HMOX1

Functionⁱ

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Catalytic activityⁱ

heme b
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+ 3
O₂
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+ 3
reduced [NADPH—hemoprotein reductase]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
biliverdin IXα
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CO
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
Fe²⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+ 3
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+ 3
oxidized [NADPH—hemoprotein reductase]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:O48782 (HMOX1_ARATH)
EC:1.14.14.18
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:O48782 (HMOX1_ARATH)
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
heme b
zoom
+
3
O₂
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+
3
reduced [NADPH—hemoprotein reductase]
FMNH₂
zoom
=
biliverdin IXα
zoom
+
CO
zoom
+
Fe²⁺
zoom
+
H⁺
zoom
+
3
H₂O
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3
oxidized [NADPH—hemoprotein reductase]
FMN
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	18	Heme	1
Metal bindingⁱ	25	Iron (heme axial ligand)	1
Binding siteⁱ	134	Heme	1
Binding siteⁱ	183	Heme	1

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 15516695
heme binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17915953
heme oxygenase (decyclizing) activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17915953
metal ion binding Source: UniProtKB-KW
phospholipase D activity Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19556236

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: BHF-UCL
Traceable author statementⁱ
- 12239590
cell death Source: BHF-UCL
cellular iron ion homeostasis
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22989377
cellular response to arsenic-containing substance Source: Ensembl
cellular response to cadmium ion Source: Ensembl
cellular response to cisplatin Source: Ensembl
cellular response to heat
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21597468
cellular response to hypoxia
Source: UniProtKB
Inferred from expression patternⁱ
- 12511571
cellular response to nutrient Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
endothelial cell proliferation
Source: BHF-UCL
Traceable author statementⁱ
- 12239590
erythrocyte homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9884342
excretion
Source: BHF-UCL
Inferred by curatorⁱ
- 17915953
heme catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 17915953
heme oxidation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17915953
intracellular signal transduction
Source: BHF-UCL
Traceable author statementⁱ
- 17652371
intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
iron ion homeostasis
Source: BHF-UCL
Inferred from direct assayⁱ
- 17915953
liver regeneration Source: Ensembl
low-density lipoprotein particle clearance
Source: BHF-UCL
Traceable author statementⁱ
- 9884342
negative regulation of DNA binding Source: Ensembl
negative regulation of DNA-binding transcription factor activity Source: Ensembl
negative regulation of epithelial cell apoptotic process Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18202225
negative regulation of leukocyte migration
Source: BHF-UCL
Traceable author statementⁱ
- 14525760
negative regulation of macroautophagy Source: Ensembl
negative regulation of mast cell cytokine production Source: Ensembl
negative regulation of mast cell degranulation Source: Ensembl
negative regulation of muscle cell apoptotic process Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of smooth muscle cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 17600318
negative regulation of vascular smooth muscle cell proliferation Source: Ensembl
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 21788589
positive regulation of apoptotic process Source: Ensembl
positive regulation of blood vessel diameter
Source: BHF-UCL
Inferred by curatorⁱ
- 17915953
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 24844779
positive regulation of cell migration involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 24844779
positive regulation of chemokine biosynthetic process
Source: BHF-UCL
Traceable author statementⁱ
- 17652371
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from high throughput mutant phenotypeⁱ
- 12761501
positive regulation of macroautophagy Source: Ensembl
positive regulation of smooth muscle cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 17600318
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 19556236
regulation of angiogenesis
Source: BHF-UCL
Traceable author statementⁱ
- 17652371
regulation of blood pressure Source: Ensembl
regulation of DNA-binding transcription factor activity Source: BHF-UCL
regulation of transcription from RNA polymerase II promoter in response to iron Source: Ensembl
regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
response to estrogen Source: Ensembl
response to hydrogen peroxide Source: BHF-UCL
response to nicotine
Source: BHF-UCL
Inferred from direct assayⁱ
- 18205746
response to oxidative stress
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9884342
small GTPase mediated signal transduction Source: Ensembl
smooth muscle hyperplasia
Source: BHF-UCL
Traceable author statementⁱ
- 18289072
wound healing involved in inflammatory response
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9884342

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Apoptosis
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02027-MONOMER
BRENDAⁱ	1.14.99.3 2681
Reactomeⁱ	R-HSA-189483 Heme degradation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-917937 Iron uptake and transport
SIGNORⁱ	P09601

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heme oxygenase 1 (EC:1.14.14.18By similarity) Short name: HO-1
Gene namesⁱ	Name:HMOX1 Synonyms:HO, HO1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100292.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5013 HMOX1
MIMⁱ	141250 gene
neXtProtⁱ	NX_P09601

