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Protein

Tropomyosin alpha-1 chain

Gene

TPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tropomyosin alpha-1 chain
Alternative name(s):
Alpha-tropomyosin
Tropomyosin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPM1
Synonyms:C15orf13, TMSA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000140416.19

Human Gene Nomenclature Database

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HGNCi
HGNC:12010 TPM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191010 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09493

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, familial hypertrophic 3 (CMH3)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:115196
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs199476306EnsemblClinVar.1
Natural variantiVAR_007601175D → N in CMH3; no change in homodimerization; no change in homodimer thermal stability; decreased actin binding; recessive effect in the homodimer; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 5 PublicationsCorresponds to variant dbSNP:rs104894503EnsemblClinVar.1
Natural variantiVAR_007602180E → G in CMH3; no change in homodimerization; decreased in hom odimer thermal stability; decreased in actin binding; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 2 PublicationsCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Cardiomyopathy, dilated 1Y (CMD1Y)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894501EnsemblClinVar.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894505EnsemblClinVar.1
Left ventricular non-compaction 9 (LVNC9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC9 is an autosomal dominant condition.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476315EnsemblClinVar.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476319EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15K → N: Impairs interaction with LMOD2 and TMOD1. 1 Publication1
Mutagenesisi283S → A: Loss of phosphorylation and decreased formation of actin stress fibers. 1 Publication1
Mutagenesisi283S → E: Increased formation of actin stress fibers. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7168

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TPM1

MalaCards human disease database

More...
MalaCardsi
TPM1
MIMi115196 phenotype
611878 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000140416

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36690

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
136092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056201 – 284Tropomyosin alpha-1 chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei45PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei186PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei283Phosphoserine; by DAPK11 Publication1
Isoform 2 (identifier: P09493-2)
Modified residuei31PhosphoserineCombined sources1
Isoform 5 (identifier: P09493-5)
Modified residuei51PhosphoserineCombined sources1
Isoform 3 (identifier: P09493-3)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 4 (identifier: P09493-4)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 8 (identifier: P09493-8)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 10 (identifier: P09493-10)
Modified residuei213N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P09493

MaxQB - The MaxQuant DataBase

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MaxQBi
P09493

PeptideAtlas

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PeptideAtlasi
P09493

PRoteomics IDEntifications database

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PRIDEi
P09493

ProteomicsDB human proteome resource

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ProteomicsDBi
52229
52230 [P09493-2]
52231 [P09493-3]
52232 [P09493-4]
52233 [P09493-5]
52234 [P09493-6]
52235 [P09493-7]

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P09493

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P09493

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P09493

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P09493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140416 Expressed in 240 organ(s), highest expression level in left ventricle myocardium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P09493 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P09493 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017698
HPA000261
HPA047089
HPA053624

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:23170982). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (PubMed:26873245).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113021, 139 interactors

Protein interaction database and analysis system

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IntActi
P09493, 50 interactors

Molecular INTeraction database

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MINTi
P09493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P09493

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P09493

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 284By similarityAdd BLAST284

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000153390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231521

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107404

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P09493

KEGG Orthology (KO)

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KOi
K10373

Database for complete collections of gene phylogenies

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PhylomeDBi
P09493

TreeFam database of animal gene trees

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TreeFami
TF351519

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000533 Tropomyosin

Pfam protein domain database

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Pfami
View protein in Pfam
PF00261 Tropomyosin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00194 TROPOMYOSIN

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 10 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09493-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle, TPM1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL
60 70 80 90 100
KGTEDELDKY SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ESRAQKDEEK MEIQEIQLKE
160 170 180 190 200
AKHIAEDADR KYEEVARKLV IIESDLERAE ERAELSEGKC AELEEELKTV
210 220 230 240 250
TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE FAERSVTKLE
260 270 280
KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):32,709
Last modified:November 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF57139E2B0972F4D
GO
Isoform 2 (identifier: P09493-2) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MCRLRIFLRTASSEHLHERKLRET
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDSDLESINAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Incomplete sequence.Combined sources
Show »
Length:228
Mass (Da):26,680
Checksum:iA6770D102A359A7B
GO
Isoform 3 (identifier: P09493-3) [UniParc]FASTAAdd to basket
Also known as: Fibroblast, TM3

