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Entry version 182 (17 Jun 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H2A

Gene

his-3

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:his-3
ORF Names:T10C6.12
AND
Name:his-7
ORF Names:F45F2.4
AND
Name:his-12
ORF Names:ZK131.6
AND
Name:his-16
ORF Names:ZK131.10
AND
Name:his-19
ORF Names:K06C4.11
AND
Name:his-21
ORF Names:K06C4.3
AND
Name:his-30
ORF Names:F35H10.1
AND
Name:his-33
ORF Names:F17E9.13
AND
Name:his-43
ORF Names:F08G2.2
AND
Name:his-47
ORF Names:B0035.7
AND
Name:his-51
ORF Names:F07B7.10
AND
Name:his-53
ORF Names:F07B7.3
AND
Name:his-57
ORF Names:F54E12.5
AND
Name:his-61
ORF Names:F55G1.10
AND
Name:his-65
ORF Names:H02I12.7
AND
Name:his-68
ORF Names:T23D8.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
B0035.7 ; CE04501 ; WBGene00001921 ; his-47
F07B7.10 ; CE04501 ; WBGene00001925 ; his-51
F07B7.3 ; CE04501 ; WBGene00001927 ; his-53
F08G2.2 ; CE04501 ; WBGene00001917 ; his-43
F17E9.13 ; CE04501 ; WBGene00001907 ; his-33
F35H10.1 ; CE04501 ; WBGene00001904 ; his-30
F45F2.4 ; CE04501 ; WBGene00001881 ; his-7
F54E12.5 ; CE04501 ; WBGene00001931 ; his-57
F55G1.10 ; CE04501 ; WBGene00001935 ; his-61
H02I12.7 ; CE04501 ; WBGene00001939 ; his-65
K06C4.11 ; CE04501 ; WBGene00001893 ; his-19
K06C4.3 ; CE04501 ; WBGene00001895 ; his-21
T10C6.12 ; CE04501 ; WBGene00001877 ; his-3
T23D8.6 ; CE04501 ; WBGene00001942 ; his-68
ZK131.10 ; CE04501 ; WBGene00001890 ; his-16
ZK131.6 ; CE04501 ; WBGene00001886 ; his-12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000552102 – 127Histone H2AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine1 Publication1
Modified residuei6N6-acetyllysine; partial1 Publication1
Modified residuei9N6-acetyllysine; partial1 Publication1
Modified residuei11N6-acetyllysine; partial1 Publication1
Modified residuei106N5-methylglutamineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.Curated
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09588

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09588

PRoteomics IDEntifications database

More...
PRIDEi
P09588

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09588

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001877 Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38282, 1 interactor
42639, 1 interactor
45064, 2 interactors
51394, 1 interactor
56170, 1 interactor
56178, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F54E12.5b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09588

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1756 Eukaryota
COG5262 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00990000203707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_062828_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P09588

KEGG Orthology (KO)

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KOi
K11251

Identification of Orthologs from Complete Genome Data

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OMAi
ATHSHEK

Database of Orthologous Groups

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OrthoDBi
1504122at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P09588

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00074 H2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00620 HISTONEH2A

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00414 H2A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09588-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA
110 120
GVTIAQGGVL PNIQAVLLPK KTGGDKE
Length:127
Mass (Da):13,405
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBF085558F1BD340
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J7SA65J7SA65_CAEEL
Histone H2A
his-57 CELE_F54E12.5, F54E12.5
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J7S164J7S164_CAEEL
Histone H2A
his-57 CELE_F54E12.5, F54E12.5
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15633 Genomic DNA Translation: CAA33641.1
FO081169 Genomic DNA Translation: CCD69634.1
FO081135 Genomic DNA Translation: CCD69397.1
FO081551 Genomic DNA Translation: CCD72371.1
FO081551 Genomic DNA Translation: CCD72361.1
FO081223 Genomic DNA Translation: CCD70021.1
Z73102 Genomic DNA Translation: CAA97414.1
Z81128 Genomic DNA Translation: CAB03399.1
Z81495 Genomic DNA Translation: CAB04056.1
Z82271 Genomic DNA Translation: CAB05212.1
Z83245 Genomic DNA Translation: CAB05836.1
Z83245 Genomic DNA Translation: CAB05838.1
Z92789 Genomic DNA Translation: CAB07221.1
Z93388 Genomic DNA Translation: CAB07656.1
FO081059 Genomic DNA Translation: CCD68872.1
FO081059 Genomic DNA Translation: CCD68866.1
FO081018 Genomic DNA Translation: CCD68534.1