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Heme oxygenase 1 deficiency (HMOX1D)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	140	D → A: Inactive as a heme oxygenase but active as a peroxidase. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3162
MalaCards human disease database More...MalaCardsⁱ	HMOX1
MIMⁱ	614034 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100292
PharmGKBⁱ	PA29341

Chemistry databases

ChEMBLⁱ	CHEMBL2823
Drug and drug target database More...DrugBankⁱ	DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DB02468 12-Phenylheme DB03906 2-Phenylheme DB02073 Biliverdine Ix Alpha DB01942 Formic Acid DB00157 NADH DB04912 Stannsoporfin DB04803 Verdoheme DB00163 Vitamin E
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1441

Polymorphism and mutation databases

BioMutaⁱ	HMOX1
DMDMⁱ	123446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209687	1 – 288	Heme oxygenase 1Add BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	229	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P09601
jPOSTⁱ	P09601
PaxDbⁱ	P09601
PeptideAtlas More...PeptideAtlasⁱ	P09601
PRIDEⁱ	P09601
ProteomicsDBⁱ	52249

PTM databases

iPTMnetⁱ	P09601
PhosphoSitePlusⁱ	P09601

Expressionⁱ

Tissue specificityⁱ

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).1 Publication

Inductionⁱ

Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.

Gene expression databases

Bgeeⁱ	ENSG00000100292 Expressed in 174 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_HMOX1
ExpressionAtlasⁱ	P09601 baseline and differential
Genevisibleⁱ	P09601 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017444 HPA000635

HPAⁱ

CAB017444
HPA000635

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POT1	Q9NUX5	2	EBI-2806151,EBI-752420

With

Entry

#Exp.

IntAct

Notes

POT1

Q9NUX5

2

EBI-2806151,EBI-752420

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 15516695
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19556236

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109405, 37 interactors
IntActⁱ	P09601, 32 interactors
Molecular INTeraction database More...MINTⁱ	P09601
STRINGⁱ	9606.ENSP00000216117

Chemistry databases

BindingDBⁱ

P09601

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 8	Combined sources	3
Helixⁱ	13 – 20	Combined sources	8
Helixⁱ	22 – 30	Combined sources	9
Helixⁱ	32 – 38	Combined sources	7
Helixⁱ	44 – 68	Combined sources	25
Turnⁱ	72 – 74	Combined sources	3
Helixⁱ	75 – 77	Combined sources	3
Helixⁱ	80 – 83	Combined sources	4
Helixⁱ	86 – 97	Combined sources	12
Helixⁱ	101 – 103	Combined sources	3
Helixⁱ	109 – 124	Combined sources	16
Helixⁱ	126 – 128	Combined sources	3
Helixⁱ	129 – 155	Combined sources	27
Beta strandⁱ	159 – 161	Combined sources	3
Helixⁱ	165 – 167	Combined sources	3
Helixⁱ	175 – 188	Combined sources	14
Helixⁱ	193 – 220	Combined sources	28

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N3U	X-ray	2.58	A/B	1-233	[»]
	1N45	X-ray	1.50	A/B	1-233	[»]
	1NI6	X-ray	2.10	A/B/C/D	1-224	[»]
	1OYK	X-ray	2.59	A/B	1-233	[»]
	1OYL	X-ray	1.59	A/B	1-233	[»]
	1OZE	X-ray	2.19	A/B	1-233	[»]
	1OZL	X-ray	1.58	A/B	1-233	[»]
	1OZR	X-ray	1.74	A/B	1-233	[»]
	1OZW	X-ray	1.55	A/B	1-233	[»]
	1S13	X-ray	2.29	A/B	1-233	[»]
	1S8C	X-ray	2.19	A/B/C/D	1-233	[»]
	1T5P	X-ray	2.11	A/B	1-233	[»]
	1TWN	X-ray	2.20	A/B	1-233	[»]
	1TWR	X-ray	2.10	A/B	1-233	[»]
	1XJZ	X-ray	1.88	A/B	1-233	[»]
	1XK0	X-ray	2.18	A/B	1-233	[»]
	1XK1	X-ray	2.08	A/B	1-233	[»]
	1XK2	X-ray	2.20	A/B	1-233	[»]
	1XK3	X-ray	2.08	A/B	1-233	[»]
	3CZY	X-ray	1.54	A/B	1-233	[»]
	3HOK	X-ray	2.19	A/B	1-233	[»]
	3K4F	X-ray	2.17	A/B	1-233	[»]
	3TGM	X-ray	2.85	A/B	1-233	[»]
	4WD4	X-ray	2.95	A/B/C/D	1-288	[»]
	5BTQ	X-ray	2.08	A/B	1-233	[»]
	6EHA	X-ray	2.00	A/B	1-288	[»]
ProteinModelPortalⁱ	P09601
SMRⁱ	P09601
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P09601

