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UniProtKB - P09546 (PUTA_ECOLI)

Entry version 203 (07 Apr 2021)
Sequence version 3 (01 Nov 1997)
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Protein

Bifunctional protein PutA

Gene

putA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (putA), Bifunctional protein PutA (putA)
  2. Bifunctional protein PutA (putA), Bifunctional protein PutA (putA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei883By similarity1
Active sitei917By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Multifunctional enzyme, Oxidoreductase, Repressor
Biological processProline metabolism, Transcription, Transcription regulation
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PUTA-MONOMER
MetaCyc:PUTA-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.2.1.88, 2026
1.5.5.2, 2026

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00261;UER00373
UPA00261;UER00374

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P09546

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional protein PutA
Including the following 2 domains:
Proline dehydrogenase (EC:1.5.5.2)
Alternative name(s):
Proline oxidase
Delta-1-pyrroline-5-carboxylate dehydrogenase (EC:1.2.1.88)
Short name:
P5C dehydrogenase
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:putA
Synonyms:poaA
Ordered Locus Names:b1014, JW0999
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03051, (S)-2-Tetrahydrofuroic acid
DB03147, Flavin adenine dinucleotide
DB04398, Lactic acid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000565241 – 1320Bifunctional protein PutAAdd BLAST1320

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09546

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09546

PRoteomics IDEntifications database

More...PRIDEi		P09546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By proline, autorepression and catabolite repression, and is potentially nitrogen controlled.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P09546
With#Exp.IntAct
itself5EBI-369718,EBI-369718

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262846, 27 interactors
849974, 1 interactor

Database of interacting proteins

More...DIPi		DIP-10620N

Protein interaction database and analysis system

More...IntActi		P09546, 24 interactors

Molecular INTeraction database

More...MINTi		P09546

STRING: functional protein association networks

More...STRINGi		511145.b1014

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09546

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09546

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni228 – 574Proline dehydrogenaseAdd BLAST347
Regioni653 – 1119Aldehyde dehydrogenaseAdd BLAST467

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the proline dehydrogenase family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0506, Bacteria
COG3905, Bacteria
COG4230, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005682_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09546

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09546

Family and domain databases

Database of protein disorder

More...DisProti		DP02030

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1220.10, 1 hit
1.20.5.550, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR013321, Arc_rbn_hlx_hlx
IPR025703, Bifunct_PutA
IPR005933, Delta1-pyrroline-5-COlate_DH-3
IPR029041, FAD-linked_oxidoreductase-like
IPR041349, PRODH
IPR024090, PRODH_PutA_dom_I
IPR024089, PRODH_PutA_dom_I/II
IPR024082, PRODH_PutA_dom_II
IPR002872, Proline_DH_dom
IPR010985, Ribbon_hlx_hlx

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF14850, Pro_dh-DNA_bdg, 1 hit
PF18327, PRODH, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000197, Bifunct_PutA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47598, SSF47598, 1 hit
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
SSF81935, SSF81935, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01238, D1pyr5carbox3, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P09546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTTTMGVKL DDATRERIKS AATRIDRTPH WLIKQAIFSY LEQLENSDTL 
        60         70         80         90        100
PELPALLSGA ANESDEAPTP AEEPHQPFLD FAEQILPQSV SRAAITAAYR 
       110        120        130        140        150
RPETEAVSML LEQARLPQPV AEQAHKLAYQ LADKLRNQKN ASGRAGMVQG 
       160        170        180        190        200
LLQEFSLSSQ EGVALMCLAE ALLRIPDKAT RDALIRDKIS NGNWQSHIGR 
       210        220        230        240        250
SPSLFVNAAT WGLLFTGKLV STHNEASLSR SLNRIIGKSG EPLIRKGVDM 
       260        270        280        290        300
AMRLMGEQFV TGETIAEALA NARKLEEKGF RYSYDMLGEA ALTAADAQAY 
       310        320        330        340        350
MVSYQQAIHA IGKASNGRGI YEGPGISIKL SALHPRYSRA QYDRVMEELY 
       360        370        380        390        400
PRLKSLTLLA RQYDIGINID AEESDRLEIS LDLLEKLCFE PELAGWNGIG 
       410        420        430        440        450
FVIQAYQKRC PLVIDYLIDL ATRSRRRLMI RLVKGAYWDS EIKRAQMDGL 
       460        470        480        490        500
EGYPVYTRKV YTDVSYLACA KKLLAVPNLI YPQFATHNAH TLAAIYQLAG 
       510        520        530        540        550
QNYYPGQYEF QCLHGMGEPL YEQVTGKVAD GKLNRPCRIY APVGTHETLL 
       560        570        580        590        600
AYLVRRLLEN GANTSFVNRI ADTSLPLDEL VADPVTAVEK LAQQEGQTGL 
       610        620        630        640        650
PHPKIPLPRD LYGHGRDNSA GLDLANEHRL ASLSSALLNS ALQKWQALPM 
       660        670        680        690        700
LEQPVAAGEM SPVINPAEPK DIVGYVREAT PREVEQALES AVNNAPIWFA 
       710        720        730        740        750
TPPAERAAIL HRAAVLMESQ MQQLIGILVR EAGKTFSNAI AEVREAVDFL 
       760        770        780        790        800
HYYAGQVRDD FANETHRPLG PVVCISPWNF PLAIFTGQIA AALAAGNSVL 
       810        820        830        840        850
AKPAEQTPLI AAQGIAILLE AGVPPGVVQL LPGRGETVGA QLTGDDRVRG 
       860        870        880        890        900
VMFTGSTEVA TLLQRNIASR LDAQGRPIPL IAETGGMNAM IVDSSALTEQ 
       910        920        930        940        950
VVVDVLASAF DSAGQRCSAL RVLCLQDEIA DHTLKMLRGA MAECRMGNPG 
       960        970        980        990       1000
RLTTDIGPVI DSEAKANIER HIQTMRSKGR PVFQAVRENS EDAREWQSGT 
      1010       1020       1030       1040       1050
FVAPTLIELD DFAELQKEVF GPVLHVVRYN RNQLPELIEQ INASGYGLTL 
      1060       1070       1080       1090       1100
GVHTRIDETI AQVTGSAHVG NLYVNRNMVG AVVGVQPFGG EGLSGTGPKA 
      1110       1120       1130       1140       1150
GGPLYLYRLL ANRPESALAV TLARQDAKYP VDAQLKAALT QPLNALREWA 
      1160       1170       1180       1190       1200
ANRPELQALC TQYGELAQAG TQRLLPGPTG ERNTWTLLPR ERVLCIADDE 
      1210       1220       1230       1240       1250
QDALTQLAAV LAVGSQVLWP DDALHRQLVK ALPSAVSERI QLAKAENITA 
      1260       1270       1280       1290       1300
QPFDAVIFHG DSDQLRALCE AVAARDGTIV SVQGFARGES NILLERLYIE 
      1310       1320
RSLSVNTAAA GGNASLMTIG
Length:1,320
Mass (Da):143,815
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4920143D536F7F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti531G → A in AAB59985 (PubMed:7966312).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U05212 Genomic DNA Translation: AAB59985.1
U00096 Genomic DNA Translation: AAC74099.1
AP009048 Genomic DNA Translation: BAA35791.1
X05653 Genomic DNA Translation: CAA29141.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		D64843

