Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ferritin heavy chain

Gene

Fth1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Iron 1PROSITE-ProRule annotation1
Metal bindingi63Iron 1PROSITE-ProRule annotation1
Metal bindingi63Iron 2PROSITE-ProRule annotation1
Metal bindingi66Iron 1PROSITE-ProRule annotation1
Metal bindingi108Iron 2PROSITE-ProRule annotation1
Metal bindingi142Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric iron binding Source: GO_Central
  • ferrous iron binding Source: GO_Central
  • ferroxidase activity Source: GO_Central
  • identical protein binding Source: GO_Central
  • iron ion binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:Fth1
Synonyms:Fth
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95588 Fth1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Homozygous mutant embryos die in utero between 3.5 and 9.5 dpc (PubMed:10652280). Heterozygous animals are healthy and fertile and do not present any apparent abnormalities. They show slightly elevated tissue light chain ferritin content and 7- to 10-fold more light chain ferritin in the serum than normal mice, but their serum iron remains unchanged.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244731 – 182Ferritin heavy chainAdd BLAST182
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002010492 – 182Ferritin heavy chain, N-terminally processedAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP09528
MaxQBiP09528
PaxDbiP09528
PeptideAtlasiP09528
PRIDEiP09528

2D gel databases

REPRODUCTION-2DPAGEiP09528

PTM databases

iPTMnetiP09528
PhosphoSitePlusiP09528
SwissPalmiP09528

Expressioni

Developmental stagei

At 9.5 dpc, detected at low levels in the developing heart and central nervous system. At later stages of development, widely expressed, predominantly in the heart and brown fat tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000024661 Expressed in 317 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_FTH1
GenevisibleiP09528 MM

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP09528, 6 interactors
MINTiP09528
STRINGi10090.ENSMUSP00000025563

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09528
SMRiP09528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 160Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
GeneTreeiENSGT00760000119129
HOGENOMiHOG000223383
HOVERGENiHBG000410
InParanoidiP09528
KOiK00522
OMAiQALHNFA
OrthoDBiEOG091G0J20
PhylomeDBiP09528
TreeFamiTF313885

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTASPSQVR QNYHQDAEAA INRQINLELY ASYVYLSMSC YFDRDDVALK
60 70 80 90 100
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA
110 120 130 140 150
MECALHLEKS VNQSLLELHK LATDKNDPHL CDFIETYYLS EQVKSIKELG
160 170 180
DHVTNLRKMG APEAGMAEYL FDKHTLGHGD ES
Length:182
Mass (Da):21,067
Last modified:January 23, 2007 - v2
Checksum:i129A8887A2BC650B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17A → S in AAA37612 (PubMed:2708374).Curated1
Sequence conflicti137Y → H in AAA37612 (PubMed:2708374).Curated1
Sequence conflicti140S → N in AAA37612 (PubMed:2708374).Curated1
Sequence conflicti164A → S in AAA37612 (PubMed:2708374).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52561 Genomic DNA Translation: CAA36795.1
X12812 mRNA Translation: CAA31300.1
J03941 mRNA Translation: AAA37611.1
M60170 Genomic DNA Translation: AAA37613.1
M24509 mRNA Translation: AAA37612.1
AK027998 mRNA Translation: BAC25694.1
AK139622 mRNA Translation: BAE24084.1
AK147082 mRNA Translation: BAE27662.1
AK150262 mRNA Translation: BAE29419.1
AK150508 mRNA Translation: BAE29621.1
AK150628 mRNA Translation: BAE29718.1
AK150679 mRNA Translation: BAE29759.1
AK150693 mRNA Translation: BAE29772.1
AK151192 mRNA Translation: BAE30189.1
AK151241 mRNA Translation: BAE30233.1
AK151399 mRNA Translation: BAE30367.1
AK151609 mRNA Translation: BAE30548.1
AK151675 mRNA Translation: BAE30600.1
AK152071 mRNA Translation: BAE30924.1
AK152542 mRNA Translation: BAE31297.1
AK152702 mRNA Translation: BAE31431.1
AK153017 mRNA Translation: BAE31651.1
AK153195 mRNA Translation: BAE31795.1
AK153199 mRNA Translation: BAE31799.1
AK159243 mRNA Translation: BAE34925.1
AK168601 mRNA Translation: BAE40468.1
AK169004 mRNA Translation: BAE40803.1
BC012314 mRNA Translation: AAH12314.1
CCDSiCCDS29567.1
PIRiS06070
RefSeqiNP_034369.1, NM_010239.2
UniGeneiMm.1776

