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UniProtKB - P09486 (SPRC_HUMAN)

Protein

SPARC

Gene

SPARC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi274 – 285Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • collagen binding Source: UniProtKB
  • extracellular matrix binding Source: GO_Central
  • extracellular matrix structural constituent Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-3000178 ECM proteoglycans
R-HSA-3000497 Scavenging by Class H Receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		P09486

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPARC
Alternative name(s):
Basement-membrane protein 40
Short name:
BM-40
Osteonectin
Short name:
ON
Secreted protein acidic and rich in cysteine
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPARC
Synonyms:ON
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000113140.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:11219 SPARC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182120 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09486

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteogenesis imperfecta 17 (OI17)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.
See also OMIM:616507
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075142166R → H in OI17; decreased secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517662Ensembl.1
Natural variantiVAR_075143263E → K in OI17; no effect on expression and secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517663Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi166R → A, L or K: Strongly reduced collagen binding. 1 Publication1
Mutagenesisi173N → A or Q: Strongly reduced collagen binding. 1 Publication1
Mutagenesisi259L → A: Loss of collagen binding. 1 Publication1
Mutagenesisi262M → A: Strongly reduced collagen binding. 1 Publication1
Mutagenesisi263E → A: Loss of collagen binding. 1 Publication1

Keywords - Diseasei

Disease mutation, Osteogenesis imperfecta

Organism-specific databases

DisGeNET

More...DisGeNETi		6678

MalaCards human disease database

More...MalaCardsi		SPARC
MIMi616507 phenotype

Open Targets

More...OpenTargetsi		ENSG00000113140

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		216820 Osteogenesis imperfecta type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36055

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPARC

Domain mapping of disease mutations (DMDM)

More...DMDMi		129283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 172 PublicationsAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002030418 – 303SPARCAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi72 ↔ 83PROSITE-ProRule annotation1 Publication
Disulfide bondi77 ↔ 93PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 130PROSITE-ProRule annotation1 Publication
Disulfide bondi101 ↔ 123PROSITE-ProRule annotation1 Publication
Disulfide bondi112 ↔ 149PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi155 ↔ 265PROSITE-ProRule annotation1 Publication
Disulfide bondi273 ↔ 289PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09486

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09486

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09486

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09486

PeptideAtlas

More...PeptideAtlasi		P09486

PRoteomics IDEntifications database

More...PRIDEi		P09486

ProteomicsDB human proteome resource

More...ProteomicsDBi		52226

2D gel databases

USC-OGP 2-DE database

More...OGPi		P09486

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		706

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09486

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09486

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P09486

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P09486

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113140 Expressed in 232 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

More...CleanExi		HS_SPARC

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09486 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09486 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002306
HPA002989
HPA003020

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112560, 11 interactors

Database of interacting proteins

More...DIPi		DIP-46426N

Protein interaction database and analysis system

More...IntActi		P09486, 14 interactors

Molecular INTeraction database

More...MINTi		P09486

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000231061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMOX-ray3.10A/B71-303[»]
1NUBX-ray2.80A/B71-303[»]
1SRAX-ray2.00A153-303[»]
2V53X-ray3.20A70-303[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P09486

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09486

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09486

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 93Follistatin-likeAdd BLAST23
Domaini89 – 151Kazal-likePROSITE-ProRule annotationAdd BLAST63
Domaini261 – 296EF-handAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 69Asp/Glu-rich (acidic; binds calcium)Add BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPARC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4004 Eukaryota
ENOG41101WW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046787

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG002746

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09486

Identification of Orthologs from Complete Genome Data

More...OMAi		KDFPRRM

Database of Orthologous Groups

More...OrthoDBi		1592225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09486

TreeFam database of animal gene trees

More...TreeFami		TF319356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR019577 SPARC/Testican_Ca-bd-dom

The PANTHER Classification System

More...PANTHERi		PTHR13866 PTHR13866, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P09486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV 
        60         70         80         90        100
EVGEFDDGAE ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS 
       110        120        130        140        150
CPAPIGEFEK VCSNDNKTFD SSCHFFATKC TLEGTKKGHK LHLDYIGPCK 
       160        170        180        190        200
YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE RDEDNNLLTE KQKLRVKKIH 
       210        220        230        240        250
ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ HPIDGYLSHT 
       260        270        280        290        300
ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD 

