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UniProtKB - P09496 (CLCA_HUMAN)

Entry version 203 (29 Sep 2021)
Sequence version 1 (01 Jul 1989)
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Protein

Clathrin light chain A

Gene

CLTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P09496

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-2132295, MHC class II antigen presentation
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis [P09496-1]
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance

SIGNOR Signaling Network Open Resource

More...SIGNORi		P09496

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.137.1.1, the clathrin (clathrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLTA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2090, CLTA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118960, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09496

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000122705

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1211

Open Targets

More...OpenTargetsi		ENSG00000122705

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26616

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09496, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295706

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLTA

Domain mapping of disease mutations (DMDM)

More...DMDMi		116501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057671 – 248Clathrin light chain AAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei242N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09496

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09496

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09496

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09496

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09496

PeptideAtlas

More...PeptideAtlasi		P09496

PRoteomics IDEntifications database

More...PRIDEi		P09496

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27239
52236 [P09496-1]
52237 [P09496-2]
52238 [P09496-3]
52239 [P09496-4]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P09496-1 [P09496-1]
P09496-2 [P09496-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P09496

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09496

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P09496

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09496

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P09496

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122705, Expressed in metanephros and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09496, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09496, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000122705, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains.

Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107621, 130 interactors

Protein interaction database and analysis system

More...IntActi		P09496, 103 interactors

Molecular INTeraction database

More...MINTi		P09496

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000242285

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09496, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09496

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 92DisorderedSequence analysisAdd BLAST92
Regioni100 – 162Involved in binding clathrin heavy chainAdd BLAST63

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4031, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157347

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09496

Identification of Orthologs from Complete Genome Data

More...OMAi		PXESNGP

Database of Orthologous Groups

More...OrthoDBi		1577821at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09496

TreeFam database of animal gene trees

More...TreeFami		TF313162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000996, Clathrin_L-chain

The PANTHER Classification System

More...PANTHERi		PTHR10639, PTHR10639, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01086, Clathrin_lg_ch, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Brain (identifier: P09496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE 
        60         70         80         90        100
AFAILDGGAP GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV 
       110        120        130        140        150
DRLQSEPESI RKWREEQMER LEALDANSRK QEAEWKEKAI KELEEWYARQ 
       160        170        180        190        200
DEQLQKTKAN NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN 
       210        220        230        240 
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):27,077
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D8A3B49E6353D93
GO
Isoform Non-brain (identifier: P09496-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,662
Checksum:i05C5037569FB6E8D
GO
Isoform 3 (identifier: P09496-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-192: Missing.

Show »
Length:236
Mass (Da):25,676
Checksum:iDAD1A01F3FD51284
GO
Isoform 4 (identifier: P09496-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-180: RVADEAFYKQPFADVIGYV → S

Show »
Length:230
Mass (Da):24,993
Checksum:iB9644FCE2C09A116
GO
Isoform 5 (identifier: P09496-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-124: Missing.
     163-192: Missing.

Show »
Length:166
Mass (Da):17,687
Checksum:i1F8381B9C1F55136
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8P9C9J8P9_HUMAN
Clathrin light chain
CLTA
196Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF69F8WF69_HUMAN
Clathrin light chain
CLTA
260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3F6S4R3F6_HUMAN
Clathrin light chain A
CLTA
64Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207P → Q in ABB76683 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04716873 – 124Missing in isoform 5. CuratedAdd BLAST52
Alternative sequenceiVSP_043239162 – 180RVADE…VIGYV → S in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_001095163 – 192Missing in isoform Non-brain and isoform 5. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_024238181 – 192Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M20471 mRNA Translation: AAA51817.1
M20472 mRNA Translation: AAA59505.1
DQ270158 mRNA Translation: ABB76683.1
BT007170 mRNA Translation: AAP35834.1
AK291078 mRNA Translation: BAF83767.1
AK295692 mRNA Translation: BAG58543.1
AL158830 Genomic DNA No translation available.
AL161792 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58312.1
BC009201 mRNA Translation: AAH09201.1
BC019287 mRNA Translation: AAH19287.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43802.1 [P09496-3]
CCDS55306.1 [P09496-4]
CCDS55307.1 [P09496-5]
CCDS6600.1 [P09496-2]
CCDS6601.1 [P09496-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A31775

NCBI Reference Sequences

More...RefSeqi		NP_001070145.1, NM_001076677.2 [P09496-3]
NP_001171689.1, NM_001184760.1 [P09496-4]
NP_001171691.1, NM_001184762.1 [P09496-5]
NP_001824.1, NM_001833.3 [P09496-2]
NP_009027.1, NM_007096.3 [P09496-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000242285; ENSP00000242285; ENSG00000122705 [P09496-1]
ENST00000345519; ENSP00000242284; ENSG00000122705 [P09496-2]
ENST00000396603; ENSP00000379848; ENSG00000122705 [P09496-3]
ENST00000433436; ENSP00000401019; ENSG00000122705 [P09496-1]
ENST00000470744; ENSP00000419746; ENSG00000122705 [P09496-4]
ENST00000538225; ENSP00000442869; ENSG00000122705 [P09496-4]
ENST00000540080; ENSP00000437508; ENSG00000122705 [P09496-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1211

