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Protein

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene

CNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei251Proton acceptor1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei253Substrate1
Active sitei330Proton donor1
Binding sitei332Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Source: GO_Central
  • cyclic nucleotide binding Source: Ensembl
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.37 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC:3.1.4.37)
Short name:
CNP
Short name:
CNPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173786.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2158 CNP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1267

Open Targets

More...
OpenTargetsi
ENSG00000173786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26680

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1705945

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899611 – 4182',3'-cyclic-nucleotide 3'-phosphodiesteraseAdd BLAST418
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000422296419 – 421Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei110PhosphotyrosineBy similarity1
Modified residuei170PhosphoserineCombined sources1
Modified residuei359PhosphoserineBy similarity1
Modified residuei418Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi418S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09543

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09543

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09543

PeptideAtlas

More...
PeptideAtlasi
P09543

PRoteomics IDEntifications database

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PRIDEi
P09543

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52244
52245 [P09543-2]

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P09543

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09543

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173786 Expressed in 237 organ(s), highest expression level in occipital lobe

CleanEx database of gene expression profiles

More...
CleanExi
HS_CNP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09543 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09543 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002672
HPA023266
HPA023278
HPA023280
HPA023338

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists as monomers and homodimers.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107667, 25 interactors

Protein interaction database and analysis system

More...
IntActi
P09543, 42 interactors

Molecular INTeraction database

More...
MINTi
P09543

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377470

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOJX-ray1.80A186-399[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P09543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09543

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09543

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IT06 Eukaryota
ENOG4111F3B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111838

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001451

KEGG Orthology (KO)

More...
KOi
K01121

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWPNDVD

Database of Orthologous Groups

More...
OrthoDBi
1248632at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09543

TreeFam database of animal gene trees

More...
TreeFami
TF332157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008431 CNPase
IPR009097 cNuc_Pdiesterase
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10156 PTHR10156, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05881 CNPase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000970 CNPase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF55144 SSF55144, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform CNPII (identifier: P09543-1) [UniParc]FASTAAdd to basket
Also known as: DNAII

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK
60 70 80 90 100
TLFILRGLPG SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY
110 120 130 140 150
KRLDEDLAAY CRRRDIRILV LDDTNHERER LEQLFEMADQ YQYQVVLVEP
160 170 180 190 200
KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG LEKDFLPLYF GWFLTKKSSE
210 220 230 240 250
TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT YFGKRPPGVL
260 270 280 290 300
HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV
310 320 330 340 350
ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE
360 370 380 390 400
ILRQEKGGSR GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK
410 420
GKPVPTQGSR KGGALQSCTI I
Length:421
Mass (Da):47,579
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA6D0097DFD87255
GO
Isoform CNPI (identifier: P09543-2) [UniParc]FASTAAdd to basket
Also known as: DNAI

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:401
Mass (Da):45,099
Checksum:i81F0E080822D3B0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERC4K7ERC4_HUMAN
2',3'-cyclic-nucleotide 3'-phosphod...
CNP
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0L8C9K0L8_HUMAN
2',3'-cyclic-nucleotide 3'-phosphod...
CNP
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERZ0K7ERZ0_HUMAN
2',3'-cyclic-nucleotide 3'-phosphod...
CNP
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN66K7EN66_HUMAN
2',3'-cyclic-nucleotide 3'-phosphod...
CNP
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ27K7EQ27_HUMAN
2',3'-cyclic-nucleotide 3'-phosphod...
CNP
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033746207Q → R. Corresponds to variant dbSNP:rs34353668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0041711 – 20Missing in isoform CNPI. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S46849
, S46843, S46845, S46846 Genomic DNA Translation: AAB23928.2
M19650 mRNA Translation: AAA35704.1
D13146 Genomic DNA Translation: BAA39694.1
D13146 Genomic DNA Translation: BAA02435.1
S50017
, S50013, S50014, S50016 Genomic DNA Translation: AAB24298.2
AC125257 Genomic DNA No translation available.
BC001362 mRNA Translation: AAH01362.1
BC006392 mRNA Translation: AAH06392.1
BC011046 mRNA Translation: AAH11046.1
BC028040 mRNA Translation: AAH28040.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11414.2 [P09543-1]
CCDS82123.1 [P09543-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1517

