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Protein

U2 small nuclear ribonucleoprotein A'

Gene

SNRPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939).6 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • U2 snRNA binding Source: GO_Central

GO - Biological processi

  • interleukin-12-mediated signaling pathway Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing Source: ProtInc
  • spermatogenesis Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein A'
Short name:
U2 snRNP A'2 Publications
Gene namesi
Name:SNRPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000131876.16
HGNCiHGNC:11152 SNRPA1
MIMi603521 gene
neXtProtiNX_P09661

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15Y → D: Results in defective spliceosome assembly. 1 Publication1
Mutagenesisi27R → Q: No change in spliceosome assembly. 1 Publication1
Mutagenesisi68T → K: No change in spliceosome assembly. 1 Publication1
Mutagenesisi72N → K: No change in spliceosome assembly. 1 Publication1
Mutagenesisi73N → K: No change in spliceosome assembly. 1 Publication1
Mutagenesisi92E → V: Results in defective spliceosome assembly. 1 Publication1
Mutagenesisi148Q → R: Results in defective spliceosome assembly. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000131876
PharmGKBiPA35994

Polymorphism and mutation databases

BioMutaiSNRPA1
DMDMi31077165

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000741732 – 255U2 small nuclear ribonucleoprotein A'Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172N6-acetyllysine; alternateCombined sources1
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei178PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei236PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09661
MaxQBiP09661
PaxDbiP09661
PeptideAtlasiP09661
PRIDEiP09661
ProteomicsDBi52261

PTM databases

iPTMnetiP09661
PhosphoSitePlusiP09661

Expressioni

Gene expression databases

BgeeiENSG00000131876 Expressed in 92 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SNRPA1
ExpressionAtlasiP09661 baseline and differential
GenevisibleiP09661 HS

Organism-specific databases

HPAiHPA045622
HPA048499

Interactioni

Subunit structurei

Identified in the spliceosome B complex (PubMed:28781166). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B (PubMed:10339552). Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2 (PubMed:9716128, PubMed:27035939).8 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112511, 149 interactors
CORUMiP09661
DIPiDIP-625N
IntActiP09661, 30 interactors
MINTiP09661
STRINGi9606.ENSP00000254193

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09661
SMRiP09661
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09661

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 41LRR 1Add BLAST22
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 86LRR 3Add BLAST22
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1644 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00510000047131
HOGENOMiHOG000175472
HOVERGENiHBG007330
KOiK11092
OMAiTKPNYRE
OrthoDBiEOG091G0M17
PhylomeDBiP09661
TreeFamiTF313776

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P09661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS
60 70 80 90 100
DNEIRKLDGF PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL
110 120 130 140 150
VELGDLDPLA SLKSLTYLSI LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV
160 170 180 190 200
KLKERQEAEK MFKGKRGAQL AKDIARRSKT FNPGAGLPTD KKKGGPSPGD
210 220 230 240 250
VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD DGEEEMEEDT

VTNGS
Length:255
Mass (Da):28,416
Last modified:May 23, 2003 - v2
Checksum:i25902F07992B7209
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKK0H0YKK0_HUMAN
Small nuclear ribonucleoprotein pol...
SNRPA1 hCG_1992004
154Annotation score:
H0YMA0H0YMA0_HUMAN
U2 small nuclear ribonucleoprotein ...
SNRPA1
142Annotation score:
H0YLR3H0YLR3_HUMAN
U2 small nuclear ribonucleoprotein ...
SNRPA1
89Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193K → R in CAA31838 (PubMed:2928112).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13482 mRNA Translation: CAA31838.1
AK312200 mRNA Translation: BAG35133.1
CH471101 Genomic DNA Translation: EAX02300.1
BC022816 mRNA Translation: AAH22816.1
BC071717 mRNA Translation: AAH71717.1
CCDSiCCDS10391.1
PIRiS03616
RefSeqiNP_003081.2, NM_003090.3
UniGeneiHs.528763

Genome annotation databases

EnsembliENST00000254193; ENSP00000254193; ENSG00000131876
GeneIDi6627
KEGGihsa:6627
UCSCiuc002bww.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13482 mRNA Translation: CAA31838.1
AK312200 mRNA Translation: BAG35133.1
CH471101 Genomic DNA Translation: EAX02300.1
BC022816 mRNA Translation: AAH22816.1
BC071717 mRNA Translation: AAH71717.1
CCDSiCCDS10391.1
PIRiS03616
RefSeqiNP_003081.2, NM_003090.3
UniGeneiHs.528763

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38A/C1-176[»]
5MQFelectron microscopy5.90W1-255[»]
5O9Zelectron microscopy4.50z1-255[»]
5XJCelectron microscopy3.60o1-255[»]
5YZGelectron microscopy4.10o1-255[»]
5Z56electron microscopy5.10o1-255[»]
5Z57electron microscopy6.50o1-255[»]
5Z58electron microscopy4.90o1-255[»]
ProteinModelPortaliP09661
SMRiP09661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112511, 149 interactors
CORUMiP09661
DIPiDIP-625N
IntActiP09661, 30 interactors
MINTiP09661
STRINGi9606.ENSP00000254193

PTM databases

iPTMnetiP09661
PhosphoSitePlusiP09661

Polymorphism and mutation databases

BioMutaiSNRPA1
DMDMi31077165

Proteomic databases

EPDiP09661
MaxQBiP09661
PaxDbiP09661
PeptideAtlasiP09661
PRIDEiP09661
ProteomicsDBi52261

Protocols and materials databases

DNASUi6627
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254193; ENSP00000254193; ENSG00000131876
GeneIDi6627
KEGGihsa:6627
UCSCiuc002bww.4 human

Organism-specific databases

CTDi6627
EuPathDBiHostDB:ENSG00000131876.16
GeneCardsiSNRPA1
H-InvDBiHIX0203213
HGNCiHGNC:11152 SNRPA1
HPAiHPA045622
HPA048499
MIMi603521 gene
neXtProtiNX_P09661
OpenTargetsiENSG00000131876
PharmGKBiPA35994
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1644 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00510000047131
HOGENOMiHOG000175472
HOVERGENiHBG007330
KOiK11092
OMAiTKPNYRE
OrthoDBiEOG091G0M17
PhylomeDBiP09661
TreeFamiTF313776

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

EvolutionaryTraceiP09661
GeneWikiiSNRPA1
GenomeRNAii6627
PROiPR:P09661
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131876 Expressed in 92 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SNRPA1
ExpressionAtlasiP09661 baseline and differential
GenevisibleiP09661 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRU2A_HUMAN
AccessioniPrimary (citable) accession number: P09661
Secondary accession number(s): B2R5I6, Q8TBD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 23, 2003
Last modified: November 7, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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