Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A4

Gene

ANXA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.By similarity

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: BHF-UCL
  • chondroitin sulfate binding Source: GO_Central
  • heparin binding Source: GO_Central
  • identical protein binding Source: BHF-UCL
  • NF-kappaB binding Source: BHF-UCL
  • phospholipase inhibitor activity Source: UniProtKB

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of interleukin-8 secretion Source: BHF-UCL
  • negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • Notch signaling pathway Source: Ensembl
  • regulation of transcription by RNA polymerase II Source: BHF-UCL
  • signal transduction Source: UniProtKB

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
35-beta calcimedin
Annexin IV
Annexin-4
Carbohydrate-binding protein p33/p41
Chromobindin-4
Endonexin I
Lipocortin IV
P32.5
PP4-X
Placental anticoagulant protein II
Short name:
PAP-II
Protein II
Gene namesi
Name:ANXA4
Synonyms:ANX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000196975.15
HGNCiHGNC:542 ANXA4
MIMi106491 gene
neXtProtiNX_P09525

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi307
PharmGKBiPA24832

Polymorphism and mutation databases

BioMutaiANXA4
DMDMi1703319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000674822 – 319Annexin A4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphothreonineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei213N6-acetyllysineCombined sources1
Modified residuei293N6-acetyllysineCombined sources1
Modified residuei300N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09525
MaxQBiP09525
PaxDbiP09525
PeptideAtlasiP09525
PRIDEiP09525
ProteomicsDBi52242

2D gel databases

DOSAC-COBS-2DPAGEiP09525
OGPiP09525
REPRODUCTION-2DPAGEiIPI00793199
P09525
SWISS-2DPAGEiP09525

PTM databases

iPTMnetiP09525
PhosphoSitePlusiP09525
SwissPalmiP09525

Expressioni

Gene expression databases

BgeeiENSG00000196975 Expressed in 234 organ(s), highest expression level in duodenum
CleanExiHS_ANXA4
ExpressionAtlasiP09525 baseline and differential
GenevisibleiP09525 HS

Organism-specific databases

HPAiCAB005076
CAB017560
HPA007393

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-2556852,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106804, 22 interactors
IntActiP09525, 6 interactors
MINTiP09525
STRINGi9606.ENSP00000377833

Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09525
SMRiP09525
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09525

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 83Annexin 1Add BLAST61
Repeati95 – 155Annexin 2Add BLAST61
Repeati179 – 239Annexin 3Add BLAST61
Repeati254 – 314Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOVERGENiHBG061815
InParanoidiP09525
KOiK17093
OrthoDBiEOG091G0H6H
PhylomeDBiP09525
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002391 ANX4
PANTHERiPTHR10502:SF28 PTHR10502:SF28, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09525-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATKGGTVKA ASGFNAMEDA QTLRKAMKGL GTDEDAIISV LAYRNTAQRQ
60 70 80 90 100
EIRTAYKSTI GRDLIDDLKS ELSGNFEQVI VGMMTPTVLY DVQELRRAMK
110 120 130 140 150
GAGTDEGCLI EILASRTPEE IRRISQTYQQ QYGRSLEDDI RSDTSFMFQR
160 170 180 190 200
VLVSLSAGGR DEGNYLDDAL VRQDAQDLYE AGEKKWGTDE VKFLTVLCSR
210 220 230 240 250
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF
260 270 280 290 300
AEKLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRAHFKRL YGKSLYSFIK
310
GDTSGDYRKV LLVLCGGDD
Length:319
Mass (Da):35,883
Last modified:January 23, 2007 - v4
Checksum:i3799FE80A93AB215
GO
Isoform 2 (identifier: P09525-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):27,063
Checksum:iC512EFA927DBDD7D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P452Q6P452_HUMAN
Annexin
ANXA4
299Annotation score:
B4E1S2B4E1S2_HUMAN
Annexin
ANXA4
142Annotation score:
A0A0U1RRE7A0A0U1RRE7_HUMAN
Annexin A4
ANXA4
8Annotation score:
A0A1Y8EKW3A0A1Y8EKW3_HUMAN
Annexin A4
ANXA4
7Annotation score:

