CLTB

Functionⁱ

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functionⁱ

clathrin heavy chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide binding Source: Ensembl
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

clathrin coat assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
clathrin-dependent endocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport Source: InterPro
membrane organization Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium

Ligand

Calcium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORⁱ	P09497

Reactomeⁱ

R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNORⁱ

P09497

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Clathrin light chain B Short name: Lcb
Gene namesⁱ	Name:CLTB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175416.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2091 CLTB
MIMⁱ	118970 gene
neXtProtⁱ	NX_P09497

Keywords - Cellular componentⁱ

Coated pit, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1212
Open Targets More...OpenTargetsⁱ	ENSG00000175416
PharmGKBⁱ	PA26617

Polymorphism and mutation databases

BioMutaⁱ	CLTB

BioMutaⁱ

CLTB

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000205771	1 – 229	Clathrin light chain BAdd BLAST		229

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	11	PhosphoserineBy similarity	1
Modified residueⁱ	13	PhosphoserineBy similarity	1
Modified residueⁱ	187	PhosphothreonineCombined sources	1
Disulfide bondⁱ	199 ↔ 209	By similarity
Modified residueⁱ	204	N6-acetyllysineBy similarity	1
Modified residueⁱ	217	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	P09497
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09497
PaxDbⁱ	P09497
PeptideAtlas More...PeptideAtlasⁱ	P09497
PRIDEⁱ	P09497
ProteomicsDBⁱ	52240 52241 [P09497-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P09497

OGPⁱ

P09497

PTM databases

iPTMnetⁱ	P09497
PhosphoSitePlusⁱ	P09497

Miscellaneous databases

PMAP-CutDBⁱ	P09497

PMAP-CutDBⁱ

P09497

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000175416 Expressed in 227 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_CLTB
ExpressionAtlasⁱ	P09497 baseline and differential
Genevisibleⁱ	P09497 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003692 HPA036458

HPAⁱ

CAB003692
HPA036458

Interactionⁱ

Subunit structureⁱ

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.2 Publications

GO - Molecular functionⁱ

clathrin heavy chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107622, 87 interactors
IntActⁱ	P09497, 75 interactors
Molecular INTeraction database More...MINTⁱ	P09497
STRINGⁱ	9606.ENSP00000309415

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P09497
SMRⁱ	P09497
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	93 – 155	Involved in binding clathrin heavy chainAdd BLAST		63

Sequence similaritiesⁱ

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4031 Eukaryota ENOG4111J5K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010441
HOGENOMⁱ	HOG000008147
HOVERGENⁱ	HBG003386
InParanoidⁱ	P09497
KEGG Orthology (KO) More...KOⁱ	K04645
OMAⁱ	TKAANRN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WEF
PhylomeDBⁱ	P09497
TreeFamⁱ	TF313162

Family and domain databases

InterProⁱ	View protein in InterPro IPR000996 Clathrin_L-chain
PANTHERⁱ	PTHR10639 PTHR10639, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01086 Clathrin_lg_ch, 1 hit
PROSITEⁱ	View protein in PROSITE PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Brain (identifier: P09497-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS 
        60         70         80         90        100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP 
       110        120        130        140        150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN 
       160        170        180        190        200
KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD 
       210        220 
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR

Length:229

Mass (Da):25,190

Last modified:July 1, 1989 - v1

Checksum:ⁱ07DBA19D44648F6F

GO

Isoform Non-brain (identifier: P09497-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
156-173: Missing.

« Hide

        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS 
        60         70         80         90        100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP 
       110        120        130        140        150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN 
       160        170        180        190        200
KINNRASEEA FVKESKEETP GTEWEKVAQL CDFNPKSSKQ CKDVSRLRSV 
       210 
LMSLKQTPLS R

Show »

Length:211

Mass (Da):23,181

Checksum:ⁱ5B40F043E1809238

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y9Q6	H0Y9Q6_HUMAN	Clathrin light chain Clathrin light chain	CLTB	81	Annotation score:
B4DTF9	B4DTF9_HUMAN	Clathrin light chain Clathrin light chain	CLTB	134	Annotation score:
D6RJD1	D6RJD1_HUMAN	Clathrin light chain Clathrin light chain	CLTB	125	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	5	F → I in CAG38814 (Ref. 3) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001098	156 – 173	Missing in isoform Non-brain. 3 PublicationsAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20469 mRNA Translation: AAA51818.1 M20470 mRNA Translation: AAA59506.1 BT007028 mRNA Translation: AAP35675.1 CR536577 mRNA Translation: CAG38814.1 CH471195 Genomic DNA Translation: EAW85079.1 BC006332 mRNA Translation: AAH06332.1 BC006457 mRNA Translation: AAH06457.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4402.1 [P09497-2] CCDS4403.1 [P09497-1]
PIRⁱ	B31775
NCBI Reference Sequences More...RefSeqⁱ	NP_001825.1, NM_001834.3 [P09497-2] NP_009028.1, NM_007097.3 [P09497-1]
UniGeneⁱ	Hs.484241

