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UniProtKB - P09651 (ROA1_HUMAN)

Protein

Heterogeneous nuclear ribonucleoprotein A1

Gene

HNRNPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).2 Publications
(Microbial infection) May play a role in HCV RNA replication.1 Publication

Caution

Variant Val-314 has been originally associated with IBMPFD3 and variant Asn-314 with ALS20 (PubMed:25616961). However in another report, variant Val-314 is associated with amyotrophic lateral sclerosis (ALS) but this variant is not supported by clinical data in this publication (PubMed:25616961).Curated

GO - Molecular functioni

  • G-rich strand telomeric DNA binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • miRNA binding Source: UniProtKB
  • mRNA binding Source: GO_Central
  • pre-mRNA binding Source: CAFA
  • protein domain specific binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: HGNC
  • single-stranded RNA binding Source: HGNC
  • telomeric repeat-containing RNA binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processHost-virus interaction, mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP09651

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1
Short name:
hnRNP A1
Alternative name(s):
Helix-destabilizing protein
Single-strand RNA-binding protein
hnRNP core protein A1
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Gene namesi
Name:HNRNPA1
Synonyms:HNRPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135486.17
HGNCiHGNC:5031 HNRNPA1
MIMi164017 gene
neXtProtiNX_P09651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Involvement in diseasei

Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance.
See also OMIM:615424
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070589314D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar.1
Amyotrophic lateral sclerosis 20 (ALS20)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:615426
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077531277Q → K in ALS20; unknown pathological significance. 1 Publication1
Natural variantiVAR_070588314D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar.1
Natural variantiVAR_070590319N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar.1
Natural variantiVAR_077533340P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi326G → A: No nuclear import nor export. 1 Publication1
Mutagenesisi327P → A: No nuclear import nor export. 1 Publication1
Mutagenesisi334 – 335GG → LL: Normal nuclear import and export. 1 Publication2

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi3178
MalaCardsiHNRNPA1
MIMi615424 phenotype
615426 phenotype
OpenTargetsiENSG00000135486
Orphaneti803 Amyotrophic lateral sclerosis
52430 Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
PharmGKBiPA162391113

Chemistry databases

ChEMBLiCHEMBL1955709

Polymorphism and mutation databases

BioMutaiHNRNPA1
DMDMi288558857

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004245091 – 372Heterogeneous nuclear ribonucleoprotein A1Add BLAST372
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000818282 – 372Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei3N6-acetyllysine; alternateCombined sources1
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei4PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei22PhosphoserineBy similarity1
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei192Phosphoserine; by MKNK21 Publication1
Modified residuei194Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei194Dimethylated arginine; alternateCombined sources1
Modified residuei194Omega-N-methylarginine; alternateBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei206Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei206Dimethylated arginine; alternateCombined sources1
Modified residuei206Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei218Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei218Omega-N-methylarginine; alternateCombined sources1
Modified residuei225Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei225Dimethylated arginine; alternateCombined sources1
Modified residuei225Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei232Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei232Omega-N-methylarginine; alternateCombined sources1
Modified residuei336Omega-N-methylarginineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei350N6-acetyllysine; alternateCombined sources1
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei352Omega-N-methylarginineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei362Phosphoserine; by MKNK21 Publication1
Modified residuei363Phosphoserine; by MKNK21 Publication1
Modified residuei364Phosphoserine; by MKNK2Combined sources1 Publication1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei370Omega-N-methylarginineCombined sources1

Post-translational modificationi

Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
Sumoylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09651
MaxQBiP09651
PaxDbiP09651
PeptideAtlasiP09651
PRIDEiP09651
ProteomicsDBi52258
52259 [P09651-2]
52260 [P09651-3]
TopDownProteomicsiP09651-1 [P09651-1]
P09651-2 [P09651-2]
P09651-3 [P09651-3]

2D gel databases

SWISS-2DPAGEiP09651

PTM databases

iPTMnetiP09651
PhosphoSitePlusiP09651
SwissPalmiP09651

Expressioni

Gene expression databases

BgeeiENSG00000135486 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_HNRNPA1
ExpressionAtlasiP09651 baseline and differential
GenevisibleiP09651 HS

Organism-specific databases

HPAiCAB010894
HPA001609
HPA001666
HPA005812
HPA007185

Interactioni

Subunit structurei

Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with SEPT6 (PubMed:17229681). Interacts with C9orf72 (PubMed:24549040). Interacts with KHDRBS1 (PubMed:17371836). Interacts with UBQLN2 (PubMed:25616961).6 Publications
(Microbial infection) Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109420, 613 interactors
CORUMiP09651
DIPiDIP-29338N
IntActiP09651, 173 interactors
MINTiP09651
STRINGi9606.ENSP00000341826

