Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P09497 (CLCB_HUMAN)

Entry version 186 (10 Feb 2021)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
Add a publicationFeedback
Protein

Clathrin light chain B

Gene

CLTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09497

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

More...SIGNORi		P09497

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.137.1.2, the clathrin (clathrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLTB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2091, CLTB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118970, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09497

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000175416.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1212

Open Targets

More...OpenTargetsi		ENSG00000175416

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26617

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09497, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLTB

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057711 – 229Clathrin light chain BAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei187PhosphothreonineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi199 ↔ 209By similarity
Modified residuei204N6-acetyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09497

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09497

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09497

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09497

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09497

PeptideAtlas

More...PeptideAtlasi		P09497

PRoteomics IDEntifications database

More...PRIDEi		P09497

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52240 [P09497-1]
52241 [P09497-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P09497

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09497

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175416, Expressed in esophagus mucosa and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09497, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09497, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175416, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains.

Interacts (via N-terminus) with HIP1.

Interacts with HIP1R.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107622, 93 interactors

Protein interaction database and analysis system

More...IntActi		P09497, 80 interactors

Molecular INTeraction database

More...MINTi		P09497

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309415

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09497, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09497

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 155Involved in binding clathrin heavy chainAdd BLAST63

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4031, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160186

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_091462_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09497

Identification of Orthologs from Complete Genome Data

More...OMAi		GSFEMIN

Database of Orthologous Groups

More...OrthoDBi		1577821at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09497

TreeFam database of animal gene trees

More...TreeFami		TF313162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000996, Clathrin_L-chain

The PANTHER Classification System

More...PANTHERi		PTHR10639, PTHR10639, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01086, Clathrin_lg_ch, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Brain (identifier: P09497-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS 
        60         70         80         90        100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP 
       110        120        130        140        150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN 
       160        170        180        190        200
KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD 
       210        220 
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
Length:229
Mass (Da):25,190
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07DBA19D44648F6F
GO
Isoform Non-brain (identifier: P09497-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-173: Missing.

Show »
Length:211
Mass (Da):23,181
Checksum:i5B40F043E1809238
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9Q6H0Y9Q6_HUMAN
Clathrin light chain
CLTB
81Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DTF9B4DTF9_HUMAN
Clathrin light chain
CLTB
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJD1D6RJD1_HUMAN
Clathrin light chain
CLTB
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5F → I in CAG38814 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001098156 – 173Missing in isoform Non-brain. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M20469 mRNA Translation: AAA51818.1
M20470 mRNA Translation: AAA59506.1
BT007028 mRNA Translation: AAP35675.1
CR536577 mRNA Translation: CAG38814.1
CH471195 Genomic DNA Translation: EAW85079.1
BC006332 mRNA Translation: AAH06332.1
BC006457 mRNA Translation: AAH06457.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4402.1 [P09497-2]
CCDS4403.1 [P09497-1]

Protein sequence database of the Protein Information Resource

More...PIRi		B31775

NCBI Reference Sequences

More...RefSeqi		NP_001825.1, NM_001834.3 [P09497-2]
NP_009028.1, NM_007097.3 [P09497-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310418; ENSP00000309415; ENSG00000175416 [P09497-1]
ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1212

UCSC genome browser

More...UCSCi		uc003meh.4, human [P09497-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20469 mRNA Translation: AAA51818.1
M20470 mRNA Translation: AAA59506.1
BT007028 mRNA Translation: AAP35675.1
CR536577 mRNA Translation: CAG38814.1
CH471195 Genomic DNA Translation: EAW85079.1
BC006332 mRNA Translation: AAH06332.1
BC006457 mRNA Translation: AAH06457.1
CCDSiCCDS4402.1 [P09497-2]
CCDS4403.1 [P09497-1]
PIRiB31775
RefSeqiNP_001825.1, NM_001834.3 [P09497-2]
NP_009028.1, NM_007097.3 [P09497-1]

3D structure databases

SMRiP09497
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107622, 93 interactors
IntActiP09497, 80 interactors
MINTiP09497
STRINGi9606.ENSP00000309415

Protein family/group databases

TCDBi8.A.137.1.2, the clathrin (clathrin) family

PTM databases

iPTMnetiP09497
PhosphoSitePlusiP09497

Genetic variation databases

BioMutaiCLTB

2D gel databases

OGPiP09497

Proteomic databases

EPDiP09497
jPOSTiP09497
MassIVEiP09497
MaxQBiP09497
PaxDbiP09497
PeptideAtlasiP09497
PRIDEiP09497
ProteomicsDBi52240 [P09497-1]
52241 [P09497-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29088, 207 antibodies

The DNASU plasmid repository

More...DNASUi		1212

Genome annotation databases

EnsembliENST00000310418; ENSP00000309415; ENSG00000175416 [P09497-1]
ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2]
GeneIDi1212
KEGGihsa:1212
UCSCiuc003meh.4, human [P09497-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1212
DisGeNETi1212

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLTB
HGNCiHGNC:2091, CLTB
HPAiENSG00000175416, Low tissue specificity
MIMi118970, gene
neXtProtiNX_P09497
OpenTargetsiENSG00000175416
PharmGKBiPA26617
VEuPathDBiHostDB:ENSG00000175416.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4031, Eukaryota
GeneTreeiENSGT00940000160186
HOGENOMiCLU_091462_1_0_1
InParanoidiP09497
OMAiGSFEMIN
OrthoDBi1577821at2759
PhylomeDBiP09497
TreeFamiTF313162

Enzyme and pathway databases

PathwayCommonsiP09497
ReactomeiR-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SIGNORiP09497

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1212, 18 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLTB, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1212
PharosiP09497, Tbio

Protein Ontology

More...PROi		PR:P09497
RNActiP09497, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175416, Expressed in esophagus mucosa and 239 other tissues
ExpressionAtlasiP09497, baseline and differential
GenevisibleiP09497, HS

Family and domain databases

InterProiView protein in InterPro
IPR000996, Clathrin_L-chain
PANTHERiPTHR10639, PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086, Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09497
Secondary accession number(s): Q53Y37, Q6FHW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 10, 2021
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again