SPARC

Functionⁱ

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca²⁺ with a low affinity and an EF-hand loop that binds a Ca²⁺ ion with a high affinity.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	274 – 285	Add BLAST		12

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7034958
collagen binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7034958
- 9501084
extracellular matrix binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone development Source: Ensembl
cellular response to growth factor stimulus Source: Ensembl
extracellular matrix organization Source: Reactome
heart development Source: Ensembl
inner ear development Source: Ensembl
lung development Source: Ensembl
negative regulation of angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 12867428
negative regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12867428
ossification Source: Ensembl
pigmentation Source: Ensembl
platelet degranulation Source: Reactome
positive regulation of endothelial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 12867428
receptor-mediated endocytosis Source: Reactome
regulation of cell morphogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 15389586
regulation of synapse organization Source: Ensembl
response to cadmium ion Source: Ensembl
response to calcium ion Source: Ensembl
response to cAMP Source: Ensembl
response to cytokine Source: Ensembl
response to ethanol Source: Ensembl
response to glucocorticoid Source: Ensembl
response to gravity Source: Ensembl
response to L-ascorbic acid Source: Ensembl
response to lead ion Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to peptide hormone Source: Ensembl
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Copper, Metal-binding

Ligand

Calcium, Copper, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-3000178 ECM proteoglycans R-HSA-3000497 Scavenging by Class H Receptors
SIGNORⁱ	P09486

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SPARC Alternative name(s): Basement-membrane protein 40 Short name: BM-40 Osteonectin Short name: ON Secreted protein acidic and rich in cysteine
Gene namesⁱ	Name:SPARC Synonyms:ON
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113140.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11219 SPARC
MIMⁱ	182120 gene
neXtProtⁱ	NX_P09486

Keywords - Cellular componentⁱ

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Osteogenesis imperfecta 17 (OI17)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_075142	166	R → H in OI17; decreased secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517662Ensembl.		1
Natural variantⁱVAR_075143	263	E → K in OI17; no effect on expression and secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517663Ensembl.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	166	R → A, L or K: Strongly reduced collagen binding. 1 Publication	1
Mutagenesisⁱ	173	N → A or Q: Strongly reduced collagen binding. 1 Publication	1
Mutagenesisⁱ	259	L → A: Loss of collagen binding. 1 Publication	1
Mutagenesisⁱ	262	M → A: Strongly reduced collagen binding. 1 Publication	1
Mutagenesisⁱ	263	E → A: Loss of collagen binding. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Osteogenesis imperfecta

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6678
MalaCards human disease database More...MalaCardsⁱ	SPARC
MIMⁱ	616507 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000113140
Orphanetⁱ	216820 Osteogenesis imperfecta type 4
PharmGKBⁱ	PA36055

Polymorphism and mutation databases

BioMutaⁱ	SPARC
DMDMⁱ	129283

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	2 PublicationsAdd BLAST		17
ChainⁱPRO_0000020304	18 – 303	SPARCAdd BLAST		286

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	72 ↔ 83	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	77 ↔ 93	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	95 ↔ 130	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	101 ↔ 123	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	112 ↔ 149	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	155 ↔ 265	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	273 ↔ 289	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P09486
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09486
PaxDbⁱ	P09486
PeptideAtlas More...PeptideAtlasⁱ	P09486
PRIDEⁱ	P09486
ProteomicsDBⁱ	52226

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P09486

OGPⁱ

P09486

PTM databases

GlyConnectⁱ	706
iPTMnetⁱ	P09486
PhosphoSitePlusⁱ	P09486
UniCarbKBⁱ	P09486

Miscellaneous databases

PMAP-CutDBⁱ	P09486

PMAP-CutDBⁱ

P09486

Expressionⁱ

Developmental stageⁱ

Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.

