UniProtKB - P09671 (SODM_MOUSE)
Protein
Superoxide dismutase [Mn], mitochondrial
Gene
Sod2
Organism
Mus musculus (Mouse)
Status
Functioni
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activityi
- EC:1.15.1.1
Cofactori
Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | ManganeseBy similarity | 1 | |
Metal bindingi | 98 | ManganeseBy similarity | 1 | |
Metal bindingi | 183 | ManganeseBy similarity | 1 | |
Metal bindingi | 187 | ManganeseBy similarity | 1 |
GO - Molecular functioni
- DNA binding Source: MGI
- enzyme binding Source: MGI
- identical protein binding Source: MGI
- manganese ion binding Source: UniProtKB
- metal ion binding Source: GO_Central
- oxidoreductase activity Source: CACAO
- oxygen binding Source: MGI
- superoxide dismutase activity Source: MGI
GO - Biological processi
- acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGI
- age-dependent response to oxidative stress Source: MGI
- age-dependent response to reactive oxygen species Source: UniProtKB
- apoptotic mitochondrial changes Source: MGI
- cellular response to ethanol Source: Ensembl
- detection of oxygen Source: MGI
- erythrophore differentiation Source: MGI
- glutathione metabolic process Source: MGI
- heart development Source: MGI
- hemopoiesis Source: MGI
- hydrogen peroxide biosynthetic process Source: MGI
- hydrogen peroxide metabolic process Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
- iron ion homeostasis Source: MGI
- liver development Source: MGI
- locomotory behavior Source: MGI
- mitochondrion organization Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of fat cell differentiation Source: MGI
- negative regulation of fibroblast proliferation Source: MGI
- negative regulation of membrane hyperpolarization Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: MGI
- negative regulation of vascular associated smooth muscle cell proliferation Source: MGI
- neuron development Source: MGI
- oxygen homeostasis Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of hydrogen peroxide biosynthetic process Source: MGI
- positive regulation of nitric oxide biosynthetic process Source: MGI
- positive regulation of vascular associated smooth muscle cell apoptotic process Source: MGI
- positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Source: MGI
- post-embryonic development Source: MGI
- protein homotetramerization Source: MGI
- regulation of blood pressure Source: MGI
- regulation of catalytic activity Source: MGI
- regulation of mitochondrial membrane potential Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- release of cytochrome c from mitochondria Source: MGI
- removal of superoxide radicals Source: MGI
- respiratory electron transport chain Source: MGI
- response to activity Source: MGI
- response to axon injury Source: MGI
- response to cadmium ion Source: Ensembl
- response to cold Source: Ensembl
- response to drug Source: MGI
- response to electrical stimulus Source: Ensembl
- response to gamma radiation Source: MGI
- response to hydrogen peroxide Source: MGI
- response to hyperoxia Source: MGI
- response to hypoxia Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to isolation stress Source: Ensembl
- response to L-ascorbic acid Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to magnetism Source: Ensembl
- response to manganese ion Source: Ensembl
- response to nutrient levels Source: MGI
- response to oxidative stress Source: MGI
- response to reactive oxygen species Source: MGI
- response to selenium ion Source: Ensembl
- response to silicon dioxide Source: Ensembl
- response to superoxide Source: MGI
- response to zinc ion Source: Ensembl
- superoxide anion generation Source: MGI
- superoxide metabolic process Source: MGI
- vasodilation Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2151201, Transcriptional activation of mitochondrial biogenesis R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Sod2 Synonyms:Sod-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98352, Sod2 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrial matrix Source: MGI
- mitochondrial nucleoid Source: MGI
- mitochondrion Source: MGI
Other locations
- cytoplasm Source: MGI
- myelin sheath Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 122 | K → R: Reverses IR-Induced increases in superoxide and genomic Instability in SIRT3-deficient mice. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 24 | MitochondrionAdd BLAST | 24 | |
ChainiPRO_0000032871 | 25 – 222 | Superoxide dismutase [Mn], mitochondrialAdd BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 58 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 68 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 68 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 75 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 75 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 114 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 122 | N6-acetyllysine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 122 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 130 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 130 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 202 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity (By similarity).By similarity
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.1 Publication
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.By similarity
Keywords - PTMi
Acetylation, Nitration, Ubl conjugationProteomic databases
EPDi | P09671 |
jPOSTi | P09671 |
PaxDbi | P09671 |
PeptideAtlasi | P09671 |
PRIDEi | P09671 |
TopDownProteomicsi | P09671 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00109109 P09671 |
SWISS-2DPAGEi | P09671 |
PTM databases
iPTMneti | P09671 |
PhosphoSitePlusi | P09671 |
SwissPalmi | P09671 |
Expressioni
Inductioni
Expression is regulated by KRIT1.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000006818, Expressed in cardiac ventricle and 352 other tissues |
ExpressionAtlasi | P09671, baseline and differential |
Genevisiblei | P09671, MM |
Interactioni
Subunit structurei
Homotetramer.
