UniProtKB - P09497 (CLCB_HUMAN)
Clathrin light chain B
CLTB
Functioni
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
GO - Molecular functioni
- clathrin heavy chain binding Source: GO_Central
- peptide binding Source: Ensembl
- structural molecule activity Source: InterPro
GO - Biological processi
- clathrin coat assembly Source: GO_Central
- clathrin-dependent endocytosis Source: GO_Central
- intracellular protein transport Source: InterPro
Keywordsi
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P09497 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P09497 |
SIGNORi | P09497 |
Protein family/group databases
TCDBi | 8.A.137.1.2, the clathrin (clathrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Clathrin light chain BShort name: Lcb |
Gene namesi | Name:CLTB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2091, CLTB |
MIMi | 118970, gene |
neXtProti | NX_P09497 |
VEuPathDBi | HostDB:ENSG00000175416 |
Subcellular locationi
Other locations
Note: Cytoplasmic face of coated pits and vesicles.
Cytosol
- cytosol Source: HPA
Golgi apparatus
- clathrin coat of trans-Golgi network vesicle Source: InterPro
- trans-Golgi network Source: Ensembl
Plasma Membrane
- ciliary membrane Source: Ensembl
- clathrin coat of coated pit Source: InterPro
- plasma membrane Source: HPA
- presynaptic endocytic zone membrane Source: Ensembl
Other locations
- clathrin coat Source: UniProtKB
- clathrin vesicle coat Source: GO_Central
- clathrin-coated endocytic vesicle Source: ARUK-UCL
- intracellular membrane-bounded organelle Source: HPA
- postsynaptic endocytic zone cytoplasmic component Source: GO_Central
- synaptic vesicle membrane Source: GO_Central
Keywords - Cellular componenti
Coated pit, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1212 |
OpenTargetsi | ENSG00000175416 |
PharmGKBi | PA26617 |
Miscellaneous databases
Pharosi | P09497, Tbio |
Genetic variation databases
BioMutai | CLTB |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205771 | 1 – 229 | Clathrin light chain BAdd BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 187 | PhosphothreonineCombined sources | 1 | |
Disulfide bondi | 199 ↔ 209 | By similarity | ||
Modified residuei | 204 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 217 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
EPDi | P09497 |
jPOSTi | P09497 |
MassIVEi | P09497 |
MaxQBi | P09497 |
PaxDbi | P09497 |
PeptideAtlasi | P09497 |
PRIDEi | P09497 |
ProteomicsDBi | 52240 [P09497-1] 52241 [P09497-2] |
2D gel databases
OGPi | P09497 |
PTM databases
GlyGeni | P09497, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09497 |
PhosphoSitePlusi | P09497 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175416, Expressed in esophagus mucosa and 240 other tissues |
ExpressionAtlasi | P09497, baseline and differential |
Genevisiblei | P09497, HS |
Organism-specific databases
HPAi | ENSG00000175416, Low tissue specificity |
Interactioni
Subunit structurei
Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains.
Interacts (via N-terminus) with HIP1.
Interacts with HIP1R.
2 PublicationsGO - Molecular functioni
- clathrin heavy chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107622, 132 interactors |
IntActi | P09497, 82 interactors |
MINTi | P09497 |
STRINGi | 9606.ENSP00000309415 |
Miscellaneous databases
RNActi | P09497, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 82 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 93 – 155 | Involved in binding clathrin heavy chainAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 77 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4031, Eukaryota |
GeneTreei | ENSGT00940000160186 |
HOGENOMi | CLU_091462_1_0_1 |
InParanoidi | P09497 |
OMAi | QWETICK |
OrthoDBi | 1577821at2759 |
PhylomeDBi | P09497 |
TreeFami | TF313162 |
Family and domain databases
InterProi | View protein in InterPro IPR000996, Clathrin_L-chain |
PANTHERi | PTHR10639, PTHR10639, 1 hit |
Pfami | View protein in Pfam PF01086, Clathrin_lg_ch, 1 hit |
PROSITEi | View protein in PROSITE PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS
60 70 80 90 100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP
110 120 130 140 150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN
160 170 180 190 200
KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD
210 220
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
