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Protein

Clathrin light chain A

Gene

CLTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:CLTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122705.16
HGNCiHGNC:2090 CLTA
MIMi118960 gene
neXtProtiNX_P09496

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1211
OpenTargetsiENSG00000122705
PharmGKBiPA26616

Polymorphism and mutation databases

BioMutaiCLTA
DMDMi116501

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057671 – 248Clathrin light chain AAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei242N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09496
MaxQBiP09496
PaxDbiP09496
PeptideAtlasiP09496
PRIDEiP09496
ProteomicsDBi52236
52237 [P09496-2]
52238 [P09496-3]
52239 [P09496-4]
TopDownProteomicsiP09496-1 [P09496-1]
P09496-2 [P09496-2]

2D gel databases

OGPiP09496

PTM databases

iPTMnetiP09496
PhosphoSitePlusiP09496
SwissPalmiP09496

Miscellaneous databases

PMAP-CutDBiP09496

Expressioni

Gene expression databases

BgeeiENSG00000122705
CleanExiHS_CLTA
ExpressionAtlasiP09496 baseline and differential
GenevisibleiP09496 HS

Organism-specific databases

HPAiCAB002665
HPA050918
HPA054667

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis. Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin heavy chain binding Source: FlyBase
  • GTPase binding Source: Ensembl

Protein-protein interaction databases

BioGridi107621, 82 interactors
IntActiP09496, 78 interactors
MINTiP09496
STRINGi9606.ENSP00000242285

Structurei

3D structure databases

ProteinModelPortaliP09496
SMRiP09496
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 162Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031 Eukaryota
ENOG4111J5K LUCA
GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiP09496
KOiK04644
OMAiINHPCYR
OrthoDBiEOG091G0WEF
PhylomeDBiP09496
TreeFamiTF313162

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P09496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV
110 120 130 140 150
DRLQSEPESI RKWREEQMER LEALDANSRK QEAEWKEKAI KELEEWYARQ
160 170 180 190 200
DEQLQKTKAN NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):27,077
Last modified:July 1, 1989 - v1
Checksum:i8D8A3B49E6353D93
GO
Isoform Non-brain (identifier: P09496-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,662
Checksum:i05C5037569FB6E8D
GO
Isoform 3 (identifier: P09496-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-192: Missing.

Show »
Length:236
Mass (Da):25,676
Checksum:iDAD1A01F3FD51284
GO
Isoform 4 (identifier: P09496-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-180: RVADEAFYKQPFADVIGYV → S

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):24,993
Checksum:iB9644FCE2C09A116
GO
Isoform 5 (identifier: P09496-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-124: Missing.
     163-192: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:166
Mass (Da):17,687
Checksum:i1F8381B9C1F55136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207P → Q in ABB76683 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04716873 – 124Missing in isoform 5. CuratedAdd BLAST52
Alternative sequenceiVSP_043239162 – 180RVADE…VIGYV → S in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_001095163 – 192Missing in isoform Non-brain and isoform 5. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_024238181 – 192Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20471 mRNA Translation: AAA51817.1
M20472 mRNA Translation: AAA59505.1
DQ270158 mRNA Translation: ABB76683.1
BT007170 mRNA Translation: AAP35834.1
AK291078 mRNA Translation: BAF83767.1
AK295692 mRNA Translation: BAG58543.1
AL158830 Genomic DNA No translation available.
AL161792 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58312.1
BC009201 mRNA Translation: AAH09201.1
BC019287 mRNA Translation: AAH19287.1
CCDSiCCDS43802.1 [P09496-3]
CCDS55306.1 [P09496-4]
CCDS55307.1 [P09496-5]
CCDS6600.1 [P09496-2]
CCDS6601.1 [P09496-1]
PIRiA31775
RefSeqiNP_001070145.1, NM_001076677.2 [P09496-3]
NP_001171689.1, NM_001184760.1 [P09496-4]
NP_001171691.1, NM_001184762.1 [P09496-5]
NP_001824.1, NM_001833.3 [P09496-2]
NP_009027.1, NM_007096.3 [P09496-1]
UniGeneiHs.522114

Genome annotation databases

EnsembliENST00000242285; ENSP00000242285; ENSG00000122705 [P09496-1]
ENST00000345519; ENSP00000242284; ENSG00000122705 [P09496-2]
ENST00000396603; ENSP00000379848; ENSG00000122705 [P09496-3]
ENST00000433436; ENSP00000401019; ENSG00000122705 [P09496-1]
ENST00000470744; ENSP00000419746; ENSG00000122705 [P09496-4]
ENST00000538225; ENSP00000442869; ENSG00000122705 [P09496-4]
ENST00000540080; ENSP00000437508; ENSG00000122705 [P09496-5]
GeneIDi1211
KEGGihsa:1211
UCSCiuc003zzc.4 human [P09496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLCA_HUMAN
AccessioniPrimary (citable) accession number: P09496
Secondary accession number(s): A8K4W3
, B4DIN1, F5H6N3, Q2XPN5, Q53XZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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