Protein sequence database of the Protein Information Resource

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PIRi
S04238 HSKW2A

NCBI Reference Sequences

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RefSeqi
NP_492642.1, NM_060241.4
NP_496887.1, NM_064486.3
NP_496891.1, NM_064490.1
NP_496898.1, NM_064497.1
NP_501201.1, NM_068800.3
NP_501404.1, NM_069003.1
NP_501408.1, NM_069007.1
NP_502131.1, NM_069730.4
NP_502141.1, NM_069740.1
NP_502150.1, NM_069749.1
NP_505198.1, NM_072797.1
NP_505277.1, NM_072876.1
NP_505280.1, NM_072879.1
NP_505293.1, NM_072892.1
NP_505296.1, NM_072895.1
NP_507032.1, NM_074631.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0035.7.1; B0035.7.1; WBGene00001921
F07B7.10.1; F07B7.10.1; WBGene00001925
F07B7.3.1; F07B7.3.1; WBGene00001927
F08G2.2.1; F08G2.2.1; WBGene00001917
F17E9.13.1; F17E9.13.1; WBGene00001907
F35H10.1.1; F35H10.1.1; WBGene00001904
F45F2.4.1; F45F2.4.1; WBGene00001881
F54E12.5a.1; F54E12.5a.1; WBGene00001931
F55G1.10.1; F55G1.10.1; WBGene00001935
H02I12.7.1; H02I12.7.1; WBGene00001939
K06C4.11.1; K06C4.11.1; WBGene00001893
K06C4.3.1; K06C4.3.1; WBGene00001895
T10C6.12.1; T10C6.12.1; WBGene00001877
T23D8.6.1; T23D8.6.1; WBGene00001942
ZK131.10.1; ZK131.10.1; WBGene00001890
ZK131.6.1; ZK131.6.1; WBGene00001886

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172860
175025
175028
175034
177521
178048
178056
179261
179265
180073
184112
186671
191669
191676
191678
259800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0035.7
cel:CELE_F07B7.10
cel:CELE_F07B7.3
cel:CELE_F08G2.2
cel:CELE_F17E9.13
cel:CELE_F35H10.1
cel:CELE_F45F2.4
cel:CELE_F55G1.10
cel:CELE_H02I12.7
cel:CELE_K06C4.11
cel:CELE_K06C4.3
cel:CELE_T10C6.12
cel:CELE_T23D8.6
cel:CELE_ZK131.10
cel:CELE_ZK131.6

UCSC genome browser

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UCSCi
T23D8.6 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA Translation: CAA33641.1
FO081169 Genomic DNA Translation: CCD69634.1
FO081135 Genomic DNA Translation: CCD69397.1
FO081551 Genomic DNA Translation: CCD72371.1
FO081551 Genomic DNA Translation: CCD72361.1
FO081223 Genomic DNA Translation: CCD70021.1
Z73102 Genomic DNA Translation: CAA97414.1
Z81128 Genomic DNA Translation: CAB03399.1
Z81495 Genomic DNA Translation: CAB04056.1
Z82271 Genomic DNA Translation: CAB05212.1
Z83245 Genomic DNA Translation: CAB05836.1
Z83245 Genomic DNA Translation: CAB05838.1
Z92789 Genomic DNA Translation: CAB07221.1
Z93388 Genomic DNA Translation: CAB07656.1
FO081059 Genomic DNA Translation: CCD68872.1
FO081059 Genomic DNA Translation: CCD68866.1
FO081018 Genomic DNA Translation: CCD68534.1
PIRiS04238 HSKW2A
RefSeqiNP_492642.1, NM_060241.4
NP_496887.1, NM_064486.3
NP_496891.1, NM_064490.1
NP_496898.1, NM_064497.1
NP_501201.1, NM_068800.3
NP_501404.1, NM_069003.1
NP_501408.1, NM_069007.1
NP_502131.1, NM_069730.4
NP_502141.1, NM_069740.1
NP_502150.1, NM_069749.1
NP_505198.1, NM_072797.1
NP_505277.1, NM_072876.1
NP_505280.1, NM_072879.1
NP_505293.1, NM_072892.1
NP_505296.1, NM_072895.1
NP_507032.1, NM_074631.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6K00X-ray2.20D10-121[»]
6K03X-ray2.86D10-121[»]
6K09X-ray2.25D10-121[»]
SMRiP09588
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi38282, 1 interactor
42639, 1 interactor
45064, 2 interactors
51394, 1 interactor
56170, 1 interactor
56178, 1 interactor
STRINGi6239.F54E12.5b

