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Protein

Tropomyosin alpha-1 chain

Gene

TPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-1 chain
Alternative name(s):
Alpha-tropomyosin
Tropomyosin-1
Gene namesi
Name:TPM1
Synonyms:C15orf13, TMSA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140416.19
HGNCiHGNC:12010 TPM1
MIMi191010 gene
neXtProtiNX_P09493

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Cardiomyopathy, familial hypertrophic 3 (CMH3)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:115196
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs199476306EnsemblClinVar.1
Natural variantiVAR_007601175D → N in CMH3; no change in homodimerization; no change in homodimer thermal stability; decreased actin binding; recessive effect in the homodimer; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 5 PublicationsCorresponds to variant dbSNP:rs104894503EnsemblClinVar.1
Natural variantiVAR_007602180E → G in CMH3; no change in homodimerization; decreased in hom odimer thermal stability; decreased in actin binding; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 2 PublicationsCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Cardiomyopathy, dilated 1Y (CMD1Y)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894501EnsemblClinVar.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894505EnsemblClinVar.1
Left ventricular non-compaction 9 (LVNC9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC9 is an autosomal dominant condition.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476315EnsemblClinVar.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476319EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15K → N: Impairs interaction with LMOD2 and TMOD1. 1 Publication1
Mutagenesisi283S → A: Loss of phosphorylation and decreased formation of actin stress fibers. 1 Publication1
Mutagenesisi283S → E: Increased formation of actin stress fibers. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi7168
GeneReviewsiTPM1
MalaCardsiTPM1
MIMi115196 phenotype
611878 phenotype
OpenTargetsiENSG00000140416
Orphaneti154 Familial isolated dilated cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA36690

Polymorphism and mutation databases

BioMutaiTPM1
DMDMi136092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056201 – 284Tropomyosin alpha-1 chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei45PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei186PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei283Phosphoserine; by DAPK11 Publication1
Isoform 2 (identifier: P09493-2)
Modified residuei31PhosphoserineCombined sources1
Isoform 5 (identifier: P09493-5)
Modified residuei51PhosphoserineCombined sources1
Isoform 3 (identifier: P09493-3)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 4 (identifier: P09493-4)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 8 (identifier: P09493-8)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 10 (identifier: P09493-10)
Modified residuei213N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09493
MaxQBiP09493
PeptideAtlasiP09493
PRIDEiP09493
ProteomicsDBi52229
52230 [P09493-2]
52231 [P09493-3]
52232 [P09493-4]
52233 [P09493-5]
52234 [P09493-6]
52235 [P09493-7]

2D gel databases

UCD-2DPAGEiP09493

PTM databases

iPTMnetiP09493
PhosphoSitePlusiP09493
SwissPalmiP09493

Expressioni

Tissue specificityi

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000140416 Expressed in 240 organ(s), highest expression level in left ventricle myocardium
ExpressionAtlasiP09493 baseline and differential
GenevisibleiP09493 HS

Organism-specific databases

HPAiCAB017698
HPA000261
HPA047089
HPA053624

Interactioni

Subunit structurei

Homodimer (PubMed:23170982). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (PubMed:26873245).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113021, 138 interactors
IntActiP09493, 49 interactors
MINTiP09493

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09493
SMRiP09493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074494
HOGENOMiHOG000231521
HOVERGENiHBG107404
InParanoidiP09493
KOiK10373
PhylomeDBiP09493
TreeFamiTF351519

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

Sequences (10+)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 10 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09493-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle, TPM1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL
60 70 80 90 100
KGTEDELDKY SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ESRAQKDEEK MEIQEIQLKE
160 170 180 190 200
AKHIAEDADR KYEEVARKLV IIESDLERAE ERAELSEGKC AELEEELKTV
210 220 230 240 250
TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE FAERSVTKLE
260 270 280
KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):32,709
Last modified:November 1, 1990 - v2
Checksum:iF57139E2B0972F4D
GO
Isoform 2 (identifier: P09493-2) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MCRLRIFLRTASSEHLHERKLRET
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDSDLESINAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Incomplete sequence.Combined sources
Show »
Length:228
Mass (Da):26,680
Checksum:iA6770D102A359A7B
GO
Isoform 3 (identifier: P09493-3) [UniParc]FASTAAdd to basket
Also known as: Fibroblast, TM3

