UniProtKB - P09581 (CSF1R_MOUSE)
Macrophage colony-stimulating factor 1 receptor
Csf1r
Functioni
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity).
Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (By similarity).
By similarity16 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation3 PublicationsEC:2.7.10.1PROSITE-ProRule annotation3 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 614 | ATPCurated | 1 | |
Active sitei | 776 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 586 – 594 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cytokine binding Source: UniProtKB
- macrophage colony-stimulating factor receptor activity Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- protein phosphatase binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- transmembrane receptor protein tyrosine kinase activity Source: MGI
GO - Biological processi
- axon guidance Source: ParkinsonsUK-UCL
- cell-cell junction maintenance Source: MGI
- cell population proliferation Source: MGI
- cellular response to cytokine stimulus Source: UniProtKB
- cellular response to macrophage colony-stimulating factor stimulus Source: UniProtKB
- cytokine-mediated signaling pathway Source: MGI
- dentate gyrus development Source: MGI
- forebrain neuron differentiation Source: ParkinsonsUK-UCL
- hematopoietic progenitor cell differentiation Source: GO_Central
- hemopoiesis Source: MGI
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- macrophage colony-stimulating factor signaling pathway Source: BHF-UCL
- microglia development Source: MGI
- microglial cell proliferation Source: ARUK-UCL
- negative regulation of apoptotic process Source: ParkinsonsUK-UCL
- negative regulation of cell population proliferation Source: ParkinsonsUK-UCL
- neuron projection extension Source: MGI
- olfactory bulb development Source: ParkinsonsUK-UCL
- osteoclast differentiation Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: UniProtKB
- phosphatidylinositol metabolic process Source: UniProtKB
- positive regulation by host of viral process Source: ARUK-UCL
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell motility Source: MGI
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of chemokine production Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of macrophage chemotaxis Source: MGI
- positive regulation of macrophage proliferation Source: MGI
- positive regulation of osteoclast differentiation Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- positive regulation of protein tyrosine kinase activity Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of actin cytoskeleton reorganization Source: UniProtKB
- regulation of bone resorption Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of mononuclear cell proliferation Source: MGI
- response to ischemia Source: ARUK-UCL
- ruffle organization Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Immunity, Inflammatory response, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-449836, Other interleukin signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Macrophage colony-stimulating factor 1 receptorAlternative name(s): Proto-oncogene c-Fms CD_antigen: CD115 |
Gene namesi | Name:Csf1r Synonyms:Csfmr, Fms |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339758, Csf1r |
VEuPathDBi | HostDB:ENSMUSG00000024621 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications
Note: The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cell surface Source: UniProtKB
- CSF1-CSF1R complex Source: BHF-UCL
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 515 | ExtracellularSequence analysisAdd BLAST | 496 | |
Transmembranei | 516 – 536 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 537 – 977 | CytoplasmicSequence analysisAdd BLAST | 441 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 544 | Y → F: No effect on binding to THOC5. 1 Publication | 1 | |
