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Protein

Pro-cathepsin H

Gene

CTSH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the overall degradation of proteins in lysosomes.

Catalytic activityi

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141By similarity1
Active sitei281By similarity1
Active sitei301By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.16 2681
ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-5683826 Surfactant metabolism
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP09668

Protein family/group databases

MEROPSiC01.040

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-cathepsin H
Cleaved into the following 4 chains:
Gene namesi
Name:CTSH
Synonyms:CPSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103811.15
HGNCiHGNC:2535 CTSH
MIMi116820 gene
neXtProtiNX_P09668

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1512
MalaCardsiCTSH
OpenTargetsiENSG00000103811
Orphaneti2073 Narcolepsy-cataplexy syndrome
PharmGKBiPA27033

Chemistry databases

ChEMBLiCHEMBL2225
DrugBankiDB08526 CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane
DB02140 N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide
DB03120 Para-Toluene Sulfonate
GuidetoPHARMACOLOGYi2349

Polymorphism and mutation databases

BioMutaiCTSH
DMDMi288558851

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
PropeptideiPRO_000002620623 – 97Activation peptide1 PublicationAdd BLAST75
PeptideiPRO_000002620798 – 105Cathepsin H mini chain8
PropeptideiPRO_0000026208106 – 1151 Publication10
ChainiPRO_0000026209116 – 335Cathepsin HAdd BLAST220
ChainiPRO_0000026210116 – 292Cathepsin H heavy chainAdd BLAST177
ChainiPRO_0000026211293 – 335Cathepsin H light chainAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi102 ↔ 327By similarity
Disulfide bondi138 ↔ 181By similarity
Disulfide bondi172 ↔ 214By similarity
Glycosylationi230N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi272 ↔ 322By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP09668
MaxQBiP09668
PaxDbiP09668
PeptideAtlasiP09668
PRIDEiP09668
ProteomicsDBi52262

PTM databases

iPTMnetiP09668
PhosphoSitePlusiP09668

Expressioni

Gene expression databases

BgeeiENSG00000103811 Expressed in 228 organ(s), highest expression level in right lung
CleanExiHS_CTSH
ExpressionAtlasiP09668 baseline and differential
GenevisibleiP09668 HS

Organism-specific databases

HPAiCAB000458
HPA003524

Interactioni

Subunit structurei

Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.

Protein-protein interaction databases

BioGridi107892, 21 interactors
IntActiP09668, 1 interactor
STRINGi9606.ENSP00000220166

Chemistry databases

BindingDBiP09668

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09668
SMRiP09668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiP09668
KOiK01366
OMAiAYNNFGC
OrthoDBiEOG091G0AKT
PhylomeDBiP09668
TreeFamiTF328985

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P09668-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE
60 70 80 90 100
YHHRLQTFAS NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ
110 120 130 140 150
NCSATKSNYL RGTGPYPPSV DWRKKGNFVS PVKNQGACGS CWTFSTTGAL
160 170 180 190 200
ESAIAIATGK MLSLAEQQLV DCAQDFNNHG CQGGLPSQAF EYILYNKGIM
210 220 230 240 250
GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV EAVALYNPVS
260 270 280 290 300
FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK
310 320 330
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV
Length:335
Mass (Da):37,394
Last modified:February 9, 2010 - v4
Checksum:iE2CF3A5EEA59C1D1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0D5A0A087X0D5_HUMAN
Pro-cathepsin H
CTSH
323Annotation score:
E9PKT6E9PKT6_HUMAN
Pro-cathepsin H
CTSH
134Annotation score:
E9PN60E9PN60_HUMAN
Pro-cathepsin H
CTSH
118Annotation score:
E9PN84E9PN84_HUMAN
Pro-cathepsin H
CTSH
41Annotation score:
A0A0B4J217A0A0B4J217_HUMAN
Pro-cathepsin H
CTSH
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306Q → E AA sequence (PubMed:3342889).Curated1
Sequence conflicti306Q → E AA sequence (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05703811G → R. Corresponds to variant dbSNP:rs2289702Ensembl.1
Natural variantiVAR_05703923A → T. Corresponds to variant dbSNP:rs35001431Ensembl.1
Natural variantiVAR_06036826C → S3 PublicationsCorresponds to variant dbSNP:rs1036938Ensembl.1
Natural variantiVAR_036478126G → R in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_067717179H → Y3 PublicationsCorresponds to variant dbSNP:rs1130856Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16832 mRNA Translation: CAA34734.1
AF426247 mRNA Translation: AAL23961.1
AK314698 mRNA Translation: BAG37247.1
AC011944 Genomic DNA No translation available.
BC002479 mRNA Translation: AAH02479.1
X07549 mRNA Translation: CAA30428.1
X07549 mRNA Translation: CAA30429.1
CCDSiCCDS10308.1
PIRiS12486 KHHUH
RefSeqiNP_004381.2, NM_004390.4
UniGeneiHs.148641

