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Entry version 128 (18 Sep 2019)
Sequence version 1 (01 Jul 1989)
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Protein

IgA-specific serine endopeptidase autotransporter

Gene

iga

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protease is specific for immunoglobulin A.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known. EC:3.4.21.72

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei278Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S06.001

Transport Classification Database

More...
TCDBi
1.B.12.3.1 the autotransporter-1 (at-1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IgA-specific serine endopeptidase autotransporter (EC:3.4.21.72)
Cleaved into the following 2 chains:
Alternative name(s):
IgA protease
Alternative name(s):
Helper peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iga
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria gonorrhoeae
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri485 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

IgA-specific serine endopeptidase translocator :

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3970

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038760328 – 1532IgA-specific serine endopeptidase autotransporterAdd BLAST1505
ChainiPRO_000002696828 – 986IgA-specific serine endopeptidaseAdd BLAST959
ChainiPRO_0000026969987 – 1532IgA-specific serine endopeptidase translocatorAdd BLAST546

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei986 – 987Cleavage; by autolysis2
Sitei1018 – 1019Cleavage; by autolysis2
Sitei1121 – 1122Cleavage; by autolysis2

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P09790

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P09790

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P09790

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09790

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 322Peptidase S6PROSITE-ProRule annotationAdd BLAST295
Domaini1280 – 1532AutotransporterPROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage.

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41063FY Bacteria
COG3468 LUCA

KEGG Orthology (KO)

