Apoa2

Functionⁱ

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Miscellaneous

The apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency.

The sequence presented here is that of strain BALB/c and C3H/HeJ.

GO - Molecular functionⁱ

apolipoprotein receptor binding Source: MGI
cholesterol binding Source: MGI
cholesterol transporter activity Source: MGI
heat shock protein binding Source: MGI
high-density lipoprotein particle binding
Source: MGI
Inferred from mutant phenotypeⁱ
- 14729860
high-density lipoprotein particle receptor binding Source: MGI
lipase inhibitor activity Source: MGI
lipid binding Source: MGI
lipid transporter activity Source: MGI
phosphatidylcholine binding Source: MGI
phosphatidylcholine-sterol O-acyltransferase activator activity Source: MGI
phospholipid binding Source: MGI
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ regeneration Source: MGI
beta-glucoside transport
Source: UniProtKB
Non-traceable author statementⁱ
- 12269810
cholesterol efflux Source: MGI
cholesterol homeostasis
Source: MGI
Inferred from direct assayⁱ
- 8422330
cholesterol metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 10357838
- 8647961
cholesterol transport Source: MGI
diacylglycerol catabolic process Source: MGI
fatty acid metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 12269810
high-density lipoprotein particle assembly Source: MGI
high-density lipoprotein particle clearance Source: MGI
high-density lipoprotein particle remodeling Source: MGI
lipid transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 14729860
lipoprotein metabolic process
Source: MGI
Inferred from direct assayⁱ
- 7837794
- 9150245
low-density lipoprotein particle remodeling Source: MGI
negative regulation of cholesterol import Source: MGI
negative regulation of cholesterol transport Source: MGI
negative regulation of cholesterol transporter activity Source: MGI
negative regulation of cytokine secretion involved in immune response Source: MGI
negative regulation of lipase activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 10357838
negative regulation of lipid catabolic process Source: MGI
negative regulation of very-low-density lipoprotein particle remodeling Source: MGI
peptidyl-methionine modification Source: MGI
phosphatidylcholine biosynthetic process Source: MGI
phospholipid catabolic process Source: MGI
phospholipid efflux Source: MGI
positive regulation of cholesterol esterification Source: MGI
positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
positive regulation of lipid catabolic process Source: MGI
protein oxidation Source: MGI
regulation of intestinal cholesterol absorption
Source: MGI
Inferred from mutant phenotypeⁱ
- 8962133
regulation of protein stability Source: MGI
response to glucose Source: MGI
reverse cholesterol transport Source: MGI
triglyceride-rich lipoprotein particle remodeling Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport

Biological process

Lipid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275 Post-translational protein phosphorylation R-MMU-8963888 Chylomicron assembly R-MMU-8963901 Chylomicron remodeling R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apolipoprotein A-II Short name: Apo-AII Short name: ApoA-II Alternative name(s): Apolipoprotein A2 Cleaved into the following chain: Proapolipoprotein A-II Short name: ProapoA-II
Gene namesⁱ	Name:Apoa2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:88050 Apoa2

Keywords - Cellular componentⁱ

Amyloid, HDL, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.2 Publications

Keywords - Diseaseⁱ

Disease mutation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	Add BLAST	18
ChainⁱPRO_0000425354	19 – 102	Proapolipoprotein A-IIAdd BLAST	84
ChainⁱPRO_0000002008	24 – 102	Apolipoprotein A-II2 PublicationsAdd BLAST	79

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	49	Methionine sulfoxideBy similarity		1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Oxidation

Proteomic databases

PaxDbⁱ	P09813
PeptideAtlas More...PeptideAtlasⁱ	P09813
PRIDEⁱ	P09813

PTM databases

iPTMnetⁱ	P09813
PhosphoSitePlusⁱ	P09813

Expressionⁱ

Tissue specificityⁱ

Plasma.