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Show »
Length:284
Mass (Da):32,876
Checksum:iFDBEEFE342C4ACE3
GO
Isoform 4 (identifier: P09493-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED

Show »
Length:284
Mass (Da):32,848
Checksum:iD29DBCA97BC3C6EE
GO
Isoform 5 (identifier: P09493-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MAGSSSLEAV...LDHERKLRET
     259-284: ELYAQKLKYKAISEELDHALNDMTSI → QLYQQLEQNRRLTNELKLALNED

Show »
Length:245
Mass (Da):28,385
Checksum:i1255A14D9F26E29F
GO
Isoform 6 (identifier: P09493-6) [UniParc]FASTAAdd to basket
Also known as: 10, TPM1kappa

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK

Show »
Length:284
Mass (Da):32,649
Checksum:i1610BB50FB8EB0F5
GO
Isoform 7 (identifier: P09493-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):32,678
Checksum:i3933E81AC289DAF8
GO
Isoform 8 (identifier: P09493-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-53: DELVSLQKKLKGT → EDIAAKEKLLRVS
     57-80: LDKYSEALKDAQEKLELAEKKATD → RDRVLEELHKAEDSLLAAEEAAAK
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:284
Mass (Da):32,817
Checksum:i1EDF6D5109DD335B
GO
Isoform 9 (identifier: P09493-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.
Show »
Length:284
Mass (Da):32,737
Checksum:iDA526AA889904540
GO
Isoform 10 (identifier: P09493-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     284-284: I → M

Note: No experimental confirmation available.Combined sources
Show »
Length:284
Mass (Da):32,866
Checksum:iD45DBCA97BC3C6EE
GO

Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z596B7Z596_HUMAN
Tropomyosin alpha-1 chain
TPM1
275Annotation score:
Q6ZN40Q6ZN40_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
326Annotation score:
H7BYY1H7BYY1_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
248Annotation score:
F5H7S3F5H7S3_HUMAN
Tropomyosin alpha-1 chain
TPM1
245Annotation score:
H0YK48H0YK48_HUMAN
Tropomyosin alpha-1 chain
TPM1
248Annotation score:
H0YNC7H0YNC7_HUMAN
Tropomyosin alpha-1 chain
TPM1
223Annotation score:
H0YL42H0YL42_HUMAN
Tropomyosin alpha-1 chain
TPM1
108Annotation score:
H0YKJ4H0YKJ4_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
248Annotation score:
A0A0S2Z4G6A0A0S2Z4G6_HUMAN
Tropomyosin 1 (Alpha), isoform CRA_...
TPM1 hCG_33495
284Annotation score:
H0YL80H0YL80_HUMAN
Tropomyosin alpha-1 chain
TPM1
68Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → V in CAA30930 (PubMed:3138425).Curated1
Sequence conflicti203N → D in AAT68294 (PubMed:15249230).Curated1
Sequence conflicti203N → D in AAT68295 (PubMed:15249230).Curated1

