UniProtKB - P09627 (PMA1_SCHPO)
Protein
Plasma membrane ATPase 1
Gene
pma1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Catalytic activityi
- EC:7.1.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 376 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 632 | MagnesiumBy similarity | 1 | |
Metal bindingi | 636 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: PomBase
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- proton binding Source: PomBase
- proton-exporting ATPase activity, phosphorylative mechanism Source: PomBase
GO - Biological processi
- proton export across plasma membrane Source: PomBase
- proton transmembrane transport Source: GO_Central
- regulation of intracellular pH Source: PomBase
Keywordsi
Molecular function | Translocase |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pma1 ORF Names:SPAC1071.10c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1071.10c, pma1 |
VEuPathDBi | FungiDB:SPAC1071.10c |
Subcellular locationi
Plasma membrane
Golgi apparatus
- Golgi apparatus Source: PomBase
Plasma Membrane
- integral component of plasma membrane Source: PomBase
- plasma membrane Source: PomBase
Other locations
- cytoplasm Source: PomBase
- integral component of membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 113 | CytoplasmicSequence analysisAdd BLAST | 113 | |
Transmembranei | 114 – 134 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 135 – 138 | ExtracellularSequence analysis | 4 | |
Transmembranei | 139 – 158 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 159 – 289 | CytoplasmicSequence analysisAdd BLAST | 131 | |
Transmembranei | 290 – 311 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 312 – 322 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 323 – 345 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 346 – 717 | CytoplasmicSequence analysisAdd BLAST | 372 | |
Transmembranei | 718 – 736 | Helical; Name=5Sequence analysisAdd BLAST | 19 | |
Topological domaini | 737 – 752 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 753 – 772 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 773 – 824 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 825 – 845 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 846 – 858 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 859 – 875 | Helical; Name=8Sequence analysisAdd BLAST | 17 | |
Topological domaini | 876 – 919 | CytoplasmicSequence analysisAdd BLAST | 44 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046269 | 1 – 919 | Plasma membrane ATPase 1Add BLAST | 919 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | Phosphoserine1 Publication | 1 | |
Modified residuei | 494 | Phosphoserine1 Publication | 1 | |
Modified residuei | 899 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P09627 |
PaxDbi | P09627 |
PRIDEi | P09627 |
PTM databases
iPTMneti | P09627 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279117, 11 interactors |
DIPi | DIP-59125N |
IntActi | P09627, 1 interactor |
STRINGi | 4896.SPAC1071.10c.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_0_1 |
InParanoidi | P09627 |
OMAi | FGVFCIM |
PhylomeDBi | P09627 |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P09627-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADNAGEYHD AEKHAPEQQA PPPQQPAHAA APAQDDEPDD DIDALIEELF
60 70 80 90 100
SEDVQEEQED NDDAPAAGEA KAVPEELLQT DMNTGLTMSE VEERRKKYGL
110 120 130 140 150
NQMKEELENP FLKFIMFFVG PIQFVMEMAA ALAAGLRDWV DFGVICALLM
160 170 180 190 200
LNAVVGFVQE YQAGSIVDEL KKSLALKAVV IREGQVHELE ANEVVPGDIL
210 220 230 240 250
KLDEGTIICA DGRVVTPDVH LQVDQSAITG ESLAVDKHYG DPTFASSGVK
260 270 280 290 300
RGEGLMVVTA TGDSTFVGRA ASLVNAAAGG TGHFTEVLNG IGTILLVLVL
310 320 330 340 350
LTLFCIYTAA FYRSVRLARL LEYTLAITII GVPVGLPAVV TTTMAVGAAY
360 370 380 390 400
LAEKQAIVQK LSAIESLAGV EVLCSDKTGT LTKNKLSLGE PFTVSGVSGD
410 420 430 440 450
DLVLTACLAA SRKRKGLDAI DKAFLKALKN YPGPRSMLTK YKVIEFQPFD
460 470 480 490 500
PVSKKVTAYV QAPDGTRITC VKGAPLWVLK TVEEDHPIPE DVLSAYKDKV
510 520 530 540 550
GDLASRGYRS LGVARKIEGQ HWEIMGIMPC SDPPRHDTAR TISEAKRLGL
560 570 580 590 600
RVKMLTGDAV DIAKETARQL GMGTNIYNAE RLGLTGGGNM PGSEVYDFVE
610 620 630 640 650
AADGFGEVFP QHKYAVVDIL QQRGYLVAMT GDGVNDAPSL KKADTGIAVE
660 670 680 690 700
GATDAARSAA DIVFLAPGLS AIIDALKTSR QIFHRMYSYV VYRIALSLHL
710 720 730 740 750
EIFLGLWLII RNQLLNLELV VFIAIFADVA TLAIAYDNAP YSMKPVKWNL
760 770 780 790 800
PRLWGLSTVI GIVLAIGTWI TNTTMIAQGQ NRGIVQNFGV QDEVLFLEIS
810 820 830 840 850
LTENWLIFVT RCNGPFWSSI PSWQLSGAVL AVDILATMFC IFGWFKGGHQ
860 870 880 890 900
TSIVAVLRIW MYSFGIFCIM AGTYYILSES AGFDRMMNGK PKESRNQRSI
910
EDLVVALQRT STRHEKGDA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03498 Genomic DNA Translation: AAA35324.1 CU329670 Genomic DNA Translation: CAB59886.1 |
PIRi | A28454, PXZP1P |
RefSeqi | NP_594360.1, NM_001019781.2 |
Genome annotation databases
EnsemblFungii | SPAC1071.10c.1; SPAC1071.10c.1:pep; SPAC1071.10c |
GeneIDi | 2542664 |
KEGGi | spo:SPAC1071.10c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03498 Genomic DNA Translation: AAA35324.1 CU329670 Genomic DNA Translation: CAB59886.1 |
PIRi | A28454, PXZP1P |
RefSeqi | NP_594360.1, NM_001019781.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 279117, 11 interactors |
DIPi | DIP-59125N |
IntActi | P09627, 1 interactor |
STRINGi | 4896.SPAC1071.10c.1 |
PTM databases
iPTMneti | P09627 |
Proteomic databases
MaxQBi | P09627 |
PaxDbi | P09627 |
PRIDEi | P09627 |
Genome annotation databases
EnsemblFungii | SPAC1071.10c.1; SPAC1071.10c.1:pep; SPAC1071.10c |
GeneIDi | 2542664 |
KEGGi | spo:SPAC1071.10c |
Organism-specific databases
PomBasei | SPAC1071.10c, pma1 |
VEuPathDBi | FungiDB:SPAC1071.10c |
Phylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_0_1 |
InParanoidi | P09627 |
OMAi | FGVFCIM |
PhylomeDBi | P09627 |
Miscellaneous databases
PROi | PR:P09627 |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PMA1_SCHPO | |
Accessioni | P09627Primary (citable) accession number: P09627 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families