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UniProtKB - P09651 (ROA1_HUMAN)

Entry version 248 (18 Sep 2019)
Sequence version 5 (09 Feb 2010)
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Protein

Heterogeneous nuclear ribonucleoprotein A1

Gene

HNRNPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).2 Publications
(Microbial infection) May play a role in HCV RNA replication.1 Publication

Caution

Variant Val-314 has been originally associated with IBMPFD3 and variant Asn-314 with ALS20 (PubMed:25616961). However in another report, variant Val-314 is associated with amyotrophic lateral sclerosis (ALS) but this variant is not supported by clinical data in this publication (PubMed:25616961).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processHost-virus interaction, mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

SIGNOR Signaling Network Open Resource

More...SIGNORi		P09651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1
Short name:
hnRNP A1
Alternative name(s):
Helix-destabilizing protein
Single-strand RNA-binding protein
hnRNP core protein A1
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPA1
Synonyms:HNRPA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5031 HNRNPA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164017 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09651

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070589314D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar.1
Amyotrophic lateral sclerosis 20 (ALS20)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077531277Q → K in ALS20; unknown pathological significance. 1 Publication1
Natural variantiVAR_070588314D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar.1
Natural variantiVAR_070590319N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar.1
Natural variantiVAR_077533340P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi326G → A: No nuclear import nor export. 1 Publication1
Mutagenesisi327P → A: No nuclear import nor export. 1 Publication1
Mutagenesisi334 – 335GG → LL: Normal nuclear import and export. 1 Publication2

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		3178

MalaCards human disease database

More...MalaCardsi		HNRNPA1
MIMi615424 phenotype
615426 phenotype

Open Targets

More...OpenTargetsi		ENSG00000135486

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		803 Amyotrophic lateral sclerosis
52430 Inclusion body myopathy with Paget disease of bone and frontotemporal dementia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391113

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1955709

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		288558857

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004245091 – 372Heterogeneous nuclear ribonucleoprotein A1Add BLAST372
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000818282 – 372Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei3N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei4PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei22PhosphoserineBy similarity1
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei192Phosphoserine; by MKNK21 Publication1
Modified residuei194Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei194Dimethylated arginine; alternateCombined sources1
Modified residuei194Omega-N-methylarginine; alternateBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei206Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei206Dimethylated arginine; alternateCombined sources1
Modified residuei206Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei218Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei218Omega-N-methylarginine; alternateCombined sources1
Modified residuei225Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei225Dimethylated arginine; alternateCombined sources1
Modified residuei225Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei232Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei232Omega-N-methylarginine; alternateCombined sources1
Modified residuei336Omega-N-methylarginineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei350N6-acetyllysine; alternateCombined sources1
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei352Omega-N-methylarginineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei362Phosphoserine; by MKNK21 Publication1
Modified residuei363Phosphoserine; by MKNK21 Publication1
Modified residuei364Phosphoserine; by MKNK2Combined sources1 Publication1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei370Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
Sumoylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09651

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09651

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09651

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09651

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09651

PeptideAtlas

More...PeptideAtlasi		P09651

PRoteomics IDEntifications database

More...PRIDEi		P09651

ProteomicsDB human proteome resource

More...ProteomicsDBi		52258 [P09651-1]
52259 [P09651-2]
52260 [P09651-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P09651-1 [P09651-1]
P09651-2 [P09651-2]
P09651-3 [P09651-3]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P09651

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09651

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09651

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P09651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135486 Expressed in 241 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09651 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09651 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB010894
HPA001609
HPA001666
HPA005812
HPA007185

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex (PubMed:11991638).

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).

Interacts with SEPT6 (PubMed:17229681).

Interacts with C9orf72 (PubMed:24549040).

Interacts with KHDRBS1 (PubMed:17371836).

Interacts with UBQLN2 (PubMed:25616961).

