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Protein

Tumor-associated calcium signal transducer 2

Gene

TACSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a growth factor receptor.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: GO_Central
  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionTumor antigen
Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1
Gene namesi
Name:TACSTD2
Synonyms:GA733-1, M1S1, TROP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000184292.6
HGNCiHGNC:11530 TACSTD2
MIMi137290 gene
neXtProtiNX_P09758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 274ExtracellularSequence analysisAdd BLAST248
Transmembranei275 – 297HelicalSequence analysisAdd BLAST23
Topological domaini298 – 323CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Amyloid, Membrane

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, gelatinous drop-like (GDLD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.
See also OMIM:204870

Keywords - Diseasei

Amyloidosis, Corneal dystrophy

Organism-specific databases

DisGeNETi4070
MalaCardsiTACSTD2
MIMi204870 phenotype
OpenTargetsiENSG00000184292
Orphaneti98957 Gelatinous drop-like corneal dystrophy
PharmGKBiPA36305

Chemistry databases

ChEMBLiCHEMBL3856163

Polymorphism and mutation databases

BioMutaiTACSTD2
DMDMi160113102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002246827 – 323Tumor-associated calcium signal transducer 2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 108PROSITE-ProRule annotation
Disulfide bondi119 ↔ 125PROSITE-ProRule annotation
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 145PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP09758
MaxQBiP09758
PaxDbiP09758
PeptideAtlasiP09758
PRIDEiP09758
ProteomicsDBi52267

PTM databases

GlyConnecti1865
iPTMnetiP09758
PhosphoSitePlusiP09758

Expressioni

Tissue specificityi

Placenta, pancreatic carcinoma cell lines.

Gene expression databases

BgeeiENSG00000184292 Expressed in 170 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_TACSTD2
GenevisibleiP09758 HS

Organism-specific databases

HPAiCAB072852
HPA043104
HPA055067

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110248, 3 interactors
IntActiP09758, 9 interactors
STRINGi9606.ENSP00000360269

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09758
SMRiP09758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 145Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the EPCAM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
HOVERGENiHBG053004
InParanoidiP09758
KOiK17288
OMAiCDHEGRF
OrthoDBiEOG091G0G85
PhylomeDBiP09758
TreeFamiTF332767

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG
60 70 80 90 100
GRCQCRALGS GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN
110 120 130 140 150
DGLYDPDCDP EGRFKARQCN QTSVCWCVNS VGVRRTDKGD LSLRCDELVR
160 170 180 190 200
THHILIDLRH RPTAGAFNHS DLDAELRRLF RERYRLHPKF VAAVHYEQPT
210 220 230 240 250
IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG GLDLRVRGEP
260 270 280 290 300
LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR
310 320
RKSGKYKKVE IKELGELRKE PSL
Length:323
Mass (Da):35,709
Last modified:November 13, 2007 - v3
Checksum:iC8081FBE1D0B9F73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220G → D in CAG47056 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051407147E → D1 PublicationCorresponds to variant dbSNP:rs1062964EnsemblClinVar.1
Natural variantiVAR_012451173D → A1 PublicationCorresponds to variant dbSNP:rs35075952EnsemblClinVar.1
Natural variantiVAR_016981216D → E2 PublicationsCorresponds to variant dbSNP:rs14008EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13425 mRNA Translation: CAA31781.1
J04152 Genomic DNA Translation: AAA52505.1
X77753 mRNA Translation: CAA54799.1
X77754 mRNA Translation: CAA54801.1
BT007255 mRNA Translation: AAP35919.1
CR542260 mRNA Translation: CAG47056.1
AL035411 Genomic DNA No translation available.
BC009409 mRNA Translation: AAH09409.1
CCDSiCCDS609.1
PIRiA48149
RefSeqiNP_002344.2, NM_002353.2
UniGeneiHs.23582

Genome annotation databases

EnsembliENST00000371225; ENSP00000360269; ENSG00000184292
GeneIDi4070
KEGGihsa:4070
UCSCiuc001cyz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13425 mRNA Translation: CAA31781.1
J04152 Genomic DNA Translation: AAA52505.1
X77753 mRNA Translation: CAA54799.1
X77754 mRNA Translation: CAA54801.1
BT007255 mRNA Translation: AAP35919.1
CR542260 mRNA Translation: CAG47056.1
AL035411 Genomic DNA No translation available.
BC009409 mRNA Translation: AAH09409.1
CCDSiCCDS609.1
PIRiA48149
RefSeqiNP_002344.2, NM_002353.2
UniGeneiHs.23582

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAENMR-A298-323[»]
2MVKNMR-A298-323[»]
2MVLNMR-A298-323[»]
ProteinModelPortaliP09758
SMRiP09758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110248, 3 interactors
IntActiP09758, 9 interactors
STRINGi9606.ENSP00000360269

Chemistry databases

ChEMBLiCHEMBL3856163

PTM databases

GlyConnecti1865
iPTMnetiP09758
PhosphoSitePlusiP09758

Polymorphism and mutation databases

BioMutaiTACSTD2
DMDMi160113102

Proteomic databases

EPDiP09758
MaxQBiP09758
PaxDbiP09758
PeptideAtlasiP09758
PRIDEiP09758
ProteomicsDBi52267

Protocols and materials databases

DNASUi4070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371225; ENSP00000360269; ENSG00000184292
GeneIDi4070
KEGGihsa:4070
UCSCiuc001cyz.5 human

Organism-specific databases

CTDi4070
DisGeNETi4070
EuPathDBiHostDB:ENSG00000184292.6
GeneCardsiTACSTD2
HGNCiHGNC:11530 TACSTD2
HPAiCAB072852
HPA043104
HPA055067
MalaCardsiTACSTD2
MIMi137290 gene
204870 phenotype
neXtProtiNX_P09758
OpenTargetsiENSG00000184292
Orphaneti98957 Gelatinous drop-like corneal dystrophy
PharmGKBiPA36305
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
HOVERGENiHBG053004
InParanoidiP09758
KOiK17288
OMAiCDHEGRF
OrthoDBiEOG091G0G85
PhylomeDBiP09758
TreeFamiTF332767

Miscellaneous databases

ChiTaRSiTACSTD2 human
GeneWikiiTACSTD2
GenomeRNAii4070
PROiPR:P09758
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184292 Expressed in 170 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_TACSTD2
GenevisibleiP09758 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTACD2_HUMAN
AccessioniPrimary (citable) accession number: P09758
Secondary accession number(s): Q15658
, Q6FG48, Q7Z7Q4, Q96QD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 192 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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