Binary interactionsi
Hide detailsGO - Molecular functioni
- enzyme binding Source: MGI
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203388, 9 interactors |
IntActi | P09671, 7 interactors |
MINTi | P09671 |
STRINGi | 10090.ENSMUSP00000007012 |
Miscellaneous databases
RNActi | P09671, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the iron/manganese superoxide dismutase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_1_1 |
InParanoidi | P09671 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P09671 |
TreeFami | TF105132 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P09671-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYTAC KK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WBF0 | A0A3B2WBF0_MOUSE | Superoxide dismutase | Sod2 | 182 | Annotation score: | ||
A0A3B2W479 | A0A3B2W479_MOUSE | Superoxide dismutase [Mn], mitochon... | Sod2 | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | A → G in AAH18173 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 18 | G → V in CAA28645 (PubMed:3797253).Curated | 1 | |
Sequence conflicti | 138 | V → M (PubMed:3797253).Curated | 1 | |
Sequence conflicti | 138 | V → M (PubMed:7875582).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04972 mRNA Translation: CAA28645.1 Z18857 mRNA Translation: CAA79308.1 L35528 , L35525, L35526, L35527 Genomic DNA Translation: AAB60902.1 S78846 , S78832, S78842, S78844 Genomic DNA Translation: AAB34899.1 AK002428 mRNA Translation: BAB22095.1 AK002534 mRNA Translation: BAB22170.1 AK012354 mRNA Translation: BAB28183.1 BC010548 mRNA Translation: AAH10548.1 BC018173 mRNA Translation: AAH18173.1 |
CCDSi | CCDS28399.1 |
PIRi | I57023 |
RefSeqi | NP_038699.2, NM_013671.3 |
Genome annotation databases
Ensembli | ENSMUST00000007012; ENSMUSP00000007012; ENSMUSG00000006818 |
GeneIDi | 20656 |
KEGGi | mmu:20656 |
UCSCi | uc008alv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04972 mRNA Translation: CAA28645.1 Z18857 mRNA Translation: CAA79308.1 L35528 , L35525, L35526, L35527 Genomic DNA Translation: AAB60902.1 S78846 , S78832, S78842, S78844 Genomic DNA Translation: AAB34899.1 AK002428 mRNA Translation: BAB22095.1 AK002534 mRNA Translation: BAB22170.1 AK012354 mRNA Translation: BAB28183.1 BC010548 mRNA Translation: AAH10548.1 BC018173 mRNA Translation: AAH18173.1 |
CCDSi | CCDS28399.1 |
PIRi | I57023 |
RefSeqi | NP_038699.2, NM_013671.3 |
3D structure databases
SMRi | P09671 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203388, 9 interactors |
IntActi | P09671, 7 interactors |
MINTi | P09671 |
STRINGi | 10090.ENSMUSP00000007012 |
PTM databases
iPTMneti | P09671 |
PhosphoSitePlusi | P09671 |
SwissPalmi | P09671 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00109109 P09671 |
SWISS-2DPAGEi | P09671 |
Proteomic databases
EPDi | P09671 |
jPOSTi | P09671 |
PaxDbi | P09671 |
PeptideAtlasi | P09671 |
PRIDEi | P09671 |
TopDownProteomicsi | P09671 |
Genome annotation databases
Ensembli | ENSMUST00000007012; ENSMUSP00000007012; ENSMUSG00000006818 |
GeneIDi | 20656 |
KEGGi | mmu:20656 |
UCSCi | uc008alv.1, mouse |
Organism-specific databases
CTDi | 6648 |
MGIi | MGI:98352, Sod2 |
Phylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_1_1 |
InParanoidi | P09671 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P09671 |
TreeFami | TF105132 |
Enzyme and pathway databases
Reactomei | R-MMU-2151201, Transcriptional activation of mitochondrial biogenesis R-MMU-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
BioGRID-ORCSi | 20656, 4 hits in 19 CRISPR screens |
ChiTaRSi | Sod2, mouse |
PROi | PR:P09671 |
RNActi | P09671, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006818, Expressed in cardiac ventricle and 352 other tissues |
ExpressionAtlasi | P09671, baseline and differential |
Genevisiblei | P09671, MM |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SODM_MOUSE | |
Accessioni | P09671Primary (citable) accession number: P09671 Secondary accession number(s): Q64670, Q8VEM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families