UniProtKB - P09601 (HMOX1_HUMAN)
Heme oxygenase 1
HMOX1
Functioni
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:7703255, PubMed:11121422).
Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).
1 Publication2 PublicationsCatalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
1 PublicationCatalytic activityi
- heme b + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] = biliverdin IXα + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH—hemoprotein reductase]2 PublicationsEC:1.14.14.182 PublicationsThis reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=6 µM for heme b1 Publication
- Vmax=102 nmol/h/mg enzyme for heme b1 Publication
- KM=3 µM for heme b1 Publication
- Vmax=40 nmol/h/mg enzyme for heme b1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 18 | Heme bCombined sources1 Publication | 1 | |
Metal bindingi | 25 | Iron (heme axial ligand)Combined sources1 Publication | 1 | |
Binding sitei | 134 | Heme bCombined sources1 Publication | 1 | |
Sitei | 140 | Important for catalytic activity1 Publication | 1 | |
Binding sitei | 183 | Heme bCombined sources1 Publication | 1 |
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- heme binding Source: BHF-UCL
- heme oxygenase (decyclizing) activity Source: BHF-UCL
- identical protein binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- phospholipase D activity Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- structural molecule activity Source: UniProtKB
GO - Biological processi
- angiogenesis Source: BHF-UCL
- cell death Source: BHF-UCL
- cellular iron ion homeostasis Source: CACAO
- cellular response to arsenic-containing substance Source: Ensembl
- cellular response to cadmium ion Source: Ensembl
- cellular response to cisplatin Source: Ensembl
- cellular response to heat Source: UniProtKB
- cellular response to hypoxia Source: UniProtKB
- cellular response to nutrient Source: Ensembl
- endothelial cell proliferation Source: BHF-UCL
- erythrocyte homeostasis Source: BHF-UCL
- heme catabolic process Source: BHF-UCL
- heme oxidation Source: BHF-UCL
- intracellular signal transduction Source: BHF-UCL
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- iron ion homeostasis Source: BHF-UCL
- liver regeneration Source: Ensembl
- low-density lipoprotein particle clearance Source: BHF-UCL
- negative regulation of DNA binding Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: Ensembl
- negative regulation of epithelial cell apoptotic process Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- negative regulation of leukocyte migration Source: BHF-UCL
- negative regulation of macroautophagy Source: Ensembl
- negative regulation of mast cell cytokine production Source: Ensembl
- negative regulation of mast cell degranulation Source: Ensembl
- negative regulation of muscle cell apoptotic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of smooth muscle cell proliferation Source: UniProtKB
- negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of macroautophagy Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- regulation of angiogenesis Source: BHF-UCL
- regulation of blood pressure Source: Ensembl
- regulation of DNA-binding transcription factor activity Source: BHF-UCL
- regulation of transcription from RNA polymerase II promoter in response to iron Source: Ensembl
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
- response to estrogen Source: Ensembl
- response to hydrogen peroxide Source: BHF-UCL
- response to nicotine Source: BHF-UCL
- response to oxidative stress Source: BHF-UCL
- response to xenobiotic stimulus Source: Ensembl
- small GTPase mediated signal transduction Source: Ensembl