More...
KOi
K01347

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR012332 P22_tailspike-like_C_sf
IPR011050 Pectin_lyase_fold/virulence
IPR000710 Peptidase_S6
IPR030396 Peptidase_S6_dom
IPR004899 Pertactin_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797 Autotransporter, 1 hit
PF02395 Peptidase_S6, 1 hit
PF03212 Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00921 IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869 Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515 SSF103515, 1 hit
SSF51126 SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit
PS51691 PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P09790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKRFKINA ISLSIFLAYA LTPYSEAALV RDDVDYQIFR DFAENKGKFF
60 70 80 90 100
VGATDLSVKN KRGQNIGNAL SNVPMIDFSV ADVNKRIATV VDPQYAVSVK
110 120 130 140 150
HAKAEVHTFY YGQYNGHNDV ADKENEYRVV EQNNYEPHKA WGASNLGRLE
160 170 180 190 200
DYNMARFNKF VTEVAPIAPT DAGGGLDTYK DKNRFSSFVR IGAGRQLVYE
210 220 230 240 250
KGVYHQEGNE KGYDLRDLSQ AYRYAIAGTP YKDINIDQTM NTEGLIGFGN
260 270 280 290 300
HNKQYSAEEL KQALSQDALT NYGVLGDSGS PLFAFDKQKN QWVFLGTYDY
310 320 330 340 350
WAGYGKKSWQ EWNIYKKEFA DKIKQHDNAG TVKGNGEHHW KTTGTNSHIG
360 370 380 390 400
STAVRLANNE GDANNGQNVT FEDNGTLVLN QNINQGAGGL FFKGDYTVKG
410 420 430 440 450
ANNDITWLGA GIDVADGKKV VWQVKNPNGD RLAKIGKGTL EINGTGVNQG
460 470 480 490 500
QLKVGDGTVI LNQKADADKK VQAFSQVGIV SGRGTLVLNS SNQINPDNLY
510 520 530 540 550
FGFRGGRLDA NGNDLTFEHI RNVDEGARIV NHNTDHASTI TLTGKSLITN
560 570 580 590 600
PNSLSVHSIQ NDYDEDDYSY YYRPRRPIPQ GKDLYYKNYR YYALKSGGRL
610 620 630 640 650
NAPMPENGVA ENNDWIFMGY TQEEARKNAM NHKNNRRIGD FGGFFDEENG
660 670 680 690 700
KGHNGALNLN FNGKSAQKRF LLTGGANLNG KISVTQGNVL LSGRPTPHAR
710 720 730 740 750
DFVNKSSARK DAHFSKNNEV VFEDDWINRT FKAAEIAVNQ SASFSSGRNV
760 770 780 790 800
SDITANITAT DNAKVNLGYK NGDEVCVRSD YTGYVTCNTG NLSDKALNSF
810 820 830 840 850
DATRINGNVN LNQNAALVLG KAALWGKIQG QGNSRVSLNQ HSKWHLTGDS
860 870 880 890 900
QVHNLSLADS HIHLNNASDA QSANKYHTIK INHLSGNGHF HYLTDLAKNL
910 920 930 940 950
GDKVLVKESA SGHYQLHVQN KTGEPNQEGL DLFDASSVQD RSRLFVSLAN
960 970 980 990 1000
HYVDLGALRY TIKTENGITR LYNPYAGNGR PVKPAPSPAA NTASQAQKAT
1010 1020 1030 1040 1050
QTDGAQIAKP QNIVVAPPSP QANQAEEALR QQAKAEQVKR QQAAEAEKVA
1060 1070 1080 1090 1100
RQKDEEAKRK AAEIARQQEE ARKAAELAAK QKAEAERKAR ELARQKAEEA
1110 1120 1130 1140 1150
SHQANAKPKR RRRRAILPRP PAPVFSLDDY DAKDNSESSI GNLARVIPRM
1160 1170 1180 1190 1200
GRELINDYEE IPLEELEDEA EEERRQATQF HSKSRNRRAI SSEPSSDEDA
1210 1220 1230 1240 1250
SESVSTSDKH PQDNTELHEK VETAGLQPRA AQPRTQAAAQ ADAVSTNTNS
1260 1270 1280 1290 1300
ALSDAMASTQ SILLDTGAYL TRHIAQKSRA DAEKNSVWMS NTGYGRDYAS
1310 1320 1330 1340 1350
AQYRRFSSKR TQTQIGIDRS LSENMQIGGV LTYSDSQHTF DQAGGKNTFV
1360 1370 1380 1390 1400
QANLYGKYYL NDAWYVAGDI GAGSLRSRLQ TQQKANFNRT SIQTGLTLGN
1410 1420 1430 1440 1450
TLKINQFEIV PSAGIRYSRL SSADYKLGDD SVKVSSMAVK TLTAGLDFAY
1460 1470 1480 1490 1500
RFKVGNLTVK PLLSAAYFAN YGKGGVNVGG KSFAYKADNQ QQYSAGVALL
1510 1520 1530
YRNVTLNVNG SITKGKQLEK QKSGQIKIQI RF
Length:1,532
Mass (Da):168,976
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68FF4112BD22F40D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326H → N (PubMed:2511009).Curated1
Sequence conflicti338H → N (PubMed:2511009).Curated1
Sequence conflicti428N → M (PubMed:2511009).Curated1
Sequence conflicti532H → N (PubMed:2511009).Curated1
Sequence conflicti616I → V (PubMed:2511009).Curated1
Sequence conflicti632H → N (PubMed:2511009).Curated1
Sequence conflicti668K → N (PubMed:2511009).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04835 Genomic DNA Translation: CAA28538.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26039

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:CAA28538

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04835 Genomic DNA Translation: CAA28538.1
PIRiA26039

3D structure databases

SMRiP09790
ModBaseiSearch...

Chemistry databases

BindingDBiP09790
ChEMBLiCHEMBL3970

Protein family/group databases

MEROPSiS06.001
TCDBi1.B.12.3.1 the autotransporter-1 (at-1) family

Proteomic databases

PRIDEiP09790

Genome annotation databases

KEGGiag:CAA28538

Phylogenomic databases

eggNOGiENOG41063FY Bacteria
COG3468 LUCA
KOiK01347

Miscellaneous databases

PMAP-CutDBiP09790

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR012332 P22_tailspike-like_C_sf
IPR011050 Pectin_lyase_fold/virulence
IPR000710 Peptidase_S6
IPR030396 Peptidase_S6_dom
IPR004899 Pertactin_central
PfamiView protein in Pfam
PF03797 Autotransporter, 1 hit
PF02395 Peptidase_S6, 1 hit
PF03212 Pertactin, 1 hit
PRINTSiPR00921 IGASERPTASE
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
SSF51126 SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit
PS51691 PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGA_NEIGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09790
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 18, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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