UniProtKB - P09496 (CLCA_HUMAN)
Clathrin light chain A
CLTA
Functioni
GO - Molecular functioni
- clathrin heavy chain binding Source: FlyBase
- GTPase binding Source: Ensembl
- peptide binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- structural molecule activity Source: InterPro
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- clathrin coat assembly Source: CAFA
- clathrin-dependent endocytosis Source: GO_Central
- intracellular protein transport Source: InterPro
- low-density lipoprotein particle clearance Source: Reactome
- low-density lipoprotein particle receptor catabolic process Source: Reactome
- membrane organization Source: Reactome
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P09496 |
Reactomei | R-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-177504, Retrograde neurotrophin signalling R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-2132295, MHC class II antigen presentation R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis [P09496-1] R-HSA-437239, Recycling pathway of L1 R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8866427, VLDLR internalisation and degradation R-HSA-8964038, LDL clearance |
SIGNORi | P09496 |
Protein family/group databases
TCDBi | 8.A.137.1.1, the clathrin (clathrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Clathrin light chain AShort name: Lca |
Gene namesi | Name:CLTA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000122705.16 |
HGNCi | HGNC:2090, CLTA |
MIMi | 118960, gene |
neXtProti | NX_P09496 |
Subcellular locationi
Cytoskeleton
- spindle 1 Publication1 Publication
Other locations
Note: Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.Curated
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Endosome
- endolysosome membrane Source: Reactome
Golgi apparatus
- clathrin coat of trans-Golgi network vesicle Source: InterPro
- trans-Golgi network membrane Source: Reactome
Lysosome
- endolysosome membrane Source: Reactome
Plasma Membrane
- clathrin coat of coated pit Source: InterPro
- plasma membrane Source: GO_Central
- presynaptic endocytic zone membrane Source: Ensembl
Other locations
- clathrin coat Source: CAFA
- clathrin complex Source: FlyBase
- clathrin vesicle coat Source: GO_Central
- clathrin-coated endocytic vesicle Source: ARUK-UCL
- cytoplasmic vesicle Source: BHF-UCL
- membrane Source: UniProtKB
- postsynaptic endocytic zone cytoplasmic component Source: GO_Central
- synaptic vesicle membrane Source: GO_Central
Keywords - Cellular componenti
Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1211 |
OpenTargetsi | ENSG00000122705 |
PharmGKBi | PA26616 |
Miscellaneous databases
Pharosi | P09496, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295706 |
Polymorphism and mutation databases
BioMutai | CLTA |
DMDMi | 116501 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205767 | 1 – 248 | Clathrin light chain AAdd BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 223 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 236 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P09496 |
jPOSTi | P09496 |
MassIVEi | P09496 |
MaxQBi | P09496 |
PaxDbi | P09496 |
PeptideAtlasi | P09496 |
PRIDEi | P09496 |
ProteomicsDBi | 27239 52236 [P09496-1] 52237 [P09496-2] 52238 [P09496-3] 52239 [P09496-4] |
TopDownProteomicsi | P09496-1 [P09496-1] P09496-2 [P09496-2] |
2D gel databases
OGPi | P09496 |
PTM databases
iPTMneti | P09496 |
MetOSitei | P09496 |
PhosphoSitePlusi | P09496 |
SwissPalmi | P09496 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122705, Expressed in metanephros and 247 other tissues |
ExpressionAtlasi | P09496, baseline and differential |
Genevisiblei | P09496, HS |
Organism-specific databases
HPAi | ENSG00000122705, Low tissue specificity |
Interactioni
Subunit structurei
Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains.
Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis.
Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions.
