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UniProtKB - P09506 (P1_TYYVF)
Protein
Protein P1
Gene
ORF1
Organism
Turnip yellows virus (isolate FL-1) (TuYV) (BWYV-FL1)
Status
Functioni
Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 254 | For protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 289 | For protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 357 | For protease activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: InterPro
- serine-type exopeptidase activity Source: InterPro
GO - Biological processi
- viral process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, RNA-binding, Serine protease |
Protein family/group databases
MEROPSi | S39.002 |
Names & Taxonomyi
Subcellular locationi
- Membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000222395 | 23 – 607 | Protein P1Add BLAST | 585 | |
ChainiPRO_0000390897 | 204 – 400 | Serine proteaseSequence analysisAdd BLAST | 197 | |
ChainiPRO_0000390898 | 401 – 607 | VPg/P1-C25Sequence analysisAdd BLAST | 207 |
Post-translational modificationi
Specific enzymatic cleavages in vivo yield mature proteins. The protease probably cleaves itself and releases the VPg protein (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 203 – 204 | Cleavage; by viral serine proteaseSequence analysis | 2 | |
Sitei | 400 – 401 | Cleavage; by viral serine proteaseBy similarity | 2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 206 – 400 | Peptidase S39PROSITE-ProRule annotationAdd BLAST | 195 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 457 – 485 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 517 – 607 | DisorderedSequence analysisAdd BLAST | 91 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 465 – 484 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 560 – 579 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
The C-terminus part of protein P1 and VPg/P1-C25 displays RNA-binding properties.By similarity
Sequence similaritiesi
Belongs to the peptidase S39B family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR018019, Luteovirus_Orf2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR000382, Peptidase_S39B_luteovirus |
Pfami | View protein in Pfam PF02122, Peptidase_S39, 1 hit |
PRINTSi | PR00913, LVIRUSORF2 |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS51868, PEPTIDASE_S39, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketIsoform Protein P1 (identifier: P09506-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYSKLMFFFA LCSISFLFTS EAASTMLLES SYLPLNQSYA PGFLYKRDML
60 70 80 90 100
PPPLQAVLTY TCPEPRPLAE ESYNDLLRAI SQKSSSDFQN AYSLALSFSS
110 120 130 140 150
DFYQHGLKTL KDVSFLAVEK FLWGLTRLWS SLILASFSAL WWLVSNFTTP
160 170 180 190 200
VFCLALLYTV TKYMVKTVSF LFGGLPIWII SIAFSLLKKS FSALRSTPKC
210 220 230 240 250
LYEKAIDGFK SFTIPQSPPK SCVIPITHAS GNHAGYASCI KLYNGENALM
260 270 280 290 300
TATHVLRDCP NAVAVSAKGL KTRIPLAEFK TIAKSDKGDV TLLRGPPNWE
310 320 330 340 350
GLLGCKAANV ITAANLAKCK ASIYSFDRDG WVSSYAEIVG SEGTDVMVLS
360 370 380 390 400
HTEGGHSGSP YFNGKTILGV HSGASATGNY NLMAPIPSLP GLTSPTYVFE
410 420 430 440 450
TTAPQGRVFA QEDIAEIEGL YAQVMKRVQQ AEDFKPKTGK YWGDMEDDED
460 470 480 490 500
IFFESKEDLS GNGVRGTVRG TNGEGSSTPK TSNVDGKEMM EKIISSLVGK
510 520 530 540 550
INLENIERKV IEEISAKAMK TPKSRRRRAP KKQPESSKDT SPRSTTGKYQ
560 570 580 590 600
PPHVRSPASV TAANCPNTTT PSKKKNLAGG RPSSGTIPRW VRKQAASAGP
SSAPKQN
Note: Produced by conventional translation.
Isoform RNA-directed RNA polymerase (identifier: P09507-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P09507.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13063 Genomic RNA Translation: CAA31463.1 |
PIRi | S01939 |
RefSeqi | NP_620486.1, NC_003743.1 |
Genome annotation databases
GeneIDi | 940483 |
KEGGi | vg:940483 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13063 Genomic RNA Translation: CAA31463.1 |
PIRi | S01939 |
RefSeqi | NP_620486.1, NC_003743.1 |
3D structure databases
SMRi | P09506 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S39.002 |
Genome annotation databases
GeneIDi | 940483 |
KEGGi | vg:940483 |
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR018019, Luteovirus_Orf2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR000382, Peptidase_S39B_luteovirus |
Pfami | View protein in Pfam PF02122, Peptidase_S39, 1 hit |
PRINTSi | PR00913, LVIRUSORF2 |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS51868, PEPTIDASE_S39, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P1_TYYVF | |
Accessioni | P09506Primary (citable) accession number: P09506 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families