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.4.1.13, 2026

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P09831

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00045
    UPA00634;UER00689

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C44.003

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutamate synthase [NADPH] large chain (EC:1.4.1.131 Publication)
    Alternative name(s):
    Glutamate synthase subunit alpha
    Short name:
    GLTS alpha chain
    NADPH-GOGAT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gltB
    Synonyms:aspB
    Ordered Locus Names:b3212, JW3179
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000116201 – 11Add BLAST11
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001162112 – 1486Glutamate synthase [NADPH] large chainAdd BLAST1475

    Keywords - PTMi

    Zymogen

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P09831

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P09831

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P09831

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Aggregate of 4 catalytic active heterodimers, consisting of a large and a small subunit.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4263210, 352 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-5041, Glutamate synthase [NADPH] complex

    Database of interacting proteins

    More...
    DIPi
    DIP-9802N

    Protein interaction database and analysis system

    More...
    IntActi
    P09831, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b3212

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P09831

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 402Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd BLAST391

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glutamate synthase family.Curated

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0067, Bacteria
    COG0069, Bacteria
    COG0070, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000422_8_2_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P09831

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P09831

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00982, gltB_C, 1 hit
    cd02808, GltS_FMN, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.160.20.60, 1 hit
    3.20.20.70, 2 hits
    3.60.20.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785, Aldolase_TIM
    IPR017932, GATase_2_dom
    IPR002489, Glu_synth_asu_C
    IPR036485, Glu_synth_asu_C_sf
    IPR006982, Glu_synth_centr_N
    IPR002932, Glu_synthdom
    IPR029055, Ntn_hydrolases_N

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00310, GATase_2, 1 hit
    PF04898, Glu_syn_central, 1 hit
    PF01645, Glu_synthase, 1 hit
    PF01493, GXGXG, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56235, SSF56235, 1 hit
    SSF69336, SSF69336, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51278, GATASE_TYPE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P09831-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLYDKSLERD NCGFGLIAHI EGEPSHKVVR TAIHALARMQ HRGAILADGK
    60 70 80 90 100
    TGDGCGLLLQ KPDRFFRIVA QERGWRLAKN YAVGMLFLNK DPELAAAARR
    110 120 130 140 150
    IVEEELQRET LSIVGWRDVP TNEGVLGEIA LSSLPRIEQI FVNAPAGWRP
    160 170 180 190 200
    RDMERRLFIA RRRIEKRLEA DKDFYVCSLS NLVNIYKGLC MPTDLPRFYL
    210 220 230 240 250
    DLADLRLESA ICLFHQRFST NTVPRWPLAQ PFRYLAHNGE INTITGNRQW
    260 270 280 290 300
    ARARTYKFQT PLIPDLHDAA PFVNETGSDS SSMDNMLELL LAGGMDIIRA
    310 320 330 340 350
    MRLLVPPAWQ NNPDMDPELR AFFDFNSMHM EPWDGPAGIV MSDGRFAACN
    360 370 380 390 400
    LDRNGLRPAR YVITKDKLIT CASEVGIWDY QPDEVVEKGR VGPGELMVID
    410 420 430 440 450
    TRSGRILHSA ETDDDLKSRH PYKEWMEKNV RRLVPFEDLP DEEVGSRELD
    460 470 480 490 500
    DDTLASYQKQ FNYSAEELDS VIRVLGENGQ EAVGSMGDDT PFAVLSSQPR
    510 520 530 540 550
    IIYDYFRQQF AQVTNPPIDP LREAHVMSLA TSIGREMNVF CEAEGQAHRL
    560 570 580 590 600
    SFKSPILLYS DFKQLTTMKE EHYRADTLDI TFDVTKTTLE ATVKELCDKA
    610 620 630 640 650
    EKMVRSGTVL LVLSDRNIAK DRLPVPAPMA VGAIQTRLVD QSLRCDANII
    660 670 680 690 700
    VETASARDPH HFAVLLGFGA TAIYPYLAYE TLGRLVDTHA IAKDYRTVML
    710 720 730 740 750
    NYRNGINKGL YKIMSKMGIS TIASYRCSKL FEAVGLHDDV VGLCFQGAVS
    760 770 780 790 800
    RIGGASFEDF QQDLLNLSKR AWLARKPISQ GGLLKYVHGG EYHAYNPDVV
    810 820 830 840 850
    RTLQQAVQSG EYSDYQEYAK LVNERPATTL RDLLAITPGE NAVNIADVEP
    860 870 880 890 900
    ASELFKRFDT AAMSIGALSP EAHEALAEAM NSIGGNSNSG EGGEDPARYG
    910 920 930 940 950
    TNKVSRIKQV ASGRFGVTPA YLVNADVIQI KVAQGAKPGE GGQLPGDKVT
    960 970 980 990 1000
    PYIAKLRYSV PGVTLISPPP HHDIYSIEDL AQLIFDLKQV NPKAMISVKL
    1010 1020 1030 1040 1050
    VSEPGVGTIA TGVAKAYADL ITIAGYDGGT GASPLSSVKY AGCPWELGLV
    1060 1070 1080 1090 1100
    ETQQALVANG LRHKIRLQVD GGLKTGVDII KAAILGAESF GFGTGPMVAL
    1110 1120 1130 1140 1150
    GCKYLRICHL NNCATGVATQ DDKLRKNHYH GLPFKVTNYF EFIARETREL
    1160 1170 1180 1190 1200
    MAQLGVTRLV DLIGRTDLLK ELDGFTAKQQ KLALSKLLET AEPHPGKALY
    1210 1220 1230 1240 1250
    CTENNPPFDN GLLNAQLLQQ AKPFVDERQS KTFWFDIRNT DRSVGASLSG
    1260 1270 1280 1290 1300
    YIAQTHGDQG LAADPIKAYF NGTAGQSFGV WNAGGVELYL TGDANDYVGK
    1310 1320 1330 1340 1350
    GMAGGLIAIR PPVGSAFRSH EASIIGNTCL YGATGGRLYA AGRAGERFGV
    1360 1370 1380 1390 1400
    RNSGAITVVE GIGDNGCEYM TGGIVCILGK TGVNFGAGMT GGFAYVLDES
    1410 1420 1430 1440 1450
    GDFRKRVNPE LVEVLSVDAL AIHEEHLRGL ITEHVQHTGS QRGEEILANW
    1460 1470 1480
    STFATKFALV KPKSSDVKAL LGHRSRSAAE LRVQAQ
    Length:1,486
    Mass (Da):163,297
    Last modified:November 30, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C1E5B04F94A33D
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA23904 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence AAA23906 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence AAA58014 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence BAE77256 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74 – 78GWRLA → LAFR in AAA23904 (PubMed:3326786).Curated5
    Sequence conflicti109E → N in AAA23904 (PubMed:3326786).Curated1
    Sequence conflicti189 – 209LCMPT…LRLES → CVCRRICRVLSGSCGPASGM in AAA23904 (PubMed:3326786).CuratedAdd BLAST21
    Sequence conflicti228 – 251LAQPF…NRQWA → WRNRSAIWRITVKSTPSPVT ANG in AAA23904 (PubMed:3326786).CuratedAdd BLAST24
    Sequence conflicti228 – 251LAQPF…NRQWA → WRNRSAIWRITVKSTPSPVT ANG in AAA23906 (PubMed:1673677).CuratedAdd BLAST24
    Sequence conflicti429N → K in AAA23904 (PubMed:3326786).Curated1
    Sequence conflicti543A → T in AAA23904 (PubMed:3326786).Curated1
    Sequence conflicti832D → H in AAA23904 (PubMed:3326786).Curated1
    Sequence conflicti1255 – 1259THGDQ → DARRS in AAA23904 (PubMed:3326786).Curated5
    Sequence conflicti1342G → A in AAA23904 (PubMed:3326786).Curated1
    Sequence conflicti1345G → R in AAA23904 (PubMed:3326786).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M18747 Genomic DNA Translation: AAA23904.1 Different initiation.
    U18997 Genomic DNA Translation: AAA58014.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76244.2
    AP009048 Genomic DNA Translation: BAE77256.1 Different initiation.
    M68876 Genomic DNA Translation: AAA23906.1 Different initiation.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    F65112

