UniProtKB - P09651 (ROA1_HUMAN)
Heterogeneous nuclear ribonucleoprotein A1
HNRNPA1
Functioni
Caution
GO - Molecular functioni
- G-rich strand telomeric DNA binding Source: BHF-UCL
- identical protein binding Source: IntAct
- miRNA binding Source: UniProtKB
- pre-mRNA binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- RNA binding Source: UniProtKB
- single-stranded DNA binding Source: HGNC-UCL
- single-stranded RNA binding Source: HGNC-UCL
- telomeric repeat-containing RNA binding Source: BHF-UCL
GO - Biological processi
- cellular response to glucose starvation Source: CAFA
- cellular response to sodium arsenite Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: Reactome
- import into nucleus Source: HGNC-UCL
- mRNA splicing, via spliceosome Source: Reactome
- mRNA transport Source: UniProtKB-KW
- negative regulation of telomere maintenance via telomerase Source: BHF-UCL
- nuclear export Source: HGNC-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- regulation of alternative mRNA splicing, via spliceosome Source: CAFA
- RNA export from nucleus Source: HGNC-UCL
- RNA metabolic process Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | Host-virus interaction, mRNA processing, mRNA splicing, mRNA transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P09651 |
Reactomei | R-HSA-6803529, FGFR2 alternative splicing R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | P09651 |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein A1Short name: hnRNP A1 Alternative name(s): Helix-destabilizing protein Single-strand RNA-binding protein hnRNP core protein A1 Cleaved into the following chain: |
Gene namesi | Name:HNRNPA1 Synonyms:HNRPA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5031, HNRNPA1 |
MIMi | 164017, gene |
neXtProti | NX_P09651 |
VEuPathDBi | HostDB:ENSG00000135486.17 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: (Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nucleoplasm Source: HGNC-UCL
- nucleus Source: UniProtKB
- spliceosomal complex Source: CAFA
Other locations
- cytoplasm Source: HGNC-UCL
- membrane Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePathology & Biotechi
Involvement in diseasei
Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070589 | 314 | D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar. | 1 |
Amyotrophic lateral sclerosis 20 (ALS20)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077531 | 277 | Q → K in ALS20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_070588 | 314 | D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar. | 1 | |
Natural variantiVAR_070590 | 319 | N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar. | 1 | |
Natural variantiVAR_077533 | 340 | P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 326 | G → A: No nuclear import nor export. 1 Publication | 1 | |
Mutagenesisi | 327 | P → A: No nuclear import nor export. 1 Publication | 1 | |
Mutagenesisi | 334 – 335 | GG → LL: Normal nuclear import and export. 1 Publication | 2 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 3178 |
GeneReviewsi | HNRNPA1 |
MalaCardsi | HNRNPA1 |
MIMi | 615424, phenotype 615426, phenotype |
OpenTargetsi | ENSG00000135486 |
Orphaneti | 803, Amyotrophic lateral sclerosis 52430, Inclusion body myopathy with Paget disease of bone and frontotemporal dementia |
PharmGKBi | PA162391113 |
Miscellaneous databases
Pharosi | P09651, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1955709 |
Genetic variation databases
BioMutai | HNRNPA1 |
DMDMi | 288558857 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424509 | 1 – 372 | Heterogeneous nuclear ribonucleoprotein A1Add BLAST | 372 | |
Initiator methioninei | Removed; alternateCombined sources1 Publication | |||
ChainiPRO_0000081828 | 2 – 372 | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedAdd BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 3 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 4 | PhosphoserineCombined sources | 1 | |
Modified residuei | 6 | PhosphoserineCombined sources | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 192 | Phosphoserine; by MKNK21 Publication | 1 | |
Modified residuei | 194 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 194 | Dimethylated arginine; alternateCombined sources | 1 | |
Modified residuei | 194 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | Asymmetric dimethylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 206 | Dimethylated arginine; alternateCombined sources | 1 | |
Modified residuei | 206 | Omega-N-methylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 218 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 218 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 225 | Asymmetric dimethylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 225 | Dimethylated arginine; alternateCombined sources | 1 | |
Modified residuei | 225 | Omega-N-methylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 232 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 232 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 336 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 350 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 350 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 352 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 361 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | Phosphoserine; by MKNK21 Publication | 1 | |
Modified residuei | 363 | Phosphoserine; by MKNK21 Publication | 1 | |
Modified residuei | 364 | Phosphoserine; by MKNK2Combined sources1 Publication | 1 | |
Modified residuei | 365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 368 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P09651 |
jPOSTi | P09651 |
MassIVEi | P09651 |
MaxQBi | P09651 |
PaxDbi | P09651 |
PeptideAtlasi | P09651 |
PRIDEi | P09651 |
ProteomicsDBi | 52258 [P09651-1] 52259 [P09651-2] 52260 [P09651-3] |
TopDownProteomicsi | P09651-1 [P09651-1] P09651-2 [P09651-2] P09651-3 [P09651-3] |
2D gel databases
SWISS-2DPAGEi | P09651 |
PTM databases
iPTMneti | P09651 |
MetOSitei | P09651 |
PhosphoSitePlusi | P09651 |
SwissPalmi | P09651 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135486, Expressed in forebrain and 250 other tissues |
ExpressionAtlasi | P09651, baseline and differential |
Genevisiblei | P09651, HS |
Organism-specific databases
HPAi | ENSG00000135486, Low tissue specificity |
Interactioni
Subunit structurei
Identified in the spliceosome C complex (PubMed:11991638).