Genome annotation databases

EnsembliENST00000220166; ENSP00000220166; ENSG00000103811
GeneIDi1512
KEGGihsa:1512
UCSCiuc021srk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16832 mRNA Translation: CAA34734.1
AF426247 mRNA Translation: AAL23961.1
AK314698 mRNA Translation: BAG37247.1
AC011944 Genomic DNA No translation available.
BC002479 mRNA Translation: AAH02479.1
X07549 mRNA Translation: CAA30428.1
X07549 mRNA Translation: CAA30429.1
CCDSiCCDS10308.1
PIRiS12486 KHHUH
RefSeqiNP_004381.2, NM_004390.4
UniGeneiHs.148641

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZNmodel-B116-335[»]
6CZKX-ray2.00A1-335[»]
6CZSX-ray1.66A1-335[»]
ProteinModelPortaliP09668
SMRiP09668
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107892, 21 interactors
IntActiP09668, 1 interactor
STRINGi9606.ENSP00000220166

Chemistry databases

BindingDBiP09668
ChEMBLiCHEMBL2225
DrugBankiDB08526 CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane
DB02140 N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide
DB03120 Para-Toluene Sulfonate
GuidetoPHARMACOLOGYi2349

Protein family/group databases

MEROPSiC01.040

PTM databases

iPTMnetiP09668
PhosphoSitePlusiP09668

Polymorphism and mutation databases

BioMutaiCTSH
DMDMi288558851

Proteomic databases

EPDiP09668
MaxQBiP09668
PaxDbiP09668
PeptideAtlasiP09668
PRIDEiP09668
ProteomicsDBi52262

Protocols and materials databases

DNASUi1512
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220166; ENSP00000220166; ENSG00000103811
GeneIDi1512
KEGGihsa:1512
UCSCiuc021srk.2 human

Organism-specific databases

CTDi1512
DisGeNETi1512
EuPathDBiHostDB:ENSG00000103811.15
GeneCardsiCTSH
H-InvDBiHIX0012481
HGNCiHGNC:2535 CTSH
HPAiCAB000458
HPA003524
MalaCardsiCTSH
MIMi116820 gene
neXtProtiNX_P09668
OpenTargetsiENSG00000103811
Orphaneti2073 Narcolepsy-cataplexy syndrome
PharmGKBiPA27033
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiP09668
KOiK01366
OMAiAYNNFGC
OrthoDBiEOG091G0AKT
PhylomeDBiP09668
TreeFamiTF328985

Enzyme and pathway databases

BRENDAi3.4.22.16 2681
ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-5683826 Surfactant metabolism
R-HSA-6798695 Neutrophil degranulation
SABIO-RKiP09668

Miscellaneous databases

ChiTaRSiCTSH human
GeneWikiiCathepsin_H
GenomeRNAii1512
PROiPR:P09668
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103811 Expressed in 228 organ(s), highest expression level in right lung
CleanExiHS_CTSH
ExpressionAtlasiP09668 baseline and differential
GenevisibleiP09668 HS

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCATH_HUMAN
AccessioniPrimary (citable) accession number: P09668
Secondary accession number(s): B2RBK0, Q96NY6, Q9BUM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 193 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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