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UniProtKB - P09601 (HMOX1_HUMAN)

Entry version 215 (25 May 2022)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
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Protein

Heme oxygenase 1

Gene

HMOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:7703255, PubMed:11121422).

Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).

1 Publication2 Publications

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6 µM for heme b1 Publication
  1. Vmax=102 nmol/h/mg enzyme for heme b1 Publication
  1. KM=3 µM for heme b1 Publication
  1. Vmax=40 nmol/h/mg enzyme for heme b1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei18Heme bCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi25Iron (heme axial ligand)Combined sources1 Publication1
Binding sitei134Heme bCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei140Important for catalytic activity1 Publication1
Binding sitei183Heme bCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.14.14.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09601

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-189483, Heme degradation
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-844456, The NLRP3 inflammasome
R-HSA-917937, Iron uptake and transport
R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
R-HSA-9660826, Purinergic signaling in leishmaniasis infection
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707587, Regulation of HMOX1 expression and activity
R-HSA-9707616, Heme signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P09601

SIGNOR Signaling Network Open Resource

More...SIGNORi		P09601

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heme oxygenase 1 (EC:1.14.14.182 Publications)
Short name:
HO-1
Cleaved into the following chain:
Heme oxygenase 1 soluble form1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMOX1
Synonyms:HO, HO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5013, HMOX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		141250, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09601

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100292

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 265Cytoplasmic1 PublicationAdd BLAST265
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei266 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Heme oxygenase 1 deficiency (HMOX1D)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi140D → A, H, N, F or L: Inactive as a heme oxygenase but active as a peroxidase. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		3162

MalaCards human disease database

More...MalaCardsi		HMOX1
MIMi614034, phenotype

Open Targets

More...OpenTargetsi		ENSG00000100292

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		586, Cystic fibrosis
562509, Heme oxygenase-1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29341

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09601, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2823

Drug and drug target database

More...DrugBanki		DB07342, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
DB06914, 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
DB02468, 12-Phenylheme
DB03906, 2-Phenylheme
DB14001, alpha-Tocopherol succinate
DB02073, Biliverdine IX Alpha
DB14002, D-alpha-Tocopherol acetate
DB01942, Formic acid
DB00157, NADH
DB09221, Polaprezinc
DB04912, Stannsoporfin
DB04803, Verdoheme
DB00163, Vitamin E

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1441

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HMOX1

Domain mapping of disease mutations (DMDM)

More...DMDMi		123446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002096871 – 288Heme oxygenase 1Add BLAST288
ChainiPRO_00004556211 – 265Heme oxygenase 1 soluble form1 PublicationAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei229PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A soluble form arises by proteolytic removal of the membrane anchor.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09601

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09601

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09601

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09601

PeptideAtlas

More...PeptideAtlasi		P09601

PRoteomics IDEntifications database

More...PRIDEi		P09601

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52249

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P09601, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09601

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09601

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100292, Expressed in layer of synovial tissue and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09601, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09601, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100292, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109405, 142 interactors

Protein interaction database and analysis system

More...IntActi		P09601, 57 interactors

Molecular INTeraction database

More...MINTi		P09601

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216117

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P09601

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09601, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P09601

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09601

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09601

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni223 – 260DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 248Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4480, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057050_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09601

Identification of Orthologs from Complete Genome Data

More...OMAi		KKSHTMA

Database of Orthologous Groups

More...OrthoDBi		1424194at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09601

TreeFam database of animal gene trees

More...TreeFami		TF314786

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.910.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002051, Haem_Oase
IPR016053, Haem_Oase-like
IPR016084, Haem_Oase-like_multi-hlx
IPR018207, Haem_oxygenase_CS

The PANTHER Classification System

More...PANTHERi		PTHR10720, PTHR10720, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01126, Heme_oxygenase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000343, Haem_Oase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00088, HAEMOXYGNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48613, SSF48613, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00593, HEME_OXYGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P09601-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV 
        60         70         80         90        100
MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR 
       110        120        130        140        150
WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI 
       160        170        180        190        200
AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI 
       210        220        230        240        250
EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV 
       260        270        280 
ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM
Length:288
Mass (Da):32,819
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB47827778694064
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7I2V3I1A0A7I2V3I1_HUMAN
Heme oxygenase
HMOX1
249Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHA8B1AHA8_HUMAN
Heme oxygenase (biliverdin-producin...
HMOX1
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3M0A0A7I2V3M0_HUMAN
Heme oxygenase 1
HMOX1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V277A0A7I2V277_HUMAN
Heme oxygenase 1
HMOX1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQL9A0A7I2YQL9_HUMAN
Heme oxygenase 1
HMOX1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0191657D → H1 PublicationCorresponds to variant dbSNP:rs2071747Ensembl.1
Natural variantiVAR_022156106P → L. Corresponds to variant dbSNP:rs9282702Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X06985 mRNA Translation: CAA30045.1
CR456505 mRNA Translation: CAG30391.1
AY460337 Genomic DNA Translation: AAR23262.1
Z82244 Genomic DNA No translation available.
M23041 mRNA Translation: AAA50403.1
X14782 Genomic DNA Translation: CAA32886.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13914.1

Protein sequence database of the Protein Information Resource

More...PIRi		S00325

NCBI Reference Sequences

More...RefSeqi		NP_002124.1, NM_002133.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216117.9; ENSP00000216117.8; ENSG00000100292.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3162