Mutagenesisi | 559 | Y → F: Reduced interaction with CBL. Prolonged signaling, due to reduced internalization and degradation. Reduced interaction with FYN. Promotes cell proliferation. Reduced autophosphorylation at Tyr-807. 3 Publications | 1 | |
Mutagenesisi | 614 | K → A: Loss of kinase activity. 3 Publications | 1 | |
Mutagenesisi | 614 | K → M: Loss of kinase activity. Abolishes binding to THOC5. 3 Publications | 1 | |
Mutagenesisi | 697 | Y → F: Abolishes interaction with GRB2. 2 Publications | 1 | |
Mutagenesisi | 706 | Y → F: No effect on binding to THOC5. Slightly reduced enhancement of cell proliferation. 2 Publications | 1 | |
Mutagenesisi | 706 | Y → G: Slightly impaired signaling. 2 Publications | 1 | |
Mutagenesisi | 721 | Y → F: Abolishes interaction with PIK3R1. Strongly reduced phosphorylation of PLCG2. No effect on binding to THOC5. 4 Publications | 1 | |
Mutagenesisi | 807 | Y → F: Reduced kinase activity. Strongly reduced phosphorylation of PLCG2. Diminishes binding to THOC5. 3 Publications | 1 | |
Mutagenesisi | 807 | Y → G: May alter protein folding or stability. Loss of kinase activity. No effect on interaction with PIK3R1. 3 Publications | 1 |
Keywords - Diseasei
Proto-oncogeneChemistry databases
ChEMBLi | CHEMBL5570 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000016766 | 20 – 977 | Macrophage colony-stimulating factor 1 receptorAdd BLAST | 958 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 84 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 45 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 73 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 127 ↔ 177 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 224 ↔ 278 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 302 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 335 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 417 ↔ 483 | PROSITE-ProRule annotation | ||
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 478 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 491 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 544 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 559 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 697 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 706 | Phosphotyrosine; by autocatalysis4 Publications | 1 | |
Modified residuei | 711 | PhosphoserineCombined sources | 1 | |
Modified residuei | 721 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 807 | Phosphotyrosine; by autocatalysis5 Publications | 1 | |
Modified residuei | 921 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 974 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | non-CPTAC-3547 non-CPTAC-3548 |
PaxDbi | P09581 |
PeptideAtlasi | P09581 |
PRIDEi | P09581 |
ProteomicsDBi | 285343 |
PTM databases
GlyGeni | P09581, 9 sites |
iPTMneti | P09581 |
PhosphoSitePlusi | P09581 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000024621, Expressed in placenta and 317 other tissues |
ExpressionAtlasi | P09581, baseline and differential |
Genevisiblei | P09581, MM |
Interactioni
Subunit structurei
Monomer. Homodimer.
Interacts with CSF1 and IL34. Interaction with dimeric CSF1 or IL34 leads to receptor homodimerization.
Interacts with INPPL1/SHIP2 and THOC5.
Interacts (tyrosine phosphorylated) with PLCG2 (via SH2 domain).
Interacts (tyrosine phosphorylated) with PIK3R1 (via SH2 domain).
Interacts (tyrosine phosphorylated) with FYN, YES1 and SRC (via SH2 domain).
Interacts (tyrosine phosphorylated) with CBL, GRB2 and SLA2.
10 PublicationsBinary interactionsi
P09581
With | #Exp. | IntAct |
---|---|---|
Csf1 [P07141] | 6 | EBI-6305373,EBI-777188 |
CSF1 [P09603] from Homo sapiens. | 2 | EBI-6305373,EBI-2872294 |