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Show »
Length:284
Mass (Da):32,876
Checksum:iFDBEEFE342C4ACE3
GO
Isoform 4 (identifier: P09493-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED

Show »
Length:284
Mass (Da):32,848
Checksum:iD29DBCA97BC3C6EE
GO
Isoform 5 (identifier: P09493-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MAGSSSLEAV...LDHERKLRET
     259-284: ELYAQKLKYKAISEELDHALNDMTSI → QLYQQLEQNRRLTNELKLALNED

Show »
Length:245
Mass (Da):28,385
Checksum:i1255A14D9F26E29F
GO
Isoform 6 (identifier: P09493-6) [UniParc]FASTAAdd to basket
Also known as: 10, TPM1kappa

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK

Show »
Length:284
Mass (Da):32,649
Checksum:i1610BB50FB8EB0F5
GO
Isoform 7 (identifier: P09493-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):32,678
Checksum:i3933E81AC289DAF8
GO
Isoform 8 (identifier: P09493-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-53: DELVSLQKKLKGT → EDIAAKEKLLRVS
     57-80: LDKYSEALKDAQEKLELAEKKATD → RDRVLEELHKAEDSLLAAEEAAAK
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:284
Mass (Da):32,817
Checksum:i1EDF6D5109DD335B
GO
Isoform 9 (identifier: P09493-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.
Show »
Length:284
Mass (Da):32,737
Checksum:iDA526AA889904540
GO
Isoform 10 (identifier: P09493-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     284-284: I → M

