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Protein

Acetylcholine receptor subunit beta

Gene

Chrnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine binding Source: UniProtKB
  • acetylcholine-gated cation-selective channel activity Source: MGI
  • acetylcholine receptor activity Source: Ensembl
  • channel activity Source: MGI
  • ligand-gated ion channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit beta
Gene namesi
Name:Chrnb1
Synonyms:Acrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:87890 Chrnb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 244ExtracellularSequence analysisAdd BLAST221
Transmembranei245 – 269HelicalSequence analysisAdd BLAST25
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei311 – 332HelicalSequence analysisAdd BLAST22
Topological domaini333 – 469CytoplasmicSequence analysisAdd BLAST137
Transmembranei470 – 488HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3137264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000031624 – 501Acetylcholine receptor subunit betaAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi151 ↔ 165By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei390Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP09690
PRIDEiP09690

PTM databases

iPTMnetiP09690
PhosphoSitePlusiP09690
SwissPalmiP09690

Expressioni

Gene expression databases

BgeeiENSMUSG00000041189 Expressed in 160 organ(s), highest expression level in paraxial mesoderm
GenevisibleiP09690 MM

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.By similarity

Protein-protein interaction databases

BioGridi197935, 1 interactor
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
IntActiP09690, 4 interactors
MINTiP09690
STRINGi10090.ENSMUSP00000047270

Chemistry databases

BindingDBiP09690

Structurei

3D structure databases

ProteinModelPortaliP09690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP09690
KOiK04812
OMAiFIDGPNR
OrthoDBiEOG091G0R20
PhylomeDBiP09690
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09690-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGALLLLL GVLGTPLAPG ARGSEAEGQL IKKLFSNYDS SVRPAREVGD
60 70 80 90 100
RVGVSIGLTL AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIDS
110 120 130 140 150
LRITAESVWL PDVVLLNNND GNFDVALDIN VVVSFEGSVR WQPPGLYRSS
160 170 180 190 200
CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS LKTGLDPEGE ERQEVYIHEG
210 220 230 240 250
TFIENGQWEI IHKPSRLIQL PGDQRGGKEG HHEEVIFYLI IRRKPLFYLV
260 270 280 290 300
NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE
310 320 330 340 350
TSLAVPIIIK YLMFTMVLVT FSVILSVVVL NLHHRSPHTH QMPFWVRQIF
360 370 380 390 400
IHKLPPYLGL KRPKPERDQL PEPHHSLSPR SGWGRGTDEY FIRKPPSDFL
410 420 430 440 450
FPKLNRFQPE SSAPDLRRFI DGPTRAVGLP QELREVISSI SYMARQLQEQ
460 470 480 490 500
EDHDALKEDW QFVAMVVDRL FLWTFIVFTS VGTLVIFLDA TYHLPPPEPF

P
Length:501
Mass (Da):56,931
Last modified:July 1, 1989 - v1
Checksum:i787BDDA90EBB0EF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14537 mRNA Translation: AAA37154.1
J04699 Genomic DNA Translation: AAA37156.1
AK087554 mRNA Translation: BAC39924.1
AL603707 Genomic DNA Translation: CAI51959.1
CCDSiCCDS24910.1
PIRiA33358 A25338
RefSeqiNP_033731.3, NM_009601.4
UniGeneiMm.86425

Genome annotation databases

EnsembliENSMUST00000045971; ENSMUSP00000047270; ENSMUSG00000041189
GeneIDi11443
KEGGimmu:11443
UCSCiuc007jrq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14537 mRNA Translation: AAA37154.1
J04699 Genomic DNA Translation: AAA37156.1
AK087554 mRNA Translation: BAC39924.1
AL603707 Genomic DNA Translation: CAI51959.1
CCDSiCCDS24910.1
PIRiA33358 A25338
RefSeqiNP_033731.3, NM_009601.4
UniGeneiMm.86425

3D structure databases

ProteinModelPortaliP09690
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197935, 1 interactor
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
IntActiP09690, 4 interactors
MINTiP09690
STRINGi10090.ENSMUSP00000047270

Chemistry databases

BindingDBiP09690
ChEMBLiCHEMBL3137264

PTM databases

iPTMnetiP09690
PhosphoSitePlusiP09690
SwissPalmiP09690

Proteomic databases

PaxDbiP09690
PRIDEiP09690

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045971; ENSMUSP00000047270; ENSMUSG00000041189
GeneIDi11443
KEGGimmu:11443
UCSCiuc007jrq.2 mouse

Organism-specific databases

CTDi1140
MGIiMGI:87890 Chrnb1

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP09690
KOiK04812
OMAiFIDGPNR
OrthoDBiEOG091G0R20
PhylomeDBiP09690
TreeFamiTF315605

Miscellaneous databases

PROiPR:P09690
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041189 Expressed in 160 organ(s), highest expression level in paraxial mesoderm
GenevisibleiP09690 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHB_MOUSE
AccessioniPrimary (citable) accession number: P09690
Secondary accession number(s): Q5F292
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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