GO - Molecular functioni
- cytokine binding Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198928, 21 interactors |
DIPi | DIP-46415N |
IntActi | P09581, 8 interactors |
MINTi | P09581 |
STRINGi | 10090.ENSMUSP00000025523 |
Chemistry databases
BindingDBi | P09581 |
Miscellaneous databases
RNActi | P09581, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P09581 |
SMRi | P09581 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09581 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 104 | Ig-like C2-type 1Add BLAST | 81 | |
Domaini | 107 – 197 | Ig-like C2-type 2Add BLAST | 91 | |
Domaini | 204 – 298 | Ig-like C2-type 3Add BLAST | 95 | |
Domaini | 299 – 397 | Ig-like C2-type 4Add BLAST | 99 | |
Domaini | 398 – 503 | Ig-like C2-type 5Add BLAST | 106 | |
Domaini | 580 – 913 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 334 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 540 – 572 | Regulatory juxtamembrane domainBy similarityAdd BLAST | 33 | |
Regioni | 794 – 816 | Activation loopBy similarityAdd BLAST | 23 | |
Regioni | 921 – 957 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 923 – 947 | Polar residuesSequence analysisAdd BLAST | 25 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000155506 |
HOGENOMi | CLU_000288_49_0_1 |
InParanoidi | P09581 |
OMAi | EQLACCE |
OrthoDBi | 236292at2759 |
PhylomeDBi | P09581 |
TreeFami | TF325768 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR030658, CSF-1_receptor IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500947, CSF-1_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MELGPPLVLL LATVWHGQGA PVIEPSGPEL VVEPGETVTL RCVSNGSVEW
60 70 80 90 100
DGPISPYWTL DPESPGSTLT TRNATFKNTG TYRCTELEDP MAGSTTIHLY
110 120 130 140 150
VKDPAHSWNL LAQEVTVVEG QEAVLPCLIT DPALKDSVSL MREGGRQVLR
160 170 180 190 200
KTVYFFSPWR GFIIRKAKVL DSNTYVCKTM VNGRESTSTG IWLKVNRVHP
210 220 230 240 250
EPPQIKLEPS KLVRIRGEAA QIVCSATNAE VGFNVILKRG DTKLEIPLNS
260 270 280 290 300
DFQDNYYKKV RALSLNAVDF QDAGIYSCVA SNDVGTRTAT MNFQVVESAY
310 320 330 340 350
LNLTSEQSLL QEVSVGDSLI LTVHADAYPS IQHYNWTYLG PFFEDQRKLE
360 370 380 390 400
FITQRAIYRY TFKLFLNRVK ASEAGQYFLM AQNKAGWNNL TFELTLRYPP
410 420 430 440 450
EVSVTWMPVN GSDVLFCDVS GYPQPSVTWM ECRGHTDRCD EAQALQVWND
460 470 480 490 500
THPEVLSQKP FDKVIIQSQL PIGTLKHNMT YFCKTHNSVG NSSQYFRAVS
510 520 530 540 550
LGQSKQLPDE SLFTPVVVAC MSVMSLLVLL LLLLLYKYKQ KPKYQVRWKI
560 570 580 590 600
IERYEGNSYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF
610 620 630 640 650
GLGKEDAVLK VAVKMLKSTA HADEKEALMS ELKIMSHLGQ HENIVNLLGA
660 670 680 690 700
CTHGGPVLVI TEYCCYGDLL NFLRRKAEAM LGPSLSPGQD SEGDSSYKNI
710 720 730 740 750
HLEKKYVRRD SGFSSQGVDT YVEMRPVSTS SSDSFFKQDL DKEASRPLEL
760 770 780 790 800
WDLLHFSSQV AQGMAFLASK NCIHRDVAAR NVLLTSGHVA KIGDFGLARD
810 820 830 840 850
IMNDSNYVVK GNARLPVKWM APESIFDCVY TVQSDVWSYG ILLWEIFSLG
860 870 880 890 900
LNPYPGILVN NKFYKLVKDG YQMAQPVFAP KNIYSIMQSC WDLEPTRRPT
910 920 930 940 950
FQQICFLLQE QARLERRDQD YANLPSSGGS SGSDSGGGSS GGSSSEPEEE
960 970
SSSEHLACCE PGDIAQPLLQ PNNYQFC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BBK8 | A0A494BBK8_MOUSE | Macrophage colony-stimulating facto... | Csf1r | 139 | Annotation score: | ||
A0A494BA23 | A0A494BA23_MOUSE | Macrophage colony-stimulating facto... | Csf1r | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | Y → I in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 72 | R → S in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 162 | F → S in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 446 – 447 | QV → HL in CAA29666 (PubMed:2966922).Curated | 2 | |
Sequence conflicti | 474 | T → P in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 660 | I → Y in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 669 | L → H in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 744 | A → H in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 814 | Missing in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 830 | Y → I in CAA29666 (PubMed:2966922).Curated | 1 | |