UCSC genome browser

More...UCSCi		uc003zzc.4, human [P09496-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20471 mRNA Translation: AAA51817.1
M20472 mRNA Translation: AAA59505.1
DQ270158 mRNA Translation: ABB76683.1
BT007170 mRNA Translation: AAP35834.1
AK291078 mRNA Translation: BAF83767.1
AK295692 mRNA Translation: BAG58543.1
AL158830 Genomic DNA No translation available.
AL161792 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58312.1
BC009201 mRNA Translation: AAH09201.1
BC019287 mRNA Translation: AAH19287.1
CCDSiCCDS43802.1 [P09496-3]
CCDS55306.1 [P09496-4]
CCDS55307.1 [P09496-5]
CCDS6600.1 [P09496-2]
CCDS6601.1 [P09496-1]
PIRiA31775
RefSeqiNP_001070145.1, NM_001076677.2 [P09496-3]
NP_001171689.1, NM_001184760.1 [P09496-4]
NP_001171691.1, NM_001184762.1 [P09496-5]
NP_001824.1, NM_001833.3 [P09496-2]
NP_009027.1, NM_007096.3 [P09496-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6E5NNMR-A46-61[»]
SMRiP09496
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107621, 130 interactors
IntActiP09496, 103 interactors
MINTiP09496
STRINGi9606.ENSP00000242285

Chemistry databases

ChEMBLiCHEMBL4295706

Protein family/group databases

TCDBi8.A.137.1.1, the clathrin (clathrin) family

PTM databases

iPTMnetiP09496
MetOSiteiP09496
PhosphoSitePlusiP09496
SwissPalmiP09496

Genetic variation databases

BioMutaiCLTA
DMDMi116501

2D gel databases

OGPiP09496

Proteomic databases

EPDiP09496
jPOSTiP09496
MassIVEiP09496
MaxQBiP09496
PaxDbiP09496
PeptideAtlasiP09496
PRIDEiP09496
ProteomicsDBi27239
52236 [P09496-1]
52237 [P09496-2]
52238 [P09496-3]
52239 [P09496-4]
TopDownProteomicsiP09496-1 [P09496-1]
P09496-2 [P09496-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3626, 434 antibodies

The DNASU plasmid repository

More...DNASUi		1211

Genome annotation databases

EnsembliENST00000242285; ENSP00000242285; ENSG00000122705 [P09496-1]
ENST00000345519; ENSP00000242284; ENSG00000122705 [P09496-2]
ENST00000396603; ENSP00000379848; ENSG00000122705 [P09496-3]
ENST00000433436; ENSP00000401019; ENSG00000122705 [P09496-1]
ENST00000470744; ENSP00000419746; ENSG00000122705 [P09496-4]
ENST00000538225; ENSP00000442869; ENSG00000122705 [P09496-4]
ENST00000540080; ENSP00000437508; ENSG00000122705 [P09496-5]
GeneIDi1211
KEGGihsa:1211
UCSCiuc003zzc.4, human [P09496-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1211
DisGeNETi1211

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLTA
HGNCiHGNC:2090, CLTA
HPAiENSG00000122705, Low tissue specificity
MIMi118960, gene
neXtProtiNX_P09496
OpenTargetsiENSG00000122705
PharmGKBiPA26616
VEuPathDBiHostDB:ENSG00000122705

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4031, Eukaryota
GeneTreeiENSGT00940000157347
InParanoidiP09496
OMAiPXESNGP
OrthoDBi1577821at2759
PhylomeDBiP09496
TreeFamiTF313162

Enzyme and pathway databases

PathwayCommonsiP09496
ReactomeiR-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-2132295, MHC class II antigen presentation
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis [P09496-1]
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance
SIGNORiP09496

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1211, 22 hits in 1026 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLTA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1211
PharosiP09496, Tbio

Protein Ontology

More...PROi		PR:P09496
RNActiP09496, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122705, Expressed in metanephros and 248 other tissues
ExpressionAtlasiP09496, baseline and differential
GenevisibleiP09496, HS

Family and domain databases

InterProiView protein in InterPro
IPR000996, Clathrin_L-chain
PANTHERiPTHR10639, PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086, Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224, CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581, CLATHRIN_LIGHT_CHN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09496
Secondary accession number(s): A8K4W3
, B4DIN1, F5H6N3, Q2XPN5, Q53XZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 29, 2021
This is version 203 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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