Gene expression databases

Bgeeⁱ	ENSMUSG00000005681 Expressed in 119 organ(s), highest expression level in liver
CleanExⁱ	MM_APOA2
Genevisibleⁱ	P09813 MM

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with APOA1BP and NDRG1 (By similarity).By similarity

GO - Molecular functionⁱ

apolipoprotein receptor binding Source: MGI
heat shock protein binding Source: MGI
high-density lipoprotein particle receptor binding Source: MGI
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198156, 1 interactor
IntActⁱ	P09813, 5 interactors
Molecular INTeraction database More...MINTⁱ	P09813
STRINGⁱ	10090.ENSMUSP00000005824

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P09813
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3V8 Eukaryota ENOG4111552 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003306
HOGENOMⁱ	HOG000033999
HOVERGENⁱ	HBG050544
InParanoidⁱ	P09813
KEGG Orthology (KO) More...KOⁱ	K08758
OMAⁱ	AYFEKTQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Z27
TreeFamⁱ	TF338165

Family and domain databases

InterProⁱ	View protein in InterPro IPR006801 ApoA-II IPR036172 ApoA-II_sf
PANTHERⁱ	PTHR11027 PTHR11027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04711 ApoA-II, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010397 ApoA-II, 1 hit
SUPFAMⁱ	SSF82936 SSF82936, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P09813-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLLAMVALL VTICSLEGAL VKRQADGPDM QSLFTQYFQS MTDYGKDLME 
        60         70         80         90        100
KAKTSEIQSQ AKAYFEKTHE QLTPLVRSAG TSLVNFFSSL MNLEEKPAPA 

AK

Length:102

Mass (Da):11,309

Last modified:October 3, 2012 - v2

Checksum:ⁱF50142E0D118665B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	43	D → E in CAA27731 (PubMed:2426658).Curated	1
Sequence conflictⁱ	43	D → E in AAA37248 (PubMed:2514123).Curated	1
Sequence conflictⁱ	43	D → E in AAA37250 (PubMed:2118905).Curated	1
Sequence conflictⁱ	43	D → E in AAH31786 (PubMed:15489334).Curated	1
Sequence conflictⁱ	48	L → F in CAA44616 (PubMed:1683229).Curated	1
Sequence conflictⁱ	49	M → V in CAA27731 (PubMed:2426658).Curated	1
Sequence conflictⁱ	49	M → V in AAA37248 (PubMed:2514123).Curated	1
Sequence conflictⁱ	49	M → V in AAA37250 (PubMed:2118905).Curated	1
Sequence conflictⁱ	49	M → V in AAH31786 (PubMed:15489334).Curated	1
Sequence conflictⁱ	61	A → V in CAA27731 (PubMed:2426658).Curated	1
Sequence conflictⁱ	61	A → V in AAA37250 (PubMed:2118905).Curated	1
Sequence conflictⁱ	61	A → V in AAH31786 (PubMed:15489334).Curated	1

Mass spectrometryⁱ

Molecular mass is 8709.2±0.071 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication

Molecular mass is 8719.5 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Molecular mass is 8725.3±0.283 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 1 methionine sulfoxide.1 Publication

Molecular mass is 8742 Da from positions 24 - 102. Determined by ESI. Strain C57BL/6. With 2 methionine sulfoxides.1 Publication

Molecular mass is 8735.2 Da from positions 24 - 102. Determined by ESI. Strain BALB/c. With 1 methionine sulfoxide.1 Publication

Molecular mass is 9294±0.707 Da from positions 19 - 102. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication

Molecular mass is 9304 Da from positions 19 - 102. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	28	P → Q in SAM. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04119 mRNA Translation: CAA27731.1 M32360 Genomic DNA Translation: AAA37248.1 M79361 mRNA Translation: AAA37249.1 M79362 mRNA Translation: AAA37250.1 X62772 mRNA Translation: CAA44616.1 AK145823 mRNA Translation: BAE26675.1 AC084821 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39118.1 CH466520 Genomic DNA Translation: EDL39119.1 CH466520 Genomic DNA Translation: EDL39120.1 CH466520 Genomic DNA Translation: EDL39121.1 BC031786 mRNA Translation: AAH31786.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35773.1
PIRⁱ	A37887 B37887 B23594 I48250 JS0392 A23594
NCBI Reference Sequences More...RefSeqⁱ	NP_001292478.1, NM_001305549.1 NP_001292479.1, NM_001305550.1 NP_001292514.1, NM_001305585.1 NP_038502.2, NM_013474.2
UniGeneⁱ	Mm.389209