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4480 Eukaryota COG5398 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017673
HOGENOMⁱ	HOG000233221
HOVERGENⁱ	HBG005982
InParanoidⁱ	P09601
KEGG Orthology (KO) More...KOⁱ	K00510
OMAⁱ	KKSHTMA
Database of Orthologous Groups More...OrthoDBⁱ	1424194at2759
PhylomeDBⁱ	P09601
TreeFamⁱ	TF314786

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00232 HemeO, 1 hit
Gene3Dⁱ	1.20.910.10, 1 hit
InterProⁱ	View protein in InterPro IPR002051 Haem_Oase IPR016053 Haem_Oase-like IPR016084 Haem_Oase-like_multi-hlx IPR018207 Haem_oxygenase_CS
PANTHERⁱ	PTHR10720 PTHR10720, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01126 Heme_oxygenase, 1 hit
PIRSFⁱ	PIRSF000343 Haem_Oase, 1 hit
PRINTSⁱ	PR00088 HAEMOXYGNASE
SUPFAMⁱ	SSF48613 SSF48613, 1 hit
PROSITEⁱ	View protein in PROSITE PS00593 HEME_OXYGENASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P09601-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV 
        60         70         80         90        100
MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR 
       110        120        130        140        150
WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI 
       160        170        180        190        200
AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI 
       210        220        230        240        250
EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV 
       260        270        280 
ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM

Length:288

Mass (Da):32,819

Last modified:July 1, 1989 - v1

Checksum:ⁱAB47827778694064

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AHA8	B1AHA8_HUMAN		Heme oxygenase 1 Heme oxygenase 1	HMOX1	187	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019165	7	D → H1 PublicationCorresponds to variant dbSNP:rs2071747Ensembl.		1
Natural variantⁱVAR_022156	106	P → L. Corresponds to variant dbSNP:rs9282702Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06985 mRNA Translation: CAA30045.1 CR456505 mRNA Translation: CAG30391.1 AY460337 Genomic DNA Translation: AAR23262.1 Z82244 Genomic DNA No translation available. M23041 mRNA Translation: AAA50403.1 X14782 Genomic DNA Translation: CAA32886.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13914.1
PIRⁱ	S00325
NCBI Reference Sequences More...RefSeqⁱ	NP_002124.1, NM_002133.2
UniGeneⁱ	Hs.517581 Hs.727017

Genome annotation databases

Ensemblⁱ	ENST00000216117; ENSP00000216117; ENSG00000100292
GeneIDⁱ	3162
KEGGⁱ	hsa:3162

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09601	Heme oxygenase		PANTR		311	UniRef100_P09601
Heme oxygenase		PANPA		311
Heme oxygenase 1 (Fragment)		HUMAN		187
HMOX1 isoform 1 (Fragment)		PANTR		187
HMOX1 (Fragment)		HUMAN		42
+4

Protein	Similar proteins		Species	Score	Length	Source
P09601	Heme oxygenase		PANTR		311	UniRef90_P09601
Heme oxygenase		PANPA		311
Heme oxygenase 1 (Fragment)		HUMAN		187
Heme oxygenase 1		RHIRO		303
Heme oxygenase		GORGO		289
+41

Protein	Similar proteins		Species	Score	Length	Source
P09601	Heme oxygenase		PANTR		311	UniRef50_P09601
Heme oxygenase		PANPA		311
Heme oxygenase 1 (Fragment)		HUMAN		187
Heme oxygenase 1		RHIRO		303
Heme oxygenase		GORGO		289
+148

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06985 mRNA Translation: CAA30045.1 CR456505 mRNA Translation: CAG30391.1 AY460337 Genomic DNA Translation: AAR23262.1 Z82244 Genomic DNA No translation available. M23041 mRNA Translation: AAA50403.1 X14782 Genomic DNA Translation: CAA32886.1
CCDSⁱ	CCDS13914.1
PIRⁱ	S00325
RefSeqⁱ	NP_002124.1, NM_002133.2
UniGeneⁱ	Hs.517581 Hs.727017

