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Protein

Tumor-associated calcium signal transducer 2

Gene

TACSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a growth factor receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: GO_Central
  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen
Biological processSensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACSTD2
Synonyms:GA733-1, M1S1, TROP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184292.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11530 TACSTD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
137290 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 274ExtracellularSequence analysisAdd BLAST248
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei275 – 297HelicalSequence analysisAdd BLAST23
Topological domaini298 – 323CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Amyloid, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Corneal dystrophy, gelatinous drop-like (GDLD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.
See also OMIM:204870

Keywords - Diseasei

Amyloidosis, Corneal dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
4070

MalaCards human disease database

More...
MalaCardsi
TACSTD2
MIMi204870 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184292

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98957 Gelatinous drop-like corneal dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36305

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3856163

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TACSTD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160113102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002246827 – 323Tumor-associated calcium signal transducer 2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi73 ↔ 108PROSITE-ProRule annotation
Disulfide bondi119 ↔ 125PROSITE-ProRule annotation
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 145PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09758

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09758

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09758

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09758

PeptideAtlas

More...
PeptideAtlasi
P09758

PRoteomics IDEntifications database

More...
PRIDEi
P09758

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52267

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1865

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09758

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09758

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta, pancreatic carcinoma cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184292 Expressed in 170 organ(s), highest expression level in nasal cavity epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_TACSTD2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09758 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB072852
HPA043104
HPA055067

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110248, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P09758, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360269

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAENMR-A298-323[»]
2MVKNMR-A298-323[»]
2MVLNMR-A298-323[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P09758

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09758

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 145Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPCAM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFI6 Eukaryota
ENOG4111M3B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018245

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074086

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053004

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09758

KEGG Orthology (KO)

More...
KOi
K17288

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDHEGRF

Database of Orthologous Groups

More...
OrthoDBi
1017141at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09758

TreeFam database of animal gene trees

More...
TreeFami
TF332767

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00086 Thyroglobulin_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P09758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG
60 70 80 90 100
GRCQCRALGS GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN
110 120 130 140 150
DGLYDPDCDP EGRFKARQCN QTSVCWCVNS VGVRRTDKGD LSLRCDELVR
160 170 180 190 200
THHILIDLRH RPTAGAFNHS DLDAELRRLF RERYRLHPKF VAAVHYEQPT
210 220 230 240 250
IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG GLDLRVRGEP
260 270 280 290 300
LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR
310 320
RKSGKYKKVE IKELGELRKE PSL
Length:323
Mass (Da):35,709
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8081FBE1D0B9F73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220G → D in CAG47056 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051407147E → D1 PublicationCorresponds to variant dbSNP:rs1062964EnsemblClinVar.1
Natural variantiVAR_012451173D → A1 PublicationCorresponds to variant dbSNP:rs35075952EnsemblClinVar.1
Natural variantiVAR_016981216D → E2 PublicationsCorresponds to variant dbSNP:rs14008EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13425 mRNA Translation: CAA31781.1
J04152 Genomic DNA Translation: AAA52505.1
X77753 mRNA Translation: CAA54799.1
X77754 mRNA Translation: CAA54801.1
BT007255 mRNA Translation: AAP35919.1
CR542260 mRNA Translation: CAG47056.1
AL035411 Genomic DNA No translation available.
BC009409 mRNA Translation: AAH09409.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS609.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48149

NCBI Reference Sequences

More...
RefSeqi
NP_002344.2, NM_002353.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.23582

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371225; ENSP00000360269; ENSG00000184292

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4070

UCSC genome browser

More...
UCSCi
uc001cyz.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13425 mRNA Translation: CAA31781.1
J04152 Genomic DNA Translation: AAA52505.1
X77753 mRNA Translation: CAA54799.1
X77754 mRNA Translation: CAA54801.1
BT007255 mRNA Translation: AAP35919.1
CR542260 mRNA Translation: CAG47056.1
AL035411 Genomic DNA No translation available.
BC009409 mRNA Translation: AAH09409.1
CCDSiCCDS609.1
PIRiA48149
RefSeqiNP_002344.2, NM_002353.2
UniGeneiHs.23582

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAENMR-A298-323[»]
2MVKNMR-A298-323[»]
2MVLNMR-A298-323[»]
ProteinModelPortaliP09758
SMRiP09758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110248, 3 interactors
IntActiP09758, 9 interactors
STRINGi9606.ENSP00000360269

Chemistry databases

ChEMBLiCHEMBL3856163

PTM databases

GlyConnecti1865
iPTMnetiP09758
PhosphoSitePlusiP09758

Polymorphism and mutation databases

BioMutaiTACSTD2
DMDMi160113102

Proteomic databases

EPDiP09758
jPOSTiP09758
MaxQBiP09758
PaxDbiP09758
PeptideAtlasiP09758
PRIDEiP09758
ProteomicsDBi52267

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371225; ENSP00000360269; ENSG00000184292
GeneIDi4070
KEGGihsa:4070
UCSCiuc001cyz.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4070
DisGeNETi4070
EuPathDBiHostDB:ENSG00000184292.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TACSTD2
HGNCiHGNC:11530 TACSTD2
HPAiCAB072852
HPA043104
HPA055067
MalaCardsiTACSTD2
MIMi137290 gene
204870 phenotype
neXtProtiNX_P09758
OpenTargetsiENSG00000184292
Orphaneti98957 Gelatinous drop-like corneal dystrophy
PharmGKBiPA36305

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
HOVERGENiHBG053004
InParanoidiP09758
KOiK17288
OMAiCDHEGRF
OrthoDBi1017141at2759
PhylomeDBiP09758
TreeFamiTF332767

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TACSTD2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TACSTD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4070

Protein Ontology

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PROi
PR:P09758

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000184292 Expressed in 170 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_TACSTD2
GenevisibleiP09758 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTACD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09758
Secondary accession number(s): Q15658
, Q6FG48, Q7Z7Q4, Q96QD2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: January 16, 2019
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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