Genome annotation databases

Ensemblⁱ	ENST00000310418; ENSP00000309415; ENSG00000175416 [P09497-1] ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2]
GeneIDⁱ	1212
KEGGⁱ	hsa:1212
UCSC genome browser More...UCSCⁱ	uc003meh.4 human [P09497-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09497	Clathrin light chain		PANTR		229	UniRef100_P09497
Clathrin light chain		PANPA		180
P09497-2	Clathrin light chain		HUMAN		211	UniRef100_A0A024R7S3
Clathrin light chain		PANTR		211
Clathrin light chain		PANPA		162
Clathrin light chain		NEOSC		144

Protein	Similar proteins		Species	Score	Length	Source
P09497	Clathrin light chain B		RAT		229	UniRef90_P08082
Clathrin light chain B		MOUSE		229
Clathrin light chain B	)	BOVIN		228
Clathrin light chain		PANTR		229
Clathrin light chain		PANPA		180
+68
P09497-2	Isoform Non-brain of Clathrin light chain B		RAT		211	UniRef90_P08082-2
Clathrin light chain		PROCO		221
Clathrin light chain		PONAB		211
Clathrin light chain		ODORO		211
Clathrin light chain		LEPWE		211
+45

Protein	Similar proteins		Species	Score	Length	Source
P09497	Clathrin light chain A		HUMAN		248	UniRef50_P09496
Clathrin light chain A		RAT		248
Clathrin light chain A	)	BOVIN		243
Clathrin light chain A		MOUSE		235
Clathrin light chain		PONAB		248
+576

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20469 mRNA Translation: AAA51818.1 M20470 mRNA Translation: AAA59506.1 BT007028 mRNA Translation: AAP35675.1 CR536577 mRNA Translation: CAG38814.1 CH471195 Genomic DNA Translation: EAW85079.1 BC006332 mRNA Translation: AAH06332.1 BC006457 mRNA Translation: AAH06457.1
CCDSⁱ	CCDS4402.1 [P09497-2] CCDS4403.1 [P09497-1]
PIRⁱ	B31775
RefSeqⁱ	NP_001825.1, NM_001834.3 [P09497-2] NP_009028.1, NM_007097.3 [P09497-1]
UniGeneⁱ	Hs.484241

3D structure databases

ProteinModelPortalⁱ	P09497
SMRⁱ	P09497
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107622, 87 interactors
IntActⁱ	P09497, 75 interactors
MINTⁱ	P09497
STRINGⁱ	9606.ENSP00000309415

PTM databases

iPTMnetⁱ	P09497
PhosphoSitePlusⁱ	P09497

Polymorphism and mutation databases

BioMutaⁱ	CLTB

BioMutaⁱ

CLTB

2D gel databases

OGPⁱ	P09497

OGPⁱ

P09497

Proteomic databases

EPDⁱ	P09497
MaxQBⁱ	P09497
PaxDbⁱ	P09497
PeptideAtlasⁱ	P09497
PRIDEⁱ	P09497
ProteomicsDBⁱ	52240 52241 [P09497-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1212
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310418; ENSP00000309415; ENSG00000175416 [P09497-1] ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2]
GeneIDⁱ	1212
KEGGⁱ	hsa:1212
UCSCⁱ	uc003meh.4 human [P09497-1]

Organism-specific databases

CTDⁱ	1212
DisGeNETⁱ	1212
EuPathDBⁱ	HostDB:ENSG00000175416.12
GeneCardsⁱ	CLTB
HGNCⁱ	HGNC:2091 CLTB
HPAⁱ	CAB003692 HPA036458
MIMⁱ	118970 gene
neXtProtⁱ	NX_P09497
OpenTargetsⁱ	ENSG00000175416
PharmGKBⁱ	PA26617
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4031 Eukaryota ENOG4111J5K LUCA
GeneTreeⁱ	ENSGT00390000010441
HOGENOMⁱ	HOG000008147
HOVERGENⁱ	HBG003386
InParanoidⁱ	P09497
KOⁱ	K04645
OMAⁱ	TKAANRN
OrthoDBⁱ	EOG091G0WEF
PhylomeDBⁱ	P09497
TreeFamⁱ	TF313162

Enzyme and pathway databases

Reactomeⁱ	R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORⁱ	P09497

Reactomeⁱ

R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNORⁱ

P09497

Miscellaneous databases

ChiTaRSⁱ	CLTB human
GenomeRNAiⁱ	1212
PMAP-CutDBⁱ	P09497
Protein Ontology More...PROⁱ	PR:P09497
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175416 Expressed in 227 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_CLTB
ExpressionAtlasⁱ	P09497 baseline and differential
Genevisibleⁱ	P09497 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000996 Clathrin_L-chain
PANTHERⁱ	PTHR10639 PTHR10639, 1 hit
Pfamⁱ	View protein in Pfam PF01086 Clathrin_lg_ch, 1 hit
PROSITEⁱ	View protein in PROSITE PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLCB_HUMAN
Accessionⁱ	P09497Primary (citable) accession number: P09497 Secondary accession number(s): Q53Y37, Q6FHW1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09497 (CLCB_HUMAN)

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Clathrin light chain B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