- smooth muscle hyperplasia Source: BHF-UCL
- wound healing involved in inflammatory response Source: BHF-UCL
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Apoptosis |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.18, 2681 |
PathwayCommonsi | P09601 |
Reactomei | R-HSA-189483, Heme degradation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844456, The NLRP3 inflammasome R-HSA-917937, Iron uptake and transport R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9660826, Purinergic signaling in leishmaniasis infection R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707587, Regulation of HMOX1 expression and activity R-HSA-9707616, Heme signaling |
SignaLinki | P09601 |
SIGNORi | P09601 |
Names & Taxonomyi
Protein namesi | Recommended name: Heme oxygenase 1 (EC:1.14.14.182 Publications)Short name: HO-1 Cleaved into the following chain: Heme oxygenase 1 soluble form1 Publication |
Gene namesi | Name:HMOX1 Synonyms:HO, HO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5013, HMOX1 |
MIMi | 141250, gene |
neXtProti | NX_P09601 |
VEuPathDBi | HostDB:ENSG00000100292 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein Sequence analysis; Cytoplasmic side 1 Publication
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Mitochondrion
- mitochondrial outer membrane Source: Reactome
Nucleus
- nucleolus Source: Ensembl
- nucleoplasm Source: Reactome
- nucleus Source: BHF-UCL
Plasma Membrane
- caveola Source: Ensembl
Other locations
- membrane Source: ProtInc
- perinuclear region of cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 265 | Cytoplasmic1 PublicationAdd BLAST | 265 | |
Transmembranei | 266 – 288 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Heme oxygenase 1 deficiency (HMOX1D)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 | D → A, H, N, F or L: Inactive as a heme oxygenase but active as a peroxidase. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 3162 |
MalaCardsi | HMOX1 |
MIMi | 614034, phenotype |
OpenTargetsi | ENSG00000100292 |
Orphaneti | 586, Cystic fibrosis 562509, Heme oxygenase-1 deficiency |
PharmGKBi | PA29341 |
Miscellaneous databases
Pharosi | P09601, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2823 |
DrugBanki | DB07342, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DB06914, 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE DB02468, 12-Phenylheme DB03906, 2-Phenylheme DB14001, alpha-Tocopherol succinate DB02073, Biliverdine IX Alpha DB14002, D-alpha-Tocopherol acetate DB01942, Formic acid DB00157, NADH DB09221, Polaprezinc DB04912, Stannsoporfin DB04803, Verdoheme DB00163, Vitamin E |
GuidetoPHARMACOLOGYi | 1441 |
Genetic variation databases
BioMutai | HMOX1 |
DMDMi | 123446 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209687 | 1 – 288 | Heme oxygenase 1Add BLAST | 288 | |
ChainiPRO_0000455621 | 1 – 265 | Heme oxygenase 1 soluble form1 PublicationAdd BLAST | 265 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 229 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P09601 |
jPOSTi | P09601 |
MassIVEi | P09601 |
PaxDbi | P09601 |
PeptideAtlasi | P09601 |
PRIDEi | P09601 |
ProteomicsDBi | 52249 |
PTM databases
GlyGeni | P09601, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09601 |
PhosphoSitePlusi | P09601 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000100292, Expressed in layer of synovial tissue and 192 other tissues |
ExpressionAtlasi | P09601, baseline and differential |
Genevisiblei | P09601, HS |
Organism-specific databases
HPAi | ENSG00000100292, Tissue enriched (lymphoid) |
Interactioni
Binary interactionsi
P09601
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109405, 142 interactors |
