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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • generation of precursor metabolites and energy Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:COX6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164919.10
HGNCiHGNC:2285 COX6C
MIMi124090 gene
neXtProtiNX_P09669

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13Mitochondrial matrixBy similarityAdd BLAST13
Transmembranei14 – 54HelicalBy similarityAdd BLAST41
Topological domaini55 – 75Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1345
OpenTargetsiENSG00000164919
PharmGKBiPA26802

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaiCOX6C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000061311 – 75Cytochrome c oxidase subunit 6CAdd BLAST75

Proteomic databases

EPDiP09669
MaxQBiP09669
PaxDbiP09669
PeptideAtlasiP09669
PRIDEiP09669
ProteomicsDBi52263
TopDownProteomicsiP09669

PTM databases

iPTMnetiP09669
PhosphoSitePlusiP09669

Expressioni

Gene expression databases

BgeeiENSG00000164919 Expressed in 241 organ(s), highest expression level in heart
CleanExiHS_COX6C
ExpressionAtlasiP09669 baseline and differential
GenevisibleiP09669 HS

Organism-specific databases

HPAiCAB016244
HPA014295

Interactioni

Protein-protein interaction databases

BioGridi107738, 41 interactors
CORUMiP09669
IntActiP09669, 37 interactors
MINTiP09669
STRINGi9606.ENSP00000297564

Structurei

3D structure databases

ProteinModelPortaliP09669
SMRiP09669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00390000004573
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiP09669
KOiK02268
OMAiKPVMRGL
OrthoDBiEOG091G10KX
PhylomeDBiP09669
TreeFamiTF353619

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit

Sequencei

Sequence statusi: Complete.

P09669-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA
60 70
DFYRNYDVMK DFEEMRKAGI FQSVK
Length:75
Mass (Da):8,781
Last modified:February 1, 1996 - v2
Checksum:iD09FEE0C0AA7A798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA Translation: CAA31624.1
AF067637, AF067636 Genomic DNA Translation: AAC73061.1
BT007007 mRNA Translation: AAP35653.1
AK311791 mRNA Translation: BAG34734.1
CH471060 Genomic DNA Translation: EAW91791.1
BC000187 mRNA Translation: AAH00187.1
CCDSiCCDS6284.1
PIRiS01960 OGHU6C
RefSeqiNP_004365.1, NM_004374.3
XP_016868509.1, XM_017013020.1
UniGeneiHs.351875

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919
ENST00000517682; ENSP00000429714; ENSG00000164919
ENST00000518171; ENSP00000429755; ENSG00000164919
ENST00000520271; ENSP00000428150; ENSG00000164919
ENST00000520468; ENSP00000428895; ENSG00000164919
ENST00000520517; ENSP00000429991; ENSG00000164919
ENST00000522934; ENSP00000428702; ENSG00000164919
ENST00000522940; ENSP00000428965; ENSG00000164919
ENST00000523016; ENSP00000429707; ENSG00000164919
ENST00000524245; ENSP00000429410; ENSG00000164919
GeneIDi1345
KEGGihsa:1345
UCSCiuc003yiy.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA Translation: CAA31624.1
AF067637, AF067636 Genomic DNA Translation: AAC73061.1
BT007007 mRNA Translation: AAP35653.1
AK311791 mRNA Translation: BAG34734.1
CH471060 Genomic DNA Translation: EAW91791.1
BC000187 mRNA Translation: AAH00187.1
CCDSiCCDS6284.1
PIRiS01960 OGHU6C
RefSeqiNP_004365.1, NM_004374.3
XP_016868509.1, XM_017013020.1
UniGeneiHs.351875

3D structure databases

ProteinModelPortaliP09669
SMRiP09669
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107738, 41 interactors
CORUMiP09669
IntActiP09669, 37 interactors
MINTiP09669
STRINGi9606.ENSP00000297564

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

PTM databases

iPTMnetiP09669
PhosphoSitePlusiP09669

Polymorphism and mutation databases

BioMutaiCOX6C

Proteomic databases

EPDiP09669
MaxQBiP09669
PaxDbiP09669
PeptideAtlasiP09669
PRIDEiP09669
ProteomicsDBi52263
TopDownProteomicsiP09669

Protocols and materials databases

DNASUi1345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919
ENST00000517682; ENSP00000429714; ENSG00000164919
ENST00000518171; ENSP00000429755; ENSG00000164919
ENST00000520271; ENSP00000428150; ENSG00000164919
ENST00000520468; ENSP00000428895; ENSG00000164919
ENST00000520517; ENSP00000429991; ENSG00000164919
ENST00000522934; ENSP00000428702; ENSG00000164919
ENST00000522940; ENSP00000428965; ENSG00000164919
ENST00000523016; ENSP00000429707; ENSG00000164919
ENST00000524245; ENSP00000429410; ENSG00000164919
GeneIDi1345
KEGGihsa:1345
UCSCiuc003yiy.3 human

Organism-specific databases

CTDi1345
DisGeNETi1345
EuPathDBiHostDB:ENSG00000164919.10
GeneCardsiCOX6C
HGNCiHGNC:2285 COX6C
HPAiCAB016244
HPA014295
MIMi124090 gene
neXtProtiNX_P09669
OpenTargetsiENSG00000164919
PharmGKBiPA26802
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00390000004573
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiP09669
KOiK02268
OMAiKPVMRGL
OrthoDBiEOG091G10KX
PhylomeDBiP09669
TreeFamiTF353619

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiCOX6C human
GeneWikiiCOX6C
GenomeRNAii1345
PROiPR:P09669
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164919 Expressed in 241 organ(s), highest expression level in heart
CleanExiHS_COX6C
ExpressionAtlasiP09669 baseline and differential
GenevisibleiP09669 HS

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX6C_HUMAN
AccessioniPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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