2 PublicationsBinary interactionsi
Hide detailsP09496
With | #Exp. | IntAct |
---|---|---|
CALY [Q9NYX4] | 4 | EBI-1171169,EBI-10904725 |
CLTC [Q00610] | 2 | EBI-1171169,EBI-354967 |
TACC3 [Q9Y6A5] | 3 | EBI-1171169,EBI-2554984 |
GO - Molecular functioni
- clathrin heavy chain binding Source: FlyBase
- GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107621, 103 interactors |
IntActi | P09496, 95 interactors |
MINTi | P09496 |
STRINGi | 9606.ENSP00000242285 |
Miscellaneous databases
RNActi | P09496, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P09496 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 162 | Involved in binding clathrin heavy chainAdd BLAST | 63 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4031, Eukaryota |
GeneTreei | ENSGT00940000157347 |
InParanoidi | P09496 |
OMAi | RQDEKLQ |
OrthoDBi | 1577821at2759 |
PhylomeDBi | P09496 |
TreeFami | TF313162 |
Family and domain databases
InterProi | View protein in InterPro IPR000996, Clathrin_L-chain |
PANTHERi | PTHR10639, PTHR10639, 1 hit |
Pfami | View protein in Pfam PF01086, Clathrin_lg_ch, 1 hit |
PROSITEi | View protein in PROSITE PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV
110 120 130 140 150
DRLQSEPESI RKWREEQMER LEALDANSRK QEAEWKEKAI KELEEWYARQ
160 170 180 190 200
DEQLQKTKAN NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
The sequence of this isoform differs from the canonical sequence as follows:
163-192: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J8P9 | C9J8P9_HUMAN | Clathrin light chain | CLTA | 196 | Annotation score: | ||
F8WF69 | F8WF69_HUMAN | Clathrin light chain | CLTA | 260 | Annotation score: | ||
S4R3F6 | S4R3F6_HUMAN | Clathrin light chain A | CLTA | 64 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | P → Q in ABB76683 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047168 | 73 – 124 | Missing in isoform 5. CuratedAdd BLAST | 52 | |
Alternative sequenceiVSP_043239 | 162 – 180 | RVADE…VIGYV → S in isoform 4. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_001095 | 163 – 192 | Missing in isoform Non-brain and isoform 5. 4 PublicationsAdd BLAST | 30 | |
Alternative sequenceiVSP_024238 | 181 – 192 | Missing in isoform 3. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20471 mRNA Translation: AAA51817.1 M20472 mRNA Translation: AAA59505.1 DQ270158 mRNA Translation: ABB76683.1 BT007170 mRNA Translation: AAP35834.1 AK291078 mRNA Translation: BAF83767.1 AK295692 mRNA Translation: BAG58543.1 AL158830 Genomic DNA No translation available. AL161792 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58312.1 BC009201 mRNA Translation: AAH09201.1 BC019287 mRNA Translation: AAH19287.1 |
CCDSi | CCDS43802.1 [P09496-3] CCDS55306.1 [P09496-4] CCDS55307.1 [P09496-5] CCDS6600.1 [P09496-2] CCDS6601.1 [P09496-1] |
PIRi | A31775 |
RefSeqi | NP_001070145.1, NM_001076677.2 [P09496-3] NP_001171689.1, NM_001184760.1 [P09496-4] NP_001171691.1, NM_001184762.1 [P09496-5] NP_001824.1, NM_001833.3 [P09496-2] NP_009027.1, NM_007096.3 [P09496-1] |
Genome annotation databases
Ensembli | ENST00000242285; ENSP00000242285; ENSG00000122705 [P09496-1] ENST00000345519; ENSP00000242284; ENSG00000122705 [P09496-2] ENST00000396603; ENSP00000379848; ENSG00000122705 [P09496-3] ENST00000433436; ENSP00000401019; ENSG00000122705 [P09496-1] ENST00000470744; ENSP00000419746; ENSG00000122705 [P09496-4] ENST00000538225; ENSP00000442869; ENSG00000122705 [P09496-4] ENST00000540080; ENSP00000437508; ENSG00000122705 [P09496-5] |
GeneIDi | 1211 |
KEGGi | hsa:1211 |