NCBI Reference Sequences

More...RefSeqi		NP_415534.1, NC_000913.3
WP_001326840.1, NZ_SSZK01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74099; AAC74099; b1014
BAA35791; BAA35791; BAA35791

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57731805
945600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0999
eco:b1014

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1257

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05212 Genomic DNA Translation: AAB59985.1
U00096 Genomic DNA Translation: AAC74099.1
AP009048 Genomic DNA Translation: BAA35791.1
X05653 Genomic DNA Translation: CAA29141.1 Sequence problems.
PIRiD64843
RefSeqiNP_415534.1, NC_000913.3
WP_001326840.1, NZ_SSZK01000002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TIWX-ray2.00A86-669[»]
1TJ0X-ray2.10A86-669[»]
1TJ1X-ray2.00A86-669[»]
1TJ2X-ray2.05A86-669[»]
2AY0X-ray2.10A/B/C/D/E/F1-52[»]
2FZMX-ray2.30A86-669[»]
2FZNX-ray2.00A86-669[»]
2GPEX-ray1.90A/B/C/D1-52[»]
2RBFX-ray2.25A/B1-52[»]
3E2QX-ray1.75A86-630[»]
3E2RX-ray1.85A86-630[»]
3E2SX-ray2.00A86-630[»]
3ITGX-ray2.15A/B86-669[»]
4JNYX-ray1.90A86-669[»]
4JNZX-ray1.85A86-669[»]
4O8AX-ray2.00A1-669[»]
SMRiP09546
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4262846, 27 interactors
849974, 1 interactor
DIPiDIP-10620N
IntActiP09546, 24 interactors
MINTiP09546
STRINGi511145.b1014

Chemistry databases

DrugBankiDB03051, (S)-2-Tetrahydrofuroic acid
DB03147, Flavin adenine dinucleotide
DB04398, Lactic acid

Protein family/group databases

MoonProtiP09546

Proteomic databases

jPOSTiP09546
PaxDbiP09546
PRIDEiP09546

Genome annotation databases

EnsemblBacteriaiAAC74099; AAC74099; b1014
BAA35791; BAA35791; BAA35791
GeneIDi57731805
945600
KEGGiecj:JW0999
eco:b1014
PATRICifig|1411691.4.peg.1257

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0794

Phylogenomic databases

eggNOGiCOG0506, Bacteria
COG3905, Bacteria
COG4230, Bacteria
HOGENOMiCLU_005682_1_0_6
InParanoidiP09546
PhylomeDBiP09546

Enzyme and pathway databases

UniPathwayiUPA00261;UER00373
UPA00261;UER00374
BioCyciEcoCyc:PUTA-MONOMER
MetaCyc:PUTA-MONOMER
BRENDAi1.2.1.88, 2026
1.5.5.2, 2026

Miscellaneous databases

EvolutionaryTraceiP09546

Protein Ontology

More...PROi		PR:P09546

Family and domain databases

DisProtiDP02030
Gene3Di1.10.1220.10, 1 hit
1.20.5.550, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR013321, Arc_rbn_hlx_hlx
IPR025703, Bifunct_PutA
IPR005933, Delta1-pyrroline-5-COlate_DH-3
IPR029041, FAD-linked_oxidoreductase-like
IPR041349, PRODH
IPR024090, PRODH_PutA_dom_I
IPR024089, PRODH_PutA_dom_I/II
IPR024082, PRODH_PutA_dom_II
IPR002872, Proline_DH_dom
IPR010985, Ribbon_hlx_hlx
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF14850, Pro_dh-DNA_bdg, 1 hit
PF18327, PRODH, 1 hit
PIRSFiPIRSF000197, Bifunct_PutA, 1 hit
SUPFAMiSSF47598, SSF47598, 1 hit
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
SSF81935, SSF81935, 1 hit
TIGRFAMsiTIGR01238, D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUTA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09546
Secondary accession number(s): P78296
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: April 7, 2021
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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