Note: No experimental confirmation available.Combined sources
Show »
Length:284
Mass (Da):32,866
Checksum:iD45DBCA97BC3C6EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z596B7Z596_HUMAN
Tropomyosin alpha-1 chain
TPM1
275Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZN40Q6ZN40_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
326Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYY1H7BYY1_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7S3F5H7S3_HUMAN
Tropomyosin alpha-1 chain
TPM1
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK48H0YK48_HUMAN
Tropomyosin alpha-1 chain
TPM1
248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNC7H0YNC7_HUMAN
Tropomyosin alpha-1 chain
TPM1
223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL42H0YL42_HUMAN
Tropomyosin alpha-1 chain
TPM1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKJ4H0YKJ4_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S2Z4G6A0A0S2Z4G6_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL80H0YL80_HUMAN
Tropomyosin alpha-1 chain
TPM1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109A → V in CAA30930 (PubMed:3138425).Curated1
Sequence conflicti203N → D in AAT68294 (PubMed:15249230).Curated1
Sequence conflicti203N → D in AAT68295 (PubMed:15249230).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Isoform 3 : Molecular mass is 32875.93 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894501EnsemblClinVar.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894505EnsemblClinVar.1
Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs199476306EnsemblClinVar.1
Natural variantiVAR_007601175D → N in CMH3; no change in homodimerization; no change in homodimer thermal stability; decreased actin binding; recessive effect in the homodimer; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 5 PublicationsCorresponds to variant dbSNP:rs104894503EnsemblClinVar.1
Natural variantiVAR_007602180E → G in CMH3; no change in homodimerization; decreased in hom odimer thermal stability; decreased in actin binding; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 2 PublicationsCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476315EnsemblClinVar.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476319EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0065761 – 80MDAIK…KKATD → MCRLRIFLRTASSEHLHERK LRET in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0174981 – 80MDAIK…KKATD → MAGSSSLEAVRRKIRSLQEQ ADAAEERAGTLQRELDHERK LRET in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_03606441 – 80DELVS…KKATD → EDIAAKEKLLRVSEDERDRV LEELHKAEDSLLAAEEAAAK in isoform 6 and isoform 7. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_04729741 – 53DELVS…KLKGT → EDIAAKEKLLRVS in isoform 8. CuratedAdd BLAST13
Alternative sequenceiVSP_04729857 – 80LDKYS…KKATD → RDRVLEELHKAEDSLLAAEE AAAK in isoform 8. CuratedAdd BLAST24
Alternative sequenceiVSP_006578189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDSDLESIN AAED in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_006577189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDQTLKALM AAED in isoform 3 and isoform 4. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_047299189 – 192KCAE → QVRQ in isoform 8 and isoform 10. Curated4
Alternative sequenceiVSP_047300196 – 212ELKTV…EAQAE → QLRIMDQTLKALMAAED in isoform 8 and isoform 10. CuratedAdd BLAST17
Alternative sequenceiVSP_006579258 – 284DELYA…DMTSI → EKVAHAKEENLSMHQMLDQT LLELNNM in isoform 2, isoform 3, isoform 7, isoform 8 and isoform 9. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_017499259 – 284ELYAQ…DMTSI → QLYQQLEQNRRLTNELKLAL NED in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_047301284I → M in isoform 10. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M19267 mRNA Translation: AAA36771.1
M19713 mRNA Translation: AAA61225.1
M19714 mRNA Translation: AAA61226.1
M19715 mRNA Translation: AAA61227.1
AY640414 mRNA Translation: AAT68294.1
AY640415 mRNA Translation: AAT68295.1
AK299387 mRNA Translation: BAH13023.1
AL050179 mRNA Translation: CAB43309.2
GU324929 Genomic DNA Translation: ADL14500.1
GU324930 Genomic DNA Translation: ADL14501.1
GU324933 Genomic DNA Translation: ADL14504.1
GU324935 Genomic DNA Translation: ADL14506.1
AC079328 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77619.1
CH471082 Genomic DNA Translation: EAW77622.1
CH471082 Genomic DNA Translation: EAW77623.1
CH471082 Genomic DNA Translation: EAW77627.1
CH471082 Genomic DNA Translation: EAW77628.1
BC007433 mRNA Translation: AAH07433.1
BC050473 mRNA Translation: AAH50473.1
BC053545 mRNA Translation: AAH53545.1
X12369 mRNA Translation: CAA30930.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10181.1 [P09493-10]
CCDS32262.1 [P09493-7]
CCDS32263.1 [P09493-3]
CCDS32264.1 [P09493-5]
CCDS45273.1 [P09493-1]
CCDS58368.1 [P09493-8]
CCDS58369.1 [P09493-9]
CCDS86459.1 [P09493-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
A27674
A27678 A25825
S05585

NCBI Reference Sequences

More...
RefSeqi
NP_000357.3, NM_000366.5 [P09493-10]
NP_001018004.1, NM_001018004.1 [P09493-9]
NP_001018005.1, NM_001018005.1 [P09493-1]
NP_001018006.1, NM_001018006.1 [P09493-3]
NP_001018007.1, NM_001018007.1 [P09493-7]
NP_001018008.1, NM_001018008.1 [P09493-5]
NP_001018020.1, NM_001018020.1 [P09493-8]
NP_001288173.1, NM_001301244.1 [P09493-6]
NP_001317273.1, NM_001330344.1
NP_001317275.1, NM_001330346.1
NP_001317280.1, NM_001330351.1
XP_016878027.1, XM_017022538.1 [P09493-10]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.133892
Hs.602995

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267996; ENSP00000267996; ENSG00000140416 [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416 [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416 [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416 [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416 [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416 [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416 [P09493-9]
ENST00000561266; ENSP00000453955; ENSG00000140416 [P09493-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7168

