Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 182 (07 Oct 2020)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09158-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P09669

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00705

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164919.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2285, COX6C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
124090, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09669

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13Mitochondrial matrix1 PublicationAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 54HelicalBy similarityAdd BLAST41
Topological domaini55 – 75Mitochondrial intermembrane1 PublicationAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1345

Open Targets

More...
OpenTargetsi
ENSG00000164919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26802

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P09669, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02659, Cholic Acid
DB04464, N-Formylmethionine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COX6C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000061311 – 75Cytochrome c oxidase subunit 6CAdd BLAST75

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09669

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09669

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P09669

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09669

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09669

PeptideAtlas

More...
PeptideAtlasi
P09669

PRoteomics IDEntifications database

More...
PRIDEi
P09669

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52263

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P09669

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09669

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09669

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164919, Expressed in caudate nucleus and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09669, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09669, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164919, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:28844695).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107738, 93 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P09669

Protein interaction database and analysis system

More...
IntActi
P09669, 43 interactors

Molecular INTeraction database

More...
MINTi
P09669

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428895

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P09669, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09669

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SEI2, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162275

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_196254_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09669

KEGG Orthology (KO)

More...
KOi
K02268

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALMKPQM

Database of Orthologous Groups

More...
OrthoDBi
1618740at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09669

TreeFam database of animal gene trees

More...
TreeFami
TF353619

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00927, Cyt_c_Oxidase_VIc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.93.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004204, COX6C
IPR034884, Cytochrome_c_oxidase_VIc/VIIs
IPR037169, Cytochrome_c_oxidase_VIc_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02937, COX6C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81415, SSF81415, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P09669-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA
60 70
DFYRNYDVMK DFEEMRKAGI FQSVK
Length:75
Mass (Da):8,781
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD09FEE0C0AA7A798
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13238 mRNA Translation: CAA31624.1
AF067637, AF067636 Genomic DNA Translation: AAC73061.1
BT007007 mRNA Translation: AAP35653.1
AK311791 mRNA Translation: BAG34734.1
CH471060 Genomic DNA Translation: EAW91791.1
BC000187 mRNA Translation: AAH00187.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6284.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S01960, OGHU6C

NCBI Reference Sequences

More...
RefSeqi
NP_004365.1, NM_004374.3
XP_016868509.1, XM_017013020.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297564; ENSP00000297564; ENSG00000164919
ENST00000517682; ENSP00000429714; ENSG00000164919
ENST00000518171; ENSP00000429755; ENSG00000164919
ENST00000520271; ENSP00000428150; ENSG00000164919
ENST00000520468; ENSP00000428895; ENSG00000164919
ENST00000520517; ENSP00000429991; ENSG00000164919
ENST00000522934; ENSP00000428702; ENSG00000164919
ENST00000522940; ENSP00000428965; ENSG00000164919
ENST00000523016; ENSP00000429707; ENSG00000164919
ENST00000524245; ENSP00000429410; ENSG00000164919

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1345

UCSC genome browser

More...
UCSCi
uc003yiy.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA Translation: CAA31624.1
AF067637, AF067636 Genomic DNA Translation: AAC73061.1
BT007007 mRNA Translation: AAP35653.1
AK311791 mRNA Translation: BAG34734.1
CH471060 Genomic DNA Translation: EAW91791.1
BC000187 mRNA Translation: AAH00187.1
CCDSiCCDS6284.1
PIRiS01960, OGHU6C
RefSeqiNP_004365.1, NM_004374.3
XP_016868509.1, XM_017013020.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z62electron microscopy3.60I3-75[»]
SMRiP09669
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107738, 93 interactors
CORUMiP09669
IntActiP09669, 43 interactors
MINTiP09669
STRINGi9606.ENSP00000428895

Chemistry databases

DrugBankiDB02659, Cholic Acid
DB04464, N-Formylmethionine

PTM databases

iPTMnetiP09669
PhosphoSitePlusiP09669

Polymorphism and mutation databases

BioMutaiCOX6C

Proteomic databases

EPDiP09669
jPOSTiP09669
MassIVEiP09669
MaxQBiP09669
PaxDbiP09669
PeptideAtlasiP09669
PRIDEiP09669
ProteomicsDBi52263
TopDownProteomicsiP09669

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4263, 228 antibodies

The DNASU plasmid repository

More...
DNASUi
1345

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919
ENST00000517682; ENSP00000429714; ENSG00000164919
ENST00000518171; ENSP00000429755; ENSG00000164919
ENST00000520271; ENSP00000428150; ENSG00000164919
ENST00000520468; ENSP00000428895; ENSG00000164919
ENST00000520517; ENSP00000429991; ENSG00000164919
ENST00000522934; ENSP00000428702; ENSG00000164919
ENST00000522940; ENSP00000428965; ENSG00000164919
ENST00000523016; ENSP00000429707; ENSG00000164919
ENST00000524245; ENSP00000429410; ENSG00000164919
GeneIDi1345
KEGGihsa:1345
UCSCiuc003yiy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1345
DisGeNETi1345
EuPathDBiHostDB:ENSG00000164919.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COX6C
HGNCiHGNC:2285, COX6C
HPAiENSG00000164919, Tissue enhanced (skeletal)
MIMi124090, gene
neXtProtiNX_P09669
OpenTargetsiENSG00000164919
PharmGKBiPA26802

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SEI2, Eukaryota
GeneTreeiENSGT00940000162275
HOGENOMiCLU_196254_0_0_1
InParanoidiP09669
KOiK02268
OMAiALMKPQM
OrthoDBi1618740at2759
PhylomeDBiP09669
TreeFamiTF353619

Enzyme and pathway databases

UniPathwayiUPA00705
BioCyciMetaCyc:HS09158-MONOMER
PathwayCommonsiP09669
ReactomeiR-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1345, 315 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COX6C, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COX6C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1345
PharosiP09669, Tbio

Protein Ontology

More...
PROi
PR:P09669
RNActiP09669, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164919, Expressed in caudate nucleus and 252 other tissues
ExpressionAtlasiP09669, baseline and differential
GenevisibleiP09669, HS

Family and domain databases

CDDicd00927, Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204, COX6C
IPR034884, Cytochrome_c_oxidase_VIc/VIIs
IPR037169, Cytochrome_c_oxidase_VIc_sf
PfamiView protein in Pfam
PF02937, COX6C, 1 hit
SUPFAMiSSF81415, SSF81415, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX6C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: October 7, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again