6 Publications

(Microbial infection)

Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109420, 643 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P09651

Database of interacting proteins

More...DIPi		DIP-29338N

Protein interaction database and analysis system

More...IntActi		P09651, 238 interactors

Molecular INTeraction database

More...MINTi		P09651

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341826

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P09651

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09651

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09651

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 97RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini105 – 184RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4 – 94Globular A domainAdd BLAST91
Regioni95 – 185Globular B domainAdd BLAST91
Regioni218 – 240RNA-binding RGG-boxAdd BLAST23
Regioni320 – 357Nuclear targeting sequence (M9)Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi195 – 372Gly-richAdd BLAST178

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0118 Eukaryota
COG0724 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234442

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09651

KEGG Orthology (KO)

More...KOi		K12741

Identification of Orthologs from Complete Genome Data

More...OMAi		LQDEHTI

Database of Orthologous Groups

More...OrthoDBi		1202220at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09651

TreeFam database of animal gene trees

More...TreeFami		TF314808

Family and domain databases

Conserved Domains Database

More...CDDi		cd12761 RRM1_hnRNPA1, 1 hit
cd12580 RRM2_hnRNPA1, 1 hit

Database of protein disorder

More...DisProti		DP00324

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021662 HnRNPA1
IPR034845 hnRNPA1_RRM1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1-B (identifier: P09651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN 
        60         70         80         90        100
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA 
       110        120        130        140        150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF 
       160        170        180        190        200
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG 
       210        220        230        240        250
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND 
       260        270        280        290        300
GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG 
       310        320        330        340        350
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK 
       360        370 
PRNQGGYGGS SSSSSYGSGR RF
Length:372
Mass (Da):38,747
Last modified:February 9, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA06683571C6C109F
GO
Isoform A1-A (identifier: P09651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-303: Missing.

Note: Is twenty times more abundant than isoform A1-B.
Show »
Length:320
Mass (Da):34,196
Checksum:i59485C9FA1FF8AE1
GO
Isoform 2 (identifier: P09651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-307: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,386
Checksum:i2B492EF73FD41977
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZ49F8VZ49_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6I7F8W6I7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH80H0YH80_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W646F8W646_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTQ5F8VTQ5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYN5F8VYN5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128Y → F in CAA29922 (PubMed:2836799).Curated1
Sequence conflicti140R → P in CAA27874 (PubMed:3023065).Curated1
Sequence conflicti146R → K in CAA29922 (PubMed:2836799).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077531277Q → K in ALS20; unknown pathological significance. 1 Publication1
Natural variantiVAR_077532283G → R Probable polymorphism. 1 PublicationCorresponds to variant dbSNP:rs375259222Ensembl.1
Natural variantiVAR_070588314D → N in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518453EnsemblClinVar.1
Natural variantiVAR_070589314D → V in IBMPFD3; reduces binding to UBQLN2. 2 PublicationsCorresponds to variant dbSNP:rs397518452EnsemblClinVar.1
Natural variantiVAR_070590319N → S in ALS20. 1 PublicationCorresponds to variant dbSNP:rs397518454EnsemblClinVar.1
Natural variantiVAR_077533340P → S in ALS20; increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034076203 – 307Missing in isoform 2. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_005824252 – 303Missing in isoform A1-A. 4 PublicationsAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12671 Genomic DNA Translation: CAA31191.1
X06747 mRNA Translation: CAA29922.1
X79536 mRNA Translation: CAA56072.1
AK291113 mRNA Translation: BAF83802.1
AC078778 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96761.1
BC002355 mRNA Translation: AAH02355.1
BC009600 mRNA Translation: AAH09600.1
BC012158 mRNA Translation: AAH12158.1
BC033714 mRNA Translation: AAH33714.1
BC052296 mRNA Translation: AAH52296.1
BC070315 mRNA Translation: AAH70315.1
BC074502 mRNA Translation: AAH74502.1
BC103707 mRNA Translation: AAI03708.1
X04347 mRNA Translation: CAA27874.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41793.1 [P09651-2]
CCDS44909.1 [P09651-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S02061
S12520

NCBI Reference Sequences

More...RefSeqi		NP_002127.1, NM_002136.3 [P09651-2]
NP_112420.1, NM_031157.3 [P09651-1]
XP_005268883.1, XM_005268826.1 [P09651-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1]
ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2]
ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3]
ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3178