Genome annotation databases

Ensemblⁱ	ENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681 ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681 ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681 ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681
GeneIDⁱ	11807
KEGGⁱ	mmu:11807
UCSC genome browser More...UCSCⁱ	uc007dnk.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09813	Apolipoprotein A-II		MOUSE		102	UniRef90_P09813
UPI000A317673		MUSCR		102
APOAII		MOUSE		102

Protein	Similar proteins		Species	Score	Length	Source
P09813	Apolipoprotein A-II		BOVIN		100	UniRef50_P09813
Apolipoprotein A-II		PONAB		93
Apolipoprotein A-II		ACIJB		100
Apolipoprotein A-II		PANTA		100
Apolipoprotein A-II		CANLF		100
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04119 mRNA Translation: CAA27731.1 M32360 Genomic DNA Translation: AAA37248.1 M79361 mRNA Translation: AAA37249.1 M79362 mRNA Translation: AAA37250.1 X62772 mRNA Translation: CAA44616.1 AK145823 mRNA Translation: BAE26675.1 AC084821 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39118.1 CH466520 Genomic DNA Translation: EDL39119.1 CH466520 Genomic DNA Translation: EDL39120.1 CH466520 Genomic DNA Translation: EDL39121.1 BC031786 mRNA Translation: AAH31786.1
CCDSⁱ	CCDS35773.1
PIRⁱ	A37887 B37887 B23594 I48250 JS0392 A23594
RefSeqⁱ	NP_001292478.1, NM_001305549.1 NP_001292479.1, NM_001305550.1 NP_001292514.1, NM_001305585.1 NP_038502.2, NM_013474.2
UniGeneⁱ	Mm.389209

3D structure databases

ProteinModelPortalⁱ	P09813
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198156, 1 interactor
IntActⁱ	P09813, 5 interactors
MINTⁱ	P09813
STRINGⁱ	10090.ENSMUSP00000005824

PTM databases

iPTMnetⁱ	P09813
PhosphoSitePlusⁱ	P09813

Proteomic databases

PaxDbⁱ	P09813
PeptideAtlasⁱ	P09813
PRIDEⁱ	P09813

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005824; ENSMUSP00000005824; ENSMUSG00000005681 ENSMUST00000111319; ENSMUSP00000106951; ENSMUSG00000005681 ENSMUST00000111320; ENSMUSP00000106952; ENSMUSG00000005681 ENSMUST00000111321; ENSMUSP00000106953; ENSMUSG00000005681
GeneIDⁱ	11807
KEGGⁱ	mmu:11807
UCSCⁱ	uc007dnk.2 mouse

Organism-specific databases

CTDⁱ	336
MGIⁱ	MGI:88050 Apoa2

Phylogenomic databases

eggNOGⁱ	ENOG410J3V8 Eukaryota ENOG4111552 LUCA
GeneTreeⁱ	ENSGT00390000003306
HOGENOMⁱ	HOG000033999
HOVERGENⁱ	HBG050544
InParanoidⁱ	P09813
KOⁱ	K08758
OMAⁱ	AYFEKTQ
OrthoDBⁱ	EOG091G0Z27
TreeFamⁱ	TF338165

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275 Post-translational protein phosphorylation R-MMU-8963888 Chylomicron assembly R-MMU-8963901 Chylomicron remodeling R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	Apoa2 mouse
Protein Ontology More...PROⁱ	PR:P09813
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005681 Expressed in 119 organ(s), highest expression level in liver
CleanExⁱ	MM_APOA2
Genevisibleⁱ	P09813 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006801 ApoA-II IPR036172 ApoA-II_sf
PANTHERⁱ	PTHR11027 PTHR11027, 1 hit
Pfamⁱ	View protein in Pfam PF04711 ApoA-II, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010397 ApoA-II, 1 hit
SUPFAMⁱ	SSF82936 SSF82936, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APOA2_MOUSE
Accessionⁱ	P09813Primary (citable) accession number: P09813 Secondary accession number(s): Q3UKX6, Q61317
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09813 (APOA2_MOUSE)

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Apolipoprotein A-II

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