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Protein

Secretin

Gene

SCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO3-rich pancreatic juice and secretion of NaHCO3-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  • G protein-coupled receptor binding Source: GO_Central
  • hormone activity Source: UniProtKB
  • protein N-terminus binding Source: Ensembl
  • signaling receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:SCT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000070031.3
HGNCiHGNC:10607 SCT
MIMi182099 gene
neXtProtiNX_P09683

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6343
OpenTargetsiENSG00000070031
PharmGKBiPA35017

Polymorphism and mutation databases

BioMutaiSCT
DMDMi12231018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001142319 – 268
PeptideiPRO_000001142428 – 54SecretinAdd BLAST27
PropeptideiPRO_000001142558 – 121Add BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54Valine amide1 Publication1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP09683
PeptideAtlasiP09683
PRIDEiP09683
ProteomicsDBi52265

PTM databases

PhosphoSitePlusiP09683

Miscellaneous databases

PMAP-CutDBiP09683

Expressioni

Gene expression databases

BgeeiENSG00000070031 Expressed in 93 organ(s), highest expression level in pituitary gland
CleanExiHS_SCT
GenevisibleiP09683 HS

Organism-specific databases

HPAiHPA050961

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112247, 2 interactors
IntActiP09683, 4 interactors
STRINGi9606.ENSP00000176195

Structurei

3D structure databases

ProteinModelPortaliP09683
SMRiP09683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG0Y Eukaryota
ENOG4111AMM LUCA
GeneTreeiENSGT00390000002624
HOGENOMiHOG000133017
HOVERGENiHBG017786
InParanoidiP09683
KOiK05263
OMAiMPLGGAW
OrthoDBiEOG091G12NH
PhylomeDBiP09683
TreeFamiTF338215

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015675 Prosecretin
PANTHERiPTHR17378 PTHR17378, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL
60 70 80 90 100
QGLVGKRSEQ DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL
110 120
PPGPMVSEPA GAAAEGTLRP R
Length:121
Mass (Da):13,016
Last modified:January 11, 2001 - v2
Checksum:i44BDB4EFC0E161CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244355 Genomic DNA Translation: AAG31443.1
CCDSiCCDS7709.1
RefSeqiNP_068739.1, NM_021920.3
UniGeneiHs.632324

Genome annotation databases

EnsembliENST00000176195; ENSP00000176195; ENSG00000070031
ENST00000622382; ENSP00000483559; ENSG00000274473
GeneIDi6343
KEGGihsa:6343
UCSCiuc001lqo.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Secretin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244355 Genomic DNA Translation: AAG31443.1
CCDSiCCDS7709.1
RefSeqiNP_068739.1, NM_021920.3
UniGeneiHs.632324

3D structure databases

ProteinModelPortaliP09683
SMRiP09683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112247, 2 interactors
IntActiP09683, 4 interactors
STRINGi9606.ENSP00000176195

PTM databases

PhosphoSitePlusiP09683

Polymorphism and mutation databases

BioMutaiSCT
DMDMi12231018

Proteomic databases

PaxDbiP09683
PeptideAtlasiP09683
PRIDEiP09683
ProteomicsDBi52265

Protocols and materials databases

DNASUi6343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000176195; ENSP00000176195; ENSG00000070031
ENST00000622382; ENSP00000483559; ENSG00000274473
GeneIDi6343
KEGGihsa:6343
UCSCiuc001lqo.2 human

Organism-specific databases

CTDi6343
DisGeNETi6343
EuPathDBiHostDB:ENSG00000070031.3
GeneCardsiSCT
HGNCiHGNC:10607 SCT
HPAiHPA050961
MIMi182099 gene
neXtProtiNX_P09683
OpenTargetsiENSG00000070031
PharmGKBiPA35017
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG0Y Eukaryota
ENOG4111AMM LUCA
GeneTreeiENSGT00390000002624
HOGENOMiHOG000133017
HOVERGENiHBG017786
InParanoidiP09683
KOiK05263
OMAiMPLGGAW
OrthoDBiEOG091G12NH
PhylomeDBiP09683
TreeFamiTF338215

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Miscellaneous databases

GeneWikiiSecretin
GenomeRNAii6343
PMAP-CutDBiP09683
PROiPR:P09683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070031 Expressed in 93 organ(s), highest expression level in pituitary gland
CleanExiHS_SCT
GenevisibleiP09683 HS

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015675 Prosecretin
PANTHERiPTHR17378 PTHR17378, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSECR_HUMAN
AccessioniPrimary (citable) accession number: P09683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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