IntActi | P09601, 57 interactors |
MINTi | P09601 |
STRINGi | 9606.ENSP00000216117 |
Chemistry databases
BindingDBi | P09601 |
Miscellaneous databases
RNActi | P09601, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P09601 |
SMRi | P09601 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09601 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 260 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 227 – 248 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4480, Eukaryota |
GeneTreei | ENSGT00390000017673 |
HOGENOMi | CLU_057050_0_0_1 |
InParanoidi | P09601 |
OMAi | KKSHTMA |
OrthoDBi | 1424194at2759 |
PhylomeDBi | P09601 |
TreeFami | TF314786 |
Family and domain databases
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PIRSFi | PIRSF000343, Haem_Oase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV
60 70 80 90 100
MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR
110 120 130 140 150
WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI
160 170 180 190 200
AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI
210 220 230 240 250
EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV
260 270 280
ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A7I2V3I1 | A0A7I2V3I1_HUMAN | Heme oxygenase | HMOX1 | 249 | Annotation score: | ||
B1AHA8 | B1AHA8_HUMAN | Heme oxygenase (biliverdin-producin... | HMOX1 | 187 | Annotation score: | ||
A0A7I2V3M0 | A0A7I2V3M0_HUMAN | Heme oxygenase 1 | HMOX1 | 157 | Annotation score: | ||
A0A7I2V277 | A0A7I2V277_HUMAN | Heme oxygenase 1 | HMOX1 | 124 | Annotation score: | ||
A0A7I2YQL9 | A0A7I2YQL9_HUMAN | Heme oxygenase 1 | HMOX1 | 75 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019165 | 7 | D → H1 PublicationCorresponds to variant dbSNP:rs2071747Ensembl. | 1 | |
Natural variantiVAR_022156 | 106 | P → L. Corresponds to variant dbSNP:rs9282702Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06985 mRNA Translation: CAA30045.1 CR456505 mRNA Translation: CAG30391.1 AY460337 Genomic DNA Translation: AAR23262.1 Z82244 Genomic DNA No translation available. M23041 mRNA Translation: AAA50403.1 X14782 Genomic DNA Translation: CAA32886.1 |
CCDSi | CCDS13914.1 |
PIRi | S00325 |
RefSeqi | NP_002124.1, NM_002133.2 |
Genome annotation databases
Ensembli | ENST00000216117.9; ENSP00000216117.8; ENSG00000100292.18 |
GeneIDi | 3162 |
KEGGi | hsa:3162 |
MANE-Selecti | ENST00000216117.9; ENSP00000216117.8; NM_002133.3; NP_002124.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06985 mRNA Translation: CAA30045.1 CR456505 mRNA Translation: CAG30391.1 AY460337 Genomic DNA Translation: AAR23262.1 Z82244 Genomic DNA No translation available. M23041 mRNA Translation: AAA50403.1 X14782 Genomic DNA Translation: CAA32886.1 |
CCDSi | CCDS13914.1 |
PIRi | S00325 |
RefSeqi | NP_002124.1, NM_002133.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N3U | X-ray | 2.58 | A/B | 1-233 | [»] | |
1N45 | X-ray | 1.50 | A/B | 1-233 | [»] | |
1NI6 | X-ray | 2.10 | A/B/C/D | 1-224 | [»] | |
1OYK | X-ray | 2.59 | A/B | 1-233 | [»] | |
1OYL | X-ray | 1.59 | A/B | 1-233 | [»] | |
1OZE | X-ray | 2.19 | A/B | 1-233 | [»] | |
1OZL | X-ray | 1.58 | A/B | 1-233 | [»] | |
1OZR | X-ray | 1.74 | A/B | 1-233 | [»] | |
1OZW | X-ray | 1.55 | A/B | 1-233 | [»] | |
1S13 | X-ray | 2.29 | A/B | 1-233 | [»] | |
1S8C | X-ray | 2.19 | A/B/C/D | 1-233 | [»] | |
1T5P | X-ray | 2.11 | A/B | 1-233 | [»] | |
1TWN | X-ray | 2.20 | A/B | 1-233 | [»] | |
1TWR | X-ray | 2.10 | A/B | 1-233 | [»] | |
1XJZ | X-ray | 1.88 | A/B | 1-233 | [»] | |
1XK0 | X-ray | 2.18 | A/B | 1-233 | [»] | |
1XK1 | X-ray | 2.08 | A/B | 1-233 | [»] | |
1XK2 | X-ray | 2.20 | A/B | 1-233 | [»] | |
1XK3 | X-ray | 2.08 | A/B | 1-233 | [»] | |
