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Protein

Non-histone chromosomal protein HMG-17

Gene

Hmgn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of development, heterochronic Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:Hmgn2
Synonyms:Hmg-17, Hmg17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 4, Chromosome 8

Organism-specific databases

MGIiMGI:96136 Hmgn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066982 – 90Non-histone chromosomal protein HMG-17Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Modified residuei29ADP-ribosylserine; alternateBy similarity1
Modified residuei29Phosphoserine; alternateBy similarity1
Modified residuei82N6-acetyllysine; alternateCombined sources1
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09602
PaxDbiP09602
PRIDEiP09602

PTM databases

iPTMnetiP09602
PhosphoSitePlusiP09602

Expressioni

Gene expression databases

BgeeiENSMUSG00000003038 Expressed in 58 organ(s), highest expression level in thymus
CleanExiMM_HMGN2
ExpressionAtlasiP09602 baseline and differential
GenevisibleiP09602 MM

Interactioni

Protein-protein interaction databases

IntActiP09602, 1 interactor
MINTiP09602
STRINGi10090.ENSMUSP00000099612

Structurei

3D structure databases

ProteinModelPortaliP09602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiP09602
KOiK11300
OMAiSARLSAX
PhylomeDBiP09602

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKAEGDA KGDKTKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKDANNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,423
Last modified:January 23, 2007 - v2
Checksum:iB614F853310532D9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3KGL9A3KGL9_MOUSE
Non-histone chromosomal protein HMG...
Hmgn2
96Annotation score:
Q5XK38Q5XK38_MOUSE
Hmgn2 protein
Hmgn2
92Annotation score:
F6W687F6W687_MOUSE
Non-histone chromosomal protein HMG...
Hmgn2
112Annotation score:
B7ZCQ3B7ZCQ3_MOUSE
MCG12939, isoform CRA_c
Hmgn2 mCG_12939
109Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA Translation: CAA31404.1
AK002374 mRNA Translation: BAB22051.1
AK078413 mRNA Translation: BAC37262.1
BC084680 mRNA Translation: AAH84680.1
CCDSiCCDS18759.1
PIRiS01946
RefSeqiNP_058653.1, NM_016957.3
UniGeneiMm.319660

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038
GeneIDi15331
KEGGimmu:15331
UCSCiuc008vdq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA Translation: CAA31404.1
AK002374 mRNA Translation: BAB22051.1
AK078413 mRNA Translation: BAC37262.1
BC084680 mRNA Translation: AAH84680.1
CCDSiCCDS18759.1
PIRiS01946
RefSeqiNP_058653.1, NM_016957.3
UniGeneiMm.319660

3D structure databases

ProteinModelPortaliP09602
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09602, 1 interactor
MINTiP09602
STRINGi10090.ENSMUSP00000099612

PTM databases

iPTMnetiP09602
PhosphoSitePlusiP09602

Proteomic databases

EPDiP09602
PaxDbiP09602
PRIDEiP09602

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038
GeneIDi15331
KEGGimmu:15331
UCSCiuc008vdq.1 mouse

Organism-specific databases

CTDi3151
MGIiMGI:96136 Hmgn2

Phylogenomic databases

eggNOGiENOG410J1B8 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiP09602
KOiK11300
OMAiSARLSAX
PhylomeDBiP09602

Miscellaneous databases

PROiPR:P09602
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003038 Expressed in 58 organ(s), highest expression level in thymus
CleanExiMM_HMGN2
ExpressionAtlasiP09602 baseline and differential
GenevisibleiP09602 MM

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN2_MOUSE
AccessioniPrimary (citable) accession number: P09602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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