UCSC genome browser

More...UCSCi		uc001sfl.4 human [P09651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12671 Genomic DNA Translation: CAA31191.1
X06747 mRNA Translation: CAA29922.1
X79536 mRNA Translation: CAA56072.1
AK291113 mRNA Translation: BAF83802.1
AC078778 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96761.1
BC002355 mRNA Translation: AAH02355.1
BC009600 mRNA Translation: AAH09600.1
BC012158 mRNA Translation: AAH12158.1
BC033714 mRNA Translation: AAH33714.1
BC052296 mRNA Translation: AAH52296.1
BC070315 mRNA Translation: AAH70315.1
BC074502 mRNA Translation: AAH74502.1
BC103707 mRNA Translation: AAI03708.1
X04347 mRNA Translation: CAA27874.1
CCDSiCCDS41793.1 [P09651-2]
CCDS44909.1 [P09651-1]
PIRiS02061
S12520
RefSeqiNP_002127.1, NM_002136.3 [P09651-2]
NP_112420.1, NM_031157.3 [P09651-1]
XP_005268883.1, XM_005268826.1 [P09651-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HA1X-ray1.75A1-184[»]
1L3KX-ray1.10A1-196[»]
1PGZX-ray2.60A2-196[»]
1PO6X-ray2.10A8-190[»]
1U1KX-ray2.00A1-196[»]
1U1LX-ray2.00A1-196[»]
1U1MX-ray2.00A1-196[»]
1U1NX-ray2.10A1-196[»]
1U1OX-ray2.00A1-196[»]
1U1PX-ray1.90A1-196[»]
1U1QX-ray1.80A1-196[»]
1U1RX-ray1.80A1-196[»]
1UP1X-ray1.90A3-184[»]
2H4MX-ray3.05C/D309-357[»]
2LYVNMR-A2-196[»]
2UP1X-ray2.10A8-190[»]
4YOEX-ray1.92A1-196[»]
5MPGNMR-A2-97[»]
5MPLNMR-A95-196[»]
5ZGDX-ray1.40A209-217[»]
5ZGLX-ray0.95A/B234-240[»]
6BXXX-ray1.10A243-248[»]
6DCLX-ray2.50A/B2-188[»]
6J60electron microscopy0.96A209-217[»]
SMRiP09651
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109420, 643 interactors
CORUMiP09651
DIPiDIP-29338N
IntActiP09651, 238 interactors
MINTiP09651
STRINGi9606.ENSP00000341826

Chemistry databases

BindingDBiP09651
ChEMBLiCHEMBL1955709

PTM databases

iPTMnetiP09651
PhosphoSitePlusiP09651
SwissPalmiP09651

Polymorphism and mutation databases

BioMutaiHNRNPA1
DMDMi288558857

2D gel databases

SWISS-2DPAGEiP09651

Proteomic databases

EPDiP09651
jPOSTiP09651
MassIVEiP09651
MaxQBiP09651
PaxDbiP09651
PeptideAtlasiP09651
PRIDEiP09651
ProteomicsDBi52258 [P09651-1]
52259 [P09651-2]
52260 [P09651-3]
TopDownProteomicsiP09651-1 [P09651-1]
P09651-2 [P09651-2]
P09651-3 [P09651-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340913; ENSP00000341826; ENSG00000135486 [P09651-1]
ENST00000546500; ENSP00000448617; ENSG00000135486 [P09651-2]
ENST00000547276; ENSP00000447260; ENSG00000135486 [P09651-3]
ENST00000547566; ENSP00000449913; ENSG00000135486 [P09651-2]
GeneIDi3178
KEGGihsa:3178
UCSCiuc001sfl.4 human [P09651-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3178
DisGeNETi3178

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPA1
HGNCiHGNC:5031 HNRNPA1
HPAiCAB010894
HPA001609
HPA001666
HPA005812
HPA007185
MalaCardsiHNRNPA1
MIMi164017 gene
615424 phenotype
615426 phenotype
neXtProtiNX_P09651
OpenTargetsiENSG00000135486
Orphaneti803 Amyotrophic lateral sclerosis
52430 Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
PharmGKBiPA162391113

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00950000183123
HOGENOMiHOG000234442
InParanoidiP09651
KOiK12741
OMAiLQDEHTI
OrthoDBi1202220at2759
PhylomeDBiP09651
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP09651

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HNRNPA1 human
EvolutionaryTraceiP09651

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Heterogeneous_nuclear_ribonucleoprotein_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3178

Pharos

More...Pharosi		P09651

Protein Ontology

More...PROi		PR:P09651

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135486 Expressed in 241 organ(s), highest expression level in forebrain
ExpressionAtlasiP09651 baseline and differential
GenevisibleiP09651 HS

Family and domain databases

CDDicd12761 RRM1_hnRNPA1, 1 hit
cd12580 RRM2_hnRNPA1, 1 hit
DisProtiDP00324
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR021662 HnRNPA1
IPR034845 hnRNPA1_RRM1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09651
Secondary accession number(s): A8K4Z8, Q3MIB7, Q6PJZ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 9, 2010
Last modified: September 18, 2019
This is version 248 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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