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Protein

Clathrin light chain B

Gene

CLTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiP09497

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
Gene namesi
Name:CLTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000175416.12
HGNCiHGNC:2091 CLTB
MIMi118970 gene
neXtProtiNX_P09497

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1212
OpenTargetsiENSG00000175416
PharmGKBiPA26617

Polymorphism and mutation databases

BioMutaiCLTB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057711 – 229Clathrin light chain BAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei187PhosphothreonineCombined sources1
Disulfide bondi199 ↔ 209By similarity
Modified residuei204N6-acetyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP09497
MaxQBiP09497
PaxDbiP09497
PeptideAtlasiP09497
PRIDEiP09497
ProteomicsDBi52240
52241 [P09497-2]

2D gel databases

OGPiP09497

PTM databases

iPTMnetiP09497
PhosphoSitePlusiP09497

Miscellaneous databases

PMAP-CutDBiP09497

Expressioni

Gene expression databases

BgeeiENSG00000175416
CleanExiHS_CLTB
ExpressionAtlasiP09497 baseline and differential
GenevisibleiP09497 HS

Organism-specific databases

HPAiCAB003692
HPA036458

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107622, 85 interactors
IntActiP09497, 74 interactors
MINTiP09497
STRINGi9606.ENSP00000309415

Structurei

3D structure databases

ProteinModelPortaliP09497
SMRiP09497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 155Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031 Eukaryota
ENOG4111J5K LUCA
GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiP09497
KOiK04645
OMAiSTFESQF
OrthoDBiEOG091G0WEF
PhylomeDBiP09497
TreeFamiTF313162

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P09497-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS
60 70 80 90 100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP
110 120 130 140 150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN
160 170 180 190 200
KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD
210 220
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
Length:229
Mass (Da):25,190
Last modified:July 1, 1989 - v1
Checksum:i07DBA19D44648F6F
GO
Isoform Non-brain (identifier: P09497-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-173: Missing.

Show »
Length:211
Mass (Da):23,181
Checksum:i5B40F043E1809238
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5F → I in CAG38814 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001098156 – 173Missing in isoform Non-brain. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20469 mRNA Translation: AAA51818.1
M20470 mRNA Translation: AAA59506.1
BT007028 mRNA Translation: AAP35675.1
CR536577 mRNA Translation: CAG38814.1
CH471195 Genomic DNA Translation: EAW85079.1
BC006332 mRNA Translation: AAH06332.1
BC006457 mRNA Translation: AAH06457.1
CCDSiCCDS4402.1 [P09497-2]
CCDS4403.1 [P09497-1]
PIRiB31775
RefSeqiNP_001825.1, NM_001834.3 [P09497-2]
NP_009028.1, NM_007097.3 [P09497-1]
UniGeneiHs.484241

Genome annotation databases

EnsembliENST00000310418; ENSP00000309415; ENSG00000175416 [P09497-1]
ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2]
GeneIDi1212
KEGGihsa:1212
UCSCiuc003meh.4 human [P09497-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLCB_HUMAN
AccessioniPrimary (citable) accession number: P09497
Secondary accession number(s): Q53Y37, Q6FHW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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