Sequence conflicti | 858 | L → H in CAA29666 (PubMed:2966922).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06368 mRNA Translation: CAA29666.1 AK004947 mRNA Translation: BAB23691.1 AK079247 mRNA Translation: BAC37587.1 AK143545 mRNA Translation: BAE25430.1 AK154653 mRNA Translation: BAE32744.1 BC043054 mRNA Translation: AAH43054.1 S62219 Genomic DNA No translation available. |
CCDSi | CCDS29280.1 |
PIRi | S01880, TVMSMD |
RefSeqi | NP_001032948.2, NM_001037859.2 XP_006525647.1, XM_006525584.1 XP_006525648.1, XM_006525585.3 XP_006525649.1, XM_006525586.3 XP_017173299.1, XM_017317810.1 |
Genome annotation databases
Ensembli | ENSMUST00000025523; ENSMUSP00000025523; ENSMUSG00000024621 ENSMUST00000115268; ENSMUSP00000110923; ENSMUSG00000024621 |
GeneIDi | 12978 |
KEGGi | mmu:12978 |
UCSCi | uc008fbn.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06368 mRNA Translation: CAA29666.1 AK004947 mRNA Translation: BAB23691.1 AK079247 mRNA Translation: BAC37587.1 AK143545 mRNA Translation: BAE25430.1 AK154653 mRNA Translation: BAE32744.1 BC043054 mRNA Translation: AAH43054.1 S62219 Genomic DNA No translation available. |
CCDSi | CCDS29280.1 |
PIRi | S01880, TVMSMD |
RefSeqi | NP_001032948.2, NM_001037859.2 XP_006525647.1, XM_006525584.1 XP_006525648.1, XM_006525585.3 XP_006525649.1, XM_006525586.3 XP_017173299.1, XM_017317810.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EJJ | X-ray | 2.40 | X | 20-296 | [»] | |
4EXP | X-ray | 2.80 | X | 20-298 | [»] | |
AlphaFoldDBi | P09581 | |||||
SMRi | P09581 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198928, 21 interactors |
DIPi | DIP-46415N |
IntActi | P09581, 8 interactors |
MINTi | P09581 |
STRINGi | 10090.ENSMUSP00000025523 |
Chemistry databases
BindingDBi | P09581 |
ChEMBLi | CHEMBL5570 |
PTM databases
GlyGeni | P09581, 9 sites |
iPTMneti | P09581 |
PhosphoSitePlusi | P09581 |
Proteomic databases
CPTACi | non-CPTAC-3547 non-CPTAC-3548 |
PaxDbi | P09581 |
PeptideAtlasi | P09581 |
PRIDEi | P09581 |
ProteomicsDBi | 285343 |
Protocols and materials databases
Antibodypediai | 1201, 1894 antibodies from 45 providers |
DNASUi | 12978 |
Genome annotation databases
Ensembli | ENSMUST00000025523; ENSMUSP00000025523; ENSMUSG00000024621 ENSMUST00000115268; ENSMUSP00000110923; ENSMUSG00000024621 |
GeneIDi | 12978 |
KEGGi | mmu:12978 |
UCSCi | uc008fbn.1, mouse |
Organism-specific databases
CTDi | 1436 |
MGIi | MGI:1339758, Csf1r |
VEuPathDBi | HostDB:ENSMUSG00000024621 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000155506 |
HOGENOMi | CLU_000288_49_0_1 |
InParanoidi | P09581 |
OMAi | EQLACCE |
OrthoDBi | 236292at2759 |
PhylomeDBi | P09581 |
TreeFami | TF325768 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-449836, Other interleukin signaling |
Miscellaneous databases
BioGRID-ORCSi | 12978, 2 hits in 74 CRISPR screens |
ChiTaRSi | Csf1r, mouse |
EvolutionaryTracei | P09581 |
PROi | PR:P09581 |
RNActi | P09581, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024621, Expressed in placenta and 317 other tissues |
ExpressionAtlasi | P09581, baseline and differential |
Genevisiblei | P09581, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR030658, CSF-1_receptor IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500947, CSF-1_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSF1R_MOUSE | |
Accessioni | P09581Primary (citable) accession number: P09581 Secondary accession number(s): Q3U3P1, Q9DBH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | May 10, 2002 | |
Last modified: | May 25, 2022 | |
This is version 232 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families