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).
Interacts with SEPT6 (PubMed:17229681).
Interacts with C9orf72 (PubMed:24549040).
Interacts with KHDRBS1 (PubMed:17371836).
Interacts with UBQLN2 (PubMed:25616961).
Interacts with PPIA/CYPA (PubMed:25678563).
7 Publications(Microbial infection) Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.
1 Publication(Microbial infection) May interact with SARS-CoV Nucleoprotein.
1 PublicationBinary interactionsi
Hide detailsP09651
HNRNPA1 - isoform A1-A [P09651-2]
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-352677,EBI-352677 |
PSMD9 [O00233] | 5 | EBI-352677,EBI-750973 |
TNPO1 [Q92973] | 2 | EBI-352677,EBI-286693 |
UBQLN2 [Q9UHD9] | 4 | EBI-352677,EBI-947187 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109420, 709 interactors |
CORUMi | P09651 |
DIPi | DIP-29338N |
IntActi | P09651, 257 interactors |
MINTi | P09651 |
STRINGi | 9606.ENSP00000341826 |
Chemistry databases
BindingDBi | P09651 |
Miscellaneous databases
RNActi | P09651, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P09651 |
SMRi | P09651 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09651 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 97 | RRM 1PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 105 – 184 | RRM 2PROSITE-ProRule annotationAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 4 – 94 | Globular A domainAdd BLAST | 91 | |
Regioni | 95 – 185 | Globular B domainAdd BLAST | 91 | |
Regioni | 218 – 240 | RNA-binding RGG-boxAdd BLAST | 23 | |
Regioni | 320 – 357 | Nuclear targeting sequence (M9)Add BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 372 | Gly-richAdd BLAST | 178 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183123 |
HOGENOMi | CLU_012062_1_0_1 |
InParanoidi | P09651 |
OMAi | VDSVIMT |
PhylomeDBi | P09651 |
TreeFami | TF314808 |
Family and domain databases
CDDi | cd12761, RRM1_hnRNPA1, 1 hit cd12580, RRM2_hnRNPA1, 1 hit |
DisProti | DP00324 |
Gene3Di | 3.30.70.330, 2 hits |
IDEALi | IID00119 |
InterProi | View protein in InterPro IPR021662, HnRNPA1 IPR034845, hnRNPA1_RRM1 IPR034803, hnRNPA1_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF11627, HnRNPA1, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 55 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG
210 220 230 240 250
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND
260 270 280 290 300
GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
310 320 330 340 350
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK
360 370
PRNQGGYGGS SSSSSYGSGR RF
The sequence of this isoform differs from the canonical sequence as follows:
252-303: Missing.