NCBI Reference Sequences

More...
RefSeqi
NP_001317145.1, NM_001330216.1 [P09543-2]
NP_149124.3, NM_033133.4 [P09543-1]
XP_011522642.1, XM_011524340.2 [P09543-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.273621

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393888; ENSP00000377466; ENSG00000173786 [P09543-2]
ENST00000393892; ENSP00000377470; ENSG00000173786 [P09543-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1267

UCSC genome browser

More...
UCSCi
uc002hyl.2 human [P09543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46849
, S46843, S46845, S46846 Genomic DNA Translation: AAB23928.2
M19650 mRNA Translation: AAA35704.1
D13146 Genomic DNA Translation: BAA39694.1
D13146 Genomic DNA Translation: BAA02435.1
S50017
, S50013, S50014, S50016 Genomic DNA Translation: AAB24298.2
AC125257 Genomic DNA No translation available.
BC001362 mRNA Translation: AAH01362.1
BC006392 mRNA Translation: AAH06392.1
BC011046 mRNA Translation: AAH11046.1
BC028040 mRNA Translation: AAH28040.1
CCDSiCCDS11414.2 [P09543-1]
CCDS82123.1 [P09543-2]
PIRiJC1517
RefSeqiNP_001317145.1, NM_001330216.1 [P09543-2]
NP_149124.3, NM_033133.4 [P09543-1]
XP_011522642.1, XM_011524340.2 [P09543-2]
UniGeneiHs.273621

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOJX-ray1.80A186-399[»]
ProteinModelPortaliP09543
SMRiP09543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107667, 25 interactors
IntActiP09543, 42 interactors
MINTiP09543
STRINGi9606.ENSP00000377470

PTM databases

iPTMnetiP09543
PhosphoSitePlusiP09543
SwissPalmiP09543

Polymorphism and mutation databases

BioMutaiCNP
DMDMi1705945

2D gel databases

UCD-2DPAGEiP09543

Proteomic databases

EPDiP09543
jPOSTiP09543
MaxQBiP09543
PaxDbiP09543
PeptideAtlasiP09543
PRIDEiP09543
ProteomicsDBi52244
52245 [P09543-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1267
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393888; ENSP00000377466; ENSG00000173786 [P09543-2]
ENST00000393892; ENSP00000377470; ENSG00000173786 [P09543-1]
GeneIDi1267
KEGGihsa:1267
UCSCiuc002hyl.2 human [P09543-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1267
DisGeNETi1267
EuPathDBiHostDB:ENSG00000173786.16

GeneCards: human genes, protein and diseases

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GeneCardsi
CNP
HGNCiHGNC:2158 CNP
HPAiCAB002672
HPA023266
HPA023278
HPA023280
HPA023338
MIMi123830 gene
neXtProtiNX_P09543
OpenTargetsiENSG00000173786
PharmGKBiPA26680

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IT06 Eukaryota
ENOG4111F3B LUCA
GeneTreeiENSGT00510000048410
HOGENOMiHOG000111838
HOVERGENiHBG001451
KOiK01121
OMAiLWPNDVD
OrthoDBi1248632at2759
PhylomeDBiP09543
TreeFamiTF332157

Enzyme and pathway databases

BRENDAi3.1.4.37 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNP human
EvolutionaryTraceiP09543

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
2%27,3%27-Cyclic-nucleotide_3%27-phosphodiesterase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1267

Protein Ontology

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PROi
PR:P09543

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173786 Expressed in 237 organ(s), highest expression level in occipital lobe
CleanExiHS_CNP
ExpressionAtlasiP09543 baseline and differential
GenevisibleiP09543 HS

Family and domain databases

InterProiView protein in InterPro
IPR008431 CNPase
IPR009097 cNuc_Pdiesterase
IPR027417 P-loop_NTPase
PANTHERiPTHR10156 PTHR10156, 1 hit
PfamiView protein in Pfam
PF05881 CNPase, 1 hit
PIRSFiPIRSF000970 CNPase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55144 SSF55144, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCN37_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09543
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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