UniProtKB - P09813 (APOA2_MOUSE)
Protein
Apolipoprotein A-II
Gene
Apoa2
Organism
Mus musculus (Mouse)
Status
Functioni
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Miscellaneous
The apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency.
The sequence presented here is that of strain BALB/c and C3H/HeJ.
GO - Molecular functioni
- apolipoprotein receptor binding Source: MGI
- cholesterol binding Source: MGI
- cholesterol transfer activity Source: MGI
- heat shock protein binding Source: MGI
- high-density lipoprotein particle binding Source: MGI
- high-density lipoprotein particle receptor binding Source: MGI
- lipase inhibitor activity Source: MGI
- lipid binding Source: MGI
- lipid transporter activity Source: MGI
- phosphatidylcholine binding Source: MGI
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: MGI
- phospholipid binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
GO - Biological processi
- animal organ regeneration Source: MGI
- cholesterol efflux Source: MGI
- cholesterol homeostasis Source: MGI
- cholesterol metabolic process Source: MGI
- cholesterol transport Source: MGI
- diacylglycerol catabolic process Source: MGI
- high-density lipoprotein particle assembly Source: MGI
- high-density lipoprotein particle clearance Source: MGI
- high-density lipoprotein particle remodeling Source: MGI
- lipid transport Source: MGI
- lipoprotein metabolic process Source: MGI
- low-density lipoprotein particle remodeling Source: MGI
- negative regulation of cholesterol import Source: MGI
- negative regulation of cholesterol transport Source: MGI
- negative regulation of cholesterol transporter activity Source: MGI
- negative regulation of cytokine production involved in immune response Source: MGI
- negative regulation of lipase activity Source: MGI
- negative regulation of lipid catabolic process Source: MGI
- negative regulation of very-low-density lipoprotein particle remodeling Source: MGI
- peptidyl-methionine modification Source: MGI
- phosphatidylcholine biosynthetic process Source: MGI
- phospholipid catabolic process Source: MGI
- phospholipid efflux Source: MGI
- positive regulation of cholesterol esterification Source: MGI
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of lipid catabolic process Source: MGI
- positive regulation of phagocytosis Source: UniProtKB
- protein oxidation Source: MGI
- protein stabilization Source: UniProtKB
- regulation of intestinal cholesterol absorption Source: MGI
- regulation of protein stability Source: MGI
- response to glucose Source: MGI
- reverse cholesterol transport Source: MGI
- triglyceride-rich lipoprotein particle remodeling Source: MGI
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation R-MMU-8963888, Chylomicron assembly R-MMU-8963901, Chylomicron remodeling R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein A-IIShort name: Apo-AII Short name: ApoA-II Alternative name(s): Apolipoprotein A2 Cleaved into the following chain: |
Gene namesi | Name:Apoa2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88050, Apoa2 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- chylomicron Source: MGI
- extracellular region Source: Reactome
- extracellular space Source: MGI
- high-density lipoprotein particle Source: MGI
- spherical high-density lipoprotein particle Source: MGI
- very-low-density lipoprotein particle Source: MGI
Keywords - Cellular componenti
Amyloid, HDL, SecretedPathology & Biotechi
Involvement in diseasei
Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.2 Publications
Keywords - Diseasei
Disease variantPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Add BLAST | 18 | |
ChainiPRO_0000425354 | 19 – 102 | Proapolipoprotein A-IIAdd BLAST | 84 | |
ChainiPRO_0000002008 | 24 – 102 | Apolipoprotein A-II2 PublicationsAdd BLAST | 79 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Methionine sulfoxideBy similarity | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, OxidationProteomic databases
CPTACi | non-CPTAC-3414 |
jPOSTi | P09813 |
PaxDbi | P09813 |
PeptideAtlasi | P09813 |
PRIDEi | P09813 |
PTM databases
iPTMneti | P09813 |
PhosphoSitePlusi | P09813 |
Expressioni
Tissue specificityi
Plasma.
Gene expression databases
Bgeei | ENSMUSG00000005681, Expressed in liver and 141 other tissues |
Genevisiblei | P09813, MM |
Interactioni
Subunit structurei
Monomer.
Interacts with APOA1BP and NDRG1 (By similarity).