Gene expression databases

Bgeeⁱ	ENSG00000113140 Expressed in 232 organ(s), highest expression level in tibia
CleanExⁱ	HS_SPARC
ExpressionAtlasⁱ	P09486 baseline and differential
Genevisibleⁱ	P09486 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002306 HPA002989 HPA003020

HPAⁱ

CAB002306
HPA002989
HPA003020

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COL3A1	P02461-1	4	EBI-2800983,EBI-15740444
faf	Q2TV77	4	EBI-2800983,EBI-6405263	From Finegoldia magna.
MYOC	Q99972	3	EBI-2800983,EBI-11692272

Protein-protein interaction databases

BioGridⁱ	112560, 11 interactors
Database of interacting proteins More...DIPⁱ	DIP-46426N
IntActⁱ	P09486, 14 interactors
Molecular INTeraction database More...MINTⁱ	P09486
STRINGⁱ	9606.ENSP00000231061

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	71 – 74	Combined sources	4
Beta strandⁱ	81 – 85	Combined sources	5
Beta strandⁱ	91 – 95	Combined sources	5
Helixⁱ	98 – 100	Combined sources	3
Helixⁱ	107 – 109	Combined sources	3
Beta strandⁱ	111 – 113	Combined sources	3
Turnⁱ	114 – 116	Combined sources	3
Beta strandⁱ	118 – 121	Combined sources	4
Helixⁱ	122 – 131	Combined sources	10
Turnⁱ	132 – 134	Combined sources	3
Helixⁱ	136 – 140	Combined sources	5
Beta strandⁱ	143 – 148	Combined sources	6
Helixⁱ	157 – 181	Combined sources	25
Beta strandⁱ	183 – 188	Combined sources	6
Helixⁱ	190 – 201	Combined sources	12
Helixⁱ	213 – 222	Combined sources	10
Helixⁱ	224 – 227	Combined sources	4
Helixⁱ	228 – 238	Combined sources	11
Beta strandⁱ	244 – 247	Combined sources	4
Turnⁱ	249 – 252	Combined sources	4
Helixⁱ	253 – 256	Combined sources	4
Turnⁱ	257 – 259	Combined sources	3
Helixⁱ	260 – 262	Combined sources	3
Helixⁱ	263 – 265	Combined sources	3
Helixⁱ	266 – 273	Combined sources	8
Beta strandⁱ	278 – 282	Combined sources	5
Helixⁱ	283 – 289	Combined sources	7
Helixⁱ	294 – 296	Combined sources	3
Helixⁱ	299 – 301	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P09486
SMRⁱ	P09486
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P09486

EvolutionaryTraceⁱ

P09486

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	71 – 93	Follistatin-likeAdd BLAST	23
Domainⁱ	89 – 151	Kazal-likePROSITE-ProRule annotationAdd BLAST	63
Domainⁱ	261 – 296	EF-handAdd BLAST	36

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	22 – 69	Asp/Glu-rich (acidic; binds calcium)Add BLAST		48

Sequence similaritiesⁱ

Belongs to the SPARC family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG4004 Eukaryota ENOG41101WW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046787
HOVERGENⁱ	HBG002746
InParanoidⁱ	P09486
OMAⁱ	KDFPRRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CPG
PhylomeDBⁱ	P09486
TreeFamⁱ	TF319356

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR001999 Osteonectin_CS IPR037641 SPARC IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERⁱ	PTHR13866 PTHR13866, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF00050 Kazal_1, 1 hit PF10591 SPARC_Ca_bdg, 1 hit
SMARTⁱ	View protein in SMART SM00274 FOLN, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS51465 KAZAL_2, 1 hit PS00612 OSTEONECTIN_1, 1 hit PS00613 OSTEONECTIN_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P09486-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV 
        60         70         80         90        100
EVGEFDDGAE ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS 
       110        120        130        140        150
CPAPIGEFEK VCSNDNKTFD SSCHFFATKC TLEGTKKGHK LHLDYIGPCK 
       160        170        180        190        200
YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE RDEDNNLLTE KQKLRVKKIH 
       210        220        230        240        250
ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ HPIDGYLSHT 
       260        270        280        290        300
ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD 