Sequence cautioni

The sequence AAC41689 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH00182 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH11659 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA11227 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96R → Q in AAC41689 (PubMed:2970257).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05550085T → M. Corresponds to variant dbSNP:rs2228203Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563961 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19383 mRNA Translation: AAC41689.1 Different initiation.
M82809 mRNA Translation: AAA51740.1
D78152 mRNA Translation: BAA11227.1 Different initiation.
AK293177 mRNA Translation: BAG56720.1
AC019206 Genomic DNA No translation available.
AC092431 Genomic DNA No translation available.
AC112787 Genomic DNA No translation available.
BC000182 mRNA Translation: AAH00182.1 Different initiation.
BC011659 mRNA Translation: AAH11659.1 Different initiation.
PIRiA42077
RefSeqiNP_001144.1, NM_001153.4
NP_001307627.1, NM_001320698.1
NP_001307629.1, NM_001320700.1
NP_001307631.1, NM_001320702.1 [P09525-2]
XP_016859432.1, XM_017003943.1
XP_016859433.1, XM_017003944.1 [P09525-2]
UniGeneiHs.422986

Genome annotation databases

EnsembliENST00000394295; ENSP00000377833; ENSG00000196975
ENST00000536030; ENSP00000441931; ENSG00000196975
GeneIDi307
KEGGihsa:307

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19383 mRNA Translation: AAC41689.1 Different initiation.
M82809 mRNA Translation: AAA51740.1
D78152 mRNA Translation: BAA11227.1 Different initiation.
AK293177 mRNA Translation: BAG56720.1
AC019206 Genomic DNA No translation available.
AC092431 Genomic DNA No translation available.
AC112787 Genomic DNA No translation available.
BC000182 mRNA Translation: AAH00182.1 Different initiation.
BC011659 mRNA Translation: AAH11659.1 Different initiation.
PIRiA42077
RefSeqiNP_001144.1, NM_001153.4
NP_001307627.1, NM_001320698.1
NP_001307629.1, NM_001320700.1
NP_001307631.1, NM_001320702.1 [P09525-2]
XP_016859432.1, XM_017003943.1
XP_016859433.1, XM_017003944.1 [P09525-2]
UniGeneiHs.422986

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZOCX-ray2.00A/B1-319[»]
ProteinModelPortaliP09525
SMRiP09525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106804, 22 interactors
IntActiP09525, 6 interactors
MINTiP09525
STRINGi9606.ENSP00000377833

PTM databases

iPTMnetiP09525
PhosphoSitePlusiP09525
SwissPalmiP09525

Polymorphism and mutation databases

BioMutaiANXA4
DMDMi1703319

2D gel databases

DOSAC-COBS-2DPAGEiP09525
OGPiP09525
REPRODUCTION-2DPAGEiIPI00793199
P09525
SWISS-2DPAGEiP09525

Proteomic databases

EPDiP09525
MaxQBiP09525
PaxDbiP09525
PeptideAtlasiP09525
PRIDEiP09525
ProteomicsDBi52242

Protocols and materials databases

DNASUi307
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394295; ENSP00000377833; ENSG00000196975
ENST00000536030; ENSP00000441931; ENSG00000196975
GeneIDi307
KEGGihsa:307

Organism-specific databases

CTDi307
DisGeNETi307
EuPathDBiHostDB:ENSG00000196975.15
GeneCardsiANXA4
HGNCiHGNC:542 ANXA4
HPAiCAB005076
CAB017560
HPA007393
MIMi106491 gene
neXtProtiNX_P09525
PharmGKBiPA24832
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOVERGENiHBG061815
InParanoidiP09525
KOiK17093
OrthoDBiEOG091G0H6H
PhylomeDBiP09525
TreeFamiTF105452

Miscellaneous databases

ChiTaRSiANXA4 human
EvolutionaryTraceiP09525
GeneWikiiANXA4
GenomeRNAii307
PROiPR:P09525
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196975 Expressed in 234 organ(s), highest expression level in duodenum
CleanExiHS_ANXA4
ExpressionAtlasiP09525 baseline and differential
GenevisibleiP09525 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002391 ANX4
PANTHERiPTHR10502:SF28 PTHR10502:SF28, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA4_HUMAN
AccessioniPrimary (citable) accession number: P09525
Secondary accession number(s): B4DDF9, Q96F33, Q9BWK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 195 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again