Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin light chain 4

Gene

Myl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 4
Alternative name(s):
MLC1EMB
Myosin light chain 1, atrial/fetal isoform
Short name:
MLC1A
Gene namesi
Name:Myl4
Synonyms:Mlc1a, Myla
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97267 Myl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001987002 – 193Myosin light chain 4Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N-dimethylprolineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP09541
PaxDbiP09541
PeptideAtlasiP09541
PRIDEiP09541

PTM databases

iPTMnetiP09541
PhosphoSitePlusiP09541

Expressioni

Tissue specificityi

Expressed in atrial muscle and in fetal skeletal and ventricular muscle.

Gene expression databases

CleanExiMM_MYL4

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP09541, 1 interactor
STRINGi10090.ENSMUSP00000018800

Structurei

3D structure databases

ProteinModelPortaliP09541
SMRiP09541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 84EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini126 – 161EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP09541
PhylomeDBiP09541

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKKPEPKK EAAKPAAAPA PAASAAPEPL KDSAFDPKSV KIDFSADQIE
60 70 80 90 100
EFKEAFSLFD RTPTGEMKIT YGQCGDVLRA LGQNPTNAEV LRVLGKPKPE
110 120 130 140 150
EMSSKTLDFE MFLPILQHIS RNKEQGTYED FVEGLRVFDK ESNGTVMGAE
160 170 180 190
LRHVLATLGE KMSEAEVEQL LSGQEDANGC INYEAFVKHI MSG
Length:193
Mass (Da):21,159
Last modified:January 23, 2007 - v3
Checksum:i10EC54C72F0E6C5E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CZ19Q9CZ19_MOUSE
Myosin light chain 4
Myl4
193Annotation score:
A2A6Q8A2A6Q8_MOUSE
Myosin light chain 4
Myl4
191Annotation score:
D6RFU4D6RFU4_MOUSE
Myosin light chain 4
Myl4
74Annotation score:
F6XL79F6XL79_MOUSE
Myosin light chain 4
Myl4
26Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20772
, M31017, M20769, M20770, M20771 Genomic DNA Translation: AAA39721.1
M19436 mRNA Translation: AAA39720.1
X12971 Genomic DNA Translation: CAA31414.1
CCDSiCCDS25535.1
PIRiA31114 MOMS4E
UniGeneiMm.390355

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20772
, M31017, M20769, M20770, M20771 Genomic DNA Translation: AAA39721.1
M19436 mRNA Translation: AAA39720.1
X12971 Genomic DNA Translation: CAA31414.1
CCDSiCCDS25535.1
PIRiA31114 MOMS4E
UniGeneiMm.390355

3D structure databases

ProteinModelPortaliP09541
SMRiP09541
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09541, 1 interactor
STRINGi10090.ENSMUSP00000018800

PTM databases

iPTMnetiP09541
PhosphoSitePlusiP09541

Proteomic databases

MaxQBiP09541
PaxDbiP09541
PeptideAtlasiP09541
PRIDEiP09541

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97267 Myl4

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP09541
PhylomeDBiP09541

Miscellaneous databases

ChiTaRSiMyl4 mouse
PROiPR:P09541
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYL4

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL4_MOUSE
AccessioniPrimary (citable) accession number: P09541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again