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Protein

Protein Wnt-2

Gene

WNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • frizzled binding Source: UniProtKB
  • receptor ligand activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • atrial cardiac muscle tissue morphogenesis Source: Ensembl
  • canonical Wnt signaling pathway Source: BHF-UCL
  • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • cardiac epithelial to mesenchymal transition Source: Ensembl
  • cell-cell signaling Source: BHF-UCL
  • cell fate commitment Source: GO_Central
  • cell proliferation in midbrain Source: ParkinsonsUK-UCL
  • cellular response to retinoic acid Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • iris morphogenesis Source: BHF-UCL
  • labyrinthine layer blood vessel development Source: Ensembl
  • lens development in camera-type eye Source: BHF-UCL
  • lung development Source: Ensembl
  • lung induction Source: Ensembl
  • mammary gland epithelium development Source: UniProtKB
  • midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • neurogenesis Source: ParkinsonsUK-UCL
  • neuron differentiation Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of cardiac muscle cell proliferation Source: Ensembl
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: Ensembl
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  • positive regulation of fibroblast proliferation Source: BHF-UCL
  • positive regulation of mesenchymal cell proliferation Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
  • Wnt signaling pathway Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SignaLinkiP09544
SIGNORiP09544

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Alternative name(s):
Int-1-like protein 1
Int-1-related protein
Short name:
IRP
Gene namesi
Name:WNT2
Synonyms:INT1L1, IRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105989.8
HGNCiHGNC:12780 WNT2
MIMi147870 gene
neXtProtiNX_P09544

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7472
OpenTargetsiENSG00000105989
PharmGKBiPA37381

Chemistry databases

ChEMBLiCHEMBL1255132

Polymorphism and mutation databases

BioMutaiWNT2
DMDMi139750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004141026 – 360Protein Wnt-2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 87By similarity
Disulfide bondi127 ↔ 135By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP09544
PeptideAtlasiP09544
PRIDEiP09544
ProteomicsDBi52246

PTM databases

iPTMnetiP09544
PhosphoSitePlusiP09544

Expressioni

Tissue specificityi

Expressed in brain in the thalamus, in fetal and adult lung and in placenta.1 Publication

Gene expression databases

BgeeiENSG00000105989
CleanExiHS_WNT2
ExpressionAtlasiP09544 baseline and differential
GenevisibleiP09544 HS

Organism-specific databases

HPAiHPA020920

Interactioni

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • frizzled binding Source: UniProtKB
  • receptor ligand activity Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi113309, 7 interactors
IntActiP09544, 5 interactors
STRINGi9606.ENSP00000265441

Structurei

3D structure databases

ProteinModelPortaliP09544
SMRiP09544
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiP09544
KOiK00182
OMAiHTCKPHK
OrthoDBiEOG091G0OFF
PhylomeDBiP09544
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS
60 70 80 90 100
QRQLCHRHPD VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV
110 120 130 140 150
LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSAKDSKG
160 170 180 190 200
IFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR
210 220 230 240 250
FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG
260 270 280 290 300
TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG
310 320 330 340 350
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA
360
PKNADWTTAT
Length:360
Mass (Da):40,418
Last modified:July 1, 1989 - v1
Checksum:iAA96325BF68C4788
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0138655L → R1 PublicationCorresponds to variant dbSNP:rs145839592Ensembl.1
Natural variantiVAR_052954294C → F. Corresponds to variant dbSNP:rs1051751Ensembl.1
Natural variantiVAR_013866299R → W1 PublicationCorresponds to variant dbSNP:rs148046128Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07876 mRNA Translation: CAA30725.1
AK056742 mRNA Translation: BAG51800.1
BT019608 mRNA Translation: AAV38415.1
AC002465 Genomic DNA Translation: AAB67043.1
AC006326 Genomic DNA Translation: AAD28351.1
CH236947 Genomic DNA Translation: EAL24355.1
CH471070 Genomic DNA Translation: EAW83525.1
BC029854 mRNA Translation: AAH29854.1
BC078170 mRNA Translation: AAH78170.1
CCDSiCCDS5771.1
PIRiS00834
RefSeqiNP_003382.1, NM_003391.2
UniGeneiHs.567356

Genome annotation databases

EnsembliENST00000265441; ENSP00000265441; ENSG00000105989
GeneIDi7472
KEGGihsa:7472
UCSCiuc003viz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWNT2_HUMAN
AccessioniPrimary (citable) accession number: P09544
Secondary accession number(s): A4D0V1, Q75N05, Q9UDP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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