LVI
Length:303
Mass (Da):34,632
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB914599F79705945
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4E2F5H4E2_HUMAN
SPARC
SPARC
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJA5E5RJA5_HUMAN
SPARC
SPARC
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY03F5GY03_HUMAN
SPARC
SPARC
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK62E5RK62_HUMAN
SPARC
SPARC
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60993 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42 – 43SV → PT AA sequence (PubMed:3597437).Curated2
Sequence conflicti205R → L in AAA60993 (PubMed:2790009).Curated1
Sequence conflicti269F → L in AAA60993 (PubMed:2790009).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05043119P → S. Corresponds to variant dbSNP:rs6874468Ensembl.1
Natural variantiVAR_05953070N → S. Corresponds to variant dbSNP:rs13359508Ensembl.1
Natural variantiVAR_075142166R → H in OI17; decreased secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517662Ensembl.1
Natural variantiVAR_075143263E → K in OI17; no effect on expression and secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517663Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00755 mRNA Translation: CAA68724.1
J03040 mRNA Translation: AAA60570.1
M25746
, M25738, M25739, M25740, M25741, M25742, M25743, M25744, M25745 Genomic DNA Translation: AAA60993.1 Sequence problems.
CR456799 mRNA Translation: CAG33080.1
CH471062 Genomic DNA Translation: EAW61668.1
CH471062 Genomic DNA Translation: EAW61669.1
CH471062 Genomic DNA Translation: EAW61670.1
CH471062 Genomic DNA Translation: EAW61672.1
BC004974 mRNA Translation: AAH04974.1
BC008011 mRNA Translation: AAH08011.1
BC072457 mRNA Translation: AAH72457.1
AL709729 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4318.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32821 GEHUN

NCBI Reference Sequences

More...RefSeqi		NP_001296372.1, NM_001309443.1
NP_001296373.1, NM_001309444.1
NP_003109.1, NM_003118.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.111779

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000231061; ENSP00000231061; ENSG00000113140

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6678

UCSC genome browser

More...UCSCi		uc003lui.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Osteonectin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00755 mRNA Translation: CAA68724.1
J03040 mRNA Translation: AAA60570.1
M25746
, M25738, M25739, M25740, M25741, M25742, M25743, M25744, M25745 Genomic DNA Translation: AAA60993.1 Sequence problems.
CR456799 mRNA Translation: CAG33080.1
CH471062 Genomic DNA Translation: EAW61668.1
CH471062 Genomic DNA Translation: EAW61669.1
CH471062 Genomic DNA Translation: EAW61670.1
CH471062 Genomic DNA Translation: EAW61672.1
BC004974 mRNA Translation: AAH04974.1
BC008011 mRNA Translation: AAH08011.1
BC072457 mRNA Translation: AAH72457.1
AL709729 mRNA No translation available.
CCDSiCCDS4318.1
PIRiA32821 GEHUN
RefSeqiNP_001296372.1, NM_001309443.1
NP_001296373.1, NM_001309444.1
NP_003109.1, NM_003118.3
UniGeneiHs.111779

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMOX-ray3.10A/B71-303[»]
1NUBX-ray2.80A/B71-303[»]
1SRAX-ray2.00A153-303[»]
2V53X-ray3.20A70-303[»]
ProteinModelPortaliP09486
SMRiP09486
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112560, 11 interactors
DIPiDIP-46426N
IntActiP09486, 14 interactors
MINTiP09486
STRINGi9606.ENSP00000231061

PTM databases

GlyConnecti706
iPTMnetiP09486
PhosphoSitePlusiP09486
UniCarbKBiP09486

Polymorphism and mutation databases

BioMutaiSPARC
DMDMi129283

2D gel databases

OGPiP09486

Proteomic databases

EPDiP09486
jPOSTiP09486
MaxQBiP09486
PaxDbiP09486
PeptideAtlasiP09486
PRIDEiP09486
ProteomicsDBi52226

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6678
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231061; ENSP00000231061; ENSG00000113140
GeneIDi6678
KEGGihsa:6678
UCSCiuc003lui.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6678
DisGeNETi6678
EuPathDBiHostDB:ENSG00000113140.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPARC
HGNCiHGNC:11219 SPARC
HPAiCAB002306
HPA002989
HPA003020
MalaCardsiSPARC
MIMi182120 gene
616507 phenotype
neXtProtiNX_P09486
OpenTargetsiENSG00000113140
Orphaneti216820 Osteogenesis imperfecta type 4
PharmGKBiPA36055

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
GeneTreeiENSGT00510000046787
HOVERGENiHBG002746
InParanoidiP09486
OMAiKDFPRRM
OrthoDBi1592225at2759
PhylomeDBiP09486
TreeFamiTF319356

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-3000178 ECM proteoglycans
R-HSA-3000497 Scavenging by Class H Receptors
SIGNORiP09486

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPARC human
EvolutionaryTraceiP09486

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Osteonectin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6678
PMAP-CutDBiP09486

Protein Ontology

More...PROi		PR:P09486

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113140 Expressed in 232 organ(s), highest expression level in tibia
CleanExiHS_SPARC
ExpressionAtlasiP09486 baseline and differential
GenevisibleiP09486 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09486
Secondary accession number(s): D3DQH9, Q6IBK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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