Chemistry databases

BindingDBiP09651

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00324
ProteinModelPortaliP09651
SMRiP09651
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09651

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 97RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini105 – 184RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 94Globular A domainAdd BLAST91
Regioni95 – 185Globular B domainAdd BLAST91
Regioni218 – 240RNA-binding RGG-boxAdd BLAST23
Regioni320 – 357Nuclear targeting sequence (M9)Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 372Gly-richAdd BLAST178

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiP09651
KOiK12741
OMAiGAHITVK
OrthoDBiEOG091G1CPI
PhylomeDBiP09651
TreeFamiTF314808

Family and domain databases

CDDicd12761 RRM1_hnRNPA1, 1 hit
cd12580 RRM2_hnRNPA1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR021662 HnRNPA1
IPR034845 hnRNPA1_RRM1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1-B (identifier: P09651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN 
        60         70         80         90        100
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA 
       110        120        130        140        150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF 
       160        170        180        190        200
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG 
       210        220        230        240        250
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND 
       260        270        280        290        300
GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG 
       310        320        330        340        350
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK 
       360        370 
PRNQGGYGGS SSSSSYGSGR RF
Length:372
Mass (Da):38,747
Last modified:February 9, 2010 - v5
Checksum:iA06683571C6C109F
GO
Isoform A1-A (identifier: P09651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-303: Missing.

Note: Is twenty times more abundant than isoform A1-B.
Show »
Length:320
Mass (Da):34,196
Checksum:i59485C9FA1FF8AE1
GO
Isoform 2 (identifier: P09651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-307: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,386
Checksum:i2B492EF73FD41977
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZ49F8VZ49_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
231Annotation score:
F8W6I7F8W6I7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
307Annotation score:
H0YH80H0YH80_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
191Annotation score:
F8W646F8W646_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
156Annotation score:
F8VTQ5F8VTQ5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
145Annotation score:
F8VYN5F8VYN5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128Y → F in CAA29922 (PubMed:2836799).Curated1
Sequence conflicti140R → P in CAA27874 (PubMed:3023065).Curated1
Sequence conflicti146R → K in CAA29922 (PubMed:2836799).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077531277Q → K in ALS20; unknown pathological significance. 1 Publication1
Natural variantiVAR_077532283G → R Probable polymorphism. 1 PublicationCorresponds to variant dbSNP:rs375259222Ensembl.1
Natural variantiVAR_070588314D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar.1
Natural variantiVAR_070589314D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar.1
Natural variantiVAR_070590319N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar.1
Natural variantiVAR_077533340P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034076203 – 307Missing in isoform 2. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_005824252 – 303Missing in isoform A1-A. 4 PublicationsAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12671 Genomic DNA Translation: CAA31191.1
X06747 mRNA Translation: CAA29922.1
X79536 mRNA Translation: CAA56072.1
AK291113 mRNA Translation: BAF83802.1
AC078778 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96761.1
BC002355 mRNA Translation: AAH02355.1
BC009600 mRNA Translation: AAH09600.1
BC012158 mRNA Translation: AAH12158.1
BC033714 mRNA Translation: AAH33714.1
BC052296 mRNA Translation: AAH52296.1
BC070315 mRNA Translation: AAH70315.1
BC074502 mRNA Translation: AAH74502.1
BC103707 mRNA Translation: AAI03708.1
X04347 mRNA Translation: CAA27874.1
CCDSiCCDS41793.1 [P09651-2]
CCDS44909.1 [P09651-1]
PIRiS02061
S12520
RefSeqiNP_002127.1, NM_002136.3 [P09651-2]
NP_112420.1, NM_031157.3 [P09651-1]
XP_005268883.1, XM_005268826.1 [P09651-1]
UniGeneiHs.546261
Hs.655424

