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Protein

Myosin light chain 3

Gene

Myl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 3Curated
Alternative name(s):
Myosin alkali light chain 1, ventricular/slow skeletal muscle isoform1 Publication
Myosin light chain 1, slow-twitch muscle B/ventricular isoformBy similarity
Short name:
MLC1SBBy similarity
Gene namesi
Name:Myl3Imported
Synonyms:Mlc1vImported, MylcImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97268 Myl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986972 – 204Myosin light chain 3Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1
Modified residuei97PhosphothreonineBy similarity1
Modified residuei136PhosphothreonineCombined sources1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphotyrosineBy similarity1
Modified residuei188PhosphoserineCombined sources1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP09542
MaxQBiP09542
PaxDbiP09542
PeptideAtlasiP09542
PRIDEiP09542

2D gel databases

UCD-2DPAGEiP09542

PTM databases

iPTMnetiP09542
PhosphoSitePlusiP09542

Expressioni

Gene expression databases

BgeeiENSMUSG00000059741 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExiMM_MYL3
ExpressionAtlasiP09542 baseline and differential
GenevisibleiP09542 MM

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201654, 1 interactor
IntActiP09542, 3 interactors
MINTiP09542
STRINGi10090.ENSMUSP00000078715

Structurei

3D structure databases

ProteinModelPortaliP09542
SMRiP09542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini137 – 172EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini172 – 204EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP09542
KOiK12749
OMAiNSKMIDF
OrthoDBiEOG091G0TQL
PhylomeDBiP09542
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P09542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKKPEPKK DDAKAAAPKA APAPAAAPAA APAAAPEPER PKEAEFDASK
60 70 80 90 100
IKIEFTPEQI EEFKEAFLLF DRTPKGEMKI TYGQCGDVLR ALGQNPTQAE
110 120 130 140 150
VLRVLGKPKQ EELNSKMMDF ETFLPMLQHI SKNKDTGTYE DFVEGLRVFD
160 170 180 190 200
KEGNGTVMGA ELRHVLATLG ERLTEDEVEK LMAGQEDSNG CINYEAFVKH

IMAS
Length:204
Mass (Da):22,422
Last modified:January 23, 2007 - v4
Checksum:i3DF39389FF5BAB41
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDW2A0A0G2JDW2_MOUSE
Myosin light chain 3
Myl3
184Annotation score:
A0A0G2JDM3A0A0G2JDM3_MOUSE
Myosin light chain 3
Myl3
127Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002312 mRNA Translation: BAB22006.1
AK011518 mRNA Translation: BAB27672.1
AK146943 mRNA Translation: BAE27552.1
BC061222 mRNA Translation: AAH61222.1
X12972 Genomic DNA Translation: CAA31415.1
CCDSiCCDS23571.1
PIRiS01945
RefSeqiNP_034989.1, NM_010859.2
UniGeneiMm.7353

Genome annotation databases

EnsembliENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741
GeneIDi17897
KEGGimmu:17897
UCSCiuc009rur.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002312 mRNA Translation: BAB22006.1
AK011518 mRNA Translation: BAB27672.1
AK146943 mRNA Translation: BAE27552.1
BC061222 mRNA Translation: AAH61222.1
X12972 Genomic DNA Translation: CAA31415.1
CCDSiCCDS23571.1
PIRiS01945
RefSeqiNP_034989.1, NM_010859.2
UniGeneiMm.7353

3D structure databases

ProteinModelPortaliP09542
SMRiP09542
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201654, 1 interactor
IntActiP09542, 3 interactors
MINTiP09542
STRINGi10090.ENSMUSP00000078715

PTM databases

iPTMnetiP09542
PhosphoSitePlusiP09542

2D gel databases

UCD-2DPAGEiP09542

Proteomic databases

EPDiP09542
MaxQBiP09542
PaxDbiP09542
PeptideAtlasiP09542
PRIDEiP09542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741
GeneIDi17897
KEGGimmu:17897
UCSCiuc009rur.1 mouse

Organism-specific databases

CTDi4634
MGIiMGI:97268 Myl3

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP09542
KOiK12749
OMAiNSKMIDF
OrthoDBiEOG091G0TQL
PhylomeDBiP09542
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

PROiPR:P09542
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059741 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExiMM_MYL3
ExpressionAtlasiP09542 baseline and differential
GenevisibleiP09542 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL3_MOUSE
AccessioniPrimary (citable) accession number: P09542
Secondary accession number(s): Q3UIF4, Q9CQZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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