PTM databases

iPTMnetiP09588

Proteomic databases

EPDiP09588
PaxDbiP09588
PRIDEiP09588

Genome annotation databases

EnsemblMetazoaiB0035.7.1; B0035.7.1; WBGene00001921
F07B7.10.1; F07B7.10.1; WBGene00001925
F07B7.3.1; F07B7.3.1; WBGene00001927
F08G2.2.1; F08G2.2.1; WBGene00001917
F17E9.13.1; F17E9.13.1; WBGene00001907
F35H10.1.1; F35H10.1.1; WBGene00001904
F45F2.4.1; F45F2.4.1; WBGene00001881
F54E12.5a.1; F54E12.5a.1; WBGene00001931
F55G1.10.1; F55G1.10.1; WBGene00001935
H02I12.7.1; H02I12.7.1; WBGene00001939
K06C4.11.1; K06C4.11.1; WBGene00001893
K06C4.3.1; K06C4.3.1; WBGene00001895
T10C6.12.1; T10C6.12.1; WBGene00001877
T23D8.6.1; T23D8.6.1; WBGene00001942
ZK131.10.1; ZK131.10.1; WBGene00001890
ZK131.6.1; ZK131.6.1; WBGene00001886
GeneIDi172860
175025
175028
175034
177521
178048
178056
179261
179265
180073
184112
186671
191669
191676
191678
259800
KEGGicel:CELE_B0035.7
cel:CELE_F07B7.10
cel:CELE_F07B7.3
cel:CELE_F08G2.2
cel:CELE_F17E9.13
cel:CELE_F35H10.1
cel:CELE_F45F2.4
cel:CELE_F55G1.10
cel:CELE_H02I12.7
cel:CELE_K06C4.11
cel:CELE_K06C4.3
cel:CELE_T10C6.12
cel:CELE_T23D8.6
cel:CELE_ZK131.10
cel:CELE_ZK131.6
UCSCiT23D8.6 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172860
175025
175028
175034
177521
178048
178056
179261
179265
180073
184112
186671
191669
191676
191678
259800
WormBaseiB0035.7 ; CE04501 ; WBGene00001921 ; his-47
F07B7.10 ; CE04501 ; WBGene00001925 ; his-51
F07B7.3 ; CE04501 ; WBGene00001927 ; his-53
F08G2.2 ; CE04501 ; WBGene00001917 ; his-43
F17E9.13 ; CE04501 ; WBGene00001907 ; his-33
F35H10.1 ; CE04501 ; WBGene00001904 ; his-30
F45F2.4 ; CE04501 ; WBGene00001881 ; his-7
F54E12.5 ; CE04501 ; WBGene00001931 ; his-57
F55G1.10 ; CE04501 ; WBGene00001935 ; his-61
H02I12.7 ; CE04501 ; WBGene00001939 ; his-65
K06C4.11 ; CE04501 ; WBGene00001893 ; his-19
K06C4.3 ; CE04501 ; WBGene00001895 ; his-21
T10C6.12 ; CE04501 ; WBGene00001877 ; his-3
T23D8.6 ; CE04501 ; WBGene00001942 ; his-68
ZK131.10 ; CE04501 ; WBGene00001890 ; his-16
ZK131.6 ; CE04501 ; WBGene00001886 ; his-12

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00990000203707
HOGENOMiCLU_062828_3_1_1
InParanoidiP09588
KOiK11251
OMAiATHSHEK
OrthoDBi1504122at2759
PhylomeDBiP09588

Miscellaneous databases

Protein Ontology

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PROi
PR:P09588

Gene expression databases

BgeeiWBGene00001877 Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2A_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09588
Secondary accession number(s): Q7JKF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 17, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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