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Protein

Homeobox protein Hox-C6

Gene

HOXC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi141 – 200HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP09630

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein CP25
Homeobox protein HHO.C8
Homeobox protein Hox-3C
Gene namesi
Name:HOXC6
Synonyms:HOX3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000197757.7
HGNCiHGNC:5128 HOXC6
MIMi142972 gene
neXtProtiNX_P09630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3223
OpenTargetsiENSG00000197757
PharmGKBiPA29403

Polymorphism and mutation databases

BioMutaiHOXC6
DMDMi115502398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001741 – 235Homeobox protein Hox-C6Add BLAST235

Proteomic databases

PaxDbiP09630
PeptideAtlasiP09630
PRIDEiP09630
ProteomicsDBi52256
52257 [P09630-2]

PTM databases

iPTMnetiP09630
PhosphoSitePlusiP09630

Expressioni

Gene expression databases

BgeeiENSG00000197757 Expressed in 156 organ(s), highest expression level in caput epididymis
CleanExiHS_HOXC6
ExpressionAtlasiP09630 baseline and differential
GenevisibleiP09630 HS

Organism-specific databases

HPAiHPA054981

Interactioni

Protein-protein interaction databases

BioGridi109463, 10 interactors
IntActiP09630, 7 interactors
MINTiP09630
STRINGi9606.ENSP00000243108

Structurei

3D structure databases

ProteinModelPortaliP09630
SMRiP09630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 127Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 171Poly-Arg4
Compositional biasi208 – 212Poly-Gly5
Compositional biasi221 – 235Glu/Lys-richAdd BLAST15

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP09630
KOiK09306
OMAiRMNSHSE
OrthoDBiEOG091G09XD
PhylomeDBiP09630
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P09630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY
60 70 80 90 100
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI
110 120 130 140 150
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR
160 170 180 190 200
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES
210 220 230
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
Length:235
Mass (Da):26,915
Last modified:October 3, 2006 - v3
Checksum:iBD695C7347CB71C0
GO
Isoform 2 (identifier: P09630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,834
Checksum:i291E2439914263AE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC34D6RC34_HUMAN
Homeobox protein Hox-C6
HOXC6
71Annotation score:
D6RBH4D6RBH4_HUMAN
Homeobox protein Hox-C6
HOXC6
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218L → M (PubMed:2885844).Curated1
Sequence conflicti218L → M (PubMed:2898768).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023921 – 82Missing in isoform 2. 2 PublicationsAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82986 mRNA Translation: AAB46892.1
M16938 mRNA Translation: AAA36007.1
AK314829 mRNA Translation: BAG37349.1
CH471054 Genomic DNA Translation: EAW96746.1
BC074844 mRNA Translation: AAH74844.1
BC074845 mRNA Translation: AAH74845.1
CCDSiCCDS41792.1 [P09630-2]
CCDS8871.1 [P09630-1]
PIRiB28030 WJHU3C
RefSeqiNP_004494.1, NM_004503.3 [P09630-1]
NP_710160.1, NM_153693.4 [P09630-2]
UniGeneiHs.549040

Genome annotation databases

EnsembliENST00000243108; ENSP00000243108; ENSG00000197757 [P09630-1]
ENST00000394331; ENSP00000377864; ENSG00000197757 [P09630-2]
GeneIDi3223
KEGGihsa:3223
UCSCiuc001ses.5 human [P09630-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHXC6_HUMAN
AccessioniPrimary (citable) accession number: P09630
Secondary accession number(s): B2RBV2, Q6DK09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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