Genome annotation databases

EnsembliENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1]
ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2]
ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3]
ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2]
GeneIDi3178
KEGGihsa:3178
UCSCiuc001sfl.4 human [P09651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12671 Genomic DNA Translation: CAA31191.1
X06747 mRNA Translation: CAA29922.1
X79536 mRNA Translation: CAA56072.1
AK291113 mRNA Translation: BAF83802.1
AC078778 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96761.1
BC002355 mRNA Translation: AAH02355.1
BC009600 mRNA Translation: AAH09600.1
BC012158 mRNA Translation: AAH12158.1
BC033714 mRNA Translation: AAH33714.1
BC052296 mRNA Translation: AAH52296.1
BC070315 mRNA Translation: AAH70315.1
BC074502 mRNA Translation: AAH74502.1
BC103707 mRNA Translation: AAI03708.1
X04347 mRNA Translation: CAA27874.1
CCDSiCCDS41793.1 [P09651-2]
CCDS44909.1 [P09651-1]
PIRiS02061
S12520
RefSeqiNP_002127.1, NM_002136.3 [P09651-2]
NP_112420.1, NM_031157.3 [P09651-1]
XP_005268883.1, XM_005268826.1 [P09651-1]
UniGeneiHs.546261
Hs.655424

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HA1X-ray1.75A1-184[»]
1L3KX-ray1.10A1-196[»]
1PGZX-ray2.60A2-196[»]
1PO6X-ray2.10A8-190[»]
1U1KX-ray2.00A1-196[»]
1U1LX-ray2.00A1-196[»]
1U1MX-ray2.00A1-196[»]
1U1NX-ray2.10A1-196[»]
1U1OX-ray2.00A1-196[»]
1U1PX-ray1.90A1-196[»]
1U1QX-ray1.80A1-196[»]
1U1RX-ray1.80A1-196[»]
1UP1X-ray1.90A3-184[»]
2H4MX-ray3.05C/D309-357[»]
2LYVNMR-A2-196[»]
2UP1X-ray2.10A8-190[»]
4YOEX-ray1.92A1-196[»]
5MPGNMR-A2-97[»]
5MPLNMR-A95-196[»]
6BXXX-ray1.10A243-248[»]
6DCLX-ray2.50A/B2-188[»]
DisProtiDP00324
ProteinModelPortaliP09651
SMRiP09651
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109420, 613 interactors
CORUMiP09651
DIPiDIP-29338N
IntActiP09651, 173 interactors
MINTiP09651
STRINGi9606.ENSP00000341826

Chemistry databases

BindingDBiP09651
ChEMBLiCHEMBL1955709

PTM databases

iPTMnetiP09651
PhosphoSitePlusiP09651
SwissPalmiP09651

Polymorphism and mutation databases

BioMutaiHNRNPA1
DMDMi288558857

2D gel databases

SWISS-2DPAGEiP09651

Proteomic databases

EPDiP09651
MaxQBiP09651
PaxDbiP09651
PeptideAtlasiP09651
PRIDEiP09651
ProteomicsDBi52258
52259 [P09651-2]
52260 [P09651-3]
TopDownProteomicsiP09651-1 [P09651-1]
P09651-2 [P09651-2]
P09651-3 [P09651-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1]
ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2]
ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3]
ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2]
GeneIDi3178
KEGGihsa:3178
UCSCiuc001sfl.4 human [P09651-1]

Organism-specific databases

CTDi3178
DisGeNETi3178
EuPathDBiHostDB:ENSG00000135486.17
GeneCardsiHNRNPA1
H-InvDBiHIX0032087
HIX0040127
HIX0202582
HGNCiHGNC:5031 HNRNPA1
HPAiCAB010894
HPA001609
HPA001666
HPA005812
HPA007185
MalaCardsiHNRNPA1
MIMi164017 gene
615424 phenotype
615426 phenotype
neXtProtiNX_P09651
OpenTargetsiENSG00000135486
Orphaneti803 Amyotrophic lateral sclerosis
52430 Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
PharmGKBiPA162391113
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiP09651
KOiK12741
OMAiGAHITVK
OrthoDBiEOG091G1CPI
PhylomeDBiP09651
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP09651

Miscellaneous databases

ChiTaRSiHNRNPA1 human
EvolutionaryTraceiP09651
GeneWikiiHeterogeneous_nuclear_ribonucleoprotein_A1
GenomeRNAii3178
PROiPR:P09651
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135486 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_HNRNPA1
ExpressionAtlasiP09651 baseline and differential
GenevisibleiP09651 HS

Family and domain databases

CDDicd12761 RRM1_hnRNPA1, 1 hit
cd12580 RRM2_hnRNPA1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR021662 HnRNPA1
IPR034845 hnRNPA1_RRM1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiROA1_HUMAN
AccessioniPrimary (citable) accession number: P09651
Secondary accession number(s): A8K4Z8, Q3MIB7, Q6PJZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 239 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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