By similarityGO - Molecular functioni
- apolipoprotein receptor binding Source: MGI
- heat shock protein binding Source: MGI
- high-density lipoprotein particle receptor binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198156, 13 interactors |
IntActi | P09813, 5 interactors |
MINTi | P09813 |
STRINGi | 10090.ENSMUSP00000005824 |
Miscellaneous databases
RNActi | P09813, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the apolipoprotein A2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SVYZ, Eukaryota |
GeneTreei | ENSGT00390000003306 |
HOGENOMi | CLU_157351_0_0_1 |
InParanoidi | P09813 |
OMAi | FLSNFMD |
OrthoDBi | 1612564at2759 |
TreeFami | TF338165 |
Family and domain databases
InterProi | View protein in InterPro IPR006801, ApoA-II IPR036172, ApoA-II_sf |
PANTHERi | PTHR11027, PTHR11027, 1 hit |
Pfami | View protein in Pfam PF04711, ApoA-II, 1 hit |
SUPFAMi | SSF82936, SSF82936, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P09813-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLLAMVALL VTICSLEGAL VKRQADGPDM QSLFTQYFQS MTDYGKDLME
60 70 80 90 100
KAKTSEIQSQ AKAYFEKTHE QLTPLVRSAG TSLVNFFSSL MNLEEKPAPA
AK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 | D → E in CAA27731 (PubMed:2426658).Curated | 1 | |
Sequence conflicti | 43 | D → E in AAA37248 (PubMed:2514123).Curated | 1 | |
Sequence conflicti | 43 | D → E in AAA37250 (PubMed:2118905).Curated | 1 | |
Sequence conflicti | 43 | D → E in AAH31786 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 48 | L → F in CAA44616 (PubMed:1683229).Curated | 1 | |
Sequence conflicti | 49 | M → V in CAA27731 (PubMed:2426658).Curated | 1 | |
Sequence conflicti | 49 | M → V in AAA37248 (PubMed:2514123).Curated | 1 | |
Sequence conflicti | 49 | M → V in AAA37250 (PubMed:2118905).Curated | 1 | |
Sequence conflicti | 49 | M → V in AAH31786 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 61 | A → V in CAA27731 (PubMed:2426658).Curated | 1 | |
Sequence conflicti | 61 | A → V in AAA37250 (PubMed:2118905).Curated | 1 | |
Sequence conflicti | 61 | A → V in AAH31786 (PubMed:15489334).Curated | 1 |
Mass spectrometryi
Molecular mass is 8709.2±0.071 Da. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 8719.5 Da. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication
Molecular mass is 8725.3±0.283 Da. Determined by ESI. Strain C57BL/6. With 1 methionine sulfoxide.1 Publication
Molecular mass is 8742 Da. Determined by ESI. Strain C57BL/6. With 2 methionine sulfoxides.1 Publication
Molecular mass is 8735.2 Da. Determined by ESI. Strain BALB/c. With 1 methionine sulfoxide.1 Publication
Molecular mass is 9294±0.707 Da. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 9304 Da. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 28 | P → Q in SAM. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04119 mRNA Translation: CAA27731.1 M32360 Genomic DNA Translation: AAA37248.1 M79361 mRNA Translation: AAA37249.1 M79362 mRNA Translation: AAA37250.1 X62772 mRNA Translation: CAA44616.1 AK145823 mRNA Translation: BAE26675.1 AC084821 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39118.1 CH466520 Genomic DNA Translation: EDL39119.1 CH466520 Genomic DNA Translation: EDL39120.1 CH466520 Genomic DNA Translation: EDL39121.1 BC031786 mRNA Translation: AAH31786.1 |
CCDSi | CCDS35773.1 |
PIRi | A37887 B37887, B23594 I48250 JS0392, A23594 |
RefSeqi | NP_001292478.1, NM_001305549.1 NP_001292479.1, NM_001305550.1 NP_001292514.1, NM_001305585.1 NP_038502.2, NM_013474.2 |
Genome annotation databases
Ensembli | ENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681 ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681 ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681 ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681 |
GeneIDi | 11807 |
KEGGi | mmu:11807 |
UCSCi | uc007dnk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04119 mRNA Translation: CAA27731.1 M32360 Genomic DNA Translation: AAA37248.1 M79361 mRNA Translation: AAA37249.1 M79362 mRNA Translation: AAA37250.1 X62772 mRNA Translation: CAA44616.1 AK145823 mRNA Translation: BAE26675.1 AC084821 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39118.1 CH466520 Genomic DNA Translation: EDL39119.1 CH466520 Genomic DNA Translation: EDL39120.1 CH466520 Genomic DNA Translation: EDL39121.1 BC031786 mRNA Translation: AAH31786.1 |
CCDSi | CCDS35773.1 |
PIRi | A37887 B37887, B23594 I48250 JS0392, A23594 |
RefSeqi | NP_001292478.1, NM_001305549.1 NP_001292479.1, NM_001305550.1 NP_001292514.1, NM_001305585.1 NP_038502.2, NM_013474.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 198156, 13 interactors |
IntActi | P09813, 5 interactors |
MINTi | P09813 |
STRINGi | 10090.ENSMUSP00000005824 |
PTM databases
iPTMneti | P09813 |
PhosphoSitePlusi | P09813 |
Proteomic databases
CPTACi | non-CPTAC-3414 |
jPOSTi | P09813 |
PaxDbi | P09813 |
PeptideAtlasi | P09813 |
PRIDEi | P09813 |
Protocols and materials databases
Antibodypediai | 20506, 491 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 336 |
MGIi | MGI:88050, Apoa2 |
Phylogenomic databases
eggNOGi | ENOG502SVYZ, Eukaryota |
GeneTreei | ENSGT00390000003306 |
HOGENOMi | CLU_157351_0_0_1 |
InParanoidi | P09813 |
OMAi | FLSNFMD |
OrthoDBi | 1612564at2759 |
TreeFami | TF338165 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation R-MMU-8963888, Chylomicron assembly R-MMU-8963901, Chylomicron remodeling R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 11807, 1 hit in 17 CRISPR screens |
ChiTaRSi | Apoa2, mouse |
PROi | PR:P09813 |
RNActi | P09813, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005681, Expressed in liver and 141 other tissues |
Genevisiblei | P09813, MM |
Family and domain databases
InterProi | View protein in InterPro IPR006801, ApoA-II IPR036172, ApoA-II_sf |
PANTHERi | PTHR11027, PTHR11027, 1 hit |
Pfami | View protein in Pfam PF04711, ApoA-II, 1 hit |
SUPFAMi | SSF82936, SSF82936, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APOA2_MOUSE | |
Accessioni | P09813Primary (citable) accession number: P09813 Secondary accession number(s): Q3UKX6, Q61317 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families