Computationally mapped potential isoform sequencesi
There are 55 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W6I7 | F8W6I7_HUMAN | Helix-destabilizing protein | HNRNPA1 | 307 | Annotation score: | ||
F8VZ49 | F8VZ49_HUMAN | Helix-destabilizing protein | HNRNPA1 | 231 | Annotation score: | ||
F8VTQ5 | F8VTQ5_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 145 | Annotation score: | ||
F8W646 | F8W646_HUMAN | Helix-destabilizing protein | HNRNPA1 | 156 | Annotation score: | ||
H0YH80 | H0YH80_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 191 | Annotation score: | ||
F8VYN5 | F8VYN5_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 69 | Annotation score: | ||
A0A7I2V2F1 | A0A7I2V2F1_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 55 | Annotation score: | ||
A0A7I2V2L6 | A0A7I2V2L6_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 242 | Annotation score: | ||
A0A7I2V2M7 | A0A7I2V2M7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 104 | Annotation score: | ||
A0A7I2V2Q7 | A0A7I2V2Q7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPA1 | 96 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 128 | Y → F in CAA29922 (PubMed:2836799).Curated | 1 | |
Sequence conflicti | 140 | R → P in CAA27874 (PubMed:3023065).Curated | 1 | |
Sequence conflicti | 146 | R → K in CAA29922 (PubMed:2836799).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077531 | 277 | Q → K in ALS20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_077532 | 283 | G → R1 PublicationCorresponds to variant dbSNP:rs375259222Ensembl. | 1 | |
Natural variantiVAR_070588 | 314 | D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar. | 1 | |
Natural variantiVAR_070589 | 314 | D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar. | 1 | |
Natural variantiVAR_070590 | 319 | N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar. | 1 | |
Natural variantiVAR_077533 | 340 | P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034076 | 203 – 307 | Missing in isoform 2. 1 PublicationAdd BLAST | 105 | |
Alternative sequenceiVSP_005824 | 252 – 303 | Missing in isoform A1-A. 4 PublicationsAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12671 Genomic DNA Translation: CAA31191.1 X06747 mRNA Translation: CAA29922.1 X79536 mRNA Translation: CAA56072.1 AK291113 mRNA Translation: BAF83802.1 AC078778 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96761.1 BC002355 mRNA Translation: AAH02355.1 BC009600 mRNA Translation: AAH09600.1 BC012158 mRNA Translation: AAH12158.1 BC033714 mRNA Translation: AAH33714.1 BC052296 mRNA Translation: AAH52296.1 BC070315 mRNA Translation: AAH70315.1 BC074502 mRNA Translation: AAH74502.1 BC103707 mRNA Translation: AAI03708.1 X04347 mRNA Translation: CAA27874.1 |
CCDSi | CCDS41793.1 [P09651-2] CCDS44909.1 [P09651-1] |
PIRi | S02061 S12520 |
RefSeqi | NP_002127.1, NM_002136.3 [P09651-2] NP_112420.1, NM_031157.3 [P09651-1] XP_005268883.1, XM_005268826.1 |
Genome annotation databases
Ensembli | ENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1] ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2] ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3] ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2] ENST00000550482; ENSP00000446486; ENSG00000135486 [P09651-2] ENST00000677210; ENSP00000503610; ENSG00000135486 [P09651-1] |
GeneIDi | 3178 |
KEGGi | hsa:3178 |
UCSCi | uc001sfl.4, human [P09651-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12671 Genomic DNA Translation: CAA31191.1 X06747 mRNA Translation: CAA29922.1 X79536 mRNA Translation: CAA56072.1 AK291113 mRNA Translation: BAF83802.1 AC078778 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96761.1 BC002355 mRNA Translation: AAH02355.1 BC009600 mRNA Translation: AAH09600.1 BC012158 mRNA Translation: AAH12158.1 BC033714 mRNA Translation: AAH33714.1 BC052296 mRNA Translation: AAH52296.1 BC070315 mRNA Translation: AAH70315.1 BC074502 mRNA Translation: AAH74502.1 BC103707 mRNA Translation: AAI03708.1 X04347 mRNA Translation: CAA27874.1 |
CCDSi | CCDS41793.1 [P09651-2] CCDS44909.1 [P09651-1] |
PIRi | S02061 S12520 |
RefSeqi | NP_002127.1, NM_002136.3 [P09651-2] NP_112420.1, NM_031157.3 [P09651-1] XP_005268883.1, XM_005268826.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HA1 | X-ray | 1.75 | A | 1-184 | [»] | |
1L3K | X-ray | 1.10 | A | 1-196 | [»] | |
1PGZ | X-ray | 2.60 | A | 2-196 | [»] | |