UCSC genome browser

More...
UCSCi
uc002alg.4 human [P09493-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19267 mRNA Translation: AAA36771.1
M19713 mRNA Translation: AAA61225.1
M19714 mRNA Translation: AAA61226.1
M19715 mRNA Translation: AAA61227.1
AY640414 mRNA Translation: AAT68294.1
AY640415 mRNA Translation: AAT68295.1
AK299387 mRNA Translation: BAH13023.1
AL050179 mRNA Translation: CAB43309.2
GU324929 Genomic DNA Translation: ADL14500.1
GU324930 Genomic DNA Translation: ADL14501.1
GU324933 Genomic DNA Translation: ADL14504.1
GU324935 Genomic DNA Translation: ADL14506.1
AC079328 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77619.1
CH471082 Genomic DNA Translation: EAW77622.1
CH471082 Genomic DNA Translation: EAW77623.1
CH471082 Genomic DNA Translation: EAW77627.1
CH471082 Genomic DNA Translation: EAW77628.1
BC007433 mRNA Translation: AAH07433.1
BC050473 mRNA Translation: AAH50473.1
BC053545 mRNA Translation: AAH53545.1
X12369 mRNA Translation: CAA30930.1
CCDSiCCDS10181.1 [P09493-10]
CCDS32262.1 [P09493-7]
CCDS32263.1 [P09493-3]
CCDS32264.1 [P09493-5]
CCDS45273.1 [P09493-1]
CCDS58368.1 [P09493-8]
CCDS58369.1 [P09493-9]
CCDS86459.1 [P09493-6]
PIRiA27674
A27678 A25825
S05585
RefSeqiNP_000357.3, NM_000366.5 [P09493-10]
NP_001018004.1, NM_001018004.1 [P09493-9]
NP_001018005.1, NM_001018005.1 [P09493-1]
NP_001018006.1, NM_001018006.1 [P09493-3]
NP_001018007.1, NM_001018007.1 [P09493-7]
NP_001018008.1, NM_001018008.1 [P09493-5]
NP_001018020.1, NM_001018020.1 [P09493-8]
NP_001288173.1, NM_001301244.1 [P09493-6]
NP_001317273.1, NM_001330344.1
NP_001317275.1, NM_001330346.1
NP_001317280.1, NM_001330351.1
XP_016878027.1, XM_017022538.1 [P09493-10]
UniGeneiHs.133892
Hs.602995

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MUDX-ray2.20C/D1-29[»]
5KHTX-ray1.50A/B/C/D1-28[»]
ProteinModelPortaliP09493
SMRiP09493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113021, 139 interactors
IntActiP09493, 50 interactors
MINTiP09493

PTM databases

iPTMnetiP09493
PhosphoSitePlusiP09493
SwissPalmiP09493

Polymorphism and mutation databases

BioMutaiTPM1
DMDMi136092

2D gel databases

UCD-2DPAGEiP09493

Proteomic databases

EPDiP09493
MaxQBiP09493
PeptideAtlasiP09493
PRIDEiP09493
ProteomicsDBi52229
52230 [P09493-2]
52231 [P09493-3]
52232 [P09493-4]
52233 [P09493-5]
52234 [P09493-6]
52235 [P09493-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267996; ENSP00000267996; ENSG00000140416 [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416 [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416 [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416 [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416 [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416 [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416 [P09493-9]
ENST00000561266; ENSP00000453955; ENSG00000140416 [P09493-6]
GeneIDi7168
KEGGihsa:7168
UCSCiuc002alg.4 human [P09493-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7168
DisGeNETi7168
EuPathDBiHostDB:ENSG00000140416.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPM1
GeneReviewsiTPM1
HGNCiHGNC:12010 TPM1
HPAiCAB017698
HPA000261
HPA047089
HPA053624
MalaCardsiTPM1
MIMi115196 phenotype
191010 gene
611878 phenotype
neXtProtiNX_P09493
OpenTargetsiENSG00000140416
Orphaneti154 Familial isolated dilated cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA36690

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153390
HOGENOMiHOG000231521
HOVERGENiHBG107404
InParanoidiP09493
KOiK10373
PhylomeDBiP09493
TreeFamiTF351519

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TPM1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TPM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7168

Protein Ontology

More...
PROi
PR:P09493

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140416 Expressed in 240 organ(s), highest expression level in left ventricle myocardium
ExpressionAtlasiP09493 baseline and differential
GenevisibleiP09493 HS

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09493
Secondary accession number(s): B7Z5T7
, D9YZV2, D9YZV3, D9YZV8, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: December 5, 2018
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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