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Protein

Apolipoprotein A-II

Gene

Apoa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Miscellaneous

The apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency.
The sequence presented here is that of strain BALB/c and C3H/HeJ.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-II
Short name:
Apo-AII
Short name:
ApoA-II
Alternative name(s):
Apolipoprotein A2
Cleaved into the following chain:
Proapolipoprotein A-II
Short name:
ProapoA-II
Gene namesi
Name:Apoa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88050 Apoa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.2 Publications

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000042535419 – 102Proapolipoprotein A-IIAdd BLAST84
ChainiPRO_000000200824 – 102Apolipoprotein A-II2 PublicationsAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Methionine sulfoxideBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Oxidation

Proteomic databases

PaxDbiP09813
PeptideAtlasiP09813
PRIDEiP09813

PTM databases

iPTMnetiP09813
PhosphoSitePlusiP09813

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000005681
CleanExiMM_APOA2
GenevisibleiP09813 MM

Interactioni

Subunit structurei

Monomer. Interacts with APOA1BP and NDRG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198156, 1 interactor
IntActiP09813, 5 interactors
MINTiP09813
STRINGi10090.ENSMUSP00000005824

Structurei

3D structure databases

ProteinModelPortaliP09813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3V8 Eukaryota
ENOG4111552 LUCA
GeneTreeiENSGT00390000003306
HOGENOMiHOG000033999
HOVERGENiHBG050544
InParanoidiP09813
KOiK08758
OMAiAYFEKTQ
OrthoDBiEOG091G0Z27
TreeFamiTF338165

Family and domain databases

InterProiView protein in InterPro
IPR006801 ApoA-II
IPR036172 ApoA-II_sf
PANTHERiPTHR11027 PTHR11027, 1 hit
PfamiView protein in Pfam
PF04711 ApoA-II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010397 ApoA-II, 1 hit
SUPFAMiSSF82936 SSF82936, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLAMVALL VTICSLEGAL VKRQADGPDM QSLFTQYFQS MTDYGKDLME
60 70 80 90 100
KAKTSEIQSQ AKAYFEKTHE QLTPLVRSAG TSLVNFFSSL MNLEEKPAPA

AK
Length:102
Mass (Da):11,309
Last modified:October 3, 2012 - v2
Checksum:iF50142E0D118665B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → E in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti43D → E in AAA37248 (PubMed:2514123).Curated1
Sequence conflicti43D → E in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti43D → E in AAH31786 (PubMed:15489334).Curated1
Sequence conflicti48L → F in CAA44616 (PubMed:1683229).Curated1
Sequence conflicti49M → V in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti49M → V in AAA37248 (PubMed:2514123).Curated1
Sequence conflicti49M → V in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti49M → V in AAH31786 (PubMed:15489334).Curated1
Sequence conflicti61A → V in CAA27731 (PubMed:2426658).Curated1
Sequence conflicti61A → V in AAA37250 (PubMed:2118905).Curated1
Sequence conflicti61A → V in AAH31786 (PubMed:15489334).Curated1

Mass spectrometryi

Molecular mass is 8709.2±0.071 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 8719.5 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication
Molecular mass is 8725.3±0.283 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 1 methionine sulfoxide.1 Publication
Molecular mass is 8742 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 2 methionine sulfoxides.1 Publication
Molecular mass is 8735.2 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. With 1 methionine sulfoxide.1 Publication
Molecular mass is 9294±0.707 Da from positions 19 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 9304 Da from positions 19 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28P → Q in SAM. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04119 mRNA Translation: CAA27731.1
M32360 Genomic DNA Translation: AAA37248.1
M79361 mRNA Translation: AAA37249.1
M79362 mRNA Translation: AAA37250.1
X62772 mRNA Translation: CAA44616.1
AK145823 mRNA Translation: BAE26675.1
AC084821 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39118.1
CH466520 Genomic DNA Translation: EDL39119.1
CH466520 Genomic DNA Translation: EDL39120.1
CH466520 Genomic DNA Translation: EDL39121.1
BC031786 mRNA Translation: AAH31786.1
CCDSiCCDS35773.1
PIRiA37887
B37887 B23594
I48250
JS0392 A23594
RefSeqiNP_001292478.1, NM_001305549.1
NP_001292479.1, NM_001305550.1
NP_001292514.1, NM_001305585.1
NP_038502.2, NM_013474.2
UniGeneiMm.389209

Genome annotation databases

EnsembliENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681
ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681
ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681
ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681
GeneIDi11807
KEGGimmu:11807
UCSCiuc007dnk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOA2_MOUSE
AccessioniPrimary (citable) accession number: P09813
Secondary accession number(s): Q3UKX6, Q61317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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