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Protein

Homeobox protein Hox-A9

Gene

Hoxa9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi205 – 264HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A9
Alternative name(s):
Homeobox protein Hox-1.7
Gene namesi
Name:Hoxa9
Synonyms:Hox-1.7, Hoxa-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96180 Hoxa9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000821 – 271Homeobox protein Hox-A9Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139Symmetric dimethylarginineBy similarity1

Post-translational modificationi

Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.By similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP09631
PaxDbiP09631
PRIDEiP09631

PTM databases

iPTMnetiP09631
PhosphoSitePlusiP09631

Expressioni

Tissue specificityi

Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.

Gene expression databases

BgeeiENSMUSG00000038227 Expressed in 179 organ(s), highest expression level in metanephric renal vesicle
CleanExiMM_HOXA9
GenevisibleiP09631 MM

Interactioni

Subunit structurei

Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ehmt2Q9Z1482EBI-925334,EBI-444966

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200373, 13 interactors
CORUMiP09631
DIPiDIP-35619N
IntActiP09631, 3 interactors
MINTiP09631
STRINGi10090.ENSMUSP00000046939

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09631
SMRiP09631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09631

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP09631
KOiK21950
OMAiTSWNPVH
OrthoDBiEOG091G0IP5
PhylomeDBiP09631
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform HoxA-9 (identifier: P09631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTGALGNY YVDSFLLGAD AADELGAGRY APGTLGQPPR QAAALAEHPD
60 70 80 90 100
FSPCSFQSKA AVFGASWNPV HAAGANAVPA AVYHHHHHPY VHPQAPVAAA
110 120 130 140 150
APDGRYMRSW LEPTPGALSF AGLPSSRPYG IKPEPLSARR GDCPTLDTHT
160 170 180 190 200
LSLTDYACGS PPVDREKQPS EGAFSENNAE NESGGDKPPI DPNNPAANWL
210 220 230 240 250
HARSTRKKRC PYTKHQTLEL EKEFLFNMYL TRDRRYEVAR LLNLTERQVK
260 270
IWFQNRRMKM KKINKDRAKD E
Length:271
Mass (Da):29,917
Last modified:July 15, 1999 - v2
Checksum:iC1E679D9CBF677B0
GO
Isoform HoxA-9T (identifier: P09631-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: R → S
     106-271: Missing.

Show »
Length:105
Mass (Da):10,684
Checksum:i923A157D0AA22579
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002382105R → S in isoform HoxA-9T. 1 Publication1
Alternative sequenceiVSP_002383106 – 271Missing in isoform HoxA-9T. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005457 mRNA Translation: BAA25800.1
AB005458 mRNA Translation: BAA25801.1
AB008914 Genomic DNA Translation: BAA25802.1
BC055059 mRNA Translation: AAH55059.1
M28449 mRNA Translation: AAA78790.1
CCDSiCCDS20146.1 [P09631-1]
PIRiA31400
JC6553
RefSeqiNP_034586.1, NM_010456.3 [P09631-1]
UniGeneiMm.4694

Genome annotation databases

EnsembliENSMUST00000048680; ENSMUSP00000046939; ENSMUSG00000038227 [P09631-1]
ENSMUST00000114425; ENSMUSP00000110068; ENSMUSG00000038227 [P09631-2]
GeneIDi15405
KEGGimmu:15405
UCSCiuc009byl.2 mouse [P09631-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005457 mRNA Translation: BAA25800.1
AB005458 mRNA Translation: BAA25801.1
AB008914 Genomic DNA Translation: BAA25802.1
BC055059 mRNA Translation: AAH55059.1
M28449 mRNA Translation: AAA78790.1
CCDSiCCDS20146.1 [P09631-1]
PIRiA31400
JC6553
RefSeqiNP_034586.1, NM_010456.3 [P09631-1]
UniGeneiMm.4694

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUFX-ray1.90A193-269[»]
ProteinModelPortaliP09631
SMRiP09631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200373, 13 interactors
CORUMiP09631
DIPiDIP-35619N
IntActiP09631, 3 interactors
MINTiP09631
STRINGi10090.ENSMUSP00000046939

PTM databases

iPTMnetiP09631
PhosphoSitePlusiP09631

Proteomic databases

MaxQBiP09631
PaxDbiP09631
PRIDEiP09631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048680; ENSMUSP00000046939; ENSMUSG00000038227 [P09631-1]
ENSMUST00000114425; ENSMUSP00000110068; ENSMUSG00000038227 [P09631-2]
GeneIDi15405
KEGGimmu:15405
UCSCiuc009byl.2 mouse [P09631-1]

Organism-specific databases

CTDi3205
MGIiMGI:96180 Hoxa9

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP09631
KOiK21950
OMAiTSWNPVH
OrthoDBiEOG091G0IP5
PhylomeDBiP09631
TreeFamiTF317819

Miscellaneous databases

EvolutionaryTraceiP09631
PROiPR:P09631
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038227 Expressed in 179 organ(s), highest expression level in metanephric renal vesicle
CleanExiMM_HOXA9
GenevisibleiP09631 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA9_MOUSE
AccessioniPrimary (citable) accession number: P09631
Secondary accession number(s): O70154, O70155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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