Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B8

Gene

Hoxb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
  • sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Gene namesi
Name:Hoxb8
Synonyms:Hox-2.4, Hoxb-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96189 Hoxb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001491 – 243Homeobox protein Hox-B8Add BLAST243

Proteomic databases

MaxQBiP09632
PaxDbiP09632
PRIDEiP09632

PTM databases

iPTMnetiP09632
PhosphoSitePlusiP09632

Expressioni

Gene expression databases

BgeeiENSMUSG00000056648 Expressed in 144 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_HOXB8
ExpressionAtlasiP09632 baseline and differential
GenevisibleiP09632 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Pbx1P417783EBI-925374,EBI-6996259

Protein-protein interaction databases

BioGridi200382, 14 interactors
DIPiDIP-35618N
IntActiP09632, 2 interactors
STRINGi10090.ENSMUSP00000052496

Structurei

3D structure databases

ProteinModelPortaliP09632
SMRiP09632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi134 – 139Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09632
KOiK09308
OrthoDBiEOG091G09XD
PhylomeDBiP09632
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P09632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK
Length:243
Mass (Da):27,618
Last modified:January 1, 1990 - v2
Checksum:i368964C77884D21F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6W0B3F6W0B3_MOUSE
Homeobox protein Hox-B8
Hoxb8
191Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13961 Genomic DNA Translation: CAA32141.1
X13721 mRNA Translation: CAA32000.1
M18399 Genomic DNA Translation: AAA88246.1 Sequence problems.
X54077 Genomic DNA Translation: CAA38014.1
CCDSiCCDS25293.1
PIRiS03712 WJMS24
RefSeqiNP_034591.1, NM_010461.2
XP_017169784.1, XM_017314295.1
XP_017169785.1, XM_017314296.1
XP_017169786.1, XM_017314297.1
UniGeneiMm.4822

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648
GeneIDi15416
KEGGimmu:15416
UCSCiuc007lbp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13961 Genomic DNA Translation: CAA32141.1
X13721 mRNA Translation: CAA32000.1
M18399 Genomic DNA Translation: AAA88246.1 Sequence problems.
X54077 Genomic DNA Translation: CAA38014.1
CCDSiCCDS25293.1
PIRiS03712 WJMS24
RefSeqiNP_034591.1, NM_010461.2
XP_017169784.1, XM_017314295.1
XP_017169785.1, XM_017314296.1
XP_017169786.1, XM_017314297.1
UniGeneiMm.4822

3D structure databases

ProteinModelPortaliP09632
SMRiP09632
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200382, 14 interactors
DIPiDIP-35618N
IntActiP09632, 2 interactors
STRINGi10090.ENSMUSP00000052496

PTM databases

iPTMnetiP09632
PhosphoSitePlusiP09632

Proteomic databases

MaxQBiP09632
PaxDbiP09632
PRIDEiP09632

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648
GeneIDi15416
KEGGimmu:15416
UCSCiuc007lbp.1 mouse

Organism-specific databases

CTDi3218
MGIiMGI:96189 Hoxb8

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09632
KOiK09308
OrthoDBiEOG091G09XD
PhylomeDBiP09632
TreeFamiTF316310

Miscellaneous databases

PROiPR:P09632
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056648 Expressed in 144 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_HOXB8
ExpressionAtlasiP09632 baseline and differential
GenevisibleiP09632 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB8_MOUSE
AccessioniPrimary (citable) accession number: P09632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again