LVI

Length:303

Mass (Da):34,632

Last modified:July 1, 1989 - v1

Checksum:ⁱB914599F79705945

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H4E2	F5H4E2_HUMAN	SPARC SPARC	SPARC	111	Annotation score:
E5RJA5	E5RJA5_HUMAN	SPARC SPARC	SPARC	53	Annotation score:
F5GY03	F5GY03_HUMAN	SPARC SPARC	SPARC	149	Annotation score:
E5RK62	E5RK62_HUMAN	SPARC SPARC	SPARC	115	Annotation score:

Sequence cautionⁱ

The sequence AAA60993 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	42 – 43	SV → PT AA sequence (PubMed:3597437).Curated	2
Sequence conflictⁱ	205	R → L in AAA60993 (PubMed:2790009).Curated	1
Sequence conflictⁱ	269	F → L in AAA60993 (PubMed:2790009).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050431	19	P → S. Corresponds to variant dbSNP:rs6874468Ensembl.	1
Natural variantⁱVAR_059530	70	N → S. Corresponds to variant dbSNP:rs13359508Ensembl.	1
Natural variantⁱVAR_075142	166	R → H in OI17; decreased secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517662Ensembl.	1
Natural variantⁱVAR_075143	263	E → K in OI17; no effect on expression and secretion of the protein; altered secretion of procollagen type I. 1 PublicationCorresponds to variant dbSNP:rs1057517663Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00755 mRNA Translation: CAA68724.1 J03040 mRNA Translation: AAA60570.1 M25746 M25745 Genomic DNA Translation: AAA60993.1 Sequence problems. CR456799 mRNA Translation: CAG33080.1 CH471062 Genomic DNA Translation: EAW61668.1 CH471062 Genomic DNA Translation: EAW61669.1 CH471062 Genomic DNA Translation: EAW61670.1 CH471062 Genomic DNA Translation: EAW61672.1 BC004974 mRNA Translation: AAH04974.1 BC008011 mRNA Translation: AAH08011.1 BC072457 mRNA Translation: AAH72457.1 AL709729 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4318.1
PIRⁱ	A32821 GEHUN
NCBI Reference Sequences More...RefSeqⁱ	NP_001296372.1, NM_001309443.1 NP_001296373.1, NM_001309444.1 NP_003109.1, NM_003118.3
UniGeneⁱ	Hs.111779

Genome annotation databases

Ensemblⁱ	ENST00000231061; ENSP00000231061; ENSG00000113140
GeneIDⁱ	6678
KEGGⁱ	hsa:6678
UCSC genome browser More...UCSCⁱ	uc003lui.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09486	SPARC		PONAB		303	UniRef100_P09486
SPARC isoform 1		PANTR		303
Uncharacterized protein		COLAP		303
Uncharacterized protein		RHIRO		303
Uncharacterized protein		PANPA		303
+6

Protein	Similar proteins		Species	Score	Length	Source
P09486	SPARC		PONAB		303	UniRef90_P09486
SPARC		BOVIN		303
SPARC isoform 1		PANTR		303
Uncharacterized protein		COLAP		303
Uncharacterized protein		RHIRO		303
+20

Protein	Similar proteins		Species	Score	Length	Source
P09486	SPARC		PONAB		303	UniRef50_P09486
SPARC		BOVIN		303
SPARC isoform 1		PANTR		303
Uncharacterized protein		COLAP		303
Uncharacterized protein		RHIRO		303
+27

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Osteonectin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00755 mRNA Translation: CAA68724.1 J03040 mRNA Translation: AAA60570.1 M25746 M25745 Genomic DNA Translation: AAA60993.1 Sequence problems. CR456799 mRNA Translation: CAG33080.1 CH471062 Genomic DNA Translation: EAW61668.1 CH471062 Genomic DNA Translation: EAW61669.1 CH471062 Genomic DNA Translation: EAW61670.1 CH471062 Genomic DNA Translation: EAW61672.1 BC004974 mRNA Translation: AAH04974.1 BC008011 mRNA Translation: AAH08011.1 BC072457 mRNA Translation: AAH72457.1 AL709729 mRNA No translation available.
CCDSⁱ	CCDS4318.1
PIRⁱ	A32821 GEHUN
RefSeqⁱ	NP_001296372.1, NM_001309443.1 NP_001296373.1, NM_001309444.1 NP_003109.1, NM_003118.3
UniGeneⁱ	Hs.111779