UCSCi | uc003zzc.4, human [P09496-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20471 mRNA Translation: AAA51817.1 M20472 mRNA Translation: AAA59505.1 DQ270158 mRNA Translation: ABB76683.1 BT007170 mRNA Translation: AAP35834.1 AK291078 mRNA Translation: BAF83767.1 AK295692 mRNA Translation: BAG58543.1 AL158830 Genomic DNA No translation available. AL161792 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58312.1 BC009201 mRNA Translation: AAH09201.1 BC019287 mRNA Translation: AAH19287.1 |
CCDSi | CCDS43802.1 [P09496-3] CCDS55306.1 [P09496-4] CCDS55307.1 [P09496-5] CCDS6600.1 [P09496-2] CCDS6601.1 [P09496-1] |
PIRi | A31775 |
RefSeqi | NP_001070145.1, NM_001076677.2 [P09496-3] NP_001171689.1, NM_001184760.1 [P09496-4] NP_001171691.1, NM_001184762.1 [P09496-5] NP_001824.1, NM_001833.3 [P09496-2] NP_009027.1, NM_007096.3 [P09496-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6E5N | NMR | - | A | 46-61 | [»] | |
SMRi | P09496 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107621, 103 interactors |
IntActi | P09496, 95 interactors |
MINTi | P09496 |
STRINGi | 9606.ENSP00000242285 |
Chemistry databases
ChEMBLi | CHEMBL4295706 |
Protein family/group databases
TCDBi | 8.A.137.1.1, the clathrin (clathrin) family |
PTM databases
iPTMneti | P09496 |
MetOSitei | P09496 |
PhosphoSitePlusi | P09496 |
SwissPalmi | P09496 |
Polymorphism and mutation databases
BioMutai | CLTA |
DMDMi | 116501 |
2D gel databases
OGPi | P09496 |
Proteomic databases
EPDi | P09496 |
jPOSTi | P09496 |
MassIVEi | P09496 |
MaxQBi | P09496 |
PaxDbi | P09496 |
PeptideAtlasi | P09496 |
PRIDEi | P09496 |
ProteomicsDBi | 27239 52236 [P09496-1] 52237 [P09496-2] 52238 [P09496-3] 52239 [P09496-4] |
TopDownProteomicsi | P09496-1 [P09496-1] P09496-2 [P09496-2] |
Protocols and materials databases
Antibodypediai | 3626, 429 antibodies |
DNASUi | 1211 |
Genome annotation databases
Organism-specific databases
CTDi | 1211 |
DisGeNETi | 1211 |
EuPathDBi | HostDB:ENSG00000122705.16 |
GeneCardsi | CLTA |
HGNCi | HGNC:2090, CLTA |
HPAi | ENSG00000122705, Low tissue specificity |
MIMi | 118960, gene |
neXtProti | NX_P09496 |
OpenTargetsi | ENSG00000122705 |
PharmGKBi | PA26616 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4031, Eukaryota |
GeneTreei | ENSGT00940000157347 |
InParanoidi | P09496 |
OMAi | RQDEKLQ |
OrthoDBi | 1577821at2759 |
PhylomeDBi | P09496 |
TreeFami | TF313162 |
Enzyme and pathway databases
PathwayCommonsi | P09496 |
Reactomei | R-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-177504, Retrograde neurotrophin signalling R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-2132295, MHC class II antigen presentation R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis [P09496-1] R-HSA-437239, Recycling pathway of L1 R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8866427, VLDLR internalisation and degradation R-HSA-8964038, LDL clearance |
SIGNORi | P09496 |
Miscellaneous databases
BioGRID-ORCSi | 1211, 18 hits in 844 CRISPR screens |
ChiTaRSi | CLTA, human |
GenomeRNAii | 1211 |
Pharosi | P09496, Tbio |
PROi | PR:P09496 |
RNActi | P09496, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122705, Expressed in metanephros and 247 other tissues |
ExpressionAtlasi | P09496, baseline and differential |
Genevisiblei | P09496, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000996, Clathrin_L-chain |
PANTHERi | PTHR10639, PTHR10639, 1 hit |
Pfami | View protein in Pfam PF01086, Clathrin_lg_ch, 1 hit |
PROSITEi | View protein in PROSITE PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLCA_HUMAN | |
Accessioni | P09496Primary (citable) accession number: P09496 Secondary accession number(s): A8K4W3 Q53XZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families