3CZY | X-ray | 1.54 | A/B | 1-233 | [»] | |
3HOK | X-ray | 2.19 | A/B | 1-233 | [»] | |
3K4F | X-ray | 2.17 | A/B | 1-233 | [»] | |
3TGM | X-ray | 2.85 | A/B | 1-233 | [»] | |
4WD4 | X-ray | 2.95 | A/B/C/D | 1-288 | [»] | |
5BTQ | X-ray | 2.08 | A/B | 1-233 | [»] | |
6EHA | X-ray | 2.00 | A/B | 1-288 | [»] | |
AlphaFoldDBi | P09601 | |||||
SMRi | P09601 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109405, 142 interactors |
IntActi | P09601, 57 interactors |
MINTi | P09601 |
STRINGi | 9606.ENSP00000216117 |
Chemistry databases
BindingDBi | P09601 |
ChEMBLi | CHEMBL2823 |
DrugBanki | DB07342, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DB06914, 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE DB02468, 12-Phenylheme DB03906, 2-Phenylheme DB14001, alpha-Tocopherol succinate DB02073, Biliverdine IX Alpha DB14002, D-alpha-Tocopherol acetate DB01942, Formic acid DB00157, NADH DB09221, Polaprezinc DB04912, Stannsoporfin DB04803, Verdoheme DB00163, Vitamin E |
GuidetoPHARMACOLOGYi | 1441 |
PTM databases
GlyGeni | P09601, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09601 |
PhosphoSitePlusi | P09601 |
Genetic variation databases
BioMutai | HMOX1 |
DMDMi | 123446 |
Proteomic databases
EPDi | P09601 |
jPOSTi | P09601 |
MassIVEi | P09601 |
PaxDbi | P09601 |
PeptideAtlasi | P09601 |
PRIDEi | P09601 |
ProteomicsDBi | 52249 |
Protocols and materials databases
Antibodypediai | 266, 1120 antibodies from 44 providers |
DNASUi | 3162 |
Genome annotation databases
Ensembli | ENST00000216117.9; ENSP00000216117.8; ENSG00000100292.18 |
GeneIDi | 3162 |
KEGGi | hsa:3162 |
MANE-Selecti | ENST00000216117.9; ENSP00000216117.8; NM_002133.3; NP_002124.1 |
Organism-specific databases
CTDi | 3162 |
DisGeNETi | 3162 |
GeneCardsi | HMOX1 |
HGNCi | HGNC:5013, HMOX1 |
HPAi | ENSG00000100292, Tissue enriched (lymphoid) |
MalaCardsi | HMOX1 |
MIMi | 141250, gene 614034, phenotype |
neXtProti | NX_P09601 |
OpenTargetsi | ENSG00000100292 |
Orphaneti | 586, Cystic fibrosis 562509, Heme oxygenase-1 deficiency |
PharmGKBi | PA29341 |
VEuPathDBi | HostDB:ENSG00000100292 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4480, Eukaryota |
GeneTreei | ENSGT00390000017673 |
HOGENOMi | CLU_057050_0_0_1 |
InParanoidi | P09601 |
OMAi | KKSHTMA |
OrthoDBi | 1424194at2759 |
PhylomeDBi | P09601 |
TreeFami | TF314786 |
Enzyme and pathway databases
BRENDAi | 1.14.14.18, 2681 |
PathwayCommonsi | P09601 |
Reactomei | R-HSA-189483, Heme degradation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-844456, The NLRP3 inflammasome R-HSA-917937, Iron uptake and transport R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9660826, Purinergic signaling in leishmaniasis infection R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707587, Regulation of HMOX1 expression and activity R-HSA-9707616, Heme signaling |
SignaLinki | P09601 |
SIGNORi | P09601 |
Miscellaneous databases
BioGRID-ORCSi | 3162, 17 hits in 1088 CRISPR screens |
ChiTaRSi | HMOX1, human |
EvolutionaryTracei | P09601 |
GeneWikii | HMOX1 |
GenomeRNAii | 3162 |
Pharosi | P09601, Tchem |
PROi | PR:P09601 |
RNActi | P09601, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100292, Expressed in layer of synovial tissue and 192 other tissues |
ExpressionAtlasi | P09601, baseline and differential |
Genevisiblei | P09601, HS |
Family and domain databases
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PIRSFi | PIRSF000343, Haem_Oase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HMOX1_HUMAN | |
Accessioni | P09601Primary (citable) accession number: P09601 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 215 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families