Mass spectrometryi

Isoform 3 : Molecular mass is 32875.93 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894501EnsemblClinVar.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant dbSNP:rs104894505EnsemblClinVar.1
Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs199476306EnsemblClinVar.1
Natural variantiVAR_007601175D → N in CMH3; no change in homodimerization; no change in homodimer thermal stability; decreased actin binding; recessive effect in the homodimer; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 5 PublicationsCorresponds to variant dbSNP:rs104894503EnsemblClinVar.1
Natural variantiVAR_007602180E → G in CMH3; no change in homodimerization; decreased in hom odimer thermal stability; decreased in actin binding; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer. 2 PublicationsCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant dbSNP:rs104894502EnsemblClinVar.1
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476315EnsemblClinVar.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant dbSNP:rs199476319EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065761 – 80MDAIK…KKATD → MCRLRIFLRTASSEHLHERK LRET in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0174981 – 80MDAIK…KKATD → MAGSSSLEAVRRKIRSLQEQ ADAAEERAGTLQRELDHERK LRET in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_03606441 – 80DELVS…KKATD → EDIAAKEKLLRVSEDERDRV LEELHKAEDSLLAAEEAAAK in isoform 6 and isoform 7. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_04729741 – 53DELVS…KLKGT → EDIAAKEKLLRVS in isoform 8. CuratedAdd BLAST13
Alternative sequenceiVSP_04729857 – 80LDKYS…KKATD → RDRVLEELHKAEDSLLAAEE AAAK in isoform 8. CuratedAdd BLAST24
Alternative sequenceiVSP_006578189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDSDLESIN AAED in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_006577189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDQTLKALM AAED in isoform 3 and isoform 4. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_047299189 – 192KCAE → QVRQ in isoform 8 and isoform 10. Curated4
Alternative sequenceiVSP_047300196 – 212ELKTV…EAQAE → QLRIMDQTLKALMAAED in isoform 8 and isoform 10. CuratedAdd BLAST17
Alternative sequenceiVSP_006579258 – 284DELYA…DMTSI → EKVAHAKEENLSMHQMLDQT LLELNNM in isoform 2, isoform 3, isoform 7, isoform 8 and isoform 9. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_017499259 – 284ELYAQ…DMTSI → QLYQQLEQNRRLTNELKLAL NED in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_047301284I → M in isoform 10. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19267 mRNA Translation: AAA36771.1
M19713 mRNA Translation: AAA61225.1
M19714 mRNA Translation: AAA61226.1
M19715 mRNA Translation: AAA61227.1
AY640414 mRNA Translation: AAT68294.1
AY640415 mRNA Translation: AAT68295.1
AK299387 mRNA Translation: BAH13023.1
AL050179 mRNA Translation: CAB43309.2
GU324929 Genomic DNA Translation: ADL14500.1
GU324930 Genomic DNA Translation: ADL14501.1
GU324933 Genomic DNA Translation: ADL14504.1
GU324935 Genomic DNA Translation: ADL14506.1
AC079328 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77619.1
CH471082 Genomic DNA Translation: EAW77622.1
CH471082 Genomic DNA Translation: EAW77623.1
CH471082 Genomic DNA Translation: EAW77627.1
CH471082 Genomic DNA Translation: EAW77628.1
BC007433 mRNA Translation: AAH07433.1
BC050473 mRNA Translation: AAH50473.1
BC053545 mRNA Translation: AAH53545.1
X12369 mRNA Translation: CAA30930.1
CCDSiCCDS10181.1 [P09493-10]
CCDS32262.1 [P09493-7]
CCDS32263.1 [P09493-3]
CCDS32264.1 [P09493-5]
CCDS45273.1 [P09493-1]
CCDS58368.1 [P09493-8]
CCDS58369.1 [P09493-9]
CCDS86459.1 [P09493-6]
PIRiA27674
A27678 A25825
S05585
RefSeqiNP_000357.3, NM_000366.5 [P09493-10]
NP_001018004.1, NM_001018004.1 [P09493-9]
NP_001018005.1, NM_001018005.1 [P09493-1]
NP_001018006.1, NM_001018006.1 [P09493-3]
NP_001018007.1, NM_001018007.1 [P09493-7]
NP_001018008.1, NM_001018008.1 [P09493-5]
NP_001018020.1, NM_001018020.1 [P09493-8]
NP_001288173.1, NM_001301244.1 [P09493-6]
NP_001317273.1, NM_001330344.1
NP_001317275.1, NM_001330346.1
NP_001317280.1, NM_001330351.1
XP_016878027.1, XM_017022538.1 [P09493-10]
UniGeneiHs.133892
Hs.602995