The sequence of this isoform differs from the canonical sequence as follows:
156-173: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y9Q6 | H0Y9Q6_HUMAN | Clathrin light chain | CLTB | 81 | Annotation score: | ||
B4DTF9 | B4DTF9_HUMAN | Clathrin light chain | CLTB | 134 | Annotation score: | ||
D6RJD1 | D6RJD1_HUMAN | Clathrin light chain | CLTB | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | F → I in CAG38814 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001098 | 156 – 173 | Missing in isoform Non-brain. 3 PublicationsAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20469 mRNA Translation: AAA51818.1 M20470 mRNA Translation: AAA59506.1 BT007028 mRNA Translation: AAP35675.1 CR536577 mRNA Translation: CAG38814.1 CH471195 Genomic DNA Translation: EAW85079.1 BC006332 mRNA Translation: AAH06332.1 BC006457 mRNA Translation: AAH06457.1 |
CCDSi | CCDS4402.1 [P09497-2] CCDS4403.1 [P09497-1] |
PIRi | B31775 |
RefSeqi | NP_001825.1, NM_001834.3 [P09497-2] NP_009028.1, NM_007097.3 [P09497-1] |
Genome annotation databases
Ensembli | ENST00000310418; ENSP00000309415; ENSG00000175416 ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2] |
GeneIDi | 1212 |
KEGGi | hsa:1212 |
MANE-Selecti | ENST00000310418.9; ENSP00000309415.4; NM_007097.5; NP_009028.1 |
UCSCi | uc003meh.4, human [P09497-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20469 mRNA Translation: AAA51818.1 M20470 mRNA Translation: AAA59506.1 BT007028 mRNA Translation: AAP35675.1 CR536577 mRNA Translation: CAG38814.1 CH471195 Genomic DNA Translation: EAW85079.1 BC006332 mRNA Translation: AAH06332.1 BC006457 mRNA Translation: AAH06457.1 |
CCDSi | CCDS4402.1 [P09497-2] CCDS4403.1 [P09497-1] |
PIRi | B31775 |
RefSeqi | NP_001825.1, NM_001834.3 [P09497-2] NP_009028.1, NM_007097.3 [P09497-1] |
3D structure databases
SMRi | P09497 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107622, 132 interactors |
IntActi | P09497, 82 interactors |
MINTi | P09497 |
STRINGi | 9606.ENSP00000309415 |
Protein family/group databases
TCDBi | 8.A.137.1.2, the clathrin (clathrin) family |
PTM databases
GlyGeni | P09497, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P09497 |
PhosphoSitePlusi | P09497 |
Genetic variation databases
BioMutai | CLTB |
2D gel databases
OGPi | P09497 |
Proteomic databases
EPDi | P09497 |
jPOSTi | P09497 |
MassIVEi | P09497 |
MaxQBi | P09497 |
PaxDbi | P09497 |
PeptideAtlasi | P09497 |
PRIDEi | P09497 |
ProteomicsDBi | 52240 [P09497-1] 52241 [P09497-2] |
Protocols and materials databases
Antibodypediai | 29088, 229 antibodies from 27 providers |
DNASUi | 1212 |
Genome annotation databases
Ensembli | ENST00000310418; ENSP00000309415; ENSG00000175416 ENST00000345807; ENSP00000310812; ENSG00000175416 [P09497-2] |
GeneIDi | 1212 |
KEGGi | hsa:1212 |
MANE-Selecti | ENST00000310418.9; ENSP00000309415.4; NM_007097.5; NP_009028.1 |
UCSCi | uc003meh.4, human [P09497-1] |
Organism-specific databases
CTDi | 1212 |
DisGeNETi | 1212 |
GeneCardsi | CLTB |
HGNCi | HGNC:2091, CLTB |
HPAi | ENSG00000175416, Low tissue specificity |
MIMi | 118970, gene |
neXtProti | NX_P09497 |
OpenTargetsi | ENSG00000175416 |
PharmGKBi | PA26617 |
VEuPathDBi | HostDB:ENSG00000175416 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4031, Eukaryota |
GeneTreei | ENSGT00940000160186 |
HOGENOMi | CLU_091462_1_0_1 |
InParanoidi | P09497 |
OMAi | QWETICK |
OrthoDBi | 1577821at2759 |
PhylomeDBi | P09497 |
TreeFami | TF313162 |
Enzyme and pathway databases
PathwayCommonsi | P09497 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P09497 |
SIGNORi | P09497 |
Miscellaneous databases
BioGRID-ORCSi | 1212, 18 hits in 1055 CRISPR screens |
ChiTaRSi | CLTB, human |
GenomeRNAii | 1212 |
Pharosi | P09497, Tbio |
PROi | PR:P09497 |
RNActi | P09497, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175416, Expressed in esophagus mucosa and 240 other tissues |
ExpressionAtlasi | P09497, baseline and differential |
Genevisiblei | P09497, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000996, Clathrin_L-chain |
PANTHERi | PTHR10639, PTHR10639, 1 hit |
Pfami | View protein in Pfam PF01086, Clathrin_lg_ch, 1 hit |
PROSITEi | View protein in PROSITE PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLCB_HUMAN | |
Accessioni | P09497Primary (citable) accession number: P09497 Secondary accession number(s): Q53Y37, Q6FHW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families