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000216117.9; ENSP00000216117.8; NM_002133.3; NP_002124.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06985 mRNA Translation: CAA30045.1
CR456505 mRNA Translation: CAG30391.1
AY460337 Genomic DNA Translation: AAR23262.1
Z82244 Genomic DNA No translation available.
M23041 mRNA Translation: AAA50403.1
X14782 Genomic DNA Translation: CAA32886.1
CCDSiCCDS13914.1
PIRiS00325
RefSeqiNP_002124.1, NM_002133.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N3UX-ray2.58A/B1-233[»]
1N45X-ray1.50A/B1-233[»]
1NI6X-ray2.10A/B/C/D1-224[»]
1OYKX-ray2.59A/B1-233[»]
1OYLX-ray1.59A/B1-233[»]
1OZEX-ray2.19A/B1-233[»]
1OZLX-ray1.58A/B1-233[»]
1OZRX-ray1.74A/B1-233[»]
1OZWX-ray1.55A/B1-233[»]
1S13X-ray2.29A/B1-233[»]
1S8CX-ray2.19A/B/C/D1-233[»]
1T5PX-ray2.11A/B1-233[»]
1TWNX-ray2.20A/B1-233[»]
1TWRX-ray2.10A/B1-233[»]
1XJZX-ray1.88A/B1-233[»]
1XK0X-ray2.18A/B1-233[»]
1XK1X-ray2.08A/B1-233[»]
1XK2X-ray2.20A/B1-233[»]
1XK3X-ray2.08A/B1-233[»]
3CZYX-ray1.54A/B1-233[»]
3HOKX-ray2.19A/B1-233[»]
3K4FX-ray2.17A/B1-233[»]
3TGMX-ray2.85A/B1-233[»]
4WD4X-ray2.95A/B/C/D1-288[»]
5BTQX-ray2.08A/B1-233[»]
6EHAX-ray2.00A/B1-288[»]
AlphaFoldDBiP09601
SMRiP09601
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109405, 142 interactors
IntActiP09601, 57 interactors
MINTiP09601
STRINGi9606.ENSP00000216117

Chemistry databases

BindingDBiP09601
ChEMBLiCHEMBL2823
DrugBankiDB07342, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
DB06914, 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
DB02468, 12-Phenylheme
DB03906, 2-Phenylheme
DB14001, alpha-Tocopherol succinate
DB02073, Biliverdine IX Alpha
DB14002, D-alpha-Tocopherol acetate
DB01942, Formic acid
DB00157, NADH
DB09221, Polaprezinc
DB04912, Stannsoporfin
DB04803, Verdoheme
DB00163, Vitamin E
GuidetoPHARMACOLOGYi1441

PTM databases

GlyGeniP09601, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP09601
PhosphoSitePlusiP09601

Genetic variation databases

BioMutaiHMOX1
DMDMi123446

Proteomic databases

EPDiP09601
jPOSTiP09601
MassIVEiP09601
PaxDbiP09601
PeptideAtlasiP09601
PRIDEiP09601
ProteomicsDBi52249

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		266, 1120 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		3162

Genome annotation databases

EnsembliENST00000216117.9; ENSP00000216117.8; ENSG00000100292.18
GeneIDi3162
KEGGihsa:3162
MANE-SelectiENST00000216117.9; ENSP00000216117.8; NM_002133.3; NP_002124.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3162
DisGeNETi3162

GeneCards: human genes, protein and diseases

More...GeneCardsi		HMOX1
HGNCiHGNC:5013, HMOX1
HPAiENSG00000100292, Tissue enriched (lymphoid)
MalaCardsiHMOX1
MIMi141250, gene
614034, phenotype
neXtProtiNX_P09601
OpenTargetsiENSG00000100292
Orphaneti586, Cystic fibrosis
562509, Heme oxygenase-1 deficiency
PharmGKBiPA29341
VEuPathDBiHostDB:ENSG00000100292

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4480, Eukaryota
GeneTreeiENSGT00390000017673
HOGENOMiCLU_057050_0_0_1
InParanoidiP09601
OMAiKKSHTMA
OrthoDBi1424194at2759
PhylomeDBiP09601
TreeFamiTF314786

Enzyme and pathway databases

BRENDAi1.14.14.18, 2681
PathwayCommonsiP09601
ReactomeiR-HSA-189483, Heme degradation
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-844456, The NLRP3 inflammasome
R-HSA-917937, Iron uptake and transport
R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
R-HSA-9660826, Purinergic signaling in leishmaniasis infection
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707587, Regulation of HMOX1 expression and activity
R-HSA-9707616, Heme signaling
SignaLinkiP09601
SIGNORiP09601

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3162, 17 hits in 1088 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HMOX1, human
EvolutionaryTraceiP09601

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HMOX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3162
PharosiP09601, Tchem

Protein Ontology

More...PROi		PR:P09601
RNActiP09601, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100292, Expressed in layer of synovial tissue and 192 other tissues
ExpressionAtlasiP09601, baseline and differential
GenevisibleiP09601, HS

Family and domain databases

Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051, Haem_Oase
IPR016053, Haem_Oase-like
IPR016084, Haem_Oase-like_multi-hlx
IPR018207, Haem_oxygenase_CS
PANTHERiPTHR10720, PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126, Heme_oxygenase, 1 hit
PIRSFiPIRSF000343, Haem_Oase, 1 hit
PRINTSiPR00088, HAEMOXYGNASE
SUPFAMiSSF48613, SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593, HEME_OXYGENASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMOX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09601
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 25, 2022
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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