Genome annotation databases

EnsembliENST00000267996; ENSP00000267996; ENSG00000140416 [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416 [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416 [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416 [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416 [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416 [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416 [P09493-9]
ENST00000561266; ENSP00000453955; ENSG00000140416 [P09493-6]
GeneIDi7168
KEGGihsa:7168
UCSCiuc002alg.4 human [P09493-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19267 mRNA Translation: AAA36771.1
M19713 mRNA Translation: AAA61225.1
M19714 mRNA Translation: AAA61226.1
M19715 mRNA Translation: AAA61227.1
AY640414 mRNA Translation: AAT68294.1
AY640415 mRNA Translation: AAT68295.1
AK299387 mRNA Translation: BAH13023.1
AL050179 mRNA Translation: CAB43309.2
GU324929 Genomic DNA Translation: ADL14500.1
GU324930 Genomic DNA Translation: ADL14501.1
GU324933 Genomic DNA Translation: ADL14504.1
GU324935 Genomic DNA Translation: ADL14506.1
AC079328 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77619.1
CH471082 Genomic DNA Translation: EAW77622.1
CH471082 Genomic DNA Translation: EAW77623.1
CH471082 Genomic DNA Translation: EAW77627.1
CH471082 Genomic DNA Translation: EAW77628.1
BC007433 mRNA Translation: AAH07433.1
BC050473 mRNA Translation: AAH50473.1
BC053545 mRNA Translation: AAH53545.1
X12369 mRNA Translation: CAA30930.1
CCDSiCCDS10181.1 [P09493-10]
CCDS32262.1 [P09493-7]
CCDS32263.1 [P09493-3]
CCDS32264.1 [P09493-5]
CCDS45273.1 [P09493-1]
CCDS58368.1 [P09493-8]
CCDS58369.1 [P09493-9]
CCDS86459.1 [P09493-6]
PIRiA27674
A27678 A25825
S05585
RefSeqiNP_000357.3, NM_000366.5 [P09493-10]
NP_001018004.1, NM_001018004.1 [P09493-9]
NP_001018005.1, NM_001018005.1 [P09493-1]
NP_001018006.1, NM_001018006.1 [P09493-3]
NP_001018007.1, NM_001018007.1 [P09493-7]
NP_001018008.1, NM_001018008.1 [P09493-5]
NP_001018020.1, NM_001018020.1 [P09493-8]
NP_001288173.1, NM_001301244.1 [P09493-6]
NP_001317273.1, NM_001330344.1
NP_001317275.1, NM_001330346.1
NP_001317280.1, NM_001330351.1
XP_016878027.1, XM_017022538.1 [P09493-10]
UniGeneiHs.133892
Hs.602995

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MUDX-ray2.20C/D1-29[»]
5KHTX-ray1.50A/B/C/D1-28[»]
ProteinModelPortaliP09493
SMRiP09493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113021, 138 interactors
IntActiP09493, 49 interactors
MINTiP09493

PTM databases

iPTMnetiP09493
PhosphoSitePlusiP09493
SwissPalmiP09493

Polymorphism and mutation databases

BioMutaiTPM1
DMDMi136092

2D gel databases

UCD-2DPAGEiP09493

Proteomic databases

EPDiP09493
MaxQBiP09493
PeptideAtlasiP09493
PRIDEiP09493
ProteomicsDBi52229
52230 [P09493-2]
52231 [P09493-3]
52232 [P09493-4]
52233 [P09493-5]
52234 [P09493-6]
52235 [P09493-7]

Protocols and materials databases

DNASUi7168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267996; ENSP00000267996; ENSG00000140416 [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416 [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416 [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416 [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416 [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416 [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416 [P09493-9]
ENST00000561266; ENSP00000453955; ENSG00000140416 [P09493-6]
GeneIDi7168
KEGGihsa:7168
UCSCiuc002alg.4 human [P09493-1]

Organism-specific databases

CTDi7168
DisGeNETi7168
EuPathDBiHostDB:ENSG00000140416.19
GeneCardsiTPM1
GeneReviewsiTPM1
HGNCiHGNC:12010 TPM1
HPAiCAB017698
HPA000261
HPA047089
HPA053624
MalaCardsiTPM1
MIMi115196 phenotype
191010 gene
611878 phenotype
neXtProtiNX_P09493
OpenTargetsiENSG00000140416
Orphaneti154 Familial isolated dilated cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA36690
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074494
HOGENOMiHOG000231521
HOVERGENiHBG107404
InParanoidiP09493
KOiK10373
PhylomeDBiP09493
TreeFamiTF351519

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRSiTPM1 human
GeneWikiiTPM1
GenomeRNAii7168
PROiPR:P09493
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140416 Expressed in 240 organ(s), highest expression level in left ventricle myocardium
ExpressionAtlasiP09493 baseline and differential
GenevisibleiP09493 HS

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPM1_HUMAN
AccessioniPrimary (citable) accession number: P09493
Secondary accession number(s): B7Z5T7
, D9YZV2, D9YZV3, D9YZV8, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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