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Protein

Homeobox protein Hox-C9

Gene

Hoxc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 251HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3.2
Gene namesi
Name:Hoxc9
Synonyms:Hox-3.2, Hoxc-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96199 Hoxc9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001851 – 260Homeobox protein Hox-C9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09633
PaxDbiP09633
PRIDEiP09633

PTM databases

iPTMnetiP09633
PhosphoSitePlusiP09633

Expressioni

Gene expression databases

BgeeiENSMUSG00000036139 Expressed in 116 organ(s), highest expression level in hindlimb
CleanExiMM_HOXC9
GenevisibleiP09633 MM

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.By similarity

Protein-protein interaction databases

BioGridi200390, 2 interactors
IntActiP09633, 1 interactor
STRINGi10090.ENSMUSP00000001706

Structurei

3D structure databases

ProteinModelPortaliP09633
SMRiP09633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP09633
KOiK09294
OMAiRRAECGP
OrthoDBiEOG091G0ECO
PhylomeDBiP09633
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09633-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGDGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,234
Last modified:July 1, 1993 - v2
Checksum:i0A978FF948F5BCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55318 mRNA Translation: CAA39026.1
AK012173 mRNA Translation: BAB28077.1
AK078758 mRNA Translation: BAC37378.1
BC050838 mRNA Translation: AAH50838.1
X07647 mRNA Translation: CAA30487.1
M35603 Genomic DNA Translation: AAA37856.1
CCDSiCCDS27893.1
PIRiA43821
RefSeqiNP_032298.1, NM_008272.3
UniGeneiMm.4765

Genome annotation databases

EnsembliENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139
GeneIDi15427
KEGGimmu:15427
UCSCiuc007xxa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55318 mRNA Translation: CAA39026.1
AK012173 mRNA Translation: BAB28077.1
AK078758 mRNA Translation: BAC37378.1
BC050838 mRNA Translation: AAH50838.1
X07647 mRNA Translation: CAA30487.1
M35603 Genomic DNA Translation: AAA37856.1
CCDSiCCDS27893.1
PIRiA43821
RefSeqiNP_032298.1, NM_008272.3
UniGeneiMm.4765

3D structure databases

ProteinModelPortaliP09633
SMRiP09633
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200390, 2 interactors
IntActiP09633, 1 interactor
STRINGi10090.ENSMUSP00000001706

PTM databases

iPTMnetiP09633
PhosphoSitePlusiP09633

Proteomic databases

MaxQBiP09633
PaxDbiP09633
PRIDEiP09633

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139
GeneIDi15427
KEGGimmu:15427
UCSCiuc007xxa.1 mouse

Organism-specific databases

CTDi3225
MGIiMGI:96199 Hoxc9

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP09633
KOiK09294
OMAiRRAECGP
OrthoDBiEOG091G0ECO
PhylomeDBiP09633
TreeFamiTF317819

Miscellaneous databases

PROiPR:P09633
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036139 Expressed in 116 organ(s), highest expression level in hindlimb
CleanExiMM_HOXC9
GenevisibleiP09633 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC9_MOUSE
AccessioniPrimary (citable) accession number: P09633
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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