Genome annotation databases

EnsembliENSMUST00000025563; ENSMUSP00000025563; ENSMUSG00000024661
GeneIDi14319
KEGGimmu:14319
UCSCiuc008got.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52561 Genomic DNA Translation: CAA36795.1
X12812 mRNA Translation: CAA31300.1
J03941 mRNA Translation: AAA37611.1
M60170 Genomic DNA Translation: AAA37613.1
M24509 mRNA Translation: AAA37612.1
AK027998 mRNA Translation: BAC25694.1
AK139622 mRNA Translation: BAE24084.1
AK147082 mRNA Translation: BAE27662.1
AK150262 mRNA Translation: BAE29419.1
AK150508 mRNA Translation: BAE29621.1
AK150628 mRNA Translation: BAE29718.1
AK150679 mRNA Translation: BAE29759.1
AK150693 mRNA Translation: BAE29772.1
AK151192 mRNA Translation: BAE30189.1
AK151241 mRNA Translation: BAE30233.1
AK151399 mRNA Translation: BAE30367.1
AK151609 mRNA Translation: BAE30548.1
AK151675 mRNA Translation: BAE30600.1
AK152071 mRNA Translation: BAE30924.1
AK152542 mRNA Translation: BAE31297.1
AK152702 mRNA Translation: BAE31431.1
AK153017 mRNA Translation: BAE31651.1
AK153195 mRNA Translation: BAE31795.1
AK153199 mRNA Translation: BAE31799.1
AK159243 mRNA Translation: BAE34925.1
AK168601 mRNA Translation: BAE40468.1
AK169004 mRNA Translation: BAE40803.1
BC012314 mRNA Translation: AAH12314.1
CCDSiCCDS29567.1
PIRiS06070
RefSeqiNP_034369.1, NM_010239.2
UniGeneiMm.1776

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WNWX-ray2.24A/B/C/D/E/F/G/H/I/J/K/L1-182[»]
5OBAX-ray2.85A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-177[»]
5OBBX-ray2.65A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-177[»]
ProteinModelPortaliP09528
SMRiP09528
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09528, 6 interactors
MINTiP09528
STRINGi10090.ENSMUSP00000025563

PTM databases

iPTMnetiP09528
PhosphoSitePlusiP09528
SwissPalmiP09528

2D gel databases

REPRODUCTION-2DPAGEiP09528

Proteomic databases

EPDiP09528
MaxQBiP09528
PaxDbiP09528
PeptideAtlasiP09528
PRIDEiP09528

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025563; ENSMUSP00000025563; ENSMUSG00000024661
GeneIDi14319
KEGGimmu:14319
UCSCiuc008got.2 mouse

Organism-specific databases

CTDi2495
MGIiMGI:95588 Fth1

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
GeneTreeiENSGT00760000119129
HOGENOMiHOG000223383
HOVERGENiHBG000410
InParanoidiP09528
KOiK00522
OMAiQALHNFA
OrthoDBiEOG091G0J20
PhylomeDBiP09528
TreeFamiTF313885

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-917937 Iron uptake and transport

Miscellaneous databases

ChiTaRSiFth1 mouse
PROiPR:P09528
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024661 Expressed in 317 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_FTH1
GenevisibleiP09528 MM

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRIH_MOUSE
AccessioniPrimary (citable) accession number: P09528
Secondary accession number(s): Q3UI44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again