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BMO	X-ray	3.10	A/B	71-303	[»]
	1NUB	X-ray	2.80	A/B	71-303	[»]
	1SRA	X-ray	2.00	A	153-303	[»]
	2V53	X-ray	3.20	A	70-303	[»]
ProteinModelPortalⁱ	P09486
SMRⁱ	P09486
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112560, 11 interactors
DIPⁱ	DIP-46426N
IntActⁱ	P09486, 14 interactors
MINTⁱ	P09486
STRINGⁱ	9606.ENSP00000231061

PTM databases

GlyConnectⁱ	706
iPTMnetⁱ	P09486
PhosphoSitePlusⁱ	P09486
UniCarbKBⁱ	P09486

Polymorphism and mutation databases

BioMutaⁱ	SPARC
DMDMⁱ	129283

2D gel databases

OGPⁱ	P09486

OGPⁱ

P09486

Proteomic databases

EPDⁱ	P09486
MaxQBⁱ	P09486
PaxDbⁱ	P09486
PeptideAtlasⁱ	P09486
PRIDEⁱ	P09486
ProteomicsDBⁱ	52226

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6678
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000231061; ENSP00000231061; ENSG00000113140
GeneIDⁱ	6678
KEGGⁱ	hsa:6678
UCSCⁱ	uc003lui.5 human

Organism-specific databases

CTDⁱ	6678
DisGeNETⁱ	6678
EuPathDBⁱ	HostDB:ENSG00000113140.10
GeneCardsⁱ	SPARC
HGNCⁱ	HGNC:11219 SPARC
HPAⁱ	CAB002306 HPA002989 HPA003020
MalaCardsⁱ	SPARC
MIMⁱ	182120 gene 616507 phenotype
neXtProtⁱ	NX_P09486
OpenTargetsⁱ	ENSG00000113140
Orphanetⁱ	216820 Osteogenesis imperfecta type 4
PharmGKBⁱ	PA36055
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4004 Eukaryota ENOG41101WW LUCA
GeneTreeⁱ	ENSGT00510000046787
HOVERGENⁱ	HBG002746
InParanoidⁱ	P09486
OMAⁱ	KDFPRRM
OrthoDBⁱ	EOG091G0CPG
PhylomeDBⁱ	P09486
TreeFamⁱ	TF319356

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-3000178 ECM proteoglycans R-HSA-3000497 Scavenging by Class H Receptors
SIGNORⁱ	P09486

Miscellaneous databases

ChiTaRSⁱ	SPARC human
EvolutionaryTraceⁱ	P09486
GeneWikiⁱ	Osteonectin
GenomeRNAiⁱ	6678
PMAP-CutDBⁱ	P09486
Protein Ontology More...PROⁱ	PR:P09486
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113140 Expressed in 232 organ(s), highest expression level in tibia
CleanExⁱ	HS_SPARC
ExpressionAtlasⁱ	P09486 baseline and differential
Genevisibleⁱ	P09486 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR001999 Osteonectin_CS IPR037641 SPARC IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERⁱ	PTHR13866 PTHR13866, 1 hit
Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF00050 Kazal_1, 1 hit PF10591 SPARC_Ca_bdg, 1 hit
SMARTⁱ	View protein in SMART SM00274 FOLN, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS51465 KAZAL_2, 1 hit PS00612 OSTEONECTIN_1, 1 hit PS00613 OSTEONECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPRC_HUMAN
Accessionⁱ	P09486Primary (citable) accession number: P09486 Secondary accession number(s): D3DQH9, Q6IBK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 202 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P09486 (SPRC_HUMAN)

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SPARC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