1PO6 | X-ray | 2.10 | A | 8-190 | [»] | |
1U1K | X-ray | 2.00 | A | 1-196 | [»] | |
1U1L | X-ray | 2.00 | A | 1-196 | [»] | |
1U1M | X-ray | 2.00 | A | 1-196 | [»] | |
1U1N | X-ray | 2.10 | A | 1-196 | [»] | |
1U1O | X-ray | 2.00 | A | 1-196 | [»] | |
1U1P | X-ray | 1.90 | A | 1-196 | [»] | |
1U1Q | X-ray | 1.80 | A | 1-196 | [»] | |
1U1R | X-ray | 1.80 | A | 1-196 | [»] | |
1UP1 | X-ray | 1.90 | A | 3-184 | [»] | |
2H4M | X-ray | 3.05 | C/D | 309-357 | [»] | |
2LYV | NMR | - | A | 2-196 | [»] | |
2UP1 | X-ray | 2.10 | A | 8-190 | [»] | |
4YOE | X-ray | 1.92 | A | 1-196 | [»] | |
5MPG | NMR | - | A | 2-97 | [»] | |
5MPL | NMR | - | A | 95-196 | [»] | |
5ZGD | X-ray | 1.40 | A | 209-217 | [»] | |
5ZGL | X-ray | 0.95 | A/B | 234-240 | [»] | |
6BXX | X-ray | 1.10 | A | 243-248 | [»] | |
6DCL | X-ray | 2.50 | A/B | 2-188 | [»] | |
6J60 | electron microscopy | 0.96 | A | 209-217 | [»] | |
7BX7 | electron microscopy | 2.80 | A/B/C/D/E/F | 186-372 | [»] | |
BMRBi | P09651 | |||||
SMRi | P09651 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109420, 709 interactors |
CORUMi | P09651 |
DIPi | DIP-29338N |
IntActi | P09651, 257 interactors |
MINTi | P09651 |
STRINGi | 9606.ENSP00000341826 |
Chemistry databases
BindingDBi | P09651 |
ChEMBLi | CHEMBL1955709 |
PTM databases
iPTMneti | P09651 |
MetOSitei | P09651 |
PhosphoSitePlusi | P09651 |
SwissPalmi | P09651 |
Genetic variation databases
BioMutai | HNRNPA1 |
DMDMi | 288558857 |
2D gel databases
SWISS-2DPAGEi | P09651 |
Proteomic databases
EPDi | P09651 |
jPOSTi | P09651 |
MassIVEi | P09651 |
MaxQBi | P09651 |
PaxDbi | P09651 |
PeptideAtlasi | P09651 |
PRIDEi | P09651 |
ProteomicsDBi | 52258 [P09651-1] 52259 [P09651-2] 52260 [P09651-3] |
TopDownProteomicsi | P09651-1 [P09651-1] P09651-2 [P09651-2] P09651-3 [P09651-3] |
Protocols and materials databases
Antibodypediai | 7969, 500 antibodies |
Genome annotation databases
Ensembli | ENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1] ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2] ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3] ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2] ENST00000550482; ENSP00000446486; ENSG00000135486 [P09651-2] ENST00000677210; ENSP00000503610; ENSG00000135486 [P09651-1] |
GeneIDi | 3178 |
KEGGi | hsa:3178 |
UCSCi | uc001sfl.4, human [P09651-1] |
Organism-specific databases
CTDi | 3178 |
DisGeNETi | 3178 |
GeneCardsi | HNRNPA1 |
GeneReviewsi | HNRNPA1 |
HGNCi | HGNC:5031, HNRNPA1 |
HPAi | ENSG00000135486, Low tissue specificity |
MalaCardsi | HNRNPA1 |
MIMi | 164017, gene 615424, phenotype 615426, phenotype |
neXtProti | NX_P09651 |
OpenTargetsi | ENSG00000135486 |
Orphaneti | 803, Amyotrophic lateral sclerosis 52430, Inclusion body myopathy with Paget disease of bone and frontotemporal dementia |
PharmGKBi | PA162391113 |
VEuPathDBi | HostDB:ENSG00000135486.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183123 |
HOGENOMi | CLU_012062_1_0_1 |
InParanoidi | P09651 |
OMAi | VDSVIMT |
PhylomeDBi | P09651 |
TreeFami | TF314808 |
Enzyme and pathway databases
PathwayCommonsi | P09651 |
Reactomei | R-HSA-6803529, FGFR2 alternative splicing R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | P09651 |
Miscellaneous databases
BioGRID-ORCSi | 3178, 107 hits in 937 CRISPR screens |
ChiTaRSi | HNRNPA1, human |
EvolutionaryTracei | P09651 |
GeneWikii | Heterogeneous_nuclear_ribonucleoprotein_A1 |
GenomeRNAii | 3178 |
Pharosi | P09651, Tchem |
PROi | PR:P09651 |
RNActi | P09651, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135486, Expressed in forebrain and 250 other tissues |
ExpressionAtlasi | P09651, baseline and differential |
Genevisiblei | P09651, HS |
Family and domain databases
CDDi | cd12761, RRM1_hnRNPA1, 1 hit cd12580, RRM2_hnRNPA1, 1 hit |
DisProti | DP00324 |
Gene3Di | 3.30.70.330, 2 hits |
IDEALi | IID00119 |
InterProi | View protein in InterPro IPR021662, HnRNPA1 IPR034845, hnRNPA1_RRM1 IPR034803, hnRNPA1_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF11627, HnRNPA1, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROA1_HUMAN | |
Accessioni | P09651Primary (citable) accession number: P09651 Secondary accession number(s): A8K4Z8, Q3MIB7, Q6PJZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | February 9, 2010 | |
Last modified: | April 7, 2021 | |
This is version 259 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references