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N3U	X-ray	2.58	A/B	1-233	[»]
	1N45	X-ray	1.50	A/B	1-233	[»]
	1NI6	X-ray	2.10	A/B/C/D	1-224	[»]
	1OYK	X-ray	2.59	A/B	1-233	[»]
	1OYL	X-ray	1.59	A/B	1-233	[»]
	1OZE	X-ray	2.19	A/B	1-233	[»]
	1OZL	X-ray	1.58	A/B	1-233	[»]
	1OZR	X-ray	1.74	A/B	1-233	[»]
	1OZW	X-ray	1.55	A/B	1-233	[»]
	1S13	X-ray	2.29	A/B	1-233	[»]
	1S8C	X-ray	2.19	A/B/C/D	1-233	[»]
	1T5P	X-ray	2.11	A/B	1-233	[»]
	1TWN	X-ray	2.20	A/B	1-233	[»]
	1TWR	X-ray	2.10	A/B	1-233	[»]
	1XJZ	X-ray	1.88	A/B	1-233	[»]
	1XK0	X-ray	2.18	A/B	1-233	[»]
	1XK1	X-ray	2.08	A/B	1-233	[»]
	1XK2	X-ray	2.20	A/B	1-233	[»]
	1XK3	X-ray	2.08	A/B	1-233	[»]
	3CZY	X-ray	1.54	A/B	1-233	[»]
	3HOK	X-ray	2.19	A/B	1-233	[»]
	3K4F	X-ray	2.17	A/B	1-233	[»]
	3TGM	X-ray	2.85	A/B	1-233	[»]
	4WD4	X-ray	2.95	A/B/C/D	1-288	[»]
	5BTQ	X-ray	2.08	A/B	1-233	[»]
	6EHA	X-ray	2.00	A/B	1-288	[»]
ProteinModelPortalⁱ	P09601
SMRⁱ	P09601
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109405, 37 interactors
IntActⁱ	P09601, 32 interactors
MINTⁱ	P09601
STRINGⁱ	9606.ENSP00000216117

Chemistry databases

BindingDBⁱ	P09601
ChEMBLⁱ	CHEMBL2823
DrugBankⁱ	DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DB02468 12-Phenylheme DB03906 2-Phenylheme DB02073 Biliverdine Ix Alpha DB01942 Formic Acid DB00157 NADH DB04912 Stannsoporfin DB04803 Verdoheme DB00163 Vitamin E
GuidetoPHARMACOLOGYⁱ	1441

PTM databases

iPTMnetⁱ	P09601
PhosphoSitePlusⁱ	P09601

Polymorphism and mutation databases

BioMutaⁱ	HMOX1
DMDMⁱ	123446

Proteomic databases

EPDⁱ	P09601
jPOSTⁱ	P09601
PaxDbⁱ	P09601
PeptideAtlasⁱ	P09601
PRIDEⁱ	P09601
ProteomicsDBⁱ	52249

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3162
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216117; ENSP00000216117; ENSG00000100292
GeneIDⁱ	3162
KEGGⁱ	hsa:3162

Organism-specific databases

CTDⁱ	3162
DisGeNETⁱ	3162
EuPathDBⁱ	HostDB:ENSG00000100292.16
GeneCardsⁱ	HMOX1
HGNCⁱ	HGNC:5013 HMOX1
HPAⁱ	CAB017444 HPA000635
MalaCardsⁱ	HMOX1
MIMⁱ	141250 gene 614034 phenotype
neXtProtⁱ	NX_P09601
OpenTargetsⁱ	ENSG00000100292
PharmGKBⁱ	PA29341
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4480 Eukaryota COG5398 LUCA
GeneTreeⁱ	ENSGT00390000017673
HOGENOMⁱ	HOG000233221
HOVERGENⁱ	HBG005982
InParanoidⁱ	P09601
KOⁱ	K00510
OMAⁱ	KKSHTMA
OrthoDBⁱ	1424194at2759
PhylomeDBⁱ	P09601
TreeFamⁱ	TF314786

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02027-MONOMER
BRENDAⁱ	1.14.99.3 2681
Reactomeⁱ	R-HSA-189483 Heme degradation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-917937 Iron uptake and transport
SIGNORⁱ	P09601

Miscellaneous databases

EvolutionaryTraceⁱ	P09601
GeneWikiⁱ	HMOX1
GenomeRNAiⁱ	3162
Protein Ontology More...PROⁱ	PR:P09601
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100292 Expressed in 174 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_HMOX1
ExpressionAtlasⁱ	P09601 baseline and differential
Genevisibleⁱ	P09601 HS

Family and domain databases

CDDⁱ	cd00232 HemeO, 1 hit
Gene3Dⁱ	1.20.910.10, 1 hit
InterProⁱ	View protein in InterPro IPR002051 Haem_Oase IPR016053 Haem_Oase-like IPR016084 Haem_Oase-like_multi-hlx IPR018207 Haem_oxygenase_CS
PANTHERⁱ	PTHR10720 PTHR10720, 1 hit
Pfamⁱ	View protein in Pfam PF01126 Heme_oxygenase, 1 hit
PIRSFⁱ	PIRSF000343 Haem_Oase, 1 hit
PRINTSⁱ	PR00088 HAEMOXYGNASE
SUPFAMⁱ	SSF48613 SSF48613, 1 hit
PROSITEⁱ	View protein in PROSITE PS00593 HEME_OXYGENASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMOX1_HUMAN
Accessionⁱ	P09601Primary (citable) accession number: P09601
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	January 16, 2019
	This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P09601 (HMOX1_HUMAN)

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Heme oxygenase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

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Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