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_417679.2, NC_000913.3
    WP_001300352.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC76244; AAC76244; b3212
    BAE77256; BAE77256; BAE77256

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    947724

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW3179
    eco:b3212

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|511145.12.peg.3307

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M18747 Genomic DNA Translation: AAA23904.1 Different initiation.
    U18997 Genomic DNA Translation: AAA58014.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76244.2
    AP009048 Genomic DNA Translation: BAE77256.1 Different initiation.
    M68876 Genomic DNA Translation: AAA23906.1 Different initiation.
    PIRiF65112
    RefSeqiNP_417679.2, NC_000913.3
    WP_001300352.1, NZ_LN832404.1

    3D structure databases

    SMRiP09831
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4263210, 352 interactors
    ComplexPortaliCPX-5041, Glutamate synthase [NADPH] complex
    DIPiDIP-9802N
    IntActiP09831, 8 interactors
    STRINGi511145.b3212

    Protein family/group databases

    MEROPSiC44.003

    Proteomic databases

    jPOSTiP09831
    PaxDbiP09831
    PRIDEiP09831

    Genome annotation databases

    EnsemblBacteriaiAAC76244; AAC76244; b3212
    BAE77256; BAE77256; BAE77256
    GeneIDi947724
    KEGGiecj:JW3179
    eco:b3212
    PATRICifig|511145.12.peg.3307

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0398

    Phylogenomic databases

    eggNOGiCOG0067, Bacteria
    COG0069, Bacteria
    COG0070, Bacteria
    HOGENOMiCLU_000422_8_2_6
    InParanoidiP09831
    PhylomeDBiP09831

    Enzyme and pathway databases

    UniPathwayiUPA00045
    UPA00634;UER00689
    BioCyciEcoCyc:GLUSYNLARGE-MONOMER
    MetaCyc:GLUSYNLARGE-MONOMER
    BRENDAi1.4.1.13, 2026
    SABIO-RKiP09831

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P09831

    Family and domain databases

    CDDicd00982, gltB_C, 1 hit
    cd02808, GltS_FMN, 1 hit
    Gene3Di2.160.20.60, 1 hit
    3.20.20.70, 2 hits
    3.60.20.10, 1 hit
    InterProiView protein in InterPro
    IPR013785, Aldolase_TIM
    IPR017932, GATase_2_dom
    IPR002489, Glu_synth_asu_C
    IPR036485, Glu_synth_asu_C_sf
    IPR006982, Glu_synth_centr_N
    IPR002932, Glu_synthdom
    IPR029055, Ntn_hydrolases_N
    PfamiView protein in Pfam
    PF00310, GATase_2, 1 hit
    PF04898, Glu_syn_central, 1 hit
    PF01645, Glu_synthase, 1 hit
    PF01493, GXGXG, 1 hit
    SUPFAMiSSF56235, SSF56235, 1 hit
    SSF69336, SSF69336, 1 hit
    PROSITEiView protein in PROSITE
    PS51278, GATASE_TYPE_2, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLTB_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09831
    Secondary accession number(s): Q2M900
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 30, 2